Scientific Publications
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PPGFQM
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2019

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Silva, J.S. ; Sun,X. ; Ahmad, S. ; Wang, H. ; Sudo, R.T. ; Varagic,J. ; Ferrario, C.M. ; Sudo, G.Z. ; Groban, L . G-Protein-Coupled-Estrogen agonist g1 improves diastolic function and attenuates cardiac ras activation in estrogen-deficient hypertensive rats. Journal of cardiovascular pharmacology , v. 1, p. 1, 2019.

Doi: 10.1097/fjc.0000000000000721

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Felix, N.S. ; Mendonça,L. ; Braga, C.L. ; Silva, J.S. ; Samary, C.S. ; Vieira, J.B. ; Cruz, F. ; Rocha, N.N. ; Sudo, G.Z. ; Rocco, P.R.M. ; Silva, P.L. Effects of infigratinib, new fibroblast growth factor receptor-1 inhibitor, with or without sildenafil in experimental pulmonary arterial hypertension. British journal of pharmacology , v. 1, p. `1, 2019.

Doi: 10.1111/bph.14807

Alves, B.E.O. ; Alencar, A.K.N. ; Gamba, L.E.R. ; Trachez, M.M.. ; Silva, J.S. ; Araújo, J.S.C. ; Montagnoli, T.L. ; Mendes, L.V.P. ; Coelho, P.M.P. ; Cunha, V.M.N. ; Otero, R.M.; Oliveira, G.M.M. ; Lima, L.M. ; Barreiro, E.J. ; sudo, roberto t. ; Sudo, G.Z . Reduction of cardiac and renal dysfunction by new inhibitor of dpp4 in diabetic rats. Pharmacological reports , v. 1, p. 1, 2019.

Doi:10.1016/j.pharep.2019.07.005

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Barbosa, J. N. ; Hernandez, R. A.; Barros, E.O. ; Branco, L. A. C. ; Feijo, P. R. O. ; Romeiro, L. A. S. ; Nasciutti, L. E. ; Noël, F.G. ; Sainz, J. A.G.; Silva, C. L. M. The α1-adrenoceptor-mediated human hyperplastic prostate cells proliferation is impaired by egf receptor inhibition. Life sciences , v. 239, p. 117048, 2019.

Doi: 10.1016/j.lfs.2019.117048

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Dias, F.C. ; Alves, V.S. ; Matias, D.O. ; Figueiredo, C.P. ; Miranda, A.L.P. ; Passos, G.F. ; Costa, R . The selective trpv4 channel antagonist hc-067047 attenuates mechanical allodynia in diabetic mice. European journal of pharmacology, v. 856, p. 172408, 2019.

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Doi: 10.1016/j.ejphar.2019.172408

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Silva, R. C. ; Veiga, F. ; Vilela, F.C. ; Pereira, A.V. ; Cunha,T.T.S, ; Tesch, R ; Viegas, C. ; Dias, D.F. ; Giusti-paiva, Alexandre ; Veloso, M.P.; Fraga, C.A.M . Design, synthesis and pharmacological evaluation of novel anti-inflammatory and analgesic o-benzyloxime compounds derived from natural eugenol. Letters in drug design & discovery, v. 15, p. 1157-1166, 2019.

Doi : 10.2174/1570180815666180620145609

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Silva, R.R ; Silva, L. T. P. ; Pompeu, T. E.T. ; Duarte, D.A. ; Fraga, C. A.M. ; Barreiro, E. J. ; Menegatti, R; Costa-neto,C. M. ; Noël, F . Evaluation of functional selectivity of haloperidol, clozapine, and lassbio-579, an experimental compound with antipsychotic-like actions in rodents, at g protein and arrestin signaling downstream of the dopamine d2 receptor. Frontiers in pharmacology, v. 10, p. 628, 2019.

Doi: 10.3389/fphar.2019.00628

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Rodrigues, D.A. ; Sagrillo, F.S . ; Fraga, C.A. M. Duvelisib: a 2018 novel fda-approved small molecule inhibiting phosphoinositide 3-kinases. Pharmaceuticals, v. 12, p. 69, 2019.

Doi:10.3390/ph12020069

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Monteiro, C.E.S. ; Franco, A.X. ; Sousa, J.A.O. ; Matos, V.E.A. ; Souza, E.P. ; Fraga, C.A.M.; Barreiro, E.J. ; Souza, M.H.L.P. ; Soares, P.M.G. ; Barbosa, A.L.R . Gastroprotective effects of n-acylarylhydrazone derivatives on ethanol-induced gastric lesions in mice are dependent on the no/cgmp/katp pathway. Biochemical pharmacology, v. 169, p. 113629, 2019.

Doi: 10.1016/j.bcp.2019.113629

Pinheiro, P.S. M.; Rodrigues, D.A. ; Maia, R. C. ; Thota, S ; Fraga, C. A. M. The use of conformational restriction in medicinal chemistry. Current topics in medicinal chemistry, v. 19, p. 1712-1733, 2019.

Doi: 10.2174/1568026619666190712205025

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Fraga, C.A.M. Strategies and tactics in medicinal chemistry. Current topics in medicinal chemistry, v. 19, p. 1677-1678, 2019.

Doi : 10.2174/156802661919191021122941

Predes, D. ; Oliveira, L. F. S. ; Ferreira, L. S. S. ; Maia, L.A.. ; Delou, J.M. A. ; Faletti, A ; Oliveira, I. ; Amado, N.G. ; Reis, A.H. ; Fraga, C.A. M. ; Kuster, R. ; Mendes, F.A. ; Borges, H. l. ; Abreu, J.G. The chalcone lonchocarpin inhibits wnt/β-catenin signaling and suppresses colorectal cancer proliferation. Cancers, v. 11, p. 1968, 2019.

Doi: 10.3390/cancers11121968

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Oliveira, S. D. S. ; Chen,J. ; Castellon, M. ; Mao, M. ; Raj,J. U. ; Comhair, S. ; Erzurum, S. ; Silva, C.L.M ; Machado, R. F. ; Bonini, M. G. ; Minshall, R. Injury-induced shedding of extracellular vesicles depletes endothelial cells of cav-1 (caveolin-1) and enables tgf-β (transforming growth factor-β)-dependent pulmonary arterial hypertension. Arteriosclerosis thrombosis and vascular biology , v. 39, p. 1, 2019.

