text:
<?xml version="1.0"?>
<rdf:RDF xmlns="http://purl.obolibrary.org/obo/upheno/patterns/imports/uberon_import.owl#"
     xml:base="http://purl.obolibrary.org/obo/upheno/patterns/imports/uberon_import.owl"
     xmlns:dc="http://purl.org/dc/elements/1.1/"
     xmlns:obo="http://purl.obolibrary.org/obo/"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:xml="http://www.w3.org/XML/1998/namespace"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:swrl="http://www.w3.org/2003/11/swrl#"
     xmlns:swrla="http://swrl.stanford.edu/ontologies/3.3/swrla.owl#"
     xmlns:swrlb="http://www.w3.org/2003/11/swrlb#"
     xmlns:terms="http://purl.org/dc/terms/"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:ncbitaxon="http://purl.obolibrary.org/obo/ncbitaxon#">
    <owl:Ontology rdf:about="http://purl.obolibrary.org/obo/upheno/patterns/imports/uberon_import.owl"/>

    <!--
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <!-- http://purl.obolibrary.org/obo/BFO_0000179 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000179"/>

    <!-- http://purl.obolibrary.org/obo/BFO_0000180 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000180"/>

    <!-- http://purl.obolibrary.org/obo/IAO_0000111 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000111"/>

    <!-- http://purl.obolibrary.org/obo/IAO_0000112 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000112"/>

    <!-- http://purl.obolibrary.org/obo/IAO_0000114 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000114"/>

    <!-- http://purl.obolibrary.org/obo/IAO_0000115 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115">
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/iao.owl"/>
        <rdfs:label>definition</rdfs:label>
        <rdfs:label xml:lang="en">definition</rdfs:label>
    </owl:AnnotationProperty>

    <!-- http://purl.obolibrary.org/obo/IAO_0000116 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000116"/>

    <!-- http://purl.obolibrary.org/obo/IAO_0000117 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000117"/>

    <!-- http://purl.obolibrary.org/obo/IAO_0000118 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000118"/>

    <!-- http://purl.obolibrary.org/obo/IAO_0000119 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000119"/>

    <!-- http://purl.obolibrary.org/obo/IAO_0000232 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000232"/>

    <!-- http://purl.obolibrary.org/obo/IAO_0000233 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000233"/>

    <!-- http://purl.obolibrary.org/obo/IAO_0000424 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000424"/>

    <!-- http://purl.obolibrary.org/obo/IAO_0000589 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000589"/>

    <!-- http://purl.obolibrary.org/obo/IAO_0000600 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000600"/>

    <!-- http://purl.obolibrary.org/obo/IAO_0000601 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000601"/>

    <!-- http://purl.obolibrary.org/obo/IAO_0000602 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000602"/>

    <!-- http://purl.obolibrary.org/obo/IAO_0010000 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0010000"/>

    <!-- http://purl.obolibrary.org/obo/IAO_isReversiblePropertyChain -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_isReversiblePropertyChain"/>

    <!-- http://purl.obolibrary.org/obo/RO_0001900 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0001900"/>

    <!-- http://purl.obolibrary.org/obo/RO_0002161 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002161"/>

    <!-- http://purl.obolibrary.org/obo/RO_0002575 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002575"/>

    <!-- http://purl.obolibrary.org/obo/RO_0002581 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002581">
        <obo:IAO_0000115>If R <- P o Q is a defining property chain axiom, then it also holds that R -> P o Q. Note that this cannot be expressed directly in OWL</obo:IAO_0000115>
        <rdfs:label>is a defining property chain axiom</rdfs:label>
    </owl:AnnotationProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002582 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002582">
        <obo:IAO_0000115>If R <- P o Q is a defining property chain axiom, then (1) R -> P o Q holds and (2) Q is either reflexive or locally reflexive. A corollary of this is that P SubPropertyOf R.</obo:IAO_0000115>
        <rdfs:label>is a defining property chain axiom where second argument is reflexive</rdfs:label>
    </owl:AnnotationProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0004049 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004049"/>

    <!-- http://purl.obolibrary.org/obo/RO_0004050 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004050"/>

    <!-- http://purl.obolibrary.org/obo/RO_0040042 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0040042"/>

    <!-- http://purl.obolibrary.org/obo/UBPROP_0000003 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/UBPROP_0000003"/>

    <!-- http://purl.obolibrary.org/obo/UBPROP_0000008 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/UBPROP_0000008"/>

    <!-- http://purl.obolibrary.org/obo/UBPROP_0000012 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/UBPROP_0000012"/>

    <!-- http://purl.obolibrary.org/obo/ncbitaxon#has_rank -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/ncbitaxon#has_rank"/>

    <!-- http://purl.org/dc/elements/1.1/date -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/elements/1.1/date"/>

    <!-- http://purl.org/dc/elements/1.1/source -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/elements/1.1/source"/>

    <!-- http://purl.org/dc/terms/creator -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/terms/creator"/>

    <!-- http://purl.org/dc/terms/source -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/terms/source"/>

    <!-- http://swrl.stanford.edu/ontologies/3.3/swrla.owl#isRuleEnabled -->

    <owl:AnnotationProperty rdf:about="http://swrl.stanford.edu/ontologies/3.3/swrla.owl#isRuleEnabled"/>

    <!-- http://www.geneontology.org/formats/oboInOwl#created_by -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#created_by"/>

    <!-- http://www.geneontology.org/formats/oboInOwl#creation_date -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#creation_date"/>

    <!-- http://www.geneontology.org/formats/oboInOwl#date_retrieved -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#date_retrieved"/>

    <!-- http://www.geneontology.org/formats/oboInOwl#external_class -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#external_class"/>

    <!-- http://www.geneontology.org/formats/oboInOwl#external_ontology -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#external_ontology"/>

    <!-- http://www.geneontology.org/formats/oboInOwl#hasAlternativeId -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasAlternativeId"/>

    <!-- http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym">
        <rdfs:label>has_broad_synonym</rdfs:label>
    </owl:AnnotationProperty>

    <!-- http://www.geneontology.org/formats/oboInOwl#hasDbXref -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasDbXref"/>

    <!-- http://www.geneontology.org/formats/oboInOwl#hasExactSynonym -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym">
        <rdfs:label>has_exact_synonym</rdfs:label>
    </owl:AnnotationProperty>

    <!-- http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym">
        <rdfs:label>has_narrow_synonym</rdfs:label>
    </owl:AnnotationProperty>

    <!-- http://www.geneontology.org/formats/oboInOwl#hasOBONamespace -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasOBONamespace"/>

    <!-- http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym">
        <rdfs:label>has_related_synonym</rdfs:label>
    </owl:AnnotationProperty>

    <!-- http://www.geneontology.org/formats/oboInOwl#hasSynonymType -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasSynonymType"/>

    <!-- http://www.geneontology.org/formats/oboInOwl#id -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#id"/>

    <!-- http://www.geneontology.org/formats/oboInOwl#inSubset -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>

    <!-- http://www.geneontology.org/formats/oboInOwl#is_cyclic -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#is_cyclic"/>

    <!-- http://www.geneontology.org/formats/oboInOwl#is_transitive -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#is_transitive"/>

    <!-- http://www.geneontology.org/formats/oboInOwl#ontology -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#ontology"/>

    <!-- http://www.geneontology.org/formats/oboInOwl#shorthand -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#shorthand"/>

    <!-- http://www.geneontology.org/formats/oboInOwl#source -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#source"/>

    <!-- http://www.geneontology.org/formats/oboInOwl#xref -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#xref"/>

    <!-- http://www.w3.org/2000/01/rdf-schema#comment -->

    <owl:AnnotationProperty rdf:about="http://www.w3.org/2000/01/rdf-schema#comment"/>

    <!-- http://www.w3.org/2000/01/rdf-schema#label -->

    <owl:AnnotationProperty rdf:about="http://www.w3.org/2000/01/rdf-schema#label"/>

    <!-- http://xmlns.com/foaf/0.1/depicted_by -->

    <owl:AnnotationProperty rdf:about="http://xmlns.com/foaf/0.1/depicted_by"/>

    <!-- http://xmlns.com/foaf/0.1/page -->

    <owl:AnnotationProperty rdf:about="http://xmlns.com/foaf/0.1/page"/>

    <!--
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Object Properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <!-- http://purl.obolibrary.org/obo/BFO_0000050 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000050">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002131"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <obo:IAO_0000111>is part of</obo:IAO_0000111>
        <obo:IAO_0000111 xml:lang="en">is part of</obo:IAO_0000111>
        <obo:IAO_0000112>my brain is part of my body (continuant parthood, two material entities)</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">my brain is part of my body (continuant parthood, two material entities)</obo:IAO_0000112>
        <obo:IAO_0000112>my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)</obo:IAO_0000112>
        <obo:IAO_0000112>this day is part of this year (occurrent parthood)</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this day is part of this year (occurrent parthood)</obo:IAO_0000112>
        <obo:IAO_0000115>a core relation that holds between a part and its whole</obo:IAO_0000115>
        <obo:IAO_0000115 xml:lang="en">a core relation that holds between a part and its whole</obo:IAO_0000115>
        <obo:IAO_0000116>Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.</obo:IAO_0000116>
        <obo:IAO_0000116>Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime</obo:IAO_0000116>
        <obo:IAO_0000116>Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.)

A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'.</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.)

A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'.</obo:IAO_0000116>
        <obo:IAO_0000118>part_of</obo:IAO_0000118>
        <obo:IAO_0000118 xml:lang="en">part_of</obo:IAO_0000118>
        <obo:RO_0001900 rdf:resource="http://purl.obolibrary.org/obo/RO_0001901"/>
        <obo:RO_0040042 rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <obo:RO_0040042 rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:RO_0040042 rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <obo:RO_0040042 rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <obo:RO_0040042 rdf:resource="http://purl.obolibrary.org/obo/BFO_0000019"/>
        <obo:RO_0040042 rdf:resource="http://purl.obolibrary.org/obo/BFO_0000020"/>
        <obo:RO_0040042 rdf:resource="http://purl.obolibrary.org/obo/BFO_0000031"/>
        <oboInOwl:hasDbXref>BFO:0000050</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>external</oboInOwl:hasOBONamespace>
        <oboInOwl:hasOBONamespace>protein</oboInOwl:hasOBONamespace>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:hasOBONamespace>spatial</oboInOwl:hasOBONamespace>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>part_of</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_ontology"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <oboInOwl:shorthand>part_of</oboInOwl:shorthand>
        <rdfs:label>part of</rdfs:label>
        <rdfs:label xml:lang="en">part of</rdfs:label>
        <rdfs:label>part_of</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections"/>
        <rdfs:seeAlso rdf:resource="http://ontologydesignpatterns.org/wiki/Submissions:PartOf"/>
        <rdfs:seeAlso>http://www.obofoundry.org/ro/#OBO_REL:part_of</rdfs:seeAlso>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/BFO_0000051 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000051">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002131"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <obo:IAO_0000111>has part</obo:IAO_0000111>
        <obo:IAO_0000111 xml:lang="en">has part</obo:IAO_0000111>
        <obo:IAO_0000112>my body has part my brain (continuant parthood, two material entities)</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">my body has part my brain (continuant parthood, two material entities)</obo:IAO_0000112>
        <obo:IAO_0000112>my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)</obo:IAO_0000112>
        <obo:IAO_0000112>this year has part this day (occurrent parthood)</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this year has part this day (occurrent parthood)</obo:IAO_0000112>
        <obo:IAO_0000115>Q1 has_part Q2 if and only if: every instance of Q1 is a quality_of an entity that has_quality some Q2.</obo:IAO_0000115>
        <obo:IAO_0000115>a core relation that holds between a whole and its part</obo:IAO_0000115>
        <obo:IAO_0000115 xml:lang="en">a core relation that holds between a whole and its part</obo:IAO_0000115>
        <obo:IAO_0000116>Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part.</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part.</obo:IAO_0000116>
        <obo:IAO_0000116>Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime</obo:IAO_0000116>
        <obo:IAO_0000116>Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.)

A continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'.</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.)

A continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'.</obo:IAO_0000116>
        <obo:IAO_0000118>has_part</obo:IAO_0000118>
        <obo:IAO_0000118 xml:lang="en">has_part</obo:IAO_0000118>
        <obo:RO_0001900 rdf:resource="http://purl.obolibrary.org/obo/RO_0001901"/>
        <oboInOwl:hasDbXref>BFO:0000051</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>chebi_ontology</oboInOwl:hasOBONamespace>
        <oboInOwl:hasOBONamespace>external</oboInOwl:hasOBONamespace>
        <oboInOwl:hasOBONamespace>protein</oboInOwl:hasOBONamespace>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:hasOBONamespace>spatial</oboInOwl:hasOBONamespace>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>has_part</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_ontology"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <oboInOwl:is_cyclic rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</oboInOwl:is_cyclic>
        <oboInOwl:shorthand>has_part</oboInOwl:shorthand>
        <rdfs:comment>We use the has_part relation to relate complex qualities to more primitive ones. A complex quality is a collection of qualities. The complex quality cannot exist without the sub-qualities. For example, the quality 'swollen' necessarily comes with the qualities of 'protruding' and 'increased size'.</rdfs:comment>
        <rdfs:label>has part</rdfs:label>
        <rdfs:label xml:lang="en">has part</rdfs:label>
        <rdfs:label>has_part</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Q1 has_part Q2 if and only if: every instance of Q1 is a quality_of an entity that has_quality some Q2.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>PATOC:CJM</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/BFO_0000062 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000062">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002086"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000063"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000062"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000111 xml:lang="en">preceded by</obo:IAO_0000111>
        <obo:IAO_0000115>X preceded_by Y iff: end(Y) before_or_simultaneous_with start(X)</obo:IAO_0000115>
        <obo:IAO_0000115 xml:lang="en">x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C.    The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">is preceded by</obo:IAO_0000118>
        <obo:IAO_0000118 xml:lang="en">preceded_by</obo:IAO_0000118>
        <dc:source>http://www.obofoundry.org/ro/#OBO_REL:preceded_by</dc:source>
        <oboInOwl:hasDbXref>BFO:0000062</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>is preceded by</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>takes place after</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>preceded_by</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <oboInOwl:shorthand>preceded_by</oboInOwl:shorthand>
        <rdfs:label>preceded by</rdfs:label>
        <rdfs:label xml:lang="en">preceded by</rdfs:label>
        <rdfs:label>preceded_by</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000062"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>is preceded by</owl:annotatedTarget>
        <oboInOwl:hasDbXref>SIO:000249</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000062"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>takes place after</owl:annotatedTarget>
        <oboInOwl:hasDbXref>Allen:precedes</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/BFO_0000063 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000063">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002222"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000063"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000111 xml:lang="en">precedes</obo:IAO_0000111>
        <obo:IAO_0000115 xml:lang="en">x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>BFO:0000063</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>precedes</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <oboInOwl:shorthand>precedes</oboInOwl:shorthand>
        <rdfs:label>precedes</rdfs:label>
        <rdfs:label xml:lang="en">precedes</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/BFO_0000066 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000066">
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000067"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000066"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000066"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000111 xml:lang="en">occurs in</obo:IAO_0000111>
        <obo:IAO_0000115 xml:lang="en">b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t</obo:IAO_0000115>
        <obo:IAO_0000118 xml:lang="en">occurs_in</obo:IAO_0000118>
        <obo:IAO_0000118 xml:lang="en">unfolds in</obo:IAO_0000118>
        <obo:IAO_0000118 xml:lang="en">unfolds_in</obo:IAO_0000118>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_ontology"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <rdfs:comment>Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant</rdfs:comment>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">occurs in</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/BFO_0000067 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000067">
        <obo:IAO_0000111 xml:lang="en">site of</obo:IAO_0000111>
        <obo:IAO_0000115 xml:lang="en">[copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t</obo:IAO_0000115>
        <oboInOwl:hasDbXref>BFO:0000067</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>contains_process</oboInOwl:id>
        <oboInOwl:shorthand>contains_process</oboInOwl:shorthand>
        <rdfs:comment>Paraphrase of definition: a relation between an independent continuant and a process, in which the process takes place entirely within the independent continuant</rdfs:comment>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label>contains process</rdfs:label>
        <rdfs:label xml:lang="en">contains process</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/BSPO_0000120 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BSPO_0000120">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BSPO_0000126"/>
        <owl:propertyDisjointWith rdf:resource="http://purl.obolibrary.org/obo/BSPO_0000121"/>
        <obo:IAO_0000115>X in left side of Y <=> if Y is subdivided into two left and right portions, X is part of the left portion.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>BSPO:0000120</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>spatial</oboInOwl:hasOBONamespace>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>in_left_side_of</oboInOwl:id>
        <oboInOwl:shorthand>in_left_side_of</oboInOwl:shorthand>
        <rdfs:label>in left side of</rdfs:label>
        <rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern</rdfs:seeAlso>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BSPO_0000120"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>X in left side of Y <=> if Y is subdivided into two left and right portions, X is part of the left portion.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>BSPO:PATO_mtg_2009</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/BSPO_0000121 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BSPO_0000121">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BSPO_0000126"/>
        <obo:IAO_0000115>X in right side of Y <=> if Y is subdivided into two left and right portions, X is part of the right portion.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>BSPO:0000121</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>spatial</oboInOwl:hasOBONamespace>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>in_right_side_of</oboInOwl:id>
        <oboInOwl:shorthand>in_right_side_of</oboInOwl:shorthand>
        <rdfs:label>in right side of</rdfs:label>
        <rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern</rdfs:seeAlso>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BSPO_0000121"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>X in right side of Y <=> if Y is subdivided into two left and right portions, X is part of the right portion.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>BSPO:PATO_mtg_2009</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/BSPO_0000126 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BSPO_0000126">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
        <obo:IAO_0000115>X in lateral side of Y <=> if X is in left side of Y or X is in right side of Y. X is often, but not always a paired structure</obo:IAO_0000115>
        <obo:IAO_0000115>X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure</obo:IAO_0000115>
        <oboInOwl:hasDbXref>BSPO:0000126</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>spatial</oboInOwl:hasOBONamespace>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>in_lateral_side_of</oboInOwl:id>
        <oboInOwl:shorthand>in_lateral_side_of</oboInOwl:shorthand>
        <rdfs:label>in lateral side of</rdfs:label>
        <rdfs:label>in_lateral_side_of</rdfs:label>
        <rdfs:seeAlso rdf:resource="https://github.com/obophenotype/uberon/issues/2453"/>
        <rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern</rdfs:seeAlso>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BSPO_0000126"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>X in lateral side of Y <=> if X is in left side of Y or X is in right side of Y. X is often, but not always a paired structure</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">UBERON:cjm</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BSPO_0000126"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="https://orcid.org/0000-0002-6601-2165"/>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/RO_0000052 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000052">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002314"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#FunctionalProperty"/>
        <obo:IAO_0000111 xml:lang="en">inheres in</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">this fragility inheres in this vase</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this red color inheres in this apple</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence.</obo:IAO_0000115>
        <obo:IAO_0000115 xml:lang="en">a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">A dependent inheres in its bearer at all times for which the dependent exists.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">inheres_in</obo:IAO_0000118>
        <obo:RO_0001900 rdf:resource="http://purl.obolibrary.org/obo/RO_0001901"/>
        <rdfs:label xml:lang="en">characteristic of</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0000053 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000053">
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#InverseFunctionalProperty"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000020"/>
        <obo:IAO_0000111 xml:lang="en">bearer of</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">this apple is bearer of this red color</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this vase is bearer of this fragility</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">Inverse of characteristic_of</obo:IAO_0000115>
        <obo:IAO_0000115 xml:lang="en">a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">bearer_of</obo:IAO_0000118>
        <obo:IAO_0000118 xml:lang="en">is bearer of</obo:IAO_0000118>
        <obo:RO_0001900 rdf:resource="http://purl.obolibrary.org/obo/RO_0001901"/>
        <oboInOwl:hasDbXref>RO:0000053</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>bearer_of</oboInOwl:id>
        <oboInOwl:shorthand>bearer_of</oboInOwl:shorthand>
        <rdfs:label xml:lang="en">has characteristic</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0000056 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000056">
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:IAO_0000111 xml:lang="en">participates in</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">this blood clot participates in this blood coagulation</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this input material (or this output material) participates in this process</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this investigator participates in this investigation</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">a relation between a continuant and a process, in which the continuant is somehow involved in the process</obo:IAO_0000115>
        <obo:IAO_0000118 xml:lang="en">participates_in</obo:IAO_0000118>
        <oboInOwl:hasDbXref>RO:0000056</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>participates_in</oboInOwl:id>
        <oboInOwl:shorthand>participates_in</oboInOwl:shorthand>
        <rdfs:label xml:lang="en">participates in</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0000057 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000057">
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000051"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0000057"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000111 xml:lang="en">has participant</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">this blood coagulation has participant this blood clot</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this investigation has participant this investigator</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this process has participant this input material (or this output material)</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">a relation between a process and a continuant, in which the continuant is somehow involved in the process</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">has_participant</obo:IAO_0000118>
        <dc:source>http://www.obofoundry.org/ro/#OBO_REL:has_participant</dc:source>
        <rdfs:label xml:lang="en">has participant</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0000079 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000079">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000052"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000085"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000034"/>
        <obo:IAO_0000115 xml:lang="en">a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence</obo:IAO_0000115>
        <rdfs:label xml:lang="en">function of</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0000080 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000080">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000052"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000086"/>
        <obo:IAO_0000112 xml:lang="en">this red color is a quality of this apple</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">A quality inheres in its bearer at all times for which the quality exists.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">is quality of</obo:IAO_0000118>
        <obo:IAO_0000118 xml:lang="en">quality_of</obo:IAO_0000118>
        <rdfs:label xml:lang="en">quality of</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0000081 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000081">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000052"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
        <obo:IAO_0000112 xml:lang="en">this investigator role is a role of this person</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">A role inheres in its bearer at all times for which the role exists, however the role need not be realized at all the times that the role exists.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">is role of</obo:IAO_0000118>
        <obo:IAO_0000118 xml:lang="en">role_of</obo:IAO_0000118>
        <rdfs:label xml:lang="en">role of</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0000085 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000085">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000034"/>
        <obo:IAO_0000115 xml:lang="en">a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence</obo:IAO_0000115>
        <rdfs:label xml:lang="en">has function</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0000086 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000086">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000019"/>
        <obo:IAO_0000112 xml:lang="en">this apple has quality this red color</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">has_quality</obo:IAO_0000118>
        <oboInOwl:hasDbXref>RO:0000086</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>protein</oboInOwl:hasOBONamespace>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>has_quality</oboInOwl:id>
        <oboInOwl:is_transitive rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</oboInOwl:is_transitive>
        <oboInOwl:shorthand>has_quality</oboInOwl:shorthand>
        <rdfs:label xml:lang="en">has quality</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0000087 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000087">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
        <obo:IAO_0000112 xml:lang="en">this person has role this investigator role (more colloquially: this person has this role of investigator)</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">has_role</obo:IAO_0000118>
        <oboInOwl:hasDbXref>RO:0000087</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>chebi_ontology</oboInOwl:hasOBONamespace>
        <oboInOwl:id>has_role</oboInOwl:id>
        <oboInOwl:is_cyclic rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</oboInOwl:is_cyclic>
        <oboInOwl:is_transitive rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</oboInOwl:is_transitive>
        <oboInOwl:shorthand>has_role</oboInOwl:shorthand>
        <rdfs:label xml:lang="en">has role</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0000091 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000091">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000092"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000016"/>
        <obo:IAO_0000115 xml:lang="en">a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence</obo:IAO_0000115>
        <rdfs:label xml:lang="en">has disposition</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0000092 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000092">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000052"/>
        <obo:IAO_0000115>inverse of has disposition</obo:IAO_0000115>
        <rdfs:label xml:lang="en">disposition of</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002013 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002013">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002017"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002334"/>
        <obo:IAO_0000115>A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B.</obo:IAO_0000115>
        <oboInOwl:created_by>dos</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-24T09:30:46Z</oboInOwl:creation_date>
        <rdfs:label>has regulatory component activity</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002014 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002014">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002013"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002335"/>
        <obo:IAO_0000115>A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole.  More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B.</obo:IAO_0000115>
        <oboInOwl:created_by>dos</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-24T09:31:01Z</oboInOwl:creation_date>
        <rdfs:comment>By convention GO molecular functions are classified by their effector function.  Internal regulatory functions are treated as components.  For example, NMDA glutmate receptor activity is a cation channel activity with positive regulatory component 'glutamate binding' and negative regulatory components including 'zinc binding' and 'magnesium binding'.</rdfs:comment>
        <rdfs:label>has negative regulatory component activity</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002015 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002015">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002013"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002336"/>
        <obo:IAO_0000115>A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole.  More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B.</obo:IAO_0000115>
        <oboInOwl:created_by>dos</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-24T09:31:17Z</oboInOwl:creation_date>
        <rdfs:comment>By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components.  So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'.</rdfs:comment>
        <rdfs:label>has positive regulatory component activity</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002017 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002017">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002018"/>
        <oboInOwl:created_by>dos</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-24T09:44:33Z</oboInOwl:creation_date>
        <rdfs:comment>A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B.</rdfs:comment>
        <rdfs:label>has component activity</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002018 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002018">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002180"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000115>w 'has process component' p if p and w are processes,  w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.</obo:IAO_0000115>
        <oboInOwl:created_by>dos</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-24T09:49:21Z</oboInOwl:creation_date>
        <rdfs:label>has component process</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002022 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002022">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002334"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002578"/>
        <oboInOwl:created_by>dos</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-09-17T13:52:24Z</oboInOwl:creation_date>
        <rdfs:comment>Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  regulates the kinase activity (P2) of protein B then P1 directly regulates P2.</rdfs:comment>
        <rdfs:label>directly regulated by</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002022"/>
        <owl:annotatedProperty rdf:resource="http://www.w3.org/2000/01/rdf-schema#comment"/>
        <owl:annotatedTarget>Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  regulates the kinase activity (P2) of protein B then P1 directly regulates P2.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dos</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/RO_0002023 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002023">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002022"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002630"/>
        <obo:IAO_0000115>Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1.</obo:IAO_0000115>
        <oboInOwl:created_by>dos</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-09-17T13:52:38Z</oboInOwl:creation_date>
        <rdfs:label>directly negatively regulated by</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002023"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dos</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/RO_0002024 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002024">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002022"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002629"/>
        <obo:IAO_0000115>Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1.</obo:IAO_0000115>
        <oboInOwl:created_by>dos</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-09-17T13:52:47Z</oboInOwl:creation_date>
        <rdfs:label>directly positively regulated by</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002024"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dos</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/RO_0002025 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002025">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002017"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#FunctionalProperty"/>
        <obo:IAO_0000115>A 'has effector activity' B if A and B are GO molecular functions (GO_0003674),  A 'has component activity' B and B is the effector (output function) of B.  Each compound function has only one effector activity.</obo:IAO_0000115>
        <oboInOwl:created_by>dos</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-09-22T14:14:36Z</oboInOwl:creation_date>
        <rdfs:comment>This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations.</rdfs:comment>
        <rdfs:label>has effector activity</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002025"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A 'has effector activity' B if A and B are GO molecular functions (GO_0003674),  A 'has component activity' B and B is the effector (output function) of B.  Each compound function has only one effector activity.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dos</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/RO_0002081 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002081">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002222"/>
        <rdfs:label xml:lang="en">before or simultaneous with</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002082 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002082">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002081"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002223"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002229"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <oboInOwl:hasDbXref>RO:0002082</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>simultaneous_with</oboInOwl:id>
        <oboInOwl:shorthand>simultaneous_with</oboInOwl:shorthand>
        <rdfs:label xml:lang="en">simultaneous with</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002086 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002086">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002222"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <obo:IAO_0000117>David Osumi-Sutherland</obo:IAO_0000117>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <rdfs:comment xml:lang="en">X ends_after Y iff: end(Y) before_or_simultaneous_with end(X)</rdfs:comment>
        <rdfs:label xml:lang="en">ends after</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002087 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002087">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000062"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002090"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002224"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002230"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)</obo:IAO_0000115>
        <obo:IAO_0000117>David Osumi-Sutherland</obo:IAO_0000117>
        <obo:IAO_0000118>starts_at_end_of</obo:IAO_0000118>
        <oboInOwl:hasDbXref>RO:0002087</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>directly preceded by</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>is directly preceded by</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>is immediately preceded by</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>starts_at_end_of</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>immediately_preceded_by</oboInOwl:id>
        <oboInOwl:shorthand>immediately_preceded_by</oboInOwl:shorthand>
        <rdfs:comment xml:lang="en">X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)</rdfs:comment>
        <rdfs:label xml:lang="en">immediately preceded by</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/SIO_000251"/>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002087"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>is immediately preceded by</owl:annotatedTarget>
        <oboInOwl:hasDbXref>SIO:000251</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/RO_0002090 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002090">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000063"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002230"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002224"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000117>David Osumi-Sutherland</obo:IAO_0000117>
        <obo:IAO_0000118>ends_at_start_of</obo:IAO_0000118>
        <obo:IAO_0000118>meets</obo:IAO_0000118>
        <obo:RO_0002575 rdf:resource="http://purl.obolibrary.org/obo/BFO_0000063"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <rdfs:comment xml:lang="en">X immediately_precedes_Y iff: end(X) simultaneous_with start(Y)</rdfs:comment>
        <rdfs:label xml:lang="en">immediately precedes</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002131 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002131">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002323"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#SymmetricProperty"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000051"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000051"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002131"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002131"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115>x overlaps y if and only if there exists some z such that x has part z and z part of y</obo:IAO_0000115>
        <obo:IAO_0000115>x overlaps y iff they have some part in common.</obo:IAO_0000115>
        <obo:IAO_0000424>http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y)</obo:IAO_0000424>
        <obo:RO_0001900 rdf:resource="http://purl.obolibrary.org/obo/RO_0001901"/>
        <oboInOwl:hasDbXref>RO:0002131</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>spatial</oboInOwl:hasOBONamespace>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>overlaps</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <oboInOwl:shorthand>overlaps</oboInOwl:shorthand>
        <rdfs:comment>"(forall (x y) (iff (overlaps x y) (exists (z) (and (part of z x) (part of z y)))))" CLIF []</rdfs:comment>
        <rdfs:label>overlaps</rdfs:label>
        <rdfs:label xml:lang="en">overlaps</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002131"/>
        <owl:annotatedProperty rdf:resource="http://www.w3.org/2002/07/owl#propertyChainAxiom"/>
        <owl:annotatedTarget rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000051"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:annotatedTarget>
        <obo:RO_0002582 rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</obo:RO_0002582>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002131"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>x overlaps y iff they have some part in common.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>BSPO:cjm</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/RO_0002160 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002160">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
        <obo:IAO_0000115>U only_in_taxon T: U is a feature found in only in organisms of species of taxon T. The feature cannot be found in an organism of any species outside of (not subsumed by) that taxon. Down-propagates in U hierarchy, up-propagates in T hierarchy (species taxonomy). Implies applicable_to_taxon.</obo:IAO_0000115>
        <obo:IAO_0000115>x only in taxon y if and only if x is in taxon y, and there is no other organism z such that y!=z a and x is in taxon z.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>RO:0002160</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>never_outside_taxon</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>specific_to</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>specific_to_taxon</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>protein</oboInOwl:hasOBONamespace>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>only_in_taxon</oboInOwl:id>
        <oboInOwl:is_transitive rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</oboInOwl:is_transitive>
        <oboInOwl:shorthand>only_in_taxon</oboInOwl:shorthand>
        <rdfs:comment>Down-propagates. The original name for this in the paper is 'specific_to'. Applicable to genes because some genes are lost in sub-species (strains) of a species.</rdfs:comment>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">only in taxon</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002160"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>U only_in_taxon T: U is a feature found in only in organisms of species of taxon T. The feature cannot be found in an organism of any species outside of (not subsumed by) that taxon. Down-propagates in U hierarchy, up-propagates in T hierarchy (species taxonomy). Implies applicable_to_taxon.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>ROC:Waclaw</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/RO_0002162 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002162">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002320"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/CARO_0001010"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002162"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000051"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002162"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002131"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002162"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002170"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002162"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002176"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002162"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002215"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002162"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002371"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002162"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>x is in taxon y if an only if y is an organism, and the relationship between x and y is one of: part of (reflexive), developmentally preceded by, derives from, secreted by, expressed.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>RO:0002162</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>in_taxon</oboInOwl:id>
        <oboInOwl:shorthand>in_taxon</oboInOwl:shorthand>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">in taxon</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002170 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002170">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002323"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/uberon/core#transitively_connected_to"/>
        <rdfs:domain>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/RO_0002577"/>
            </owl:Restriction>
        </rdfs:domain>
        <rdfs:range>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/RO_0002577"/>
            </owl:Restriction>
        </rdfs:range>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description>
                <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002176"/>
            </rdf:Description>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002176"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>Binary relationship: x connected_to y if and only if there exists some z such that z connects x and y in a ternary connected_to(x,y,z) relationship.</obo:IAO_0000115>
        <obo:IAO_0000115>a is connected to b if and only if a and b are discrete structure, and there exists some connecting structure c, such that c connects a and b</obo:IAO_0000115>
        <oboInOwl:hasDbXref>RO:0002170</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>connected_to</oboInOwl:id>
        <oboInOwl:shorthand>connected_to</oboInOwl:shorthand>
        <rdfs:comment>Connection does not imply overlaps.</rdfs:comment>
        <rdfs:label xml:lang="en">connected to</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/SIO_000652"/>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002170"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Binary relationship: x connected_to y if and only if there exists some z such that z connects x and y in a ternary connected_to(x,y,z) relationship.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern"/>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/RO_0002176 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002176">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002323"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <rdfs:range>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/RO_0002577"/>
            </owl:Restriction>
        </rdfs:range>
        <obo:IAO_0000115>Binary relationship: z connects x if and only if there exists some y such that z connects x and y in a ternary connected_to(x,y,z) relationship.</obo:IAO_0000115>
        <obo:IAO_0000115>c connects a if and only if there exist some b such that a and b are similar parts of the same system, and c connects b, specifically, c connects a with b. When one structure connects two others it unites some aspect of the function or role they play within the system.</obo:IAO_0000115>
        <obo:IAO_0000116>this is currently used for both structural relationships (such as between a valve and the chamber it connects) and abstract relationships (anatomical lines and the entities they connect)</obo:IAO_0000116>
        <oboInOwl:hasDbXref>RO:0002176</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>connects</oboInOwl:id>
        <oboInOwl:shorthand>connects</oboInOwl:shorthand>
        <rdfs:label xml:lang="en">connects</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002176"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Binary relationship: z connects x if and only if there exists some y such that z connects x and y in a ternary connected_to(x,y,z) relationship.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern"/>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/RO_0002177 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002177">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002323"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002567"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/CARO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/CARO_0000003"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002371"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002371"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>a is attached to part of b if a is attached to b, or a is attached to some p, where p is part of b.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>RO:0002177</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>attaches_to_part_of</oboInOwl:id>
        <oboInOwl:shorthand>attaches_to_part_of</oboInOwl:shorthand>
        <rdfs:label xml:lang="en">attached to part of</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002177"/>
        <owl:annotatedProperty rdf:resource="http://www.w3.org/2002/07/owl#propertyChainAxiom"/>
        <owl:annotatedTarget rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002371"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:annotatedTarget>
        <obo:IAO_isReversiblePropertyChain>true</obo:IAO_isReversiblePropertyChain>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002177"/>
        <owl:annotatedProperty rdf:resource="http://www.w3.org/2002/07/owl#propertyChainAxiom"/>
        <owl:annotatedTarget rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002371"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:annotatedTarget>
        <obo:RO_0002582 rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</obo:RO_0002582>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/RO_0002180 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002180">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115>w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.</obo:IAO_0000115>
        <obo:IAO_0000116>The definition of 'has component' is still under discussion. The challenge is in providing a definition that does not imply transitivity.</obo:IAO_0000116>
        <obo:IAO_0000232 xml:lang="en">For use in recording has_part with a cardinality constraint, because OWL does not permit cardinality constraints to be used in combination with transitive object properties. In situations where you would want to say something like 'has part exactly 5 digit, you would instead use has_component exactly 5 digit.</obo:IAO_0000232>
        <obo:RO_0001900 rdf:resource="http://purl.obolibrary.org/obo/RO_0001901"/>
        <oboInOwl:hasDbXref>RO:0002180</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>protein</oboInOwl:hasOBONamespace>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>has_component</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <oboInOwl:is_transitive rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</oboInOwl:is_transitive>
        <oboInOwl:shorthand>has_component</oboInOwl:shorthand>
        <rdfs:label xml:lang="en">has component</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://ontologydesignpatterns.org/wiki/Submissions:Componency"/>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002211 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002211">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002334"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002211"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002025"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002230"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002211"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002578"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002578"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115>process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2.</obo:IAO_0000115>
        <obo:IAO_0000116>We use 'regulates' here to specifically imply control. However, many colloquial usages of the term correctly correspond to the weaker relation of 'causally upstream of or within' (aka influences). Consider relabeling to make things more explicit</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000117>David Hill</obo:IAO_0000117>
        <obo:IAO_0000117>Tanya Berardini</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000119>GO</obo:IAO_0000119>
        <obo:IAO_0000232>Regulation precludes parthood; the regulatory process may not be within the regulated process.</obo:IAO_0000232>
        <obo:IAO_0000589>regulates (processual)</obo:IAO_0000589>
        <obo:IAO_0000600 rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</obo:IAO_0000600>
        <oboInOwl:hasDbXref>RO:0002211</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>external</oboInOwl:hasOBONamespace>
        <oboInOwl:id>regulates</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_ontology"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <oboInOwl:shorthand>regulates</oboInOwl:shorthand>
        <rdfs:label xml:lang="en">regulates</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002212 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002212">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002305"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002335"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002230"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002212"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000589>negatively regulates (process to process)</obo:IAO_0000589>
        <obo:RO_0004050 rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
        <oboInOwl:hasDbXref>RO:0002212</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>external</oboInOwl:hasOBONamespace>
        <oboInOwl:id>negatively_regulates</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_ontology"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <oboInOwl:shorthand>negatively_regulates</oboInOwl:shorthand>
        <rdfs:label xml:lang="en">negatively regulates</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002213 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002213">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002304"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002336"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002212"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002212"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002230"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002213"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>Process(P1) postively regulates process(P2) iff: P1 initiates P2, or P1 increases the the frequency of initiation of P2 or the magnitude or rate of output of P2.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000589>positively regulates (process to process)</obo:IAO_0000589>
        <obo:RO_0004049 rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
        <oboInOwl:hasDbXref>RO:0002213</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>external</oboInOwl:hasOBONamespace>
        <oboInOwl:id>positively_regulates</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_ontology"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <oboInOwl:shorthand>positively_regulates</oboInOwl:shorthand>
        <rdfs:label xml:lang="en">positively regulates</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002215 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002215">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002216"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002328"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000112>mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974)</obo:IAO_0000112>
        <obo:IAO_0000112>osteoclast SubClassOf 'capable of' some 'bone resorption'</obo:IAO_0000112>
        <obo:IAO_0000115>A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. </obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>has function realized in</obo:IAO_0000118>
        <obo:IAO_0000119 rdf:resource="http://www.ncbi.nlm.nih.gov/pubmed/20123131"/>
        <obo:IAO_0000119 rdf:resource="http://www.ncbi.nlm.nih.gov/pubmed/21208450"/>
        <obo:IAO_0000232>For compatibility with BFO, this relation has a shortcut definition in which the expression "capable of some P" expands to "bearer_of (some realized_by only P)".</obo:IAO_0000232>
        <obo:IAO_0000424>RO_0000053 some (RO_0000054 only ?Y)</obo:IAO_0000424>
        <oboInOwl:hasDbXref>RO:0002215</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>external</oboInOwl:hasOBONamespace>
        <oboInOwl:hasOBONamespace>protein</oboInOwl:hasOBONamespace>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>capable_of</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/cl#ro-eco"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <oboInOwl:is_transitive rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</oboInOwl:is_transitive>
        <oboInOwl:shorthand>capable_of</oboInOwl:shorthand>
        <rdfs:label xml:lang="en">capable of</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002216 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002216">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002328"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002500"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002215"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>has function in</obo:IAO_0000118>
        <obo:IAO_0000424>RO_0000053 some (RO_0000054 only (BFO_0000050 some ?Y))</obo:IAO_0000424>
        <oboInOwl:hasDbXref>RO:0002216</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>capable_of_part_of</oboInOwl:id>
        <oboInOwl:shorthand>capable_of_part_of</oboInOwl:shorthand>
        <rdfs:label xml:lang="en">capable of part of</rdfs:label>
        <rdfs:seeAlso rdf:resource="https://github.com/oborel/obo-relations/wiki/ROGuide#defining-property-chains-involving-reflexivity"/>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002216"/>
        <owl:annotatedProperty rdf:resource="http://www.w3.org/2002/07/owl#propertyChainAxiom"/>
        <owl:annotatedTarget rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002215"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:annotatedTarget>
        <obo:RO_0002582 rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</obo:RO_0002582>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/RO_0002222 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002222">
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="https://en.wikipedia.org/wiki/Allen%27s_interval_algebra"/>
        <obo:IAO_0000232>Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends.</obo:IAO_0000232>
        <terms:source rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit?pli=1</terms:source>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <rdfs:comment>A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations.</rdfs:comment>
        <rdfs:label xml:lang="en">temporally related to</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002223 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002223">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002222"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002224"/>
        <obo:IAO_0000115>Relation between occurrents, shares a start boundary with.</obo:IAO_0000115>
        <obo:IAO_0000115>inverse of starts with</obo:IAO_0000115>
        <oboInOwl:hasDbXref>RO:0002223</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>starts</oboInOwl:id>
        <oboInOwl:shorthand>starts</oboInOwl:shorthand>
        <rdfs:label xml:lang="en">starts</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002223"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Relation between occurrents, shares a start boundary with.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="https://orcid.org/0000-0002-6601-2165"/>
        <oboInOwl:hasDbXref>Allen:starts</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/RO_0002224 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002224">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002222"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <obo:IAO_0000115>x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>RO:0002224</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>starts_with</oboInOwl:id>
        <oboInOwl:shorthand>starts_with</oboInOwl:shorthand>
        <rdfs:label xml:lang="en">starts with</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002229 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002229">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002222"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002230"/>
        <obo:IAO_0000115>Relation between occurrents, shares an end boundary with.</obo:IAO_0000115>
        <obo:IAO_0000115>inverse of ends with</obo:IAO_0000115>
        <oboInOwl:hasDbXref>RO:0002229</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>finishes</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>ends</oboInOwl:id>
        <oboInOwl:shorthand>ends</oboInOwl:shorthand>
        <rdfs:label xml:lang="en">ends</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002229"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Relation between occurrents, shares an end boundary with.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="https://orcid.org/0000-0002-6601-2165"/>
        <oboInOwl:hasDbXref>Allen:starts</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ZFS:finishes</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/RO_0002230 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002230">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002222"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <obo:IAO_0000115>x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>RO:0002230</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>ends_with</oboInOwl:id>
        <oboInOwl:shorthand>ends_with</oboInOwl:shorthand>
        <rdfs:label xml:lang="en">ends with</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002231 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002231">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002479"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002224"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000066"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>x 'has starts location' y if and only if there exists some process z such that x 'starts with' z and z 'occurs in' y</obo:IAO_0000115>
        <rdfs:label xml:lang="en">has start location</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002232 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002232">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002479"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002230"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000066"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>x 'has end location' y if and only if there exists some process z such that x 'ends with' z and z 'occurs in' y</obo:IAO_0000115>
        <rdfs:label xml:lang="en">has end location</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002233 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002233">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002352"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002224"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002233"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115>p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>consumes</obo:IAO_0000118>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_ontology"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <rdfs:label xml:lang="en">has input</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002263 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002263">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002264"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002411"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000112>A faulty traffic light (material entity) whose malfunctioning (a process) is causally upstream of a traffic collision (a process): the traffic light acts upstream of the collision.</obo:IAO_0000112>
        <obo:IAO_0000115>c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes.</obo:IAO_0000115>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <rdfs:label>acts upstream of</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://wiki.geneontology.org/index.php/Acts_upstream_of"/>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002264 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002264">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002500"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002418"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000112>A gene product that has some activity, where that activity may be a part of a pathway or upstream of the pathway.</obo:IAO_0000112>
        <obo:IAO_0000115>c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process.</obo:IAO_0000115>
        <oboInOwl:hasRelatedSynonym>affects</oboInOwl:hasRelatedSynonym>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <rdfs:label>acts upstream of or within</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within"/>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002304 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002304">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004047"/>
        <obo:RO_0004049 rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
        <terms:creator>cjm</terms:creator>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <rdfs:comment>holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y</rdfs:comment>
        <rdfs:label>causally upstream of, positive effect</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002305 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002305">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004046"/>
        <obo:RO_0004050 rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
        <terms:creator>cjm</terms:creator>
        <rdfs:comment>holds between x and y if and only if x is causally upstream of y and the progression of x decreases the frequency, rate or extent of y</rdfs:comment>
        <rdfs:label>causally upstream of, negative effect</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002314 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002314">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002502"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0000052"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002314"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w.</obo:IAO_0000115>
        <obo:IAO_0000115>q inheres in part of w if and only if there exists some p such that q inheres in p and p part of w.</obo:IAO_0000115>
        <obo:IAO_0000116>Because part_of is transitive, inheres in is a sub-relation of inheres in part of</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://www.ncbi.nlm.nih.gov/pubmed/20064205"/>
        <obo:RO_0001900 rdf:resource="http://purl.obolibrary.org/obo/RO_0001901"/>
        <rdfs:label xml:lang="en">characteristic of part of</rdfs:label>
        <rdfs:seeAlso rdf:resource="https://github.com/oborel/obo-relations/wiki/ROGuide#defining-property-chains-involving-reflexivity"/>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002314"/>
        <owl:annotatedProperty rdf:resource="http://www.w3.org/2002/07/owl#propertyChainAxiom"/>
        <owl:annotatedTarget rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0000052"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:annotatedTarget>
        <obo:RO_0002582 rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</obo:RO_0002582>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/RO_0002320 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002320">
        <obo:IAO_0000115>A relationship that holds via some environmental process</obo:IAO_0000115>
        <rdfs:label xml:lang="en">evolutionarily related to</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002323 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002323">
        <obo:IAO_0000115>A mereological relationship or a topological relationship</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000232>Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships</obo:IAO_0000232>
        <obo:RO_0001900 rdf:resource="http://purl.obolibrary.org/obo/RO_0001901"/>
        <rdfs:label xml:lang="en">mereotopologically related to</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002327 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002327">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002215"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002333"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000051"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002017"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000112>a particular instances of akt-2 enables some instance of protein kinase activity</obo:IAO_0000112>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>catalyzes</obo:IAO_0000118>
        <obo:IAO_0000118>executes</obo:IAO_0000118>
        <obo:IAO_0000118>has</obo:IAO_0000118>
        <obo:IAO_0000118>is catalyzing</obo:IAO_0000118>
        <obo:IAO_0000118>is executing</obo:IAO_0000118>
        <obo:IAO_0000232>This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized.</obo:IAO_0000232>
        <obo:IAO_0000232>This relation is currently used experimentally by the Gene Ontology Consortium. It may not be stable and may be obsoleted at some future time.</obo:IAO_0000232>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <rdfs:label xml:lang="en">enables</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002328 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002328">
        <obo:IAO_0000115>A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000232>This is a grouping relation that collects relations used for the purpose of connecting structure and function</obo:IAO_0000232>
        <oboInOwl:hasDbXref>RO:0002328</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>functionally_related_to</oboInOwl:id>
        <oboInOwl:shorthand>functionally_related_to</oboInOwl:shorthand>
        <rdfs:label xml:lang="en">functionally related to</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002329 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002329">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002328"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002215"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>this relation holds between c and p when c is part of some c', and c' is capable of p.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</obo:IAO_0000118>
        <rdfs:label xml:lang="en">part of structure that is capable of</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002329"/>
        <owl:annotatedProperty rdf:resource="http://www.w3.org/2002/07/owl#propertyChainAxiom"/>
        <owl:annotatedTarget rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002215"/>
        </owl:annotatedTarget>
        <obo:RO_0002581 rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</obo:RO_0002581>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/RO_0002331 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002331">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002431"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002331"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>c involved_in p if and only if c enables some process p', and p' is part of p</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>actively involved in</obo:IAO_0000118>
        <obo:IAO_0000118>enables part of</obo:IAO_0000118>
        <rdfs:label xml:lang="en">involved in</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://wiki.geneontology.org/index.php/Involved_in"/>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002333 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002333">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002328"/>
        <obo:IAO_0000115>inverse of enables</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <rdfs:label xml:lang="en">enabled by</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002334 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002334">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002427"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000115>inverse of regulates</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000589>regulated by (processual)</obo:IAO_0000589>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/RO_0002259"/>
        <rdfs:label xml:lang="en">regulated by</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002335 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002335">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002334"/>
        <obo:IAO_0000115>inverse of negatively regulates</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/RO_0002259"/>
        <rdfs:label xml:lang="en">negatively regulated by</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002336 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002336">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002334"/>
        <obo:IAO_0000115>inverse of positively regulates</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/RO_0002259"/>
        <rdfs:label xml:lang="en">positively regulated by</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002352 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002352">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002328"/>
        <obo:IAO_0000115>inverse of has input</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <oboInOwl:hasDbXref>RO:0002352</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>input_of</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/RO_0002259"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <oboInOwl:shorthand>input_of</oboInOwl:shorthand>
        <rdfs:label xml:lang="en">input of</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002371 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002371">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002170"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002176"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002177"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#SymmetricProperty"/>
        <obo:IAO_0000115>a is attached to b if and only if a and b are discrete objects or object parts, and there are physical connections between a and b such that a force pulling a will move b, or a force pulling b will move a</obo:IAO_0000115>
        <oboInOwl:hasDbXref>RO:0002371</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>attaches_to</oboInOwl:id>
        <oboInOwl:shorthand>attaches_to</oboInOwl:shorthand>
        <rdfs:label xml:lang="en">attached to</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/FMA_85990"/>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002404 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002404">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000062"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002427"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
        <obo:IAO_0000115>inverse of upstream of</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <rdfs:label xml:lang="en">causally downstream of</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002405 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002405">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002087"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002404"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002412"/>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <rdfs:label xml:lang="en">immediately causally downstream of</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002410 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002410">
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
        <obo:IAO_0000115>This relation groups causal relations between material entities and causal relations between processes</obo:IAO_0000115>
        <obo:IAO_0000116>This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an 'activity flow-centric approach', with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents.

