Thu H. Le, M.D.
The University of Rochester Medical Center (URMC) is one of the nation’s leading academic medical centers. It forms the centerpiece of the University of Rochester’s health research, teaching and patient care missions.

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University of Rochester Medical Center
Extracellular Vesicles in Kidney Diseases: Moving Forward.

Erdbrügger U, Hoorn EJ, Le TH, Blijdorp CJ, Burger D

Kidney360.. 2023 February 14 (2):245-257. Epub 12/18/2022.

Collectrin ( deficiency in proximal tubules causes hypertension in mice and a variant associates with blood pressure in males in a Latino cohort.

Chu PL, Gigliotti JC, Cechova S, Bodonyi-Kovacs G, Wang YT, Chen L, Wassertheil-Smoller S, Cai J, Isakson BE, Franceschini N, Le TH

American journal of physiology. Renal physiology.. 2023 January 1324 (1):F30-F42. Epub 10/20/2022.

The Clinicopathologic Spectrum of Membranous Nephropathy with Lupus-Like Features.

Choung HYG, Moore C, Le TH, Guirguis P, McKeown JM, Jean-Gilles J, Goldman B

Nephron.. 2023 147 (7):424-433. Epub 02/06/2023.

Role of in Hypertension, CKD, and Related Diseases across the Life Span.

Levy R, Le TH

Kidney360.. 2022 December 293 (12):2153-2163. Epub 10/18/2022.

The spectrum of renal diseases with lupus-like features: a single-center study.

Ahmed M, Love T, Moore C, Le TH, Jean-Gilles J, Goldman B, Choung HYG

Renal failure.. 2022 December 44 (1):581-593. Epub 1900 01 01.

TMEM27 expression and clinical characteristics and survival in clear cell renal cell carcinoma.

Grewal R, Choung HYG, Roberts LL, Beane T, Chen L, Gilroy DX, Rappold PM, Le TH

Acta oncologica.. 2022 December 61 (12):1507-1511. Epub 11/11/2022.

Association of GSTM1 Deletion With Progression of CKD in Children: Findings From the Chronic Kidney Disease in Children (CKiD) Study.

Levy RV, Reidy KJ, Le TH, David V, Winkler C, Xu Y, Warady B, Furth S, Kaskel F, Melamed ML

American journal of kidney diseases : the official journal of the National Kidney Foundation.. 2022 July 80 (1):79-86. Epub 12/04/2021.

Urine Uromodulin and Genetics of its Variation.

Franceschini N, Le TH

Journal of the American Society of Nephrology : JASN.. 2022 March 33 (3):461-462. Epub 1900 01 01.

Gene, Diet, and Kidney Disease: Implication for Precision Medicine?: Recent Advances in Hypertension.

Le TH

Hypertension.. 2021 September 78 (4):936-945. Epub 08/30/2021.

Eat Your Broccoli: Oxidative Stress, NRF2, and Sulforaphane in Chronic Kidney Disease.

Liebman SE, Le TH

Nutrients.. 2021 January 1813 (1)Epub 01/18/2021.

T cell-derived extracellular vesicles are elevated in essential HTN.

La Salvia S, Musante L, Lannigan J, Gigliotti JC, Le TH, Erdbrügger U

American journal of physiology. Renal physiology.. 2020 November 1319 (5):F868-F875. Epub 10/05/2020.

Vitamin K deficiency: an emerging player in the pathogenesis of vascular calcification and an iatrogenic consequence of therapies in advanced renal disease.

Levy DS, Grewal R, Le TH

American journal of physiology. Renal physiology.. 2020 October 1319 (4):F618-F623. Epub 08/24/2020.

Ethical challenges in nephrology: a call for action.

Martin DE, Harris DCH, Jha V, Segantini L, Demme RA, Le TH, McCann L, Sands JM, Vong G, Wolpe PR, Fontana M, London GM, Vanderhaegen B, Vanholder R,

Nature reviews. Nephrology.. 2020 October 16 (10):603-613. Epub 06/25/2020.

Pannexin 1 channels in renin-expressing cells influence renin secretion and blood pressure homeostasis.

DeLalio LJ, Masati E, Mendu S, Ruddiman CA, Yang Y, Johnstone SR, Milstein JA, Keller TCS, Weaver RB, Guagliardo NA, Best AK, Ravichandran KS, Bayliss DA, Sequeira-Lopez MLS, Sonkusare SN, Shu XH, Desai B, Barrett PQ, Le TH, Gomez RA, Isakson BE

Kidney international.. 2020 September 98 (3):630-644. Epub 05/21/2020.