Doi:10.1161/atvbaha.118.312038

Chaves, M. M. ; Sinflorio, D. A. ; Thorstenberg, M. L. ; Martins, M. D. A. ; Souza, A. C. A.M. ; Rangel, T. P. ; Silva, C.L.M. ; Bellio, M. ; Canetti, C. ; Silva, R.C. Non-canonical nlrp3 inflammasome activation and il-1β signaling are necessary to l. Amazonensis control mediated by p2x7 receptor and leukotriene b4. Plos pathogens , v. 15, p. E1007887, 2019.

Doi:10.1371/journal.ppat.1007887

Quaresma, B.M.C.S. ; Pimenta, A.R. ; Silva, A.C.S ; Pupo, A.S. ; Romeiro, L.A.S. ; Silva, C.L.M ; Noel, F.G . Revisiting the pharmacodynamics uroselectivity of alpha1-adrenergic receptor antagonists. Journal of pharmacology and experimental therapeutics , v. 270, p. Jpet.119.260216, 2019.

Doi:10.1124/jpet.119.260216

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Amaral, D.N.; Lategahn,J. ; Fokoue, H.H. ; Silva, E.M.B. ; Sant’anna, C.M.R. ; Rauh, D. ; Barreiro, E.J.. ; Laufer, S. ; Lima, L.M . A novel scaffold for egfr inhibition: introducing n-(3-(3-phenylureido)quinoxalin-6-yl) acrylamide derivatives. Scientific reports , v. 9, p. 1-12, 2019.

Doi:10.1038/s41598-018-36846-7

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Queiroz, A.C. ; Alves, M.A. ; Barreiro, E.J. ; Lima, L.M. ; Moreira, M.S.A . Semicarbazone derivatives as promising therapeutic alternatives in leishmaniasis. Experimental parasitology , v. 201, p. 57-66, 2019.

Doi:10.1016/j.exppara.2019.04.003

Barreiro, E.J. What is hidden in the biodiversity? The role of natural products and medicinal chemistry in the drug discovery process. Anais da academia brasileira de ciências (online) , v. 91, p. E20190306-e20190306, 2019.

Doi:10.1590/0001-3765201920190306

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Camaforte, N.A. P. ; Saldanha, L.L. ; Vareda, P. M. P. ; Neto, J.M.R. ; Senger, M.R. ; Delgado, A.Q.; Morgan, H. J. N. ; Violato, N. M. ; Pieroni, L.G. ; Dokkedal, A.L. ; Júnior, F.P.S. ; Bosqueiro, J.R. Hypoglycaemic activity of bauhinia holophylla through gsk3-β inhibition and glycogenesis activation. Pharmaceutical biology , v. 57, p. 269-279, 2019.

Doi: 10.1080/13880209.2019.1599962

Merigueti, T. ; Carneiro, M. W. ; Assef, A. P. D. C. ; Júnior, F.P.S. ; Silva, F. A. B. Findtargetsweb: a user-friendly tool for identification of potential therapeutic targets in metabolic networks of bacteria. Frontiers in genetics , v. 10, p. 1-14, 2019.

Doi: 10.3389/fgene.2019.00633

Pereyra, C.E. ; Dantas, R.F. ; Ferreira, S.B. ; Gomes, L.P. ; Júnior, F.PS. The diverse mechanisms and anticancer potential of naphthoquinones. Cancer cell international , v. 19, p. 1-20, 2019.

Doi:10.1186/s12935-019-0925

Dantas, R.F. ; Senger, M.R. ; Cardoso, M.F. C. ; Ferreira, V.F. ; Souza, M.C. B. V. ; Silva, F.C. ; Jùnior, F.P.S. Screening of 1,2-furanonaphthoquinones 1,2,3-1h-triazoles for glycosidases inhibitory activity and free radical scavenging potential: an insight in anticancer activity. Medicinal chemistry research , v. 28, p. 1579-1588, 2019.

Doi:10.1007/s00044-019-02396-4

Dantas, R.F. ; Evangelista, T.C.S. ; Neves, B.J. ; Senger, M.R. ; Andrade, C.H. ; Ferreira, S.B. ; Junior, F.P.S . Dealing with frequent hitters in drug discovery: a multidisciplinary view on the issue of filtering compounds on biological screenings. Expert opinion on drug discovery , p. 1-14, 2019.

Doi: 10.1080/17460441.2019.1654453

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Torres, P.H. M. ; Sodero, A.C. R. ; Jofily, P. ; Jùnior, F.P.S. Key topics in molecular docking for drug design. International journal of molecular sciences , v. 20, p. 4574, 2019.

Doi: 10.3390/ijms20184574

Lopes, J.P.B. ; Silva, L. ; Ceschi, M.A. ; Lüdtke, D.S. ; Zimmer, A.R. ; Ruaro, T.C. ; Dantas, R.F. ; Salles, C.M.C. ; Júnior, F.P.S. ; Senger,M.R. ; Barbosa, G. ; Lima, L.M. ; Guedes, I.A. ; Dardenne, L.E . Synthesis of new lophine-carbohydrate hybrids as cholinesterase inhibitors: cytotoxicity evaluation and molecular modeling. Medchemcomm , p. 99, 2019.

Doi:10.1039/c9md00358d

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Neves, G.; Grace, A. A. Α7 nicotinic receptor full agonist reverse basolateral amygdala hyperactivity and attenuation of dopaminergic neuron activity in rats exposed to chronic mild stress. European neuropsychopharmacology , v. 10/12, p. 1, 2019.

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Doi: 10.1016/j.euroneuro.2019.09.009

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Monteiro, J. ; Lemos, G.A. ; Ferreira, E.S. ; Marques, A. M. ; Neves, G. ; Silveira, M. S. ; Galina, A. Energization by multiple substrates and calcium challenge reveal dysfunctions in brain mitochondria in a model related to acute psychosis. Journal of bioenergetics and biomembranes , v. 1, p. 1, 2019.

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Doi: 10.1007/s10863-019-09816-5

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Akuthota, P. ; Neves, J.S. ; Ueki, S . Editorial: severe eosinophilic disorders: mechanisms and clinical management. Frontiers in immunology , v. 10, 2019.