To define causal relations in an activity-flow type network, we make use of 3 primitives:

 * Temporal: how do the intervals of the two occurrents relate?
 * Is the causal relation regulatory?
 * Is the influence positive or negative

The first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are 'direct', 'indirect' or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under 'temporally related to'). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified.

For the second, we consider a relationship to be regulatory if the system in which the activities occur is capable of altering the relationship to achieve some objective. This could include changing the rate of production of a molecule.

For the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral.

Each of these 3 primitives can be composed to yield a cross-product of different relation types.</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000232>Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.</obo:IAO_0000232>
        <rdfs:label xml:lang="en">causally related to</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002411 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002411">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000063"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002418"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
        <obo:IAO_0000115>p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <rdfs:label xml:lang="en">causally upstream of</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002412 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002412">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002090"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
        <obo:IAO_0000115>p is immediately causally upstream of q iff both (a) p immediately precedes q and (b) p is causally upstream of q. In addition, the output of p  must be an input of q.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:RO_0002575 rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
        <rdfs:label xml:lang="en">immediately causally upstream of</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002418 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002418">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002501"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002427"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <obo:IAO_0000115>p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q.</obo:IAO_0000115>
        <obo:IAO_0000116>We would like to make this disjoint with 'preceded by', but this is prohibited in OWL2</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>influences (processual)</obo:IAO_0000118>
        <oboInOwl:hasRelatedSynonym>affects</oboInOwl:hasRelatedSynonym>
        <rdfs:label>causally upstream of or within</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002427 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002427">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002501"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <obo:IAO_0000115>inverse of causally upstream of or within</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/RO_0002259"/>
        <rdfs:label>causally downstream of or within</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002428 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002428">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002263"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002431"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002211"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002331"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002211"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>c involved in regulation of p if c is involved in some p' and p' regulates some p</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <rdfs:label>involved in regulation of</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002429 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002429">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002428"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002213"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002331"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002213"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>c involved in regulation of p if c is involved in some p' and p' positively regulates some p</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:RO_0004049 rdf:resource="http://purl.obolibrary.org/obo/RO_0002428"/>
        <rdfs:label>involved in positive regulation of</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002430 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002430">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002428"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002212"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002331"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002212"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>c involved in regulation of p if c is involved in some p' and p' negatively regulates some p</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:RO_0004050 rdf:resource="http://purl.obolibrary.org/obo/RO_0002428"/>
        <rdfs:label>involved in negative regulation of</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002431 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002431">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002264"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002328"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002500"/>
        <obo:IAO_0000115>c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p</obo:IAO_0000115>
        <obo:IAO_0000116>OWL does not allow defining object properties via a Union</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>involved in or reguates</obo:IAO_0000118>
        <rdfs:label>involved in or involved in regulation of</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002432 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002432">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002131"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002328"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000066"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000112>A protein that enables activity in a cytosol.</obo:IAO_0000112>
        <obo:IAO_0000115>c executes activity in d if and only if c enables p and p occurs_in d.  Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>executes activity in</obo:IAO_0000118>
        <oboInOwl:hasExactSynonym>enables activity in</oboInOwl:hasExactSynonym>
        <rdfs:comment></rdfs:comment>
        <rdfs:label>is active in</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002432"/>
        <owl:annotatedProperty rdf:resource="http://www.w3.org/2002/07/owl#propertyChainAxiom"/>
        <owl:annotatedTarget rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000066"/>
        </owl:annotatedTarget>
        <obo:RO_0002581 rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</obo:RO_0002581>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002432"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>c executes activity in d if and only if c enables p and p occurs_in d.  Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>GOC:cjm</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dos</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/RO_0002434 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002434">
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#SymmetricProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>A relationship that holds between two entities in which the processes executed by the two entities are causally connected.</obo:IAO_0000115>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">Considering relabeling as 'pairwise interacts with'</obo:IAO_0000116>
        <obo:IAO_0000116>This relation and all sub-relations can be applied to either (1) pairs of entities that are interacting at any moment of time (2) populations or species of entity whose members have the disposition to interact (3) classes whose members have the disposition to interact.</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000232>Note that this relationship type, and sub-relationship types may be redundant with process terms from other ontologies. For example, the symbiotic relationship hierarchy parallels GO. The relations are provided as a convenient shortcut. Consider using the more expressive processual form to capture your data. In the future, these relations will be linked to their cognate processes through rules.</obo:IAO_0000232>
        <oboInOwl:hasExactSynonym>in pairwise interaction with</oboInOwl:hasExactSynonym>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <rdfs:label>interacts with</rdfs:label>
        <rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">http://purl.obolibrary.org/obo/MI_0914</rdfs:seeAlso>
        <foaf:page rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/oborel/obo-relations/wiki/InteractionRelations</foaf:page>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002436 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002436">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002434"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#SymmetricProperty"/>
        <obo:IAO_0000115>An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>binds</obo:IAO_0000118>
        <obo:IAO_0000118>molecularly binds with</obo:IAO_0000118>
        <rdfs:label>molecularly interacts with</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/ECO_0000353"/>
        <rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">http://purl.obolibrary.org/obo/MI_0915</rdfs:seeAlso>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002447 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002447">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002436"/>
        <obo:IAO_0000116>Axiomatization to GO to be added later</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>An interaction relation between x and y in which x catalyzes a reaction in which a phosphate group is added to y.</obo:IAO_0000118>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">phosphorylates</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002448 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002448">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002436"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0011002"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002211"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002333"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B.