Rigorous characterization of urinary extracellular vesicles (uEVs) in the low centrifugation pellet - a neglected source for uEVs.

Musante L, Bontha SV, La Salvia S, Fernandez-Piñeros A, Lannigan J, Le TH, Mas V, Erdbrügger U

Scientific reports.. 2020 February 2810 (1):3701. Epub 02/28/2020.

Deletion Exaggerates Kidney Injury in Experimental Mouse Models and Confers the Protective Effect of Cruciferous Vegetables in Mice and Humans.

Gigliotti JC, Tin A, Pourafshar S, Cechova S, Wang YT, Sung SJ, Bodonyi-Kovacs G, Cross JV, Yang G, Nguyen N, Chan F, Rebholz C, Yu B, Grove ML, Grams ME, Köttgen A, Scharpf R, Ruiz P, Boerwinkle E, Coresh J, Le TH

Journal of the American Society of Nephrology : JASN.. 2020 January 31 (1):102-116. Epub 11/14/2019.

Circulating Extracellular Vesicles in Normotension Restrain Vasodilation in Resistance Arteries.

Good ME, Musante L, La Salvia S, Howell NL, Carey RM, Le TH, Isakson BE, Erdbrügger U

Hypertension.. 2020 January 75 (1):218-228. Epub 11/25/2019.

Extracellular vesicles as a novel diagnostic and research tool for patients with HTN and kidney disease.

Erdbrügger U, Le TH

American journal of physiology. Renal physiology.. 2019 September 1317 (3):F641-F647. Epub 07/17/2019.

Loss of reticulocalbin 2 lowers blood pressure and restrains ANG II-induced hypertension in vivo.

Li J, Cechova S, Wang L, Isakson BE, Le TH, Shi W

American journal of physiology. Renal physiology.. 2019 June 1316 (6):F1141-F1150. Epub 04/03/2019.

Adrenal Tissue-Specific Deletion of TASK Channels Causes Aldosterone-Driven Angiotensin II-Independent Hypertension.

Guagliardo NA, Yao J, Stipes EJ, Cechova S, Le TH, Bayliss DA, Breault DT, Barrett PQ

Hypertension.. 2019 February 73 (2):407-414. Epub 1900 01 01.

Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies.

Morris AP, Le TH, Wu H, Akbarov A, van der Most PJ, Hemani G, Smith GD, Mahajan A, Gaulton KJ, Nadkarni GN, Valladares-Salgado A, Wacher-Rodarte N, Mychaleckyj JC, Dueker ND, Guo X, Hai Y, Haessler J, Kamatani Y, Stilp AM, Zhu G, Cook JP, Ärnlöv J, Blanton SH, de Borst MH, Bottinger EP, Buchanan TA, Cechova S, Charchar FJ, Chu PL, Damman J, Eales J, Gharavi AG, Giedraitis V, Heath AC, Ipp E, Kiryluk K, Kramer HJ, Kubo M, Larsson A, Lindgren CM, Lu Y, Madden PAF, Montgomery GW, Papanicolaou GJ, Raffel LJ, Sacco RL, Sanchez E, Stark H, Sundstrom J, Taylor KD, Xiang AH, Zivkovic A, Lind L, Ingelsson E, Martin NG, Whitfield JB, Cai J, Laurie CC, Okada Y, Matsuda K, Kooperberg C, Chen YI, Rundek T, Rich SS, Loos RJF, Parra EJ, Cruz M, Rotter JI, Snieder H, Tomaszewski M, Humphreys BD, Franceschini N

Nature communications.. 2019 January 310 (1):29. Epub 01/03/2019.

RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na/H exchanger.

Artamonov MV, Sonkusare SK, Good ME, Momotani K, Eto M, Isakson BE, Le TH, Cope EL, Derewenda ZS, Derewenda U, Somlyo AV

Science signaling.. 2018 October 3011 (554)Epub 10/30/2018.

Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension.

Brown IAM, Diederich L, Good ME, DeLalio LJ, Murphy SA, Cortese-Krott MM, Hall JL, Le TH, Isakson BE

Arteriosclerosis, thrombosis, and vascular biology.. 2018 September 38 (9):1969-1985. Epub 1900 01 01.

E1841K Mutation Augments Proteinuria and Podocyte Injury and Migration.