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Neto, F.M. ; Matos, M.S. ; Costa, A.C.R. ; Reis, R.A.M. ; Atella, G.C. ; Alves, L.M. ; Carvalho, D.P. ; Ketzer, L.A. ; Costa, V.M.C . Brown adipose tissue remodeling induced by corticosterone in wistar male rats. Experimental physiology , v. 104, p. 514-528, 2019.

Doi: 10.1113/ep087332

Portovedo, S. ; Gaido, N. ; Nunes, B. ; Nascimento, A. G. ; Rocha, A. ; Magalhaes, M. ; Nascimento, G. ; Carvalho, D.P. ; Soares, P. ; Takiya, C. ; Faria, M. S. ; Alves, L.M . Differential expression of hmga1 and hmga2 in pituitary neuroendocrine tumors. Molecular and cellular endocrinology , v. 19, p. 30110-30118, 2019.

Doi:10.1016/j.mce.2019.04.010

Silva, M.M. ; Gonçalves, C.F.L. ; Alves, L.M. ; Fortunato, R.S. ; Carvalho, D.P. ; Ferreira, A.C.F . Inhibition of type 1 iodothyronine deiodinase by bisphenol a. Hormone and metabolic research , v. 51, p. 671-677, 2019.

Doi: 10.1055/a-0919-3879

Costa, C. S. ; Alves, L.M. ; Merrill, M. A. L. ; Silva, L. V. ; Graceli, J. B. The tributyltin leads to obesogenic mammary gland abnormalities in adult female rats. Toxicology letters , v. 307, p. 59-71, 2019.

Doi: 10.1016/j.toxlet.2019.02.016

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Lima, L.M.; Alves, M.A. ; Amaral, D.N . Homologation: a versatile molecular modification strategy to drug discovery. Current topics in medicinal chemistry , v. 19, p. 1-17, 2019.

Doi : 10.2174/1568026619666190808145235

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Gonsalez, S.R. ; Cortês, A.L. ; Silva, R.C. ; Lowe,J. ; Prieto, M.C. ; Lara, L.S . Acute kidney injury overview: from basic findings to new prevention and therapy strategies. Pharmacology & therapeutics , v. 200, p. 1-12, 2019.

Doi: 10.1016/j.pharmthera.2019.04.001

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Pereira, D. G. ; Rendeiro, M. M. ; Cortes, V. F. ; Barbosa, L.A. ; Quintas, L. E. M. . Antagonistic anticancer effect of paclitaxel and digoxin combination. Journal of cellular biochemistry , v. 1, p. 1, 2019.

Doi:10.1002/jcb.28583

Carvalho, D. C. M. ; Silva, L. H. C. ; Lima, E. A. ; Galvao, J. ; Alves, A. ; Feijo, P.R. ; Quintas, L. E. M. ; Mascarenhas, S. . Marinobufagenin inhibits neutrophil migration and proinflammatory cytokines. Journal of immunology research , v. 2019, p. 1-11, 2019.

Doi:10.1155/2019/1094520

Bastos, U. M. C. ; Rosa, I. A. ; Teixeira, J. D. ; Santos, G. G. ; Costa, M. L. ; Quintas, L. E. M. ; Mermelstein, C. Isoproterenol induces an increase in muscle fiber size by the proliferation of pax7 positive cells and in a mtor independent mechanism. Cell biology international , v. 1, p. 1-10, 2019.

Doi:10.1002/cbin.11190

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Chater, J.M. ; Mathon, C. ; Larive, C.K. ; Merhaut, D.J. ; Tinoco, L.W. ; Mauk, P.A. ; Jia, Z. ; Preece, J.E. Juice quality traits, potassium content, and 1h nmr derived metabolites of 14 pomegranate cultivars. Journal of berry research, v. 9, p. 1-17, 2019.

Doi: 10.3233/jbr-180344

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Nirma, C.; Rangel, G.T. ; Alves, M.A. ; Casanova,L.M. ; Moreira, M.M. ; Rodrigues, L.M.; Hamerski, L. ; Tinoco, L.W . New nucleoside hydrolase inhibitors from brazilian flora. Rsc advances , v. 9, p. 18663-18669, 2019.

Doi: 10.1039/c9ra02382h

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Figueiredo, C. P. ; Aragao, F. G. Q.B. ; Neris, R. L. S. ; Frost, P. S. ; Mello, C. S. P. S. ; Souza, I. N. O. ; Zeidler, J. D. ; Zamberlan, D. C. ; Sousa, V. L. ; Souza, A. S. ; Guimaraes, A. L. A. ; Bellio, M. ; Souza, J. M. ; Leon, S. V.A. ; Neves, G.A. ; Neto, H. A.P. ; Castro,N.G.; Felice, F. G. ; Miranda, I.A. ; Clarke, J. R. ; Poian, A. T. ; Ferreira, S. T. Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice. Nature communications, v. 10, p. 3890, 2019.

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Doi:10.1038/s41467-019-11866-7

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Menezes, A. C. ; Reis, G. H. ; Nunes, M. C.O. ; Mariath, F. ; Cabanel, M. ;Pontes, B. ; Castro, N. G. ; Neto, J. M.B. ; Carneiro, K. Live cell imaging supports a key role for histone deacetylase as a molecular target during glioblastoma malignancy downgrade through tumor competence modulation. Journal of oncology, v. 2019, p. 1-16, 2019.

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Doi:10.1155/2019/9043675

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Freitas, C.S. Higa, L.M. Sacramento, C.Q. Ferreira, A.C. Reis,P.A. Delvecchio, R.M., Fabio , L. Lima, G.J.W.B., Vieira, Y.R.M.H., Rocha, N.H.M., Leme, R.P.P.B.L.V.B., Mônica M. L. Rodrigues, G.O.M. Lopes, C.E.Q.J. Lima,C.M. Costa, V.V. Teixeira, M.M.. Bozza, F.A.. Bozza, P.T. Boechat, N.T. Amilcar. Yellow fever virus is susceptible to sofosbuvir both in vitro and in vivo. Plos neglected tropical diseases , v. 13, p. E0007072, 2019.

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Doi:10.1371/journal.pntd.0007072

Silva, R.M.R.J. ; Gandi,M.O. ; Mendonça,J.S. ; Carvalho,A.S. ; Coutinho,J.P.; Aguiar, A.C.C.; Krettli,A.U. ; Boechat,N . New hybrid trifluoromethylquinolines as antiplasmodium agents. Bioorganic & medicinal chemistry , v. 27, p. 1002-1008, 2019.