A and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <oboInOwl:hasExactSynonym>molecularly controls</oboInOwl:hasExactSynonym>
        <rdfs:label>directly regulates activity of</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002449 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002449">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002448"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002630"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002333"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B.
For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <obo:IAO_0000118>directly inhibits</obo:IAO_0000118>
        <oboInOwl:hasExactSynonym>molecularly decreases activity of</oboInOwl:hasExactSynonym>
        <rdfs:label>directly negatively regulates activity of</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002450 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002450">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002448"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002629"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002333"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B.
For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <obo:IAO_0000118>directly activates</obo:IAO_0000118>
        <oboInOwl:hasExactSynonym>molecularly increases activity of</oboInOwl:hasExactSynonym>
        <rdfs:label>directly positively regulates activity of</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002464 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002464">
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000232>This property or its subproperties is not to be used directly. These properties exist as helper properties that are used to support OWL reasoning.</obo:IAO_0000232>
        <rdfs:label>helper property (not for use in curation)</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002479 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002479">
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000051"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000066"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <rdfs:label>has part that occurs in</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002479"/>
        <owl:annotatedProperty rdf:resource="http://www.w3.org/2002/07/owl#propertyChainAxiom"/>
        <owl:annotatedTarget rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000051"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000066"/>
        </owl:annotatedTarget>
        <obo:RO_0002581 rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</obo:RO_0002581>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/RO_0002481 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002481">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002564"/>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <rdfs:label>is kinase activity</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002487 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002487">
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:label>relation between physical entity and a process or stage</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002496 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002496">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002487"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002496"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002496"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002496"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000062"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002496"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002082"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>x existence starts during or after y if and only if the time point at which x starts is after or equivalent to the time point at which y starts. Formally: x existence starts during or after y iff α (x) >= α (y).</obo:IAO_0000115>
        <oboInOwl:hasDbXref>RO:0002496</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>existence_starts_during_or_after</oboInOwl:id>
        <oboInOwl:shorthand>existence_starts_during_or_after</oboInOwl:shorthand>
        <rdfs:label>existence starts during or after</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002497 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002497">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002487"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002497"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002497"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000050"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002497"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000063"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002497"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002082"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>x existence ends during or before y if and only if the time point at which x ends is before or equivalent to the time point at which y ends.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>RO:0002497</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>existence_ends_during_or_before</oboInOwl:id>
        <oboInOwl:shorthand>existence_ends_during_or_before</oboInOwl:shorthand>
        <rdfs:label>existence ends during or before</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002500 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002500">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002595"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002608"/>
        <obo:IAO_0000115>A relationship between a material entity and a process where the material entity has some causal role that influences the process</obo:IAO_0000115>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <rdfs:label>causal agent in process</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002501 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002501">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:IAO_0000115>p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000232>Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.</obo:IAO_0000232>
        <rdfs:label>causal relation between processes</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002502 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002502">
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <rdfs:label>depends on</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/BFO_0000169"/>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002506 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002506">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <obo:IAO_0000116>The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000232>Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.</obo:IAO_0000232>
        <rdfs:label>causal relation between entities</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002559 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002559">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002506"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002566"/>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000589>causally influenced by (entity-centric)</obo:IAO_0000589>
        <rdfs:label>causally influenced by</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002563 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002563">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002464"/>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <rdfs:label>interaction relation helper property</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://ontologydesignpatterns.org/wiki/Submissions:N-Ary_Relation_Pattern_%28OWL_2%29"/>
        <foaf:page rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/oborel/obo-relations/wiki/InteractionRelations</foaf:page>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002564 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002564">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002563"/>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <rdfs:label>molecular interaction relation helper property</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002566 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002566">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002506"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002411"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002233"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002411"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002333"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size).</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000589>causally influences (entity-centric)</obo:IAO_0000589>
        <rdfs:label>causally influences</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002567 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002567">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002328"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/CARO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/CARO_0000003"/>
        <obo:IAO_0000115>A relation that holds between elements of a musculoskeletal system or its analogs.</obo:IAO_0000115>
        <rdfs:label>biomechanically related to</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002578 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002578">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002412"/>
        <obo:IAO_0000115>Process(P1) directly regulates process(P2) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  regulates the kinase activity (P2) of protein B then P1 directly regulates P2.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000589>directly regulates (processual)</obo:IAO_0000589>
        <obo:RO_0002575 rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_ontology"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <rdfs:label>directly regulates</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002584 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002584">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002328"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002595"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000051"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002215"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000112>gland SubClassOf 'has part structure that is capable of' some 'secretion by cell'</obo:IAO_0000112>
        <obo:IAO_0000115>s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <rdfs:label>has part structure that is capable of</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002595 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002595">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000115>A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity.</obo:IAO_0000115>
        <obo:IAO_0000116>Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <rdfs:label>causal relation between material entity and a process</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002596 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002596">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002500"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002215"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002211"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000112>pyrethroid -> growth</obo:IAO_0000112>
        <obo:IAO_0000115>Holds between c and p if and only if c is capable of some activity a, and a regulates p.</obo:IAO_0000115>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <rdfs:label>capable of regulating</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002597 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002597">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002596"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002215"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002212"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p.</obo:IAO_0000115>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <rdfs:label>capable of negatively regulating</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002598 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002598">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002596"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002215"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002213"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000112>renin -> arteriolar smooth muscle contraction</obo:IAO_0000112>
        <obo:IAO_0000115>Holds between c and p if and only if c is capable of some activity a, and a positively regulates p.</obo:IAO_0000115>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <rdfs:label>capable of positively regulating</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002608 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002608">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
        <obo:IAO_0000115>Inverse of 'causal agent in process'</obo:IAO_0000115>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <rdfs:label>process has causal agent</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002629 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002629">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002213"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002578"/>
        <obo:IAO_0000115>Process(P1) directly postively regulates process(P2) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P1 directly positively regulates P2.</obo:IAO_0000115>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000589>directly positively regulates (process to process)</obo:IAO_0000589>
        <obo:RO_0004049 rdf:resource="http://purl.obolibrary.org/obo/RO_0002578"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_ontology"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <rdfs:label>directly positively regulates</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0002630 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002630">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002212"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002578"/>
        <obo:IAO_0000115>Process(P1) directly negatively regulates process(P2) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  negatively regulates the kinase activity (P2) of protein B then P1 directly negatively regulates P2.</obo:IAO_0000115>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000589>directly negatively regulates (process to process)</obo:IAO_0000589>
        <obo:RO_0004050 rdf:resource="http://purl.obolibrary.org/obo/RO_0002578"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_ontology"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <rdfs:label>directly negatively regulates</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0004031 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004031">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002328"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000051"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P.</obo:IAO_0000115>
        <oboInOwl:created_by>cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-01-25T23:20:13Z</oboInOwl:creation_date>
        <rdfs:label>enables subfunction</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0004032 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004032">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002264"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0004047"/>
        </owl:propertyChainAxiom>
        <obo:RO_0004049 rdf:resource="http://purl.obolibrary.org/obo/RO_0002264"/>
        <oboInOwl:created_by>cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-01-26T23:49:30Z</oboInOwl:creation_date>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <rdfs:label>acts upstream of or within, positive effect</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within,_positive_effect"/>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0004033 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004033">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002264"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0004046"/>
        </owl:propertyChainAxiom>
        <obo:RO_0004050 rdf:resource="http://purl.obolibrary.org/obo/RO_0002264"/>
        <oboInOwl:created_by>cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-01-26T23:49:51Z</oboInOwl:creation_date>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <rdfs:label>acts upstream of or within, negative effect</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0004034 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004034">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002263"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004032"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002304"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive</obo:IAO_0000115>
        <obo:RO_0004049 rdf:resource="http://purl.obolibrary.org/obo/RO_0002263"/>
        <oboInOwl:created_by>cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-01-26T23:53:14Z</oboInOwl:creation_date>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <rdfs:label>acts upstream of, positive effect</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://wiki.geneontology.org/index.php/Acts_upstream_of,_positive_effect"/>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0004035 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004035">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002263"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004033"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002305"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative</obo:IAO_0000115>
        <obo:RO_0004050 rdf:resource="http://purl.obolibrary.org/obo/RO_0002263"/>
        <oboInOwl:created_by>cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-01-26T23:53:22Z</oboInOwl:creation_date>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <rdfs:label>acts upstream of, negative effect</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://wiki.geneontology.org/index.php/Acts_upstream_of,_negative_effect"/>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0004046 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004046">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002418"/>
        <obo:RO_0004050 rdf:resource="http://purl.obolibrary.org/obo/RO_0002418"/>
        <oboInOwl:created_by>cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-03-13T23:55:05Z</oboInOwl:creation_date>
        <rdfs:label>causally upstream of or within, negative effect</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0004047 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004047">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002418"/>
        <obo:RO_0004049 rdf:resource="http://purl.obolibrary.org/obo/RO_0002418"/>
        <oboInOwl:created_by>cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-03-13T23:55:19Z</oboInOwl:creation_date>
        <rdfs:label>causally upstream of or within, positive effect</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0011002 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0011002">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002566"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B.</obo:IAO_0000115>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <rdfs:label>regulates activity of</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0017001 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0017001">
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002215"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002233"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">device utilizes material</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0019000 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0019000">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/PATO_0000001"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002211"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0019000"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>A relationship that holds between a process and a characteristic in which process (P) regulates characteristic (C) iff: P results in the existence of C OR affects the intensity or magnitude of C.</obo:IAO_0000115>
        <rdfs:label>regulates characteristic</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0019001 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0019001">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0019000"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002213"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0019001"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>A relationship that holds between a process and a characteristic in which process (P) positively regulates characteristic (C) iff: P results in an increase in the intensity or magnitude of C.</obo:IAO_0000115>
        <rdfs:label>positively regulates characteristic</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/RO_0019002 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0019002">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0019000"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002212"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0019001"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002213"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0019002"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>A relationship that holds between a process and a characteristic in which process (P) negatively regulates characteristic (C) iff: P results in a decrease in the intensity or magnitude of C.</obo:IAO_0000115>
        <rdfs:label>negatively regulates characteristic</rdfs:label>
    </owl:ObjectProperty>

    <!-- http://purl.obolibrary.org/obo/uberon/core#transitively_connected_to -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/uberon/core#transitively_connected_to">
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>transitively_connected_to</oboInOwl:id>
        <rdfs:label>transitively_connected to</rdfs:label>
    </owl:ObjectProperty>

    <!--
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <!-- http://purl.obolibrary.org/obo/BFO_0000001 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000001">
        <obo:BFO_0000179>entity</obo:BFO_0000179>
        <obo:BFO_0000180>Entity</obo:BFO_0000180>
        <obo:IAO_0000112 xml:lang="en">Julius Caesar</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">Verdi’s Requiem</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the Second World War</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">your body mass index</obo:IAO_0000112>
        <obo:IAO_0000116 xml:lang="en">BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf</obo:IAO_0000116>
        <obo:IAO_0000600 xml:lang="en">An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])</obo:IAO_0000600>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">entity</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000001"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000116"/>
        <owl:annotatedTarget xml:lang="en">Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf</owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/0000004"/>
        <rdfs:comment>per discussion with Barry Smith</rdfs:comment>
        <rdfs:seeAlso rdf:resource="http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000001"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000600"/>
        <owl:annotatedTarget xml:lang="en">An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])</owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/001-001"/>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/BFO_0000002 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000002">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000001"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <owl:disjointWith>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
            </owl:Restriction>
        </owl:disjointWith>
        <obo:BFO_0000179>continuant</obo:BFO_0000179>
        <obo:BFO_0000180>Continuant</obo:BFO_0000180>
        <obo:IAO_0000115 xml:lang="en">An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants</obo:IAO_0000116>
        <obo:IAO_0000600 xml:lang="en">A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])</obo:IAO_0000600>
        <obo:IAO_0000601 xml:lang="en">if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])</obo:IAO_0000601>
        <obo:IAO_0000601 xml:lang="en">if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])</obo:IAO_0000601>
        <obo:IAO_0000601 xml:lang="en">if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])</obo:IAO_0000601>
        <obo:IAO_0000602>(forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002] </obo:IAO_0000602>
        <obo:IAO_0000602>(forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001] </obo:IAO_0000602>
        <obo:IAO_0000602>(forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002] </obo:IAO_0000602>
        <obo:IAO_0000602>(forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002] </obo:IAO_0000602>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">continuant</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000116"/>
        <owl:annotatedTarget xml:lang="en">Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants</owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/0000007"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000600"/>
        <owl:annotatedTarget xml:lang="en">A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])</owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/008-002"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000601"/>
        <owl:annotatedTarget xml:lang="en">if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])</owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/126-001"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000601"/>
        <owl:annotatedTarget xml:lang="en">if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])</owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/009-002"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000601"/>
        <owl:annotatedTarget xml:lang="en">if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])</owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/011-002"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000602"/>
        <owl:annotatedTarget>(forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002] </owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/009-002"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000602"/>
        <owl:annotatedTarget>(forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001] </owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/126-001"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000602"/>
        <owl:annotatedTarget>(forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002] </owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/008-002"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000602"/>
        <owl:annotatedTarget>(forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002] </owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/011-002"/>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/BFO_0000003 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000003">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000001"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <owl:disjointWith>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
            </owl:Restriction>
        </owl:disjointWith>
        <obo:IAO_0000115 xml:lang="en">An entity that has temporal parts and that happens, unfolds or develops through time.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">occurrent</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/BFO_0000004 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000004">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/BFO_0000020"/>
        <obo:BFO_0000179>ic</obo:BFO_0000179>
        <obo:BFO_0000180>IndependentContinuant</obo:BFO_0000180>
        <obo:IAO_0000112 xml:lang="en">a chair</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">a heart</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">a leg</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">a molecule</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">a spatial region</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">an atom</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">an orchestra.</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">an organism</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the bottom right portion of a human torso</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the interior of your mouth</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.</obo:IAO_0000115>
        <obo:IAO_0000115 xml:lang="en">b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])</obo:IAO_0000115>
        <obo:IAO_0000601 xml:lang="en">For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])</obo:IAO_0000601>
        <obo:IAO_0000601 xml:lang="en">For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])</obo:IAO_0000601>
        <obo:IAO_0000602>(forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001] </obo:IAO_0000602>
        <obo:IAO_0000602>(forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002] </obo:IAO_0000602>
        <obo:IAO_0000602>(iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002] </obo:IAO_0000602>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">independent continuant</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget xml:lang="en">b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])</owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/017-002"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000601"/>
        <owl:annotatedTarget xml:lang="en">For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])</owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/134-001"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000601"/>
        <owl:annotatedTarget xml:lang="en">For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])</owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/018-002"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000602"/>
        <owl:annotatedTarget>(forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001] </owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/134-001"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000602"/>
        <owl:annotatedTarget>(forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002] </owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/018-002"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000602"/>
        <owl:annotatedTarget>(iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002] </owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/017-002"/>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/BFO_0000015 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000015">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:IAO_0000115 xml:lang="en">An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">process</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/BFO_0000016 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000016">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
        <obo:BFO_0000179>disposition</obo:BFO_0000179>
        <obo:BFO_0000180>Disposition</obo:BFO_0000180>
        <obo:IAO_0000112 xml:lang="en">an atom of element X has the disposition to decay to an atom of element Y</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">certain people have a predisposition to colon cancer</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">children are innately disposed to categorize objects in certain ways.</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the cell wall is disposed to filter chemicals in endocytosis and exocytosis</obo:IAO_0000112>
        <obo:IAO_0000116 xml:lang="en">BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type.</obo:IAO_0000116>
        <obo:IAO_0000600 xml:lang="en">b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002])</obo:IAO_0000600>
        <obo:IAO_0000601 xml:lang="en">If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002])</obo:IAO_0000601>
        <obo:IAO_0000602>(forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002] </obo:IAO_0000602>
        <obo:IAO_0000602>(forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002] </obo:IAO_0000602>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">disposition</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000016"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000600"/>
        <owl:annotatedTarget xml:lang="en">b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002])</owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/062-002"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000016"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000601"/>
        <owl:annotatedTarget xml:lang="en">If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002])</owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/063-002"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000016"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000602"/>
        <owl:annotatedTarget>(forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002] </owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/063-002"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000016"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000602"/>
        <owl:annotatedTarget>(forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002] </owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/062-002"/>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/BFO_0000017 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000017">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000020"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/BFO_0000019"/>
        <obo:BFO_0000179>realizable</obo:BFO_0000179>
        <obo:BFO_0000180>RealizableEntity</obo:BFO_0000180>
        <obo:IAO_0000112 xml:lang="en">the disposition of this piece of metal to conduct electricity.</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the disposition of your blood to coagulate</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the function of your reproductive organs</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the role of being a doctor</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the role of this boundary to delineate where Utah and Colorado meet</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">A specifically dependent continuant  that inheres in continuant  entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances.</obo:IAO_0000115>
        <obo:IAO_0000600 xml:lang="en">To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002])</obo:IAO_0000600>
        <obo:IAO_0000601 xml:lang="en">All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002])</obo:IAO_0000601>
        <obo:IAO_0000602>(forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002] </obo:IAO_0000602>
        <obo:IAO_0000602>(forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002] </obo:IAO_0000602>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">realizable entity</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000600"/>
        <owl:annotatedTarget xml:lang="en">To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002])</owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/058-002"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000601"/>
        <owl:annotatedTarget xml:lang="en">All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002])</owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/060-002"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000602"/>
        <owl:annotatedTarget>(forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002] </owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/060-002"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000602"/>
        <owl:annotatedTarget>(forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002] </owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/058-002"/>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/BFO_0000019 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000019">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000020"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000019"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <oboInOwl:hasOBONamespace>bfo</oboInOwl:hasOBONamespace>
        <oboInOwl:id>BFO:0000019</oboInOwl:id>
        <rdfs:label>quality</rdfs:label>
        <rdfs:label xml:lang="en">quality</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/BFO_0000020 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000020">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000020"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:BFO_0000179>sdc</obo:BFO_0000179>
        <obo:BFO_0000180>SpecificallyDependentContinuant</obo:BFO_0000180>
        <obo:IAO_0000112 xml:lang="en">Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">of one-sided specifically dependent continuants: the mass of this tomato</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates.</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the disposition of this fish to decay</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the function of this heart: to pump blood</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the mutual dependence of proton donors and acceptors in chemical reactions [79</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the pink color of a medium rare piece of grilled filet mignon at its center</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the role of being a doctor</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the shape of this hole.</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the smell of this portion of mozzarella</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.</obo:IAO_0000115>
        <obo:IAO_0000115 xml:lang="en">b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc.</obo:IAO_0000116>
        <obo:IAO_0000602>(iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003] </obo:IAO_0000602>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">specifically dependent continuant</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000020"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget xml:lang="en">b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])</owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/050-003"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000020"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000116"/>
        <owl:annotatedTarget xml:lang="en">Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc.</owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/0000005"/>
        <rdfs:comment>per discussion with Barry Smith</rdfs:comment>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000020"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000602"/>
        <owl:annotatedTarget>(iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003] </owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/050-003"/>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/BFO_0000023 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000023">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <obo:BFO_0000179>role</obo:BFO_0000179>
        <obo:BFO_0000180>Role</obo:BFO_0000180>
        <obo:IAO_0000112 xml:lang="en">John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married.</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the priest role</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the role of a boundary to demarcate two neighboring administrative territories</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the role of a building in serving as a military target</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the role of a stone in marking a property boundary</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the role of subject in a clinical trial</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the student role</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">A realizable entity  the manifestation of which brings about some result or end that is not essential to a continuant  in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant  in some kinds of natural, social or institutional contexts.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals –  professor, sergeant, nurse – only during certain phases in their lives.</obo:IAO_0000116>
        <obo:IAO_0000600 xml:lang="en">b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001])</obo:IAO_0000600>
        <obo:IAO_0000602>(forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001] </obo:IAO_0000602>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">role</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000600"/>
        <owl:annotatedTarget xml:lang="en">b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001])</owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/061-001"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000602"/>
        <owl:annotatedTarget>(forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001] </owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/061-001"/>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/BFO_0000030 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000030">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <oboInOwl:hasOBONamespace>bfo</oboInOwl:hasOBONamespace>
        <oboInOwl:id>BFO:0000030</oboInOwl:id>
        <rdfs:label>object</rdfs:label>
        <rdfs:label xml:lang="en">object</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/BFO_0000034 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000034">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000016"/>
        <obo:BFO_0000179>function</obo:BFO_0000179>
        <obo:BFO_0000180>Function</obo:BFO_0000180>
        <obo:IAO_0000112 xml:lang="en">the function of a hammer to drive in nails</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the function of a heart pacemaker to regulate the beating of a heart through electricity</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the function of amylase in saliva to break down starch into sugar</obo:IAO_0000112>
        <obo:IAO_0000116 xml:lang="en">BFO 2 Reference: In the past, we have distinguished two varieties of function, artifactual function and biological function. These are not asserted subtypes of BFO:function however, since the same function – for example: to pump, to transport – can exist both in artifacts and in biological entities. The asserted subtypes of function that would be needed in order to yield a separate monoheirarchy are not artifactual function, biological function, etc., but rather transporting function, pumping function, etc.</obo:IAO_0000116>
        <obo:IAO_0000600 xml:lang="en">A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001])</obo:IAO_0000600>
        <obo:IAO_0000602>(forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001] </obo:IAO_0000602>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">function</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000034"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000600"/>
        <owl:annotatedTarget xml:lang="en">A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001])</owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/064-001"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/BFO_0000034"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000602"/>
        <owl:annotatedTarget>(forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001] </owl:annotatedTarget>
        <obo:IAO_0010000 rdf:resource="http://purl.obolibrary.org/obo/bfo/axiom/064-001"/>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/BFO_0000040 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000040">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <obo:IAO_0000115 xml:lang="en">An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>bfo</oboInOwl:hasOBONamespace>
        <oboInOwl:id>BFO:0000040</oboInOwl:id>
        <rdfs:label>material entity</rdfs:label>
        <rdfs:label xml:lang="en">material entity</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/CARO_0000003 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CARO_0000003"/>