Cechova S, Dong F, Chan F, Kelley MJ, Ruiz P, Le TH

Journal of the American Society of Nephrology : JASN.. 2018 January 29 (1):155-167. Epub 10/09/2017.

The Loss of Associates with Kidney Failure and Heart Failure.

Tin A, Scharpf R, Estrella MM, Yu B, Grove ML, Chang PP, Matsushita K, Köttgen A, Arking DE, Boerwinkle E, Le TH, Coresh J, Grams ME

Journal of the American Society of Nephrology : JASN.. 2017 November 28 (11):3345-3352. Epub 07/18/2017.

in the Kidney-Unraveling the Molecular Mechanism Underlying Renal Damage in Salt-Sensitive Hypertension.

Gigliotti JC, Le TH

Journal of the American Society of Nephrology : JASN.. 2017 November 28 (11):3131-3133. Epub 10/16/2017.

Genome-Wide Association Study of Blood Pressure Traits by Hispanic/Latino Background: the Hispanic Community Health Study/Study of Latinos.

Sofer T, Wong Q, Hartwig FP, Taylor K, Warren HR, Evangelou E, Cabrera CP, Levy D, Kramer H, Lange LA, Horta BL, , Kerr KF, Reiner AP, Franceschini N

Scientific reports.. 2017 September 47 (1):10348. Epub 09/04/2017.

Testing the trajectory difference in a semi-parametric longitudinal model.

Niu F, Zhou J, Le TH, Ma JZ

Statistical methods in medical research.. 2017 June 26 (3):1519-1531. Epub 05/13/2015.

Renal Collectrin Protects against Salt-Sensitive Hypertension and Is Downregulated by Angiotensin II.

Chu PL, Gigliotti JC, Cechova S, Bodonyi-Kovacs G, Chan F, Ralph DL, Howell N, Kalantari K, Klibanov AL, Carey RM, McDonough AA, Le TH

Journal of the American Society of Nephrology : JASN.. 2017 June 28 (6):1826-1837. Epub 01/06/2017.

Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.

Liang J, Le TH, Edwards DRV, Tayo BO, Gaulton KJ, Smith JA, Lu Y, Jensen RA, Chen G, Yanek LR, Schwander K, Tajuddin SM, Sofer T, Kim W, Kayima J, McKenzie CA, Fox E, Nalls MA, Young JH, Sun YV, Lane JM, Cechova S, Zhou J, Tang H, Fornage M, Musani SK, Wang H, Lee J, Adeyemo A, Dreisbach AW, Forrester T, Chu PL, Cappola A, Evans MK, Morrison AC, Martin LW, Wiggins KL, Hui Q, Zhao W, Jackson RD, Ware EB, Faul JD, Reiner AP, Bray M, Denny JC, Mosley TH, Palmas W, Guo X, Papanicolaou GJ, Penman AD, Polak JF, Rice K, Taylor KD, Boerwinkle E, Bottinger EP, Liu K, Risch N, Hunt SC, Kooperberg C, Zonderman AB, Laurie CC, Becker DM, Cai J, Loos RJF, Psaty BM, Weir DR, Kardia SLR, Arnett DK, Won S, Edwards TL, Redline S, Cooper RS, Rao DC, Rotter JI, Rotimi C, Levy D, Chakravarti A, Zhu X, Franceschini N

PLoS genetics.. 2017 May 13 (5):e1006728. Epub 05/12/2017.

ACE2 and the Homolog Collectrin in the Modulation of Nitric Oxide and Oxidative Stress in Blood Pressure Homeostasis and Vascular Injury.

Yang G, Chu PL, Rump LC, Le TH, Stegbauer J

Antioxidants & redox signaling.. 2017 April 2026 (12):645-659. Epub 01/12/2017.

Dependence of Glomerulonephritis Induction on Novel Intraglomerular Alternatively Activated Bone Marrow-Derived Macrophages and Mac-1 and PD-L1 in Lupus-Prone NZM2328 Mice.

Sung SJ, Ge Y, Dai C, Wang H, Fu SM, Sharma R, Hahn YS, Yu J, Le TH, Okusa MD, Bolton WK, Lawler JR

The Journal of immunology : official journal of the American Association of Immunologists.. 2017 April 1198 (7):2589-2601. Epub 02/20/2017.

Cross-Presentation of Soluble and Cell-Associated Antigen by Murine Hepatocytes Is Enhanced by Collectrin Expression.

Dolina JS, Cechova S, Rudy CK, Sung SJ, Tang WW, Lee J, Hahn YS, Le TH

The Journal of immunology : official journal of the American Association of Immunologists.. 2017 March 15198 (6):2341-2351. Epub 02/03/2017.