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Doi: 10.1016/j.bmc.2019.01.044

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Gonzaga, D. T. G. ; Oliveira, F. H. ; Salles, J. P. ; Bello, M. L. ; Rodrigues, C. R. ; Castro, H. C. ; Souza, H. ; Reis, C. ;Leme, R. ; Mafra, J. C. M. ; Pinheiro, L.C.S. ; Boechat, N. ; Faria, R. X. Synthesis, biological evaluation, and molecular modeling studies of new thiadiazole derivatives as potent p2x7 receptor inhibitors. Frontiers in chemistry , v. 7, p. 1-15, 2019.

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Doi:10.3389/fchem.2019.00261

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45. Ferreira, A.C. ; Reis, P.A. ; Freitas, C.S. ; Sacramento, C.Q. ; Hoelz, L.V.B. ; Bastos, M.M. ; Mattos, M ; Rocha, N ; Quintanilha, I.G.A. ; Pedrosa, C.S.G. ; Souza, L.R.Q. ; Loiola, E.C. ; Trindade, P.; Vieira, Y.R. ; Lima, G.B. ; Neto,H.C.C.F.; Boechat,N. ; Rehen,S.K. ; Brüning,K.; Bozza,F.A. ; Bozza,P.T. ; Souza,T.M.L. Beyond members of the flaviviridae family, sofosbuvir also inhibits chikungunya virus replication. Antimicrobial agents and chemotherapy (online) , v. 63, p. E01389-18, 2019.

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Doi: 10.1128/aac.01389-18

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Venâncio, T.; Oliveira,L.M.; Pawlak, T.; Ellena, J.; Boechat,N. ; Brown,S.P. The use of variable temperature 13 c solid-state mas nmr and gipaw dft calculations to explore the dynamics of diethylcarbamazine citrate. Magnetic resonance in chemistry , v. 57, p. 200-208, 2019.

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Doi:10.1002/mrc.4790

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Lima,D.A.; Andreotti, C.E.A.; Ferreira, F.A. ; Pauli,K.B.; Silva,G.R.; Ribeiro,R.C.L. ; Dalsenter,P.R.; Boechat,N. ; Junior, G.A. ; Lourenço,E.L.B.; Lívero,F.A.R. Safety assessment of mefas: an innovative hybrid salt of mefloquine and artesunate for malaria treatment. Drug and chemical toxicology , v. 42, p. 1-6, 2019.

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Doi: 10.1080/01480545.2019.1607371

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Feitosa,L.M. ; Silva,E.R. ; Hoelz,L.V.B.; Souza,D.L. ; Come, J.A.A.S.S.; Santos, C.C. ; Batista,M.M. ; Soeiro,M.N.C. ; Boechat,N. ; Pinheiro,L.C.S. New pyrazolopyrimidine derivatives as leishmania amazonensis arginase inhibitors. Bioorganic & medicinal chemistry, v. 27, p. 3061-3069, 2019.

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Doi: 10.1016/j.bmc.2019.05.026

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Silva, M. R.S. ; Araújo, J. S. ; Peres, R. B. ; Silva, P. B. ; Batista, M. M. ; Azevedo, L. D. ; Bastos, M. M. ; Bahia, M. T. ; Boechat, N. ; Soeiro, M. N. C. Repurposing strategies for chagas disease therapy: the effect of imatinib and derivatives against trypanosoma cruzi. Parasitology , v. 146, p. 1-7, 2019.

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Doi: 10.1017/s0031182019000234.

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Trompowsky, A.C.M.V. ; Conde, T.R. ; Lemos, R.C. ; Quaresma, B.M.C.S ; Pitombeira, M.C.R.S. ; Carvalho, A.S. ; Boechat, N. ; Salomão,K ; Castro, S.L. ; Zamith, H.P.S . In vitro genotoxicity of nitroimidazoles as a tool in the search of new trypanocidal agents. Memórias do instituto oswaldo cruz , v. 114, p. 1-10, 2019.

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Doi: 10.1590/0074-02760190017

Pinheiro, L.C.S ; Ferreira, M.L.G. ; Silveira, F.F. ; Feitosa, L.M. ; Boechat, N . Synthetic compounds with sulfonamide moiety against leishmaniasis: an overview. Medicinal chemistry research , v. 28, p. 1807-1817, 2019.

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Doi:10.1007/s00044-019-02432-3

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Lima, E.C. ; Castelo-branco, F.S. ; Maquiaveli, C.C. ; Farias, A.B. ; Rennó, M.N. ; Boechat, N. ; Silva, E.R. Phenylhydrazides as inhibitors of leishmania amazonensis arginase and antileishmanial activity. Bioorganic & medicinal chemistry, v. 27, p. 3853-3859, 2019.

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Doi:10.1016/j.bmc.2019.07.022

C. S. Pinheiro, luiz ; Lívia, M.F. ; Gandi, M.O. ; Silveira, F.F. ; Boechat, N. The development of novel compounds against malaria: quinolines, triazolpyridines, pyrazolopyridines and pyrazolopyrimidines. Molecules , v. 24, p. 4095, 2019.

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Doi:10.3390/molecules24224095

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Vale, C.M.F. ; Quaresma, B.M.S ; Pitombeira, M.C.R. ; Brito, M.A. ; Farias, P.P.; Castro, S.L. ; Salomão, K. Carvalho, A.S. ; Paula, J.I.O. ; Nascimento, S.B. ; Cupello, M.P. ; Paes, M.C.; Boechat, N. ; Felzenszwalb, I . Novel nitroimidazole derivatives evaluated for their trypanocidal, cytotoxic, and genotoxic activities. European journal of medicinal chemistry , v. 2019, p. 111887-111902, 2019.

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Doi: 10.1016/j.ejmech.2019.111887.

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Boechat, núbia a; magalhães j.l. ; zulmira hartz ; marlede menezes ; mendonça, jorge s. An overview of antibiotics in brazil:a sovereign been lost of the amoxicillin. Chimica oggi-chemistry today , v. 37, p. 73, 2019.

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Trompowsky, A.C.M.V. ; Conde, T.R. ; Lemos, R.C. ; Quaresma, B.M.C.S ; Pitombeira, M.C.R.S. ; Carvalho, A.S. ; Boechat, N. ; Salomão,K ; Castro, S.L. ; Zamith, H.P.S . In vitro genotoxicity of nitroimidazoles as a tool in the search of new trypanocidal agents. Memórias do instituto oswaldo cruz , v. 114, p. 1-10, 2019.