    <!-- http://purl.obolibrary.org/obo/CARO_0001010 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CARO_0001010"/>

    <!-- http://purl.obolibrary.org/obo/CHEBI_24431 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_24431">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000030"/>
        <obo:IAO_0000115>A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.</obo:IAO_0000115>
        <oboInOwl:hasExactSynonym>chemical entity</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>chebi_ontology</oboInOwl:hasOBONamespace>
        <oboInOwl:id>CHEBI:24431</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
        <rdfs:label>chemical entity</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24431"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>chemical entity</owl:annotatedTarget>
        <oboInOwl:hasDbXref>UniProt</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/CHEBI_50906 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_50906">
        <obo:IAO_0000115>A role is particular behaviour which a material entity may exhibit.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>chebi_ontology</oboInOwl:hasOBONamespace>
        <oboInOwl:id>CHEBI:50906</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
        <rdfs:label>role</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/CL_0000000 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CL_0000000">
        <obo:IAO_0000115>A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>CALOHA:TS-2035</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FBbt:00007002</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FMA:68646</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>GO:0005623</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>KUPO:0000002</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MESH:D002477</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>VHOG:0001533</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>WBbt:0004017</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>XAO:0003012</oboInOwl:hasDbXref>
        <oboInOwl:id>CL:0000000</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ubprop#_upper_level"/>
        <rdfs:comment>The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one).</rdfs:comment>
        <rdfs:label>cell</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/CL_0000003 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CL_0000003">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000000"/>
        <obo:IAO_0000115>A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment).</obo:IAO_0000115>
        <oboInOwl:hasDbXref>CARO:0000013</oboInOwl:hasDbXref>
        <oboInOwl:hasNarrowSynonym>cell in vivo</oboInOwl:hasNarrowSynonym>
        <oboInOwl:id>CL:0000003</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ubprop#_upper_level"/>
        <rdfs:comment>To accommodate unicellular organisms better, 'cell in vivo' has been re-labeled 'native cell' to better represent its intended meaning - that is, that it is a cell in the context of a multicellular organism or in a natural environment. 'Native' is intended to contrast with 'in vitro', which refers to cells or other biological entities that have been intentionally placed in a controlled, non-natural setting for the purpose of study or manipulation. (MAH 1.12.12).</rdfs:comment>
        <rdfs:label>native cell</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/CL_0000039 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CL_0000039">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000003"/>
        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/CL_0002371"/>
        <obo:IAO_0000115>A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring.</obo:IAO_0000115>
        <oboInOwl:id>CL:0000039</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ubprop#_upper_level"/>
        <rdfs:comment>Originally this term had some plant germ line cell children.</rdfs:comment>
        <rdfs:label>germ line cell</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/CL_0002371 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CL_0002371">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/CL_0000003"/>
                    <owl:Class>
                        <owl:complementOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000039"/>
                    </owl:Class>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000003"/>
        <obo:IAO_0000115>A cell of an organism that does not pass on its genetic material to the organism's offspring (i.e. a non-germ line cell).</obo:IAO_0000115>
        <oboInOwl:created_by>tmeehan</oboInOwl:created_by>
        <oboInOwl:creation_date>2010-09-24T09:44:42Z</oboInOwl:creation_date>
        <oboInOwl:hasDbXref>BTO:0001268</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FMA:72300</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>WBbt:0008378</oboInOwl:hasDbXref>
        <oboInOwl:id>CL:0002371</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ubprop#_upper_level"/>
        <rdfs:label>somatic cell</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/GO_0001704 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0001704">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0048646"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0007369"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>The formation of the ectoderm, mesoderm and endoderm during gastrulation.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0001704</oboInOwl:id>
        <rdfs:label>formation of primary germ layer</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0001704"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The formation of the ectoderm, mesoderm and endoderm during gastrulation.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:go_curators</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0001705 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0001705">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0001704"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0007398"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>The formation of ectoderm during gastrulation.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0001705</oboInOwl:id>
        <rdfs:label>ectoderm formation</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0001705"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The formation of ectoderm during gastrulation.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:go_curators</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0001706 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0001706">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0001704"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0007492"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>The formation of the endoderm during gastrulation.</obo:IAO_0000115>
        <oboInOwl:hasNarrowSynonym>endoblast formation</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0001706</oboInOwl:id>
        <rdfs:label>endoderm formation</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0001706"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The formation of the endoderm during gastrulation.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:go_curators</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0001706"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym"/>
        <owl:annotatedTarget>endoblast formation</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dph</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>GOC:sdb_2009</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:tb</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0001707 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0001707">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0001704"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0048332"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0001707</oboInOwl:id>
        <rdfs:label>mesoderm formation</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0001707"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:go_curators</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0001838 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0001838">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0072175"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0016331"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>The morphogenesis of an embryonic epithelium into a tube-shaped structure.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0001838</oboInOwl:id>
        <rdfs:label>embryonic epithelial tube formation</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0001838"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The morphogenesis of an embryonic epithelium into a tube-shaped structure.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dph</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ISBN:0824072820</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0001841 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0001841">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0001838"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0021915"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.</obo:IAO_0000115>
        <oboInOwl:hasAlternativeId>GO:0001679</oboInOwl:hasAlternativeId>
        <oboInOwl:hasDbXref>Wikipedia:Neurulation</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>neural tube morphogenesis</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>neurulation</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0001841</oboInOwl:id>
        <rdfs:label>neural tube formation</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0001841"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dph</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ISBN:0878932437</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0001841"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>neural tube morphogenesis</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dph</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0002009 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0002009">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0048729"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0060429"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.</obo:IAO_0000115>
        <oboInOwl:hasExactSynonym>epithelium morphogenesis</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0002009</oboInOwl:id>
        <rdfs:label>morphogenesis of an epithelium</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0002009"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dph</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:jl</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:tb</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ISBN:0198506732</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0003674 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0003674">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000115>A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process.</obo:IAO_0000115>
        <obo:IAO_0000589>molecular process</obo:IAO_0000589>
        <oboInOwl:hasAlternativeId>GO:0005554</oboInOwl:hasAlternativeId>
        <oboInOwl:hasExactSynonym>molecular function</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>molecular_function</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0003674</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_candida"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_chembl"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_metagenomics"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pir"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_plant"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_yeast"/>
        <rdfs:comment>Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex.</rdfs:comment>
        <rdfs:label>molecular_function</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0003674"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>GOC:pdt</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0003824 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0003824">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0003674"/>
        <rdfs:label>catalytic activity</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/GO_0005575 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0005575">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome).</obo:IAO_0000115>
        <obo:IAO_0000115>The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.</obo:IAO_0000115>
        <oboInOwl:hasAlternativeId>GO:0008372</oboInOwl:hasAlternativeId>
        <oboInOwl:hasDbXref>NIF_Subcellular:sao1337158144</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>cell or subcellular entity</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>cellular component</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>cellular_component</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>subcellular entity</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>GO:0005575</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_candida"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_chembl"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_metagenomics"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pir"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_plant"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_yeast"/>
        <rdfs:comment>Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. Note that when this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.</rdfs:comment>
        <rdfs:comment>Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this.</rdfs:comment>
        <rdfs:label>cellular_component</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0005575"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome).</owl:annotatedTarget>
        <oboInOwl:hasDbXref>GOC:pdt</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>NIF_Subcellular:sao1337158144</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0005575"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:go_curators</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0005575"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>subcellular entity</owl:annotatedTarget>
        <oboInOwl:hasDbXref>NIF_Subcellular:nlx_subcell_100315</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0006928 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0006928">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0009987"/>
        <rdfs:label>movement of cell or subcellular component</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/GO_0007275 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0007275">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0032501"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0048856"/>
        <obo:IAO_0000115>The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).</obo:IAO_0000115>
        <obo:IAO_0000233 rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/geneontology/go-ontology/issues/21234</obo:IAO_0000233>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0007275</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_chembl"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_plant"/>
        <rdfs:comment>Note that this term was 'developmental process'.</rdfs:comment>
        <rdfs:label>multicellular organism development</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0007275"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dph</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>GOC:ems</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>GOC:isa_complete</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:tb</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0007369 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0007369">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0048598"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0001705"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0001706"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0001707"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>Wikipedia:Gastrulation</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0007369</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_drosophila"/>
        <rdfs:label>gastrulation</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0007369"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>GOC:curators</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ISBN:9780878933846</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0007398 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0007398">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0009888"/>
        <obo:IAO_0000115>The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0007398</oboInOwl:id>
        <rdfs:label>ectoderm development</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0007398"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dph</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:tb</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0007399 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0007399">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0048731"/>
        <obo:IAO_0000115>The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>pan-neural process</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>GO:0007399</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_drosophila"/>
        <rdfs:label>nervous system development</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0007399"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>GOC:dgh</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0007492 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0007492">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0009888"/>
        <obo:IAO_0000115>The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0007492</oboInOwl:id>
        <rdfs:label>endoderm development</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0007492"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dph</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:tb</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0007498 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0007498">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0009888"/>
        <obo:IAO_0000115>The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0007498</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_drosophila"/>
        <rdfs:label>mesoderm development</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0007498"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dph</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:tb</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0007610 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0007610">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0032501"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0050896"/>
        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/GO_0032502"/>
        <obo:IAO_0000115>The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.</obo:IAO_0000115>
        <oboInOwl:created_by>jl</oboInOwl:created_by>
        <oboInOwl:creation_date>2012-09-20T14:06:08Z</oboInOwl:creation_date>
        <oboInOwl:hasAlternativeId>GO:0023032</oboInOwl:hasAlternativeId>
        <oboInOwl:hasAlternativeId>GO:0044708</oboInOwl:hasAlternativeId>
        <oboInOwl:hasAlternativeId>GO:0044709</oboInOwl:hasAlternativeId>
        <oboInOwl:hasDbXref>Wikipedia:Behavior</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>behavioral response to stimulus</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>behaviour</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>behavioural response to stimulus</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>single-organism behavior</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>GO:0007610</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_agr"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon"/>
        <rdfs:comment>1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews.
2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis).</rdfs:comment>
        <rdfs:label>behavior</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0007610"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>GOC:ems</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:jl</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ISBN:0395448956</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:20160973</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0008104 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0008104">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0070727"/>
        <obo:IAO_0000115>Any process in which a protein is transported to, or maintained in, a specific location.</obo:IAO_0000115>
        <obo:IAO_0000233 rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/geneontology/go-ontology/issues/23112</obo:IAO_0000233>
        <oboInOwl:hasAlternativeId>GO:0008105</oboInOwl:hasAlternativeId>
        <oboInOwl:hasAlternativeId>GO:0016249</oboInOwl:hasAlternativeId>
        <oboInOwl:hasAlternativeId>GO:0034613</oboInOwl:hasAlternativeId>
        <oboInOwl:hasExactSynonym>cellular protein localisation</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>cellular protein localization</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>protein localisation</oboInOwl:hasExactSynonym>
        <oboInOwl:hasNarrowSynonym>channel localizer activity</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>asymmetric protein localisation</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>asymmetric protein localization</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>establishment and maintenance of asymmetric protein localization</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>establishment and maintenance of protein localization</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>GO:0008104</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_drosophila"/>
        <rdfs:label>protein localization</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0008104"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Any process in which a protein is transported to, or maintained in, a specific location.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:ai</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0008104"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>cellular protein localisation</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:mah</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0008104"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>protein localisation</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:mah</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0008104"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym"/>
        <owl:annotatedTarget>channel localizer activity</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:mah</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0008104"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>asymmetric protein localisation</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:mah</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0008150 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0008150">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000115>A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.</obo:IAO_0000115>
        <oboInOwl:created_by>jl</oboInOwl:created_by>
        <oboInOwl:creation_date>2012-09-19T15:05:24Z</oboInOwl:creation_date>
        <oboInOwl:hasAlternativeId>GO:0000004</oboInOwl:hasAlternativeId>
        <oboInOwl:hasAlternativeId>GO:0007582</oboInOwl:hasAlternativeId>
        <oboInOwl:hasAlternativeId>GO:0044699</oboInOwl:hasAlternativeId>
        <oboInOwl:hasDbXref>Wikipedia:Biological_process</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>biological process</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>physiological process</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>single organism process</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>single-organism process</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>GO:0008150</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_aspergillus"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_candida"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_chembl"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_generic"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_metagenomics"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pir"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_plant"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pombe"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_yeast"/>
        <rdfs:comment>Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this.</rdfs:comment>
        <rdfs:label>biological_process</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0008150"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>GOC:pdt</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0008283 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0008283">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0009987"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
                <owl:someValuesFrom>
                    <owl:Class>
                        <owl:complementOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4751"/>
                    </owl:Class>
                </owl:someValuesFrom>
            </owl:Restriction>
        </rdfs:subClassOf>
        <owl:disjointWith>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4751"/>
            </owl:Restriction>
        </owl:disjointWith>
        <obo:IAO_0000115>The multiplication or reproduction of cells, resulting in the expansion of a cell population.</obo:IAO_0000115>
        <obo:RO_0002161 rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4751"/>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>cell proliferation</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>GO:0008283</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_agr"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_chembl"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_drosophila"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_mouse"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pir"/>
        <rdfs:comment>This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms.</rdfs:comment>
        <rdfs:label>cell population proliferation</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0008283"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The multiplication or reproduction of cells, resulting in the expansion of a cell population.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:mah</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>GOC:mb</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0009653 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0009653">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0032502"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0048856"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.</obo:IAO_0000115>
        <oboInOwl:hasBroadSynonym>embryogenesis and morphogenesis</oboInOwl:hasBroadSynonym>
        <oboInOwl:hasDbXref>Wikipedia:Morphogenesis</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>anatomical structure organization</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>morphogenesis</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0009653</oboInOwl:id>
        <rdfs:label>anatomical structure morphogenesis</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0009653"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:go_curators</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ISBN:0521436125</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0009790 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0009790">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0007275"/>
        <obo:IAO_0000115>The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.</obo:IAO_0000115>
        <oboInOwl:hasAlternativeId>GO:0009795</oboInOwl:hasAlternativeId>
        <oboInOwl:hasBroadSynonym>embryogenesis and morphogenesis</oboInOwl:hasBroadSynonym>
        <oboInOwl:hasDbXref>Wikipedia:Embryogenesis</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>embryogenesis</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>embryonal development</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0009790</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_chembl"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_plant"/>
        <rdfs:label>embryo development</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0009790"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:go_curators</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>GOC:isa_complete</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>GOC:mtg_sensu</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0009791 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0009791">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0032501"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0007275"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0009791</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_plant"/>
        <rdfs:label>post-embryonic development</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0009791"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:go_curators</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0009792 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0009792">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0009790"/>
        <obo:IAO_0000115>The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.</obo:IAO_0000115>
        <oboInOwl:hasBroadSynonym>embryogenesis</oboInOwl:hasBroadSynonym>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0009792</oboInOwl:id>
        <rdfs:label>embryo development ending in birth or egg hatching</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0009792"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:go_curators</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>GOC:isa_complete</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>GOC:mtg_sensu</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0009888 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0009888">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0048856"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
                <owl:someValuesFrom>
                    <owl:Class>
                        <owl:complementOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_147554"/>
                    </owl:Class>
                </owl:someValuesFrom>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
                <owl:someValuesFrom>
                    <owl:Class>
                        <owl:complementOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_33630"/>
                    </owl:Class>
                </owl:someValuesFrom>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
                <owl:someValuesFrom>
                    <owl:Class>
                        <owl:complementOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_33682"/>
                    </owl:Class>
                </owl:someValuesFrom>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
                <owl:someValuesFrom>
                    <owl:Class>
                        <owl:complementOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_38254"/>
                    </owl:Class>
                </owl:someValuesFrom>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
                <owl:someValuesFrom>
                    <owl:Class>
                        <owl:complementOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4891"/>
                    </owl:Class>
                </owl:someValuesFrom>
            </owl:Restriction>
        </rdfs:subClassOf>
        <owl:disjointWith>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_147554"/>
            </owl:Restriction>
        </owl:disjointWith>
        <owl:disjointWith>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_33630"/>
            </owl:Restriction>
        </owl:disjointWith>
        <owl:disjointWith>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_33682"/>
            </owl:Restriction>
        </owl:disjointWith>
        <owl:disjointWith>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_38254"/>
            </owl:Restriction>
        </owl:disjointWith>
        <owl:disjointWith>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4891"/>
            </owl:Restriction>
        </owl:disjointWith>
        <obo:IAO_0000115>The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.</obo:IAO_0000115>
        <obo:RO_0002161 rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_147554"/>
        <obo:RO_0002161 rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_33630"/>
        <obo:RO_0002161 rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_33682"/>
        <obo:RO_0002161 rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_38254"/>
        <obo:RO_0002161 rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4891"/>
        <oboInOwl:hasBroadSynonym>histogenesis and organogenesis</oboInOwl:hasBroadSynonym>
        <oboInOwl:hasDbXref>Wikipedia:Histogenesis</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>histogenesis</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0009888</oboInOwl:id>
        <rdfs:label>tissue development</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0009888"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>ISBN:0471245208</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0009987 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0009987">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0008150"/>
        <obo:IAO_0000115>Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.</obo:IAO_0000115>
        <oboInOwl:created_by>jl</oboInOwl:created_by>
        <oboInOwl:creation_date>2012-12-11T16:56:55Z</oboInOwl:creation_date>
        <oboInOwl:hasAlternativeId>GO:0008151</oboInOwl:hasAlternativeId>
        <oboInOwl:hasAlternativeId>GO:0044763</oboInOwl:hasAlternativeId>
        <oboInOwl:hasAlternativeId>GO:0050875</oboInOwl:hasAlternativeId>
        <oboInOwl:hasExactSynonym>cell physiology</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>cellular physiological process</oboInOwl:hasExactSynonym>
        <oboInOwl:hasNarrowSynonym>cell growth and/or maintenance</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>single-organism cellular process</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>GO:0009987</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_plant"/>
        <rdfs:label>cellular process</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0009987"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:go_curators</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>GOC:isa_complete</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0016301 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0016301">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0016772"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002481"/>
                <owl:hasSelf rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:hasSelf>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:label>kinase activity</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/GO_0016331 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0016331">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0002009"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0048598"/>
        <obo:IAO_0000115>The process in which the anatomical structures of embryonic epithelia are generated and organized.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0016331</oboInOwl:id>
        <rdfs:label>morphogenesis of embryonic epithelium</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0016331"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The process in which the anatomical structures of embryonic epithelia are generated and organized.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:jl</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0016740 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0016740">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0003824"/>
        <rdfs:label>transferase activity</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/GO_0016772 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0016772">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0016740"/>
        <rdfs:label>transferase activity, transferring phosphorus-containing groups</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/GO_0021915 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0021915">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0035295"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0060429"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0007399"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0043009"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0021915</oboInOwl:id>
        <rdfs:label>neural tube development</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0021915"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>GOC:cls</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>GOC:dgh</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dph</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:jid</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>GO_REF:0000021</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0032501 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0032501">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0008150"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
                <owl:someValuesFrom>
                    <owl:Class>
                        <owl:complementOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2"/>
                    </owl:Class>
                </owl:someValuesFrom>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
                <owl:someValuesFrom>
                    <owl:Class>
                        <owl:complementOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2157"/>
                    </owl:Class>
                </owl:someValuesFrom>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
                <owl:someValuesFrom>
                    <owl:Class>
                        <owl:complementOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4896"/>
                    </owl:Class>
                </owl:someValuesFrom>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
                <owl:someValuesFrom>
                    <owl:Class>
                        <owl:complementOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4932"/>
                    </owl:Class>
                </owl:someValuesFrom>
            </owl:Restriction>
        </rdfs:subClassOf>
        <owl:disjointWith>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2"/>
            </owl:Restriction>
        </owl:disjointWith>
        <owl:disjointWith>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2157"/>
            </owl:Restriction>
        </owl:disjointWith>
        <owl:disjointWith>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4896"/>
            </owl:Restriction>
        </owl:disjointWith>
        <owl:disjointWith>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4932"/>
            </owl:Restriction>
        </owl:disjointWith>
        <obo:IAO_0000115>Any biological process, occurring at the level of a multicellular organism, pertinent to its function.</obo:IAO_0000115>
        <obo:RO_0002161 rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2"/>
        <obo:RO_0002161 rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2157"/>
        <obo:RO_0002161 rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4896"/>
        <obo:RO_0002161 rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4932"/>
        <oboInOwl:created_by>jl</oboInOwl:created_by>
        <oboInOwl:creation_date>2012-09-19T16:07:47Z</oboInOwl:creation_date>
        <oboInOwl:hasAlternativeId>GO:0044707</oboInOwl:hasAlternativeId>
        <oboInOwl:hasAlternativeId>GO:0050874</oboInOwl:hasAlternativeId>
        <oboInOwl:hasExactSynonym>organismal physiological process</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>single-multicellular organism process</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>GO:0032501</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pir"/>
        <rdfs:label>multicellular organismal process</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0032501"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Any biological process, occurring at the level of a multicellular organism, pertinent to its function.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>GOC:curators</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dph</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>GOC:isa_complete</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:tb</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0032502 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0032502">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0008150"/>
        <obo:IAO_0000115>A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.</obo:IAO_0000115>
        <oboInOwl:created_by>jl</oboInOwl:created_by>
        <oboInOwl:creation_date>2012-12-19T12:21:31Z</oboInOwl:creation_date>
        <oboInOwl:hasAlternativeId>GO:0044767</oboInOwl:hasAlternativeId>
        <oboInOwl:hasNarrowSynonym>development</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>single-organism developmental process</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>GO:0032502</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_agr"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pir"/>
        <rdfs:label>developmental process</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0032502"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>GOC:isa_complete</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0033036 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0033036">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0051179"/>
        <obo:IAO_0000115>Any process in which a macromolecule is transported to, or maintained in, a specific location.</obo:IAO_0000115>
        <oboInOwl:hasExactSynonym>macromolecule localisation</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0033036</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon"/>
        <rdfs:label>macromolecule localization</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0033036"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Any process in which a macromolecule is transported to, or maintained in, a specific location.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:mah</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0033036"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>macromolecule localisation</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:mah</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0035148 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0035148">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0048646"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0035239"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow.</obo:IAO_0000115>
        <oboInOwl:hasExactSynonym>tube lumen formation</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>lumen formation in an anatomical structure</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>GO:0035148</oboInOwl:id>
        <rdfs:label>tube formation</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0035148"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:bf</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0035148"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>tube lumen formation</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dph</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:mah</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0035148"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>lumen formation in an anatomical structure</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dph</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:mah</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0035239 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0035239">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0009653"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0035295"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0035239</oboInOwl:id>
        <rdfs:label>tube morphogenesis</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0035239"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:bf</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:14624839</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0035295 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0035295">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0048856"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0007275"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0035295</oboInOwl:id>
        <rdfs:label>tube development</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0035295"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>PMID:12526790</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0040016 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0040016">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0051301"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0009790"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>The first few specialized divisions of an activated animal egg.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0040016</oboInOwl:id>
        <rdfs:label>embryonic cleavage</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0040016"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The first few specialized divisions of an activated animal egg.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>GOC:clt</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ISBN:0070524300</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0043009 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0043009">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0009792"/>
        <obo:IAO_0000115>The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0043009</oboInOwl:id>
        <rdfs:label>chordate embryonic development</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0043009"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>GOC:mtg_sensu</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0048332 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0048332">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0048729"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0007498"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>The process in which the anatomical structures of the mesoderm are generated and organized.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0048332</oboInOwl:id>
        <rdfs:label>mesoderm morphogenesis</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0048332"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The process in which the anatomical structures of the mesoderm are generated and organized.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:go_curators</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0048513 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0048513">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0048856"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0048731"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>Wikipedia:Organogenesis</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>development of an organ</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>organogenesis</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0048513</oboInOwl:id>
        <rdfs:label>animal organ development</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0048513"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dph</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:jid</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0048598 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0048598">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0009653"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0009790"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.</obo:IAO_0000115>
        <oboInOwl:hasAlternativeId>GO:0048828</oboInOwl:hasAlternativeId>
        <oboInOwl:hasExactSynonym>embryonic anatomical structure morphogenesis</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0048598</oboInOwl:id>
        <rdfs:label>embryonic morphogenesis</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0048598"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:jid</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>GOC:mtg_sensu</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0048598"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>embryonic anatomical structure morphogenesis</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dph</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:tb</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0048646 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0048646">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0032502"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0009653"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.</obo:IAO_0000115>
        <oboInOwl:hasExactSynonym>formation of an anatomical structure involved in morphogenesis</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0048646</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_chembl"/>
        <rdfs:comment>Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense.</rdfs:comment>
        <rdfs:label>anatomical structure formation involved in morphogenesis</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0048646"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dph</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:jid</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:tb</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0048646"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>formation of an anatomical structure involved in morphogenesis</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dph</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:tb</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0048729 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0048729">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0009653"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0009888"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>The process in which the anatomical structures of a tissue are generated and organized.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0048729</oboInOwl:id>
        <rdfs:label>tissue morphogenesis</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0048729"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The process in which the anatomical structures of a tissue are generated and organized.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dph</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:jid</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0048731 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0048731">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0048856"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0007275"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0048731</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_mouse"/>
        <rdfs:label>system development</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0048731"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dph</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:jid</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0048856 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0048856">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0032502"/>
        <obo:IAO_0000115>The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.</obo:IAO_0000115>
        <oboInOwl:hasExactSynonym>development of an anatomical structure</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0048856</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_chembl"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_generic"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_plant"/>
        <rdfs:label>anatomical structure development</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0048856"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>GO_REF:0000021</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0048869 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0048869">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0009987"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0032502"/>
        <obo:IAO_0000115>A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0048869</oboInOwl:id>
        <rdfs:label>cellular developmental process</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0048869"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>GOC:isa_complete</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0050896 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0050896">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0008150"/>
        <obo:IAO_0000115>Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.</obo:IAO_0000115>
        <oboInOwl:hasAlternativeId>GO:0051869</oboInOwl:hasAlternativeId>
        <oboInOwl:hasExactSynonym>physiological response to stimulus</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0050896</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#gocheck_do_not_manually_annotate"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_agr"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_mouse"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pir"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#prokaryote_subset"/>
        <rdfs:comment>Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.</rdfs:comment>
        <rdfs:label>response to stimulus</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0050896"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:ai</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:bf</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0051179 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0051179">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0008150"/>
        <obo:IAO_0000115>Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation.</obo:IAO_0000115>
        <oboInOwl:created_by>jl</oboInOwl:created_by>
        <oboInOwl:creation_date>2013-12-18T13:51:04Z</oboInOwl:creation_date>
        <oboInOwl:hasAlternativeId>GO:1902578</oboInOwl:hasAlternativeId>
        <oboInOwl:hasExactSynonym>establishment and maintenance of localization</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>establishment and maintenance of position</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>localisation</oboInOwl:hasExactSynonym>
        <oboInOwl:hasNarrowSynonym>establishment and maintenance of cellular component location</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasNarrowSynonym>establishment and maintenance of substance location</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasNarrowSynonym>establishment and maintenance of substrate location</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>single organism localization</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>single-organism localization</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>GO:0051179</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pir"/>
        <rdfs:label>localization</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0051179"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:ai</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dos</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0051179"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>localisation</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:mah</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0051179"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>single organism localization</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:TermGenie</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0051301 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0051301">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0009987"/>
        <obo:IAO_0000115>The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>Wikipedia:Cell_division</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0051301</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_chembl"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_drosophila"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pir"/>
        <rdfs:comment>Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division.</rdfs:comment>
        <rdfs:label>cell division</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0051301"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>GOC:di</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:go_curators</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:pr</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0051641 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0051641">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0009987"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0051179"/>
        <obo:IAO_0000115>A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane.</obo:IAO_0000115>
        <oboInOwl:created_by>jl</oboInOwl:created_by>
        <oboInOwl:creation_date>2013-12-18T14:04:32Z</oboInOwl:creation_date>
        <oboInOwl:hasAlternativeId>GO:1902580</oboInOwl:hasAlternativeId>
        <oboInOwl:hasExactSynonym>cellular localisation</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>establishment and maintenance of cellular localization</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>establishment and maintenance of localization in cell or cell membrane</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>single organism cellular localization</oboInOwl:hasExactSynonym>
        <oboInOwl:hasNarrowSynonym>intracellular localization</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasNarrowSynonym>localization within cell</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>single-organism cellular localization</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>GO:0051641</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_pir"/>
        <rdfs:label>cellular localization</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0051641"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:tb</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:vw</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0051641"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>cellular localisation</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:mah</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0051641"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>single organism cellular localization</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:TermGenie</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0060429 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0060429">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0009888"/>
        <obo:IAO_0000115>The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0060429</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/go#goslim_drosophila"/>
        <rdfs:label>epithelium development</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0060429"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dph</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>GOC:mtg_lung</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0060562 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0060562">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0002009"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0035239"/>
        <obo:IAO_0000115>The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.</obo:IAO_0000115>
        <oboInOwl:created_by>dph</oboInOwl:created_by>
        <oboInOwl:creation_date>2009-04-28T09:33:36Z</oboInOwl:creation_date>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0060562</oboInOwl:id>
        <rdfs:label>epithelial tube morphogenesis</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0060562"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dph</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0070727 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0070727">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0033036"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0051641"/>
        <obo:IAO_0000115>Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.</obo:IAO_0000115>
        <oboInOwl:created_by>mah</oboInOwl:created_by>
        <oboInOwl:creation_date>2009-06-16T04:08:29Z</oboInOwl:creation_date>
        <oboInOwl:hasExactSynonym>cellular macromolecule localisation</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0070727</oboInOwl:id>
        <rdfs:label>cellular macromolecule localization</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0070727"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:mah</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0070727"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>cellular macromolecule localisation</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:mah</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/GO_0072175 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0072175">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0035148"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0060562"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>The developmental process pertaining to the initial formation of an epithelial tube.</obo:IAO_0000115>
        <obo:IAO_0000233 rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/geneontology/go-ontology/issues/22302</obo:IAO_0000233>
        <oboInOwl:created_by>mah</oboInOwl:created_by>
        <oboInOwl:creation_date>2010-02-26T02:15:40Z</oboInOwl:creation_date>
        <oboInOwl:hasOBONamespace>biological_process</oboInOwl:hasOBONamespace>
        <oboInOwl:id>GO:0072175</oboInOwl:id>
        <rdfs:label>epithelial tube formation</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/GO_0072175"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The developmental process pertaining to the initial formation of an epithelial tube.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>GOC:mtg_kidney_jan10</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/NBO_0000313 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NBO_0000313">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0007610"/>
        <obo:IAO_0000115>"The action, reaction, or performance of an organism in response to external or internal stimuli." [GO:GO\:0007610]</obo:IAO_0000115>
        <dc:date>2011-04-05T09:53:10Z</dc:date>
        <oboInOwl:created_by>George Gkoutos</oboInOwl:created_by>
        <oboInOwl:hasAlternativeId>NBO:0000000</oboInOwl:hasAlternativeId>
        <oboInOwl:hasExactSynonym>behavior</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>behaviour</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>behavior_ontology</oboInOwl:hasOBONamespace>
        <oboInOwl:xref>GO:0007610</oboInOwl:xref>
        <rdfs:label>behavior process</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/NBO_0001786 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NBO_0001786">
        <owl:equivalentClass>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NBO_0000313"/>
            </owl:Restriction>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NBO_0000313"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NBO_0000313"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>"Any process that modulates the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli." [GO:0050795]</obo:IAO_0000115>
        <oboInOwl:created_by>George Gkoutos</oboInOwl:created_by>
        <oboInOwl:xref>GO:0050795</oboInOwl:xref>
        <rdfs:label xml:lang="en">regulation of behavior</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/NCBITaxon_1 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_1">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <oboInOwl:hasDbXref>GC_ID:1</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>ncbi_taxonomy</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>all</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>NCBITaxon:1</oboInOwl:id>
        <rdfs:label>root</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_1"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>all</owl:annotatedTarget>
        <oboInOwl:hasSynonymType rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon#synonym"/>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/NCBITaxon_10239 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_10239">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0100026"/>
        <rdfs:label>Viruses</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/NCBITaxon_131567 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_131567">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_1"/>
        <oboInOwl:hasDbXref>GC_ID:1</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>ncbi_taxonomy</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>biota</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>NCBITaxon:131567</oboInOwl:id>
        <rdfs:label>cellular organisms</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_131567"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>biota</owl:annotatedTarget>
        <oboInOwl:hasSynonymType rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon#synonym"/>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/NCBITaxon_147554 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_147554"/>