Proximal Tubule CD73 Is Critical in Renal Ischemia-Reperfusion Injury Protection.

Sung SJ, Li L, Huang L, Lawler J, Ye H, Rosin DL, Vincent IS, Le TH, Yu J, Görldt N, Schrader J, Okusa MD

Journal of the American Society of Nephrology : JASN.. 2017 March 28 (3):888-902. Epub 09/14/2016.

Rare variants in fox-1 homolog A (RBFOX1) are associated with lower blood pressure.

He KY, Wang H, Cade BE, Nandakumar P, Giri A, Ware EB, Haessler J, Liang J, Smith JA, Franceschini N, Le TH, Kooperberg C, Edwards TL, Kardia SL, Lin X, Chakravarti A, Redline S, Zhu X

PLoS genetics.. 2017 March 13 (3):e1006678. Epub 03/27/2017.

Modulating Vascular Hemodynamics With an Alpha Globin Mimetic Peptide (Hb?X).

Keller TC, Butcher JT, Broseghini-Filho GB, Marziano C, DeLalio LJ, Rogers S, Ning B, Martin JN, Chechova S, Cabot M, Shu X, Best AK, Good ME, Simão Padilha A, Purdy M, Yeager M, Peirce SM, Hu S, Doctor A, Barrett E, Le TH, Columbus L, Isakson BE

Hypertension.. 2016 December 68 (6):1494-1503. Epub 10/31/2016.

Combined Effects of GSTM1 Null Allele and APOL1 Renal Risk Alleles in CKD Progression in the African American Study of Kidney Disease and Hypertension Trial.

Bodonyi-Kovacs G, Ma JZ, Chang J, Lipkowitz MS, Kopp JB, Winkler CA, Le TH

Journal of the American Society of Nephrology : JASN.. 2016 October 27 (10):3140-3152. Epub 03/03/2016.

Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity.

Mahajan A, Rodan AR, Le TH, Gaulton KJ, Haessler J, Stilp AM, Kamatani Y, Zhu G, Sofer T, Puri S, Schellinger JN, Chu PL, Cechova S, van Zuydam N, , , Arnlov J, Flessner MF, Giedraitis V, Heath AC, Kubo M, Larsson A, Lindgren CM, Madden PAF, Montgomery GW, Papanicolaou GJ, Reiner AP, Sundström J, Thornton TA, Lind L, Ingelsson E, Cai J, Martin NG, Kooperberg C, Matsuda K, Whitfield JB, Okada Y, Laurie CC, Morris AP, Franceschini N

American journal of human genetics.. 2016 September 199 (3):636-646. Epub 1900 01 01.

Extracellular Vesicles in Renal Diseases: More than Novel Biomarkers?

Erdbrügger U, Le TH

Journal of the American Society of Nephrology : JASN.. 2016 January 27 (1):12-26. Epub 08/06/2015.

Epigenetics in Kidney Transplantation: Current Evidence, Predictions, and Future Research Directions.

Mas VR, Le TH, Maluf DG

Transplantation.. 2016 January 100 (1):23-38. Epub 1900 01 01.

A molecular signature in the pannexin1 intracellular loop confers channel activation by the ?1 adrenoreceptor in smooth muscle cells.

Billaud M, Chiu YH, Lohman AW, Parpaite T, Butcher JT, Mutchler SM, DeLalio LJ, Artamonov MV, Sandilos JK, Best AK, Somlyo AV, Thompson RJ, Le TH, Ravichandran KS, Bayliss DA, Isakson BE

Science signaling.. 2015 February 178 (364):ra17. Epub 02/17/2015.

Hemoglobin ?/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction.

Straub AC, Butcher JT, Billaud M, Mutchler SM, Artamonov MV, Nguyen AT, Johnson T, Best AK, Miller MP, Palmer LA, Columbus L, Somlyo AV, Le TH, Isakson BE

Arteriosclerosis, thrombosis, and vascular biology.. 2014 December 34 (12):2594-600. Epub 10/02/2014.

Role of collectrin, an ACE2 homologue, in blood pressure homeostasis.

Chu PL, Le TH

Current hypertension reports.. 2014 November 16 (11):490. Epub 1900 01 01.

Genetics of hypertension: discoveries from the bench to human populations.

Franceschini N, Le TH

American journal of physiology. Renal physiology.. 2014 January 1306 (1):F1-F11. Epub 10/16/2013.