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Doi: 10.1590/0074-02760190017

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Soares, S.S. ; Bekbolatova,E. ; Cotrim, M.D. ; Sakipova, Z. ; Ibragimova, L.; Koch,W.K. ; Giorno, T.B.S. ; Fernandes, P.D. ; Fonseca, D.A. ; Boylan, F. Chemistry and pharmacology of the kazakh crataegus almaatensis pojark: an asian herbal medicine. Antioxidants, v. 8, p. 300, 2019.

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Doi: 10.3390/antiox8080300

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Giorno, T.B.S. ; Santos, C.H.C. ; Carvalho, M.G. ; Silva, V.C. ; Sousa, P.T. ; Fernandes, P.D. ; Boylan,F . Study on the antinociceptive activity and mechanism of action of isolated saponins from siolmatra brasiliensis (cogn.) Baill. Molecules , v. 24, p. 4584, 2019.

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Doi: 10.3390/molecules24244584

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Strauch, M.A. ; Tomaz, M.A. ; Machado, M.M. ; Cons, B.L.; Neto, F.C.P. ; Cruz, J.M.T. ; Henriques, M.S.T. ; Souza, P.D.N. ; Gomes, S.L.S. ; Costa, P.R.R. ; Schaeffer, E. ; Silva, A.J. M. ; Melo, P.A . Lapachol and synthetic derivatives: in vitro and in vivo activities against bothrops snake venoms. Plos one , v. 14, p. E0211229-18, 2019.

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Doi: 10.1371/journal.pone.0211229.

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Telles, T. S. ; Silva,P.M. ; Martins, M.A. ; Carvalho, V. Glucocorticoids decrease the numbers and activation of mast cells by inducing the transactivation receptors of ages. Journal of leukocyte biology, v. 2018, p. 1-12, 2019.

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Doi: 10.1002/jlb.3a0917-364rr

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Viegas, F.P.F.S.D., Rocha, M.C.M.D., Riquiel, M.M.M.M.R., Vaz, S.M.S.L.R.P., Mancini, L.M. Oliveira,K.C.M. Morais,P.C.;Gontijo,E.P.; Silva,V.S.; Motta,F.; Peçanha,D.F.; Castro, D.; Gonçalves, N.; Neves, G.A.; Paiva,G.; Vilela,A. Orlandi,F.C. Camps, L.; ihosvany veloso, Coelho,M.P.L. Ionta,L.F. Silva, M.F. Pereira,G.A. Machado ,R. Design, synthesis and pharmacological evaluation of n -benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: discovery of novel multi-target anti-alzheimer prototype drug candidates. European journal of medicinal chemistry, v. 147, p. 48-65, 2018.

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Guimarães, M.Z. P. ; Vecchi, R.; Vitória, G.; Sochacki,J.K. ; Paulsen,B.S. ; Lima, I.; Silva, F.R. ; Costa, R.F. M. ; Castro,N.G. ; Breton, L.; Rehen,S.K. Generation of ipsc-derived human peripheral sensory neurons releasing substance p elicited by trpv1 agonists. Frontiers in molecular neuroscience, v. 11, p. 1-17, 2018.

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Branco, F.S.C. ; Lima, E.C. ; Domingos, J.L.O.; Pinto, A.C. ; Lourenço, M.C.S. ; Gomes, K.M. ; Lima, M.M.C. ; Lima, C.F.A. ; Aiub, C.A.F. ; Felzenszwalb, I. ; Costa, T.E.M.M. ; Penido, C. ; Henriques, M.G. ; Boechat,N. . New hydrazides derivatives of isoniazid against mycobacterium tuberculosis: higher potency and lower hepatocytotoxicity. European journal of medicinal chemistry, v. 146, p. 529-540, 2018.

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Leite, D.I. ; Fontes,F.V. ; Bastos, M.M. ; Hoelz, L.V.B. ; BiancoM.C.A.D. ; Oliveira, A.P. ; Silva, P.B. ; Silva, C.F. ; Batista, D.G.J. ; Gama, A.N.S. ; Peres, R.B. ; VillarJ.D.F. ; Soeiro, M.N.C.; Boechat, N. New 1,2,3-triazole-based analogues of benznidazole for use against trypanosoma cruzi infection: in vitro and in vivo evaluations. Chemical biology & drug design , v. 2018, p. 1-7, 2018.

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Boechat, N.; Pinheiro, L.C.S. ; Feitosa, L. M. ; Silveira, F. F. Current antimalarial therapies and advances in the development of semi-synthetic artemisinin derivatives. Anais da academia brasileira de ciências (online) , v. 90, p. 1251-1271, 2018.

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Costa, C.C.P. ; Boechat, N. ; Bastos, M.M. ; Silva, F.C. ; Marttorelli, A. ; Souza, T.M.L. ; Baptista, M.S.. ; Hoelz, L.V.B. ; Cafffarena, E.R . New efavirenz derivatives and 1,2,3-triazolyl-phosphonates as inhibitors of reverse transcriptase of hiv-1. Current topics in medicinal chemistry, v. 18, p. 1494-1505, 2018.

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Giorno, T.B.S. ; Moreira, I.G.S. ; Rezende, C.M. ; Fernandes, P.D . New βn-octadecanoyl-5-hydroxytryptamide: antinociceptive effect and possible mechanism of action in mice. Scientific reports , v. 8, p. 10027, 2018.

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Cortes, A.L. ; Gonsalez, S.R. ; Rioja, L.S. ; Oliveira, S.S.C. ; Santos, A.L.S. ; Prieto, M. C. ; Melo, P.A. ; Lara, L.S. Protective outcomes of low-dose doxycycline on renal function of wistar rats subjected to acute ischemia/reperfusion injury. Biochimica et biophysica acta-molecular basis of disease , v. 1864, p. 102-114, 2018.

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Strauch, M.A. ; Souza, G.J. ; Pereira, J.N. ; Ramos, T.S. ; Cesar, M.O. ; Tomaz, M.A.; Machado, M.M.S.; Neto, F.C.P. ; Melo, P.A. True or false coral snake: is it worth the risk? A micrurus corallinus case report. Journal of venomous animals and toxins including tropical diseases , v. 24, p. 10, 2018.