    <!-- http://purl.obolibrary.org/obo/NCBITaxon_2 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_2">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_131567"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0100026"/>
        <rdfs:label>Bacteria</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/NCBITaxon_2157 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_2157">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0100026"/>
        <rdfs:label>Archaea</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/NCBITaxon_2759 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_2759">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_131567"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0100026"/>
        <ncbitaxon:has_rank rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_superkingdom"/>
        <oboInOwl:hasDbXref>GC_ID:1</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:23020233</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:30257078</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>eucaryotes</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>eukaryotes</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>ncbi_taxonomy</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>Eucarya</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>Eucaryotae</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>Eukarya</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>Eukaryotae</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>euk-</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>eukaryotes</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>NCBITaxon:2759</oboInOwl:id>
        <rdfs:label>Eukaryota</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2759"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>eucaryotes</owl:annotatedTarget>
        <oboInOwl:hasSynonymType rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon#genbank_common_name"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2759"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>eukaryotes</owl:annotatedTarget>
        <oboInOwl:hasSynonymType rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon#common_name"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2759"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>Eucarya</owl:annotatedTarget>
        <oboInOwl:hasSynonymType rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon#synonym"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2759"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>Eucaryotae</owl:annotatedTarget>
        <oboInOwl:hasSynonymType rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon#synonym"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2759"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>Eukarya</owl:annotatedTarget>
        <oboInOwl:hasSynonymType rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon#synonym"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2759"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>Eukaryotae</owl:annotatedTarget>
        <oboInOwl:hasSynonymType rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon#synonym"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2759"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>euk-</owl:annotatedTarget>
        <oboInOwl:hasDbXref>PRO:DAN</oboInOwl:hasDbXref>
        <oboInOwl:hasSynonymType rdf:resource="http://purl.obolibrary.org/obo/pr#PRO-short-label"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2759"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>eukaryotes</owl:annotatedTarget>
        <oboInOwl:hasSynonymType rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon#blast_name"/>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/NCBITaxon_33154 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_33154">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2759"/>
        <ncbitaxon:has_rank rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_clade"/>
        <oboInOwl:hasDbXref>GC_ID:1</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>ncbi_taxonomy</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>Fungi/Metazoa group</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>opisthokonts</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>NCBITaxon:33154</oboInOwl:id>
        <rdfs:label>Opisthokonta</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_33154"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>Fungi/Metazoa group</owl:annotatedTarget>
        <oboInOwl:hasSynonymType rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon#synonym"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_33154"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>opisthokonts</owl:annotatedTarget>
        <oboInOwl:hasSynonymType rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon#synonym"/>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/NCBITaxon_33208 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_33208">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_33154"/>
        <ncbitaxon:has_rank rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_kingdom"/>
        <oboInOwl:hasDbXref>GC_ID:1</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>metazoans</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>multicellular animals</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>ncbi_taxonomy</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>Animalia</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>animals</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>metazoan-</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>NCBITaxon:33208</oboInOwl:id>
        <rdfs:label>Metazoa</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_33208"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>metazoans</owl:annotatedTarget>
        <oboInOwl:hasSynonymType rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon#genbank_common_name"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_33208"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>multicellular animals</owl:annotatedTarget>
        <oboInOwl:hasSynonymType rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon#common_name"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_33208"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>Animalia</owl:annotatedTarget>
        <oboInOwl:hasSynonymType rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon#synonym"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_33208"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>animals</owl:annotatedTarget>
        <oboInOwl:hasSynonymType rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon#blast_name"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_33208"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>metazoan-</owl:annotatedTarget>
        <oboInOwl:hasDbXref>PRO:DAN</oboInOwl:hasDbXref>
        <oboInOwl:hasSynonymType rdf:resource="http://purl.obolibrary.org/obo/pr#PRO-short-label"/>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/NCBITaxon_33213 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_33213">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_6072"/>
        <ncbitaxon:has_rank rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_clade"/>
        <oboInOwl:hasDbXref>GC_ID:1</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>ncbi_taxonomy</oboInOwl:hasOBONamespace>
        <oboInOwl:id>NCBITaxon:33213</oboInOwl:id>
        <rdfs:label>Bilateria</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/NCBITaxon_33630 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_33630"/>

    <!-- http://purl.obolibrary.org/obo/NCBITaxon_33682 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_33682"/>

    <!-- http://purl.obolibrary.org/obo/NCBITaxon_38254 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_38254"/>

    <!-- http://purl.obolibrary.org/obo/NCBITaxon_4751 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_4751"/>

    <!-- http://purl.obolibrary.org/obo/NCBITaxon_4891 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_4891"/>

    <!-- http://purl.obolibrary.org/obo/NCBITaxon_4896 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_4896"/>

    <!-- http://purl.obolibrary.org/obo/NCBITaxon_4932 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_4932"/>