Loss of collectrin, an angiotensin-converting enzyme 2 homolog, uncouples endothelial nitric oxide synthase and causes hypertension and vascular dysfunction.

Cechova S, Zeng Q, Billaud M, Mutchler S, Rudy CK, Straub AC, Chi L, Chan FR, Hu J, Griffiths R, Howell NL, Madsen K, Jensen BL, Palmer LA, Carey RM, Sung SS, Malakauskas SM, Isakson BE, Le TH

Circulation.. 2013 October 15128 (16):1770-80. Epub 09/18/2013.

Loss of GSTM1, a NRF2 target, is associated with accelerated progression of hypertensive kidney disease in the African American Study of Kidney Disease (AASK).

Chang J, Ma JZ, Zeng Q, Cechova S, Gantz A, Nievergelt C, O'Connor D, Lipkowitz M, Le TH

American journal of physiology. Renal physiology.. 2013 February 15304 (4):F348-55. Epub 12/05/2012.

Effects of the antioxidant drug tempol on renal oxygenation in mice with reduced renal mass.

Lai EY, Luo Z, Onozato ML, Rudolph EH, Solis G, Jose PA, Wellstein A, Aslam S, Quinn MT, Griendling K, Le T, Li P, Palm F, Welch WJ, Wilcox CS

American journal of physiology. Renal physiology.. 2012 July 1303 (1):F64-74. Epub 04/04/2012.

Angiotensin II acts through the angiotensin 1a receptor to upregulate pendrin.

Verlander JW, Hong S, Pech V, Bailey JL, Agazatian D, Matthews SW, Coffman TM, Le T, Inagami T, Whitehill FM, Weiner ID, Farley DB, Kim YH, Wall SM

American journal of physiology. Renal physiology.. 2011 December 301 (6):F1314-25. Epub 09/14/2011.

AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure.

Gurley SB, Riquier-Brison ADM, Schnermann J, Sparks MA, Allen AM, Haase VH, Snouwaert JN, Le TH, McDonough AA, Koller BH, Coffman TM

Cell metabolism.. 2011 April 613 (4):469-475. Epub 1900 01 01.

Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension.

Sparks MA, Parsons KK, Stegbauer J, Gurley SB, Vivekanandan-Giri A, Fortner CN, Snouwaert J, Raasch EW, Griffiths RC, Haystead TA, Le TH, Pennathur S, Koller B, Coffman TM

Hypertension.. 2011 March 57 (3):577-85. Epub 01/17/2011.

Cardiac phenotype and angiotensin II levels in AT1a, AT1b, and AT2 receptor single, double, and triple knockouts.

van Esch JH, Gembardt F, Sterner-Kock A, Heringer-Walther S, Le TH, Lassner D, Stijnen T, Coffman TM, Schultheiss HP, Danser AH, Walther T

Cardiovascular research.. 2010 June 186 (3):401-9. Epub 01/12/2010.

Glutathione S-transferase-micro1 regulates vascular smooth muscle cell proliferation, migration, and oxidative stress.

Yang Y, Parsons KK, Chi L, Malakauskas SM, Le TH

Hypertension.. 2009 December 54 (6):1360-8. Epub 10/12/2009.

Systemic polyarteritis nodosa mimicking pyoderma gangrenosum in a rare association with small lymphocytic leukaemia/chronic lymphocytic leukaemia.

Branagan NM, Higgins SP, Halim SA, Le TH

Clinical and experimental dermatology.. 2009 July 34 (5):e127-9. Epub 04/27/2009.

Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha.

Malakauskas SM, Kourany WM, Zhang XY, Lu D, Stevens RD, Koves TR, Hohmeier HE, Muoio DM, Newgard CB, Le TH

Molecular endocrinology.. 2009 June 23 (6):881-92. Epub 02/26/2009.

Collectrin is involved in the development of salt-sensitive hypertension by facilitating the membrane trafficking of apical membrane proteins via interaction with soluble N-ethylmaleiamide-sensitive factor attachment protein receptor complex.

Yasuhara A, Wada J, Malakauskas SM, Zhang Y, Eguchi J, Nakatsuka A, Murakami K, Kanzaki M, Teshigawara S, Yamagata K, Le TH, Makino H

Circulation.. 2008 November 18118 (21):2146-55. Epub 11/03/2008.

Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptors.

Gembardt F, Heringer-Walther S, van Esch JH, Sterner-Kock A, van Veghel R, Le TH, Garrelds IM, Coffman TM, Danser AH, Schultheiss HP, Walther T

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2008 August 22 (8):3068-77. Epub 05/22/2008.