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2022

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de Almeida, Lana R.; Alves, Marina A.; Mastella, Ana M. O.; Garret, Rafael; Pereira, Maria J. R.. Neotropical mustelids: fecal metabolome diversity and its potential for taxonomic discrimination. Integrative Zoology, 2022.

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Amorim, Carolinne S.; Moraes, João A.; Magdalena, Ingrid J.; López, Sheila G.; Carneiro, Ana C. D.; Nunes, Isabelle K. C.; Pizzatti, Luciana; Sardela, Vinícius, F.; Neto, Aquino F. R.; Mirotti, Luciana C.; Pereira, Henrique M. G.; Renovato-Martins, Mariana. Extracellular Vesicles From Stored Red Blood Cells Convey Heme and Induce Spic Expression on Human Monocytes. Frontiers in Immunology, v. 13, p. 1, 2022.

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Amorim, Carolinne S.; Docasar, Clara L.; Guimarães-Bastos, Daniel; Frony, Ana C.; Barja-Fidalgo, Christina; Renovato-Martins, Mariana; Moraes, João A.. Extracellular Vesicles Derived from MDA-MB-231 Cells Trigger Neutrophils to a Pro-Tumor Profile. Cells, v. 11, p. 1875, 2022.

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Andrade, Marcelle N.; Melo-Paiva, Francisca; Teixeira, Mariana P.; de Lima-Junior, Nieldson C.; Soares, Paula; Graceli, Jones B.; de Carvalho, Denise P.; Morris, Eduardo A. R.; Ferreira, Andrea C. F.; Miranda-Alves, Leandro. Environmentally relevant dose of the endocrine disruptor tributyltin disturbs redox balance in female thyroid gland. Molecular and Cellular Endocrinology, v. 553, p. 111689, 2022.

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Barbosa, G.; Gelves, Luis G. V.; Costa, Caroline M. X.; Franco, Lucas S.; De Lima, João A. L.; Aparecida-Silva, Cristiane; Teixeira, John D.; Mermelstein, Cláudia S.; Barreiro, Eliezer J.; Lima, Lídia M.. Discovery of Putative Dual Inhibitor of Tubulin and EGFR by Phenotypic Approach on LASSBio-1586 Homologs. Pharmaceuticals, v. 15(8), p. 1-22, 2022.

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Brasiel, Poliana G. A.; Guimarães, Fernanda V.; e Silva, Patricia M. R.; Bou-Habib, Dumith C.; Carvalho, Vinicius F.. Therapeutic Efficacy of Flavonoids in Allergies: A Systematic Review of Randomized Controlled Trials. Journal of Immunology Research, v. 2022, 2022.

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Cardoso, Tassya C.; Rocha, Marianna A.; Monteiro, Matheus M. L. V.; Alves, Vinícius S.; Savio, Luiz E. B.; Silva, Cláudia L. M.. The blockage of downstream P2Y2 receptor signaling inhibits the prostate cancer cell adhesion to endothelial cells. Life Sciences, v. 306(1), p. 120793, 2022.

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Costa, Bianca; Corrêa, Luana B.; e Silva, Patricia M. R.; de Sá, Yago A. P. J.; Guimarães, Fernanda V.; Alencar, Luciana M. R.; Simões, Rafael L. Helal-Neto, Edward; Ricci-Júnior, Eduardo; Henriques, Maria G. M. O.; Rosas, Elaine C.; Santos-Oliveira, Ralph. Using pure Fucoidan and radiolabeled Fucoidan (99mTc-Fucoidan) as a new agent for inflammation diagnosis and therapy. Food Hydrocolloids for Health, v. 2, p. 10049, 2022.

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Caruso, Lucas ; Nadur, N. Fonseca ; Da Fonseca, M. Brandão ; Peixoto, De Almeida, Larissa; Lacerda, R. Barbosa; Graebin, C. Stephan; Kümmerle, Arthur Eugen. The Design of Multi-target Drugs to Treat Cardiovascular Diseases: Two(or more) Birds on One Stone. Current Topics in Medicinal Chemistry, v. 22, p. 366-394, 2022.

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Costa, Tamara G. F.; Oliveira, Marina M.; Toledo, Marina M.; Santos, Helio B.; Thome, Ralph G.; Cortes, Vanessa F.; Santos, Herica L.; Quintas, Luis E. M.; Fontes, Carlos F. L.; Barbosa, Leandro A.. Effect of Fe3+ on Na,K-ATPase: Unexpected activation of ATP hydrolysis. Biochimica et Biophysica Acta (BBA), v. 1864, p. 183868, 2022.

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Cunha, Thayssa T. S.; Silva, Rafaela R.; Rodrigues, Daniel A.; Pinheiro, Pedro S. M.; Kronenberger, T.; Sant’Anna, Carlos M. R.; Noël, François. Fraga, Carlos A. M.. Design, Synthesis and Pharmacological Evaluation of Novel Conformationally Restricted N-arylpiperazine Derivatives Characterized as D2/D3 Receptor Ligands, Candidates for the Treatment of Neurodegenerative Diseases. Biomolecules, v. 12(8), p. 1-18, 2022.

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Dantas, Rafael F.; Torres-Santos, Eduardo; Silva-Júnior, Floriano P.. Past and future of trypanosomatids high-throughput phenotypic screening. Mem Inst Oswaldo Cruz, v. 117, p. e210402, 2022.

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Faria, Jessica V.; Passos, Fernanda P.Z.; da Costa, Paulo H.A.; de Oliveira, Andressa P.; Cruz, Yasmin O.D. da; Castelo-Branco, Frederico S.; Lourenço, Maria C.S.; Murta, Silvane M.F.; Junior, Policarpo A.S.; Bernardino, Alice M.R.; Bastos, Monica M.; Boechat, Nubia. Novel 2-Nitroimidazole and Imidazooxazole Derivatives and their Activity against Trypanosoma cruzi and Mycobacterium tuberculosis. Medicinal Chemistry, v. 18, p. 701-709, 2022.

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de Faria, Rachel A.; Oliveira, Pamella C. O.; de Carvalho, Mariana D. P.; Peixoto, Bruno S.; Severino, Vanessa G. P.; Tinoco, Luzineide W.; Rodrigues, Silvana V.; de Moraes, Marcela C.. High-resolution inhibition profiling and ligand fishing for screening of nucleoside hydrolase ligands in Moringa oleifera Lamarck. Journal of Pharmaceutical and Biomedical Analysis, v. 211, p. 114614, 2022.