    <!-- http://purl.obolibrary.org/obo/NCBITaxon_6072 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_6072">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_33208"/>
        <ncbitaxon:has_rank rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_clade"/>
        <oboInOwl:hasDbXref>GC_ID:1</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>ncbi_taxonomy</oboInOwl:hasOBONamespace>
        <oboInOwl:id>NCBITaxon:6072</oboInOwl:id>
        <rdfs:label>Eumetazoa</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/OBI_0100026 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0100026">
        <owl:equivalentClass>
            <owl:Class>
                <owl:unionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_10239"/>
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_2"/>
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_2157"/>
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_2759"/>
                </owl:unionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000030"/>
        <oboInOwl:hasOBONamespace>obi</oboInOwl:hasOBONamespace>
        <oboInOwl:id>OBI:0100026</oboInOwl:id>
        <rdfs:comment>Category=external.</rdfs:comment>
        <rdfs:label>organism</rdfs:label>
        <rdfs:label xml:lang="en">organism</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0000001 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000001">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000020"/>
        <obo:IAO_0000115>A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities</obo:IAO_0000115>
        <obo:IAO_0000589>quality (PATO)</obo:IAO_0000589>
        <oboInOwl:hasAlternativeId>PATO:0000072</oboInOwl:hasAlternativeId>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0000001</oboInOwl:id>
        <rdfs:label>quality</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0000001"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities</owl:annotatedTarget>
        <oboInOwl:hasDbXref>PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/PATO_0000014 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000014">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000051"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001300"/>
        <rdfs:label>color</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0000033 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000033">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002182"/>
        <rdfs:label>concentration of</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0000051 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000051">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001241"/>
        <obo:IAO_0000115>A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0000051</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#attribute_slim"/>
        <rdfs:label>morphology</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0000051"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/PATO_0000052 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000052">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000051"/>
        <obo:IAO_0000115>A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc).</obo:IAO_0000115>
        <oboInOwl:hasAlternativeId>PATO:0001647</oboInOwl:hasAlternativeId>
        <oboInOwl:hasExactSynonym>relational shape quality</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0000052</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#attribute_slim"/>
        <rdfs:comment>Shapes are invariant on size transformations. Shapes can be subdivided into 2D and 3D shapes, We can also make a distinction between shapes of complete self-connected objects, and shapes of parts of objects.</rdfs:comment>
        <rdfs:label>shape</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0000052"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc).</owl:annotatedTarget>
        <oboInOwl:hasDbXref>PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/PATO_0000060 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000060">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000051"/>
        <rdfs:label>spatial pattern</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0000068 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000068">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000001"/>
        <rdfs:label>qualitative</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0000069 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000069">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000068"/>
        <rdfs:label>deviation (from_normal)</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0000117 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000117">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000051"/>
        <rdfs:label>size</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0000125 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000125">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001018"/>
        <rdfs:label>mass</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0000136 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000136">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000051"/>
        <rdfs:label>closure</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0000140 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000140">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001018"/>
        <rdfs:label>position</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0000404 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000404">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001794"/>
        <rdfs:label>coiled</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0000406 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000406">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001591"/>
        <rdfs:label>curved</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0000587 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000587">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000117"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002303"/>
        <rdfs:label>decreased size</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0000608 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000608">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000136"/>
        <rdfs:label>closed</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0000610 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000610">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000136"/>
        <rdfs:label>open</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0001018 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001018">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001241"/>
        <obo:IAO_0000115>A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities.</obo:IAO_0000115>
        <oboInOwl:hasAlternativeId>PATO:0002079</oboInOwl:hasAlternativeId>
        <oboInOwl:hasDbXref>Wikipedia:Physical_property</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>relational physical quality</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0001018</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/pato#attribute_slim"/>
        <rdfs:label>physical quality</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0001018"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/PATO_0001236 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001236">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000001"/>
        <rdfs:label>process quality</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0001241 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001241">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000019"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000001"/>
        <obo:IAO_0000115>A quality which inheres in a continuant.</obo:IAO_0000115>
        <oboInOwl:hasAlternativeId>PATO:0001237</oboInOwl:hasAlternativeId>
        <oboInOwl:hasAlternativeId>PATO:0001238</oboInOwl:hasAlternativeId>
        <oboInOwl:hasDbXref>snap:Quality</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>monadic quality of a continuant</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>multiply inhering quality of a physical entity</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>quality of a continuant</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>quality of a single physical entity</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>quality of an object</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>quality of continuant</oboInOwl:hasExactSynonym>
        <oboInOwl:hasNarrowSynonym>monadic quality of an object</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasNarrowSynonym>monadic quality of continuant</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasOBONamespace>quality</oboInOwl:hasOBONamespace>
        <oboInOwl:id>PATO:0001241</oboInOwl:id>
        <rdfs:comment>Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles.</rdfs:comment>
        <rdfs:label>physical object quality</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/PATO_0001241"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A quality which inheres in a continuant.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>PATOC:GVG</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/PATO_0001291 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001291">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001739"/>
        <rdfs:label>electromagnetic (EM) radiation quality</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0001300 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001300">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001291"/>
        <rdfs:label>optical quality</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0001476 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001476">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000140"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002303"/>
        <rdfs:label>decreased position</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0001563 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001563">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000125"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002305"/>
        <rdfs:label>increased mass</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0001591 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001591">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000052"/>
        <rdfs:label>curvature</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0001598 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001598">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000140"/>
        <rdfs:label>protruding</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0001739 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001739">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001018"/>
        <rdfs:label>radiation quality</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0001794 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001794">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000052"/>
        <rdfs:label>coiling</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0001910 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001910">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001925"/>
        <rdfs:label>folded</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0001925 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001925">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000052"/>
        <rdfs:label>surface feature shape</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0001992 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001992">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001995"/>
        <rdfs:label>cellularity</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0001993 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001993">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001992"/>
        <rdfs:label>multicellular</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0001995 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001995">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001241"/>
        <rdfs:label>organismal quality</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0002182 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0002182">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001241"/>
        <rdfs:label>molecular quality</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0002300 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0002300">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000069"/>
        <rdfs:label>increased quality</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0002301 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0002301">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0000069"/>
        <rdfs:label>decreased quality</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0002303 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0002303">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001241"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002301"/>
        <rdfs:label>decreased object quality</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/PATO_0002305 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0002305">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0001241"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/PATO_0002300"/>
        <rdfs:label>increased object quality</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/RO_0002577 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/RO_0002577">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:label>system</rdfs:label>
    </owl:Class>

    <!-- http://purl.obolibrary.org/obo/UBERON_0000000 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000000">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001062"/>
        <obo:IAO_0000115>An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity.</obo:IAO_0000115>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>UBERON:0000000</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#upper_level"/>
        <rdfs:label>processual entity</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000000"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>span:ProcessualEntity</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/UBERON_0000061 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000061">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000465"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002497"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000071"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.</obo:IAO_0000115>
        <oboInOwl:hasDbXref rdf:resource="http://dbpedia.org/ontology/AnatomicalStructure"/>
        <oboInOwl:hasDbXref rdf:resource="http://www.snomedbrowser.com/Codes/Details/362889002"/>
        <oboInOwl:hasDbXref>AAO:0010825</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>AEO:0000003</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>BILA:0000003</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>CARO:0000003</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>EHDAA2:0003003</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>EMAPA:0</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FBbt:00007001</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FMA:305751</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FMA:67135</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>GAID:781</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>HAO:0000003</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MA:0003000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MESH:D000825</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>TAO:0000037</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>TGMA:0001823</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>VHOG:0001759</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>XAO:0003000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ZFA:0000037</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>biological structure</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>connected biological structure</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>UBERON:0000061</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#upper_level"/>
        <rdfs:label>anatomical structure</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000061"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>CARO:0000003</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000061"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>connected biological structure</owl:annotatedTarget>
        <oboInOwl:hasDbXref>CARO:0000003</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/UBERON_0000066 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000066">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000105"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000092"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000062"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000111"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000063"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000071"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage.</obo:IAO_0000115>
        <oboInOwl:hasBroadSynonym>adult stage</oboInOwl:hasBroadSynonym>
        <oboInOwl:hasDbXref>BTO:0001043</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>BilaDO:0000004</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>EFO:0001272</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FBdv:00005369</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>WBls:0000041</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>XtroDO:0000084</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>fully formed animal stage</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>juvenile-adult stage</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>UBERON:0000066</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#efo_slim"/>
        <rdfs:label>fully formed stage</rdfs:label>
        <rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/obophenotype/uberon/issues/566</rdfs:seeAlso>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000066"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="https://orcid.org/0000-0002-6601-2165"/>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/UBERON_0000068 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000068">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000105"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0009790"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000104"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000063"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000066"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000063"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000092"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002082"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0009790"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000092"/>
        <obo:IAO_0000115>A life cycle stage that starts with fertilization and ends with the fully formed embryo.</obo:IAO_0000115>
        <oboInOwl:hasDbXref rdf:resource="http://www.snomedbrowser.com/Codes/Details/296280003"/>
        <oboInOwl:hasDbXref>BilaDO:0000002</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>EV:0300001</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FBdv:00005289</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FMA:72652</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>HsapDv:0000002</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MmusDv:0000002</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000022</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>WBls:0000003</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>WBls:0000092</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>WBls:0000102</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>XAO:1000012</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>embryonic stage</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>embryogenesis</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>UBERON:0000068</oboInOwl:id>
        <rdfs:label>embryo stage</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000068"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A life cycle stage that starts with fertilization and ends with the fully formed embryo.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="http://orcid.org/0000-0002-6601-2165"/>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/UBERON_0000071 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000071">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000105"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000104"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002229"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000104"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>End of the life of an organism.</obo:IAO_0000115>
        <obo:UBPROP_0000012>ncit:Death is an outcome</obo:UBPROP_0000012>
        <oboInOwl:hasDbXref>XAO:0000437</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>XtroDO:0000085</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>death</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>UBERON:0000071</oboInOwl:id>
        <rdfs:label>death stage</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000071"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>End of the life of an organism.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>XAO:0000437</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000071"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/UBPROP_0000012"/>
        <owl:annotatedTarget>ncit:Death is an outcome</owl:annotatedTarget>
        <oboInOwl:external_ontology>ncit</oboInOwl:external_ontology>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/UBERON_0000092 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000092">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000105"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0009791"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000104"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000062"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000068"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002082"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0009791"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>Stage succeeding embryo, including mature structure.</obo:IAO_0000115>
        <obo:UBPROP_0000008>In birds, the postnatal stage begins when the beak penetrates the shell (i.e., external pipping) (Brown et al. 1997)</obo:UBPROP_0000008>
        <oboInOwl:hasDbXref>BilaDO:0000003</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000010</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000014</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000024</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>WBls:0000022</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>WBls:0000093</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>WBls:0000103</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>postembryonic stage</oboInOwl:hasExactSynonym>
        <oboInOwl:hasNarrowSynonym>post-hatching stage</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>postembryonic</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>UBERON:0000092</oboInOwl:id>
        <rdfs:label>post-embryonic stage</rdfs:label>
        <rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/obophenotype/uberon/issues/344</rdfs:seeAlso>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000092"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Stage succeeding embryo, including mature structure.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="https://orcid.org/0000-0002-6601-2165"/>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/UBERON_0000104 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000104">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000000"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000105"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002230"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000071"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>An entire span of an organism's life, commencing with the zygote stage and ending in the death of the organism.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>FBdv:00000000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>HsapDv:0000001</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MmusDv:0000001</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000011</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ncithesaurus:Life</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>entire life cycle</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>entire lifespan</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>life</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>lifespan</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>UBERON:0000104</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#upper_level"/>
        <rdfs:label>life cycle</rdfs:label>
        <rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/obophenotype/uberon/issues/532</rdfs:seeAlso>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000104"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>An entire span of an organism's life, commencing with the zygote stage and ending in the death of the organism.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="https://orcid.org/0000-0002-6601-2165"/>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/UBERON_0000105 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000105">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000000"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000104"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>A spatiotemporal region encompassing some part of the life cycle of an organism.</obo:IAO_0000115>
        <obo:IAO_0000116>this class represents a proper part of the life cycle of an organism. The class 'life cycle' should not be placed here</obo:IAO_0000116>
        <obo:UBPROP_0000012>the WBls class 'all stages' belongs here as it is the superclass of other WBls stages</obo:UBPROP_0000012>
        <obo:UBPROP_0000012>we map the ZFS unknown stage here as it is logically equivalent to saying *some* life cycle stage</obo:UBPROP_0000012>
        <oboInOwl:hasDbXref>BILS:0000105</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>EFO:0000399</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FBdv:00007012</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FMA:24120</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>HsapDv:0000000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MESH:D008018</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MmusDv:0000000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OlatDv:0000010</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PdumDv:0000090</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>WBls:0000002</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>XAO:1000000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ZFS:0000000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ZFS:0100000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ncithesaurus:Developmental_Stage</oboInOwl:hasDbXref>
        <oboInOwl:hasNarrowSynonym>developmental stage</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasNarrowSynonym>stage</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>UBERON:0000105</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#efo_slim"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#upper_level"/>
        <rdfs:label>life cycle stage</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000105"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A spatiotemporal region encompassing some part of the life cycle of an organism.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="https://orcid.org/0000-0002-6601-2165"/>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/UBERON_0000106 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000106">
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        <rdfs:subClassOf>
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            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>A stage at which the organism is a single cell produced by means of sexual reproduction.</obo:IAO_0000115>
        <obo:UBPROP_0000003>As in all metazoans, eumetazoan development begins with a fertilized egg, or zygote.[well established][VHOG]</obo:UBPROP_0000003>
        <oboInOwl:hasDbXref rdf:resource="http://en.wikipedia.org/wiki/Zygote"/>
        <oboInOwl:hasDbXref>BILS:0000106</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>BilaDO:0000005</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>EFO:0001322</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>EHDAA:27</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FBdv:00005288</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>NCIT:C12601</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PdumDv:0000100</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>VHOG:0000745</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>XAO:1000001</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ZFS:0000001</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>1-cell stage</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>fertilized egg stage</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>one cell stage</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>fertilized egg stage</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>one-cell stage</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>zygote</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>zygotum</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>UBERON:0000106</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#efo_slim"/>
        <rdfs:label>zygote stage</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/EMAPA_16033"/>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000106"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A stage at which the organism is a single cell produced by means of sexual reproduction.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="http://en.wikipedia.org/wiki/Zygote"/>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000106"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/UBPROP_0000003"/>
        <owl:annotatedTarget>As in all metazoans, eumetazoan development begins with a fertilized egg, or zygote.[well established][VHOG]</owl:annotatedTarget>
        <oboInOwl:date_retrieved rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2012-09-17</oboInOwl:date_retrieved>
        <oboInOwl:external_class>VHOG:0000745</oboInOwl:external_class>
        <oboInOwl:ontology rdf:datatype="http://www.w3.org/2001/XMLSchema#string">VHOG</oboInOwl:ontology>
        <oboInOwl:source rdf:resource="http://bgee.unil.ch/"/>
        <oboInOwl:source>ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.107</oboInOwl:source>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000106"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>fertilized egg stage</owl:annotatedTarget>
        <oboInOwl:hasDbXref>BTO:0000854</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000106"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>one-cell stage</owl:annotatedTarget>
        <oboInOwl:hasDbXref>VHOG:0000745</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000106"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>zygote</owl:annotatedTarget>
        <oboInOwl:hasDbXref>VHOG:0000745</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000106"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
        <owl:annotatedTarget>zygotum</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="http://en.wikipedia.org/wiki/Zygote"/>
        <oboInOwl:hasSynonymType rdf:resource="http://purl.obolibrary.org/obo/uberon/core#LATIN"/>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/UBERON_0000107 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000107">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/UBERON_0000105"/>
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                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0040016"/>
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        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000105"/>
        <rdfs:subClassOf>
            <owl:Restriction>
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        </rdfs:subClassOf>
        <rdfs:subClassOf>
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        <rdfs:subClassOf>
            <owl:Restriction>
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        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
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            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula.</obo:IAO_0000115>
        <oboInOwl:hasDbXref rdf:resource="http://en.wikipedia.org/wiki/Cleavage_(embryo)"/>
        <oboInOwl:hasDbXref>BILS:0000107</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>BilaDO:0000006</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>EFO:0001290</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FBdv:00000054</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MESH:D002970</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MmusDv:0000004</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000015</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000020</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PdumDv:0000200</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>XAO:1000004</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ZFS:0000046</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>UBERON:0000107</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#efo_slim"/>
        <rdfs:label>cleavage stage</rdfs:label>
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    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000107"/>
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        <owl:annotatedTarget>The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="http://en.wikipedia.org/wiki/Cleavage_(embryo)"/>
        <oboInOwl:hasDbXref>GO:0040016</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/UBERON_0000108 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000108">
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            <owl:Restriction>
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        <rdfs:subClassOf>
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        </rdfs:subClassOf>
        <obo:IAO_0000115>An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence.</obo:IAO_0000115>
        <obo:IAO_0000116>consider adding a preceding stage 'morula stage' as part of cleavage</obo:IAO_0000116>
        <oboInOwl:hasDbXref rdf:resource="http://en.wikipedia.org/wiki/Blastula"/>
        <oboInOwl:hasDbXref>BILS:0000108</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>BilaDO:0000007</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>EFO:0001282</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>HsapDv:0000006</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MmusDv:0000007</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000003</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000016</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000021</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OpenCyc:Mx4rEetFnKP2EdqAAAACs4vPlg</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>WBls:0000005</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>XAO:1000003</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ZFS:0000045</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>UBERON:0000108</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#efo_slim"/>
        <rdfs:label>blastula stage</rdfs:label>
        <foaf:depicted_by rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png</foaf:depicted_by>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000108"/>
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        <owl:annotatedTarget>An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="http://en.wikipedia.org/wiki/Blastula"/>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/UBERON_0000109 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000109">
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            <owl:Restriction>
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        <rdfs:subClassOf>
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        <rdfs:subClassOf>
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        <rdfs:subClassOf>
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                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002160"/>
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        </rdfs:subClassOf>
        <obo:IAO_0000115>A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>BILS:0000109</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>BilaDO:0000008</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>EFO:0001296</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FBdv:00005317</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>HsapDv:0000010</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MmusDv:0000013</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000004</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000019</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>WBls:0000010</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>XAO:1000005</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ZFS:0000047</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>blastocystis trilaminaris stage</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>trilaminar blastocyst stage</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>trilaminar blastoderm stage</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>trilaminar disk stage</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>trilaminar germ stage</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>trilaminar stage</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>UBERON:0000109</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#efo_slim"/>
        <rdfs:label>gastrula stage</rdfs:label>
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    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000109"/>
        <owl:annotatedProperty rdf:resource="http://www.w3.org/2000/01/rdf-schema#subClassOf"/>
        <owl:annotatedTarget>
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        </owl:annotatedTarget>
        <oboInOwl:source>BILS</oboInOwl:source>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000109"/>
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        <owl:annotatedTarget>A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>GO:0007369</oboInOwl:hasDbXref>
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    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000109"/>
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        <owl:annotatedTarget>blastocystis trilaminaris stage</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="https://orcid.org/0000-0002-6601-2165"/>
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    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000109"/>
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        <owl:annotatedTarget>trilaminar blastocyst stage</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="https://orcid.org/0000-0002-6601-2165"/>
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    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000109"/>
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        <owl:annotatedTarget>trilaminar blastoderm stage</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="https://orcid.org/0000-0002-6601-2165"/>
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    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000109"/>
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        <owl:annotatedTarget>trilaminar disk stage</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="https://orcid.org/0000-0002-6601-2165"/>
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    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000109"/>
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        <owl:annotatedTarget>trilaminar germ stage</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="https://orcid.org/0000-0002-6601-2165"/>
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    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000109"/>
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        <owl:annotatedTarget>trilaminar stage</owl:annotatedTarget>
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    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/UBERON_0000110 -->