Targeting genes in the renin-angiotensin system.

Le TH, Coffman TM

Current opinion in nephrology and hypertension.. 2008 January 17 (1):57-63. Epub 1900 01 01.

Hypertension and albuminuria in chronic kidney disease mapped to a mouse chromosome 11 locus.

Salzler HR, Griffiths R, Ruiz P, Chi L, Frey C, Marchuk DA, Rockman HA, Le TH

Kidney international.. 2007 November 72 (10):1226-32. Epub 09/12/2007.

Aminoaciduria and altered renal expression of luminal amino acid transporters in mice lacking novel gene collectrin.

Malakauskas SM, Quan H, Fields TA, McCall SJ, Yu MJ, Kourany WM, Frey CW, Le TH

American journal of physiology. Renal physiology.. 2007 February 292 (2):F533-44. Epub 09/19/2006.

Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.

Crowley SD, Gurley SB, Herrera MJ, Ruiz P, Griffiths R, Kumar AP, Kim HS, Smithies O, Le TH, Coffman TM

Proceedings of the National Academy of Sciences of the United States of America.. 2006 November 21103 (47):17985-90. Epub 11/07/2006.

Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice.

Gurley SB, Allred A, Le TH, Griffiths R, Mao L, Philip N, Haystead TA, Donoghue M, Breitbart RE, Acton SL, Rockman HA, Coffman TM

The Journal of clinical investigation.. 2006 August 116 (8):2218-25. Epub 07/27/2006.

A new cardiac MASTer switch for the renin-angiotensin system.

Le TH, Coffman TM

The Journal of clinical investigation.. 2006 April 116 (4):866-9. Epub 1900 01 01.

Th1 inflammatory response with altered expression of profibrotic and vasoactive mediators in AT1A and AT1B double-knockout mice.

Ouyang X, Le TH, Roncal C, Gersch C, Herrera-Acosta J, Rodriguez-Iturbe B, Coffman TM, Johnson RJ, Mu W

American journal of physiology. Renal physiology.. 2005 October 289 (4):F902-10. Epub 05/31/2005.

Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system.

Crowley SD, Gurley SB, Oliverio MI, Pazmino AK, Griffiths R, Flannery PJ, Spurney RF, Kim HS, Smithies O, Le TH, Coffman TM

The Journal of clinical investigation.. 2005 April 115 (4):1092-9. Epub 1900 01 01.

A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice.

Le TH, Oliverio MI, Kim HS, Salzler H, Dash RC, Howell DN, Smithies O, Bronson S, Coffman TM

Physiological genomics.. 2004 August 1118 (3):290-8. Epub 08/11/2004.

Modifier locus on mouse chromosome 3 for renal vascular pathology in AT1A receptor-deficiency.

Le TH, Fogo AB, Salzler HR, Vinogradova T, Oliverio MI, Marchuk DA, Coffman TM

Hypertension.. 2004 February 43 (2):445-51. Epub 01/12/2004.

Physiological impact of increased expression of the AT1 angiotensin receptor.

Le TH, Kim HS, Allen AM, Spurney RF, Smithies O, Coffman TM

Hypertension.. 2003 October 42 (4):507-14. Epub 09/08/2003.

RGS2: a &quot;turn-off&quot; in hypertension.

Le TH, Coffman TM

The Journal of clinical investigation.. 2003 February 111 (4):441-3. Epub 1900 01 01.

Gene-targeting studies of the renin-angiotensin system: mechanisms of hypertension and cardiovascular disease.

Gurley SB, Le TH, Coffman TM

Cold Spring Harbor symposia on quantitative biology.. 2002 67 :451-7. Epub 1900 01 01.

What can knockout mice contribute to an understanding of hypertension?

Audoly LP, Le TH, Coffman TM

Current hypertension reports.. 2000 April 2 (2):192-7. Epub 1900 01 01.

Genetic manipulation of the renin-angiotensin system.

Le TH, Coffman TM

Current opinion in nephrology and hypertension.. 1999 July 8 (4):397-403. Epub 1900 01 01.

Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II.

Oliverio MI, Kim HS, Ito M, Le T, Audoly L, Best CF, Hiller S, Kluckman K, Maeda N, Smithies O, Coffman TM

Proceedings of the National Academy of Sciences of the United States of America.. 1998 December 2295 (26):15496-501. Epub 1900 01 01.