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França, Patrícia R. C.; Lontra, Anna C. P.; Fernandes, Patricia D.. Endometriosis: A Disease with Few Direct Treatment Options. Molecules, v. 27, p. 4034, 2022.

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Ferreira, Tatiana P. T.; Guimarães, Fernanda V.; Sá, Yago A. P. J.; Ribeiro, Natalia B. S.; de Arantes, Ana C. S.; Carvalho, Vinicius F.; Sousa, Lirlândia P.; Perretti, Mauro; Martins, Marcos A.; e Silva, Patricia M. R.. Annexin-A1-Derived Peptide Ac2-26 Suppresses Allergic Airway Inflammation and Remodelling in Mice. Cells, v. 11, p. 759, 2022.

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Figueiredo-Junior, Alexsandro T.; Valença, Samuel S.; Fintonelli, Priscilla V.; dos Anjos, Francisca F.; de Brito-Gitirana, Lycia; Takiya, Christina M.; de Deus, Manuella L. D.. Treatment with Bixin-Loaded Polymeric Nanoparticles Prevents Cigarette Smoke-Induced Acute Lung Inflammation and Oxidative Stress in Mice. Antioxidants, v. 11, p. 1293, 2022.

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Gouvêa, Marcos M.; de Carvalho, Renata C.; Castelo-Branco, Frederico C.; Boechat, Nubia; Netto, Annibal D. P.; Marques, Flávia F. C.. The cleavage kinetics of hydrazide derivatives of isoniazid by HPLC-UV/DAD and its impact on activity against Mycobacterium tuberculosis. Journal of Chromatography B, v. 1188, p. 123080, 2022.

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Lamichhane, Santosh; Sen, Partho; Dickens, Alex M.; Alves, Marina A.; Härkönen, Taina; Honkanen, Jarno; Vatanen, Tommi; Xavier, Ramnik J.; Hyötyläinen, Tuulia; Knip, Mikael; Orešič, Matej. Dysregulation of secondary bile acid metabolism precedes islet autoimmunity and type 1 diabetes. Cell Reports Medicine, p. 100762, 2022.

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Lara, Lucienne S.; Gonzalez, Alexis A.; Hennrikus, Mathew T.; Prieto, Minofa C.. Hormone-dependent regulation of renin and effects on prorenin receptor signaling in the collecting duct. Current Hypertens Review, 2022.

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Leite, Jacqueline A.; Pôças, Elisa; Maia, Gisele S.; Barbosa, Leandro; Quintas, Luis E. M.; Kawamoto, Elisa M.; da Silva, Maria L. C.; Scavone, Cristoforo; de Carvalho, Luciana E. D.. Effect of ouabain on calcium signaling in rodent brain: A systematic review of in vitro studies. Frontiers in Pharmacology, v. 13, p. 916312, 2022.

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Leser, Felipe S.; Fiuza, Diogo N.; Miranda-Alves, Leandro. Importance of students congresses for medical training: A pioneer experience at Federal University of Rio de Janeiro. Revista Brasileira de Educação e Saúde-REBES, v. 11, p. 464-475, 2022.

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Mansoldo, Felipe R. P.; Garrett, Rafael; Cardoso, Veronica S.; Alves, Marina A.; Vermelho, Alane B.. Metabology: Analysis of metabolomics data using community ecology tools. Analytica Chimica Acta, v. 1232, p. 340469, 2022.

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Mendes, Ana B. A.; Motta, Nadia A. V.; Lima, Gabriel F.; Autran, Lis J.; Brazão, Stephani C.; Magliano, D'Angelo C.; Sepúlveda-Fragoso, Vinícius; Scaramello, Christiane B. V.; Graceli, Jones B.; Miranda-Alves, Leandro; Brito, Fernanda C. F.. Evaluation of the effects produced by subacute tributyltin administration on vascular reactivity of male wistar rats. Toxicology, v. 465, p. 153067, 2022.

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Moreira, Lorrane K. S.; Silva, Rafaela R.; da Silva, Dayane M.; Mendes, Mirella A. S.; de Brito, Adriane F.; de Carvalho, Flávio S.; Sanz, Germán; Rodrigues, Marcella F.; da Silva, Artur C. G.; Thomaz, Douglas V.; de Oliveira, Valéria; Vaz, Boniek G.; Lião, Luciano M.; Valadares, Marize C.; Gil, Eric S.; Costa, Elson A.; Noël, François; Menegatti, Ricardo. Anxiolytic- and antidepressant-like effects of new phenylpiperazine derivative LQFM005 and its hydroxylated metabolite in mice. Behavioural Brain Research, v. 417(24), p. 113582, 2022.

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Nunes, Bruno; Pópulo, Helena; Lopes, José M.; Reis, Marta; Nascimento, Gilvan; Nascimento, Ana G.; Fernandes, Janaína; Faria, Manuel; de Carvalho, Denise P.; Soares, Paula; Miranda-Alves, Leaandro. Connexin Expression in Pituitary Adenomas and the Effects of Overexpression of Connexin 43 in Pituitary Tumor Cell Lines. Genes, v. 13, p. 674, 2022.

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Oliveira, Andressa; Moura, Stefany; Pimentel, Luiz; Neto, João; Dantas, Rafael; Silva-Júnior, Floriano P.; Bastos, Monica; Boechat, Nubia. New Imatinib Derivatives with Antiproliferative Activity against A549 and K562 Cancer Cells. Molecules, v. 27(3), p. 750, 2022.

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Ortiz, Cindy J. C.; Silva, Matheus F.; Pruccoli, Letizia; Nadur, Nathália F.; De Azevedo, Luciana L.; Kümmerle, Arthur E.; Guedes, Isabella A.; Dardenne, Laurent E.; Coelho, Luiz F. L.; Guimarães, Marcos J.; Da Silva, Fernanda M. R.; Castro, Newton; Gontijo, Vanessa S.; Rojas, Viviana C. T.; De Oliveira, Merelym K.; Vitela, Fabiana C.; Giusti-Paiva, Alexandre; Barbosa, Gisele; Lima, Lídia M.; Pinheiro, Gabriel B.; Veras, Letícia G.; Mortari, Márcia R.; Tarozzi, Andrea; Júnior, Cláudio V.. Design, synthesis, and biological evaluation of new thalidomide–donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation. RSC Medicinal Chemistry, v. 13, p. 568-584, 2022.

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Portovedo, Sérgio; Neto, Leonardo V.; Soares, Paula; de Carvalho, Denise P.; Takiya, Christina M.; Miranda-Alves, Leandro. Aggressive nonfunctioning pituitary neuroendocrine tumors. Brain Tumor Pathology, 2022.

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de Queiroz, Aline C.; Barbosa, G.; de Oliveira, Victória R. T.; Alves, Hélio M.; Alves, Marina A.; Carregaro, V.; da Silva, João S.; Barreiro, Eliezer J.; Alexandre-Moreira, Magna S.; Lima, Lídia M.. Pre-clinical evaluation of LASSBio-1491: From in vitro pharmacokinetic study to in vivo leishmanicidal activity. Plos One, v. 17(6), p. e0269447, 2022.

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Rodrigues-Pereira, Paula; Andrade, Marcelle N.; Santos-Silva, Ana P.; Teixeira, Mariana P.; Soares, Paula; Graceli, Jones B.; de Carvalho, Denise P.; Dias, Glaecir R. M.; Ferreira, Andrea C. F.; Miranda-Alves, Leandro. Subacute and low-dose tributyltin exposure disturbs the mammalian hypothalamus-pituitary-thyroid axis in a sex-dependent manner. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, v. 254, p. 109279, 2022.

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Santos, Carine; Pimentel, Luiz; Cazian, Henayle; Oliveira, Andressa; Silva-Júnior, Floriano P.; Dantas, Rafael; Hoelz, Lucas; Marinho, Debora; Cunha, Anna; Bastos, Monica; Boechat, Nubia. Hybrids of Imatinib with Quinoline: Synthesis, Antimyeloproliferative Activity Evaluation, and Molecular Docking. Pharmaceuticals, v.15(3), p. 309, 2022.

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Santos, Stephanie A. C. S.; Persechini, Pedro M.; Henrique-Santos, Bianca M.; Bello-Santos, Victória G.; Castro, Newton C.; de Sousa, Júlia C.; Genta, Fernando A.; Santiago, Marcelo F.; Coutinho-Silva, Robson; Savio, Luiz E. B.; Kurtenbach, Eleonora. P2X7 Receptor Triggers Lysosomal Leakage Through Calcium Mobilization in a Mechanism Dependent on Pannexin-1 Hemichannels. Frontiers in Immunology, v. 13, p. 752105, 2022.

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Serra, Magda F.; Cotias, Amanda C.; Pimentel, Andreza S.; de Arantes, Ana C. S.; Pires, Ana L. A.; Lanzetti, Manuella; Hickmann, Jandir M.; Barreto, Emiliano; Carvalho, Vinicius F.; Silva, Patrícia M. R.; Cordeiro, Renato S. B.; Martins, Marco A.. Gold Nanoparticles Inhibit Steroid-Insensitive Asthma in Mice Preserving Histone Deacetylase 2 and NRF2 Pathways. v. 11, p. 1659, 2022.

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Silva, Grazielle F.; da Silva, Jaqueline S.; de Alencar, Allan K. N.; da Silva, Marina M. C.; Montagnoli, Tadeu L.; Rocha, Bruna S.; de Freitas, Rosana H. C. N.; Sudo, Roberto T.; Fraga, Carlos A. M.; Zapata-Sudo, Gisele. Novel p38 Mitogen-Activated Protein Kinase Inhibitor Reverses Hypoxia-Induced Pulmonary Arterial Hypertension in Rats. Pharmaceuticals, v.15(7), p. 1-16, 2022.

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Silva, Girlaine P.; Fernandes, Daniele C.; Vigliano, Mariana V.; Pinto, Fabiana A.; Fonseca, Eduardo N.; Santos, Shirley V. M.; Marques, Paulo R.; Gayer, Carlos R. M.; Velozo, Leosvaldo S. M.; de Lima, Cleverton K. F.; de Miranda, Ana L. P.; Justo, Maria G.; Sabino, Kátia C. C.; Coelho, Marsen G. P.. Echinodorus macrophyllus: Hydroxycinnamoyl derivatives reduces neutrophil migration through modulation of cytokines, chemokines, and prostaglandin in the air-pouch model. Journal of Ethnopharmacology, v. 284(10), p. 114757, 2022.

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da Silva, Jaqueline S.; Gonçalves, Renata G. J.; Vasques, Juliana F.; Rocha, Bruna S.; Nascimento-Carlos, Bianca; Montagnoli, Tadeu L.; Mendez-Otero, Rosália; de Sá, Mauro P. L.; Zapata-Sudo, Gisele. Mesenchymal Stem Cell Therapy in Diabetic Cardiomyopathy. Cells, v. 11, p. 240, 2022.

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de Souza, Hygor M. R.; Guedes, Jéssica S.; Freitas, Rosana H. C.; Gelves, Luis G. V.; Fokoue, Harold H.; Sant’Anna, Carlos M. R.; Barreiro, Eliezer J.; Lima, Lídia M.. Comparative chemical and biological hydrolytic stability of homologous esters and isosteres. Journal of Enzyme Inhibition and Medicinal Chemistry, v. 37(1), p. 718-727, 2022.

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Valença, Samuel S.; Dong, Brittany E.; Gordon, Elizabeth M.; Sun, Ramon C.; Waters, Christopher M.. ASK1 Regulates Bleomycin-induced Pulmonary Fibrosis. American Journal of Respiratory Cell and Molecular Biology, v. 66, p. 484-496, 2022.

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Valença, Helber M.; e Silva, Cyntia P.; Gitirana, Lycia B.; Valença, Samuel S.; Lanzetti, Manuella. Beneficial effects of Ilex paraguariensis in the prevention of obesity-associated metabolic disorders in mice. Phytotherapy Research, v. 36, p. 1032-1042, 2022.

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Viana, Elaine O. R.; da Silva, Marília J.; da Silva, Bernadete P.; Tinoc, Luzineide W.; Parente, José P.. Two new triterpenoid saponins from the flowers of Albizia lebbeck. Natural Product Research, p. 1-10, 2022.

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