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        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000062"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000109"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002082"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0001841"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002160"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_6072"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>BILS:0000110</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>BilaDO:0000009</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>HsapDv:0000012</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MmusDv:0000017</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>XAO:1000006</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>UBERON:0000110</oboInOwl:id>
        <rdfs:label>neurula stage</rdfs:label>
        <rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/obophenotype/uberon/issues/343</rdfs:seeAlso>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000110"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>GO:0001841</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/UBERON_0000111 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000111">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000105"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0048513"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000068"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000062"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000110"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002082"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0048513"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002160"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_6072"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism.</obo:IAO_0000115>
        <oboInOwl:hasDbXref rdf:resource="http://en.wikipedia.org/wiki/Organogenesis"/>
        <oboInOwl:hasDbXref>BILS:0000111</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>BilaDO:0000010</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>HsapDv:0000015</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MmusDv:0000018</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000005</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>OGES:000032</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>segmentation stage</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>UBERON:0000111</oboInOwl:id>
        <rdfs:label>organogenesis stage</rdfs:label>
        <rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/obophenotype/uberon/issues/533</rdfs:seeAlso>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000111"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="http://en.wikipedia.org/wiki/Organogenesis"/>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/UBERON_0000465 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0000465">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001062"/>
        <obo:IAO_0000115>Anatomical entity that has mass.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>AAO:0010264</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>AEO:0000006</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>BILA:0000006</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>CARO:0000006</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>EHDAA2:0003006</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FBbt:00007016</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FMA:67165</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>HAO:0000006</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>TAO:0001836</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>TGMA:0001826</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>VHOG:0001721</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>UBERON:0000465</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#upper_level"/>
        <rdfs:label>material anatomical entity</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000465"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Anatomical entity that has mass.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="http://orcid.org/0000-0001-9114-8737"/>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/UBERON_0001062 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0001062">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <obo:IAO_0000115>Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species.</obo:IAO_0000115>
        <oboInOwl:hasDbXref rdf:resource="http://linkedlifedata.com/resource/umls/id/C1515976"/>
        <oboInOwl:hasDbXref>AAO:0010841</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>AEO:0000000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>BILA:0000000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>BIRNLEX:6</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>CARO:0000000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>EHDAA2:0002229</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FBbt:10000000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FMA:62955</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>HAO:0000000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MA:0000001</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>NCIT:C12219</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>TAO:0100000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>TGMA:0001822</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>UMLS:C1515976</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>WBbt:0000100</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>XAO:0000000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ZFA:0100000</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>UBERON:0001062</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#upper_level"/>
        <rdfs:label>anatomical entity</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001062"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="http://orcid.org/0000-0001-9114-8737"/>
        <oboInOwl:hasDbXref>FMA:62955</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001062"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasDbXref"/>
        <owl:annotatedTarget>UMLS:C1515976</owl:annotatedTarget>
        <oboInOwl:source>ncithesaurus:Anatomic_Structure_System_or_Substance</oboInOwl:source>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/UBERON_0010000 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0010000">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/UBERON_0000061"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000086"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0001993"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000061"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CL_0000000"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000086"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0001993"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>An anatomical structure that has more than one cell as a part.</obo:IAO_0000115>
        <oboInOwl:hasDbXref>CARO:0010000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>FBbt:00100313</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>multicellular structure</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>UBERON:0010000</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#upper_level"/>
        <rdfs:label>multicellular anatomical structure</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0010000"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>An anatomical structure that has more than one cell as a part.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>CARO:0010000</oboInOwl:hasDbXref>
    </owl:Axiom>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0010000"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>multicellular structure</owl:annotatedTarget>
        <oboInOwl:hasDbXref>FBbt:00100313</oboInOwl:hasDbXref>
    </owl:Axiom>

    <!-- http://purl.obolibrary.org/obo/UBERON_0015212 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0015212">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/UBERON_0000061"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BSPO_0000126"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000465"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000061"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000465"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BSPO_0000126"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000465"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002160"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_33213"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000115>Any structure that is placed on one side of the left-right axis of a bilaterian.</obo:IAO_0000115>
        <obo:IAO_0000232>This class is primarily to implement taxon constraints. It may be removed in the future.</obo:IAO_0000232>
        <oboInOwl:hasOBONamespace>uberon</oboInOwl:hasOBONamespace>
        <oboInOwl:id>UBERON:0015212</oboInOwl:id>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#grouping_class"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#non_informative"/>
        <rdfs:label>lateral structure</rdfs:label>
    </owl:Class>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/UBERON_0015212"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Any structure that is placed on one side of the left-right axis of a bilaterian.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:resource="http://orcid.org/0000-0002-6601-2165"/>
    </owl:Axiom>

    <!--
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // General axioms
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <owl:Class>
        <owl:unionOf rdf:parseType="Collection">
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000068"/>
            </owl:Restriction>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000092"/>
            </owl:Restriction>
        </owl:unionOf>
        <owl:equivalentClass>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000104"/>
            </owl:Restriction>
        </owl:equivalentClass>
    </owl:Class>
    <owl:Class>
        <owl:intersectionOf rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/UBERON_0000061"/>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_33208"/>
            </owl:Restriction>
        </owl:intersectionOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002496"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000106"/>
            </owl:Restriction>
        </rdfs:subClassOf>
    </owl:Class>
    <owl:Class>
        <owl:intersectionOf rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/UBERON_0000104"/>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002162"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_33208"/>
            </owl:Restriction>
        </owl:intersectionOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002224"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000106"/>
            </owl:Restriction>
        </rdfs:subClassOf>
    </owl:Class>
    <owl:Restriction>
        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002566"/>
        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:subClassOf>
            <owl:Class>
                <owl:unionOf rdf:parseType="Collection">
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
                        <owl:someValuesFrom>
                            <owl:Restriction>
                                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002418"/>
                                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
                            </owl:Restriction>
                        </owl:someValuesFrom>
                    </owl:Restriction>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002215"/>
                        <owl:someValuesFrom>
                            <owl:Restriction>
                                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
                                <owl:someValuesFrom>
                                    <owl:Restriction>
                                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002418"/>
                                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
                                    </owl:Restriction>
                                </owl:someValuesFrom>
                            </owl:Restriction>
                        </owl:someValuesFrom>
                    </owl:Restriction>
                </owl:unionOf>
            </owl:Class>
        </rdfs:subClassOf>
    </owl:Restriction>
    <owl:Restriction>
        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000068"/>
        <owl:disjointWith>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0000092"/>
            </owl:Restriction>
        </owl:disjointWith>
    </owl:Restriction>

    <!--
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Rules
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <rdf:Description rdf:about="urn:swrl#w">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl#p">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl#d">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl#e">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/ro.owl#z">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/ro.owl#y">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/ro.owl#x">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl#y">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl#x">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl#z">
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                            <rdf:Description>
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                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002578"/>
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                            <rdf:Description>
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                                    <rdf:Description>
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    <rdf:Description>
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e.g.  if GP X enables ATPase coupled transporter activity' and 'ATPase coupled transporter activity' has_part 'ATPase activity' then GP(X) enables 'ATPase activity'</rdfs:comment>
        <rdfs:label>enabling an MF enables its parts</rdfs:label>
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                            <rdf:Description>
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                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002327"/>
                                <swrl:argument1 rdf:resource="urn:swrl#x"/>
                                <swrl:argument2 rdf:resource="urn:swrl#y"/>
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                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                                <rdf:first>
                                    <rdf:Description>
                                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                                        <swrl:argument1 rdf:resource="urn:swrl#y"/>
                                        <swrl:argument2 rdf:resource="urn:swrl#z"/>
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                                </rdf:first>
                                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
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            <rdf:Description>
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                    <rdf:Description>
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                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
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    <rdf:Description>
        <swrla:isRuleEnabled rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</swrla:isRuleEnabled>
        <rdfs:comment>GP(X)-enables->MF(Y)-part_of->BP(Z) => GP(X) involved_in BP(Z) e.g. if X enables 'protein kinase activity' and Y 'part of' 'signal tranduction' then X involved in 'signal transduction'</rdfs:comment>
        <rdfs:label>involved in BP</rdfs:label>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
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                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#ClassAtom"/>
                        <swrl:classPredicate rdf:resource="http://purl.obolibrary.org/obo/GO_0008150"/>
                        <swrl:argument1 rdf:resource="urn:swrl#z"/>
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                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                                <swrl:argument1 rdf:resource="urn:swrl#y"/>
                                <swrl:argument2 rdf:resource="urn:swrl#z"/>
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                        </rdf:first>
                        <rdf:rest>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                                <rdf:first>
                                    <rdf:Description>
                                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002327"/>
                                        <swrl:argument1 rdf:resource="urn:swrl#x"/>
                                        <swrl:argument2 rdf:resource="urn:swrl#y"/>
                                    </rdf:Description>
                                </rdf:first>
                                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                            </rdf:Description>
                        </rdf:rest>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002331"/>
                        <swrl:argument1 rdf:resource="urn:swrl#x"/>
                        <swrl:argument2 rdf:resource="urn:swrl#z"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
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            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
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                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002578"/>
                        <swrl:argument1 rdf:resource="urn:swrl#a1"/>
                        <swrl:argument2 rdf:resource="urn:swrl#a2"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#ClassAtom"/>
                                <swrl:classPredicate rdf:resource="http://purl.obolibrary.org/obo/GO_0016301"/>
                                <swrl:argument1 rdf:resource="urn:swrl#a1"/>
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                        <rdf:rest>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                                <rdf:first>
                                    <rdf:Description>
                                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002333"/>
                                        <swrl:argument1 rdf:resource="urn:swrl#a1"/>
                                        <swrl:argument2 rdf:resource="urn:swrl#g1"/>
                                    </rdf:Description>
                                </rdf:first>
                                <rdf:rest>
                                    <rdf:Description>
                                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                                        <rdf:first>
                                            <rdf:Description>
                                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002333"/>
                                                <swrl:argument1 rdf:resource="urn:swrl#a2"/>
                                                <swrl:argument2 rdf:resource="urn:swrl#g2"/>
                                            </rdf:Description>
                                        </rdf:first>
                                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                                    </rdf:Description>
                                </rdf:rest>
                            </rdf:Description>
                        </rdf:rest>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
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                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
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            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdfs:comment>This can't be added as a property chain because it causes a circularity violation for 'part of'.</rdfs:comment>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
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                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/BSPO_0000120"/>
                        <swrl:argument1 rdf:resource="urn:swrl:var#y"/>
                        <swrl:argument2 rdf:resource="urn:swrl:var#z"/>
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                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                                <swrl:argument1 rdf:resource="urn:swrl:var#x"/>
                                <swrl:argument2 rdf:resource="urn:swrl:var#y"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/BSPO_0000120"/>
                        <swrl:argument1 rdf:resource="urn:swrl:var#x"/>
                        <swrl:argument2 rdf:resource="urn:swrl:var#z"/>
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                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdfs:comment>This can't be added as a property chain because it causes a circularity violation for 'part of'.</rdfs:comment>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/BSPO_0000121"/>
                        <swrl:argument1 rdf:resource="urn:swrl:var#y"/>
                        <swrl:argument2 rdf:resource="urn:swrl:var#z"/>
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                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                                <swrl:argument1 rdf:resource="urn:swrl:var#x"/>
                                <swrl:argument2 rdf:resource="urn:swrl:var#y"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
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                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
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                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdfs:comment>This can't be added as a property chain because it causes a circularity violation for 'part of'.</rdfs:comment>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
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                    <rdf:Description>
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                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                                <swrl:argument1 rdf:resource="urn:swrl:var#x"/>
                                <swrl:argument2 rdf:resource="urn:swrl:var#y"/>
                            </rdf:Description>
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                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
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                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
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                        <swrl:argument2 rdf:resource="urn:swrl:var#z"/>
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                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdfs:comment>This rule is dubious: added as a quick fix for expected inference in GO-CAM.  The problem is most acute for transmembrane proteins, such as receptors or cell adhesion molecules, which have some subfunctions inside the cell (e.g. kinase activity) and some subfunctions outside (e.g. ligand binding).  Correct annotation of where these functions occurs leads to incorrect inference about the location of the whole protein.  This should probably be weakened to "... -> overlaps"</rdfs:comment>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
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            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
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                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002327"/>
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                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/BFO_0000066"/>
                                <swrl:argument1 rdf:resource="urn:swrl#y"/>
                                <swrl:argument2 rdf:resource="urn:swrl#z"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
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                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdfs:comment>If a molecular function (X) has a regulatory subfunction, then any gene product which is an input to that subfunction has an activity that directly_regulates X.  Note:  this is intended for cases where the regaultory subfunction is protein binding, so it could be tightened with an additional clause to specify this.</rdfs:comment>
        <rdfs:label>inferring direct reg edge from input to regulatory subfunction</rdfs:label>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
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                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002352"/>
                        <swrl:argument1 rdf:resource="urn:swrl#B"/>
                        <swrl:argument2 rdf:resource="urn:swrl#C"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002333"/>
                                <swrl:argument1 rdf:resource="urn:swrl#A"/>
                                <swrl:argument2 rdf:resource="urn:swrl#B"/>
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                        </rdf:first>
                        <rdf:rest>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                                <rdf:first>
                                    <rdf:Description>
                                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002013"/>
                                        <swrl:argument1 rdf:resource="urn:swrl#D"/>
                                        <swrl:argument2 rdf:resource="urn:swrl#C"/>
                                    </rdf:Description>
                                </rdf:first>
                                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                            </rdf:Description>
                        </rdf:rest>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002578"/>
                        <swrl:argument1 rdf:resource="urn:swrl#A"/>
                        <swrl:argument2 rdf:resource="urn:swrl#D"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdfs:label>inferring direct neg reg edge from input to regulatory subfunction</rdfs:label>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002352"/>
                        <swrl:argument1 rdf:resource="urn:swrl#B"/>
                        <swrl:argument2 rdf:resource="urn:swrl#C"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002333"/>
                                <swrl:argument1 rdf:resource="urn:swrl#A"/>
                                <swrl:argument2 rdf:resource="urn:swrl#B"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                                <rdf:first>
                                    <rdf:Description>
                                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002014"/>
                                        <swrl:argument1 rdf:resource="urn:swrl#D"/>
                                        <swrl:argument2 rdf:resource="urn:swrl#C"/>
                                    </rdf:Description>
                                </rdf:first>
                                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                            </rdf:Description>
                        </rdf:rest>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002630"/>
                        <swrl:argument1 rdf:resource="urn:swrl#A"/>
                        <swrl:argument2 rdf:resource="urn:swrl#D"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdfs:label>inferring direct positive reg edge from input to regulatory subfunction</rdfs:label>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002352"/>
                        <swrl:argument1 rdf:resource="urn:swrl#B"/>
                        <swrl:argument2 rdf:resource="urn:swrl#C"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002333"/>
                                <swrl:argument1 rdf:resource="urn:swrl#A"/>
                                <swrl:argument2 rdf:resource="urn:swrl#B"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                                <rdf:first>
                                    <rdf:Description>
                                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002015"/>
                                        <swrl:argument1 rdf:resource="urn:swrl#D"/>
                                        <swrl:argument2 rdf:resource="urn:swrl#C"/>
                                    </rdf:Description>
                                </rdf:first>
                                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                            </rdf:Description>
                        </rdf:rest>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002629"/>
                        <swrl:argument1 rdf:resource="urn:swrl#A"/>
                        <swrl:argument2 rdf:resource="urn:swrl#D"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdfs:label>effector input is compound function input</rdfs:label>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002025"/>
                        <swrl:argument1 rdf:resource="urn:swrl#mf"/>
                        <swrl:argument2 rdf:resource="urn:swrl#eff"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002233"/>
                                <swrl:argument1 rdf:resource="urn:swrl#eff"/>
                                <swrl:argument2 rdf:resource="urn:swrl#in"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002233"/>
                        <swrl:argument1 rdf:resource="urn:swrl#mf"/>
                        <swrl:argument2 rdf:resource="urn:swrl#in"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdfs:label>Input of effector is input of its parent MF</rdfs:label>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002025"/>
                        <swrl:argument1 rdf:resource="urn:swrl#mf"/>
                        <swrl:argument2 rdf:resource="urn:swrl#eff"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002233"/>
                                <swrl:argument1 rdf:resource="urn:swrl#mf"/>
                                <swrl:argument2 rdf:resource="urn:swrl#in"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002233"/>
                        <swrl:argument1 rdf:resource="urn:swrl#eff"/>
                        <swrl:argument2 rdf:resource="urn:swrl#in"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdfs:comment>if effector directly regulates X,  its parent MF directly regulates X</rdfs:comment>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002578"/>
                        <swrl:argument1 rdf:resource="urn:swrl#mf"/>
                        <swrl:argument2 rdf:resource="urn:swrl#mf2"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002025"/>
                                <swrl:argument1 rdf:resource="urn:swrl#mf"/>
                                <swrl:argument2 rdf:resource="urn:swrl#eff"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002578"/>
                        <swrl:argument1 rdf:resource="urn:swrl#eff"/>
                        <swrl:argument2 rdf:resource="urn:swrl#mf2"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdfs:comment>if effector directly positively regulates X,  its parent MF directly positively regulates X</rdfs:comment>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002025"/>
                        <swrl:argument1 rdf:resource="urn:swrl#mf"/>
                        <swrl:argument2 rdf:resource="urn:swrl#eff"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002629"/>
                                <swrl:argument1 rdf:resource="urn:swrl#mf"/>
                                <swrl:argument2 rdf:resource="urn:swrl#mf2"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002629"/>
                        <swrl:argument1 rdf:resource="urn:swrl#eff"/>
                        <swrl:argument2 rdf:resource="urn:swrl#mf2"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdfs:label>if effector directly negatively regulates X,  its parent MF directly negatively regulates X</rdfs:label>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002630"/>
                        <swrl:argument1 rdf:resource="urn:swrl#mf"/>
                        <swrl:argument2 rdf:resource="urn:swrl#mf2"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002025"/>
                                <swrl:argument1 rdf:resource="urn:swrl#mf"/>
                                <swrl:argument2 rdf:resource="urn:swrl#eff"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002630"/>
                        <swrl:argument1 rdf:resource="urn:swrl#eff"/>
                        <swrl:argument2 rdf:resource="urn:swrl#mf2"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdfs:label>'causally downstream of' and 'overlaps' should be disjoint properties (a SWRL rule is required because these are non-simple properties).</rdfs:label>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002131"/>
                        <swrl:argument1 rdf:resource="urn:swrl#x"/>
                        <swrl:argument2 rdf:resource="urn:swrl#y"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002404"/>
                                <swrl:argument1 rdf:resource="urn:swrl#x"/>
                                <swrl:argument2 rdf:resource="urn:swrl#y"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#ClassAtom"/>
                        <swrl:classPredicate rdf:resource="http://www.w3.org/2002/07/owl#Nothing"/>
                        <swrl:argument1 rdf:resource="urn:swrl#y"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#ClassAtom"/>
                                <swrl:classPredicate rdf:resource="http://www.w3.org/2002/07/owl#Nothing"/>
                                <swrl:argument1 rdf:resource="urn:swrl#x"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdfs:label>'causally upstream of' and 'overlaps' should be disjoint properties (a SWRL rule is required because these are non-simple properties).</rdfs:label>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002131"/>
                        <swrl:argument1 rdf:resource="urn:swrl#x"/>
                        <swrl:argument2 rdf:resource="urn:swrl#y"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
                                <swrl:argument1 rdf:resource="urn:swrl#x"/>
                                <swrl:argument2 rdf:resource="urn:swrl#y"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#ClassAtom"/>
                        <swrl:classPredicate rdf:resource="http://www.w3.org/2002/07/owl#Nothing"/>
                        <swrl:argument1 rdf:resource="urn:swrl#y"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#ClassAtom"/>
                                <swrl:classPredicate rdf:resource="http://www.w3.org/2002/07/owl#Nothing"/>
                                <swrl:argument1 rdf:resource="urn:swrl#x"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002212"/>
                        <swrl:argument1 rdf:resource="urn:swrl#x"/>
                        <swrl:argument2 rdf:resource="urn:swrl#y"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002213"/>
                                <swrl:argument1 rdf:resource="urn:swrl#y"/>
                                <swrl:argument2 rdf:resource="urn:swrl#z"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002212"/>
                        <swrl:argument1 rdf:resource="urn:swrl#x"/>
                        <swrl:argument2 rdf:resource="urn:swrl#z"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002212"/>
                        <swrl:argument1 rdf:resource="urn:swrl#y"/>
                        <swrl:argument2 rdf:resource="urn:swrl#z"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002213"/>
                                <swrl:argument1 rdf:resource="urn:swrl#x"/>
                                <swrl:argument2 rdf:resource="urn:swrl#y"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002212"/>
                        <swrl:argument1 rdf:resource="urn:swrl#x"/>
                        <swrl:argument2 rdf:resource="urn:swrl#z"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002212"/>
                        <swrl:argument1 rdf:resource="urn:swrl:var#x"/>
                        <swrl:argument2 rdf:resource="urn:swrl:var#y"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0019002"/>
                                <swrl:argument1 rdf:resource="urn:swrl:var#y"/>
                                <swrl:argument2 rdf:resource="urn:swrl:var#z"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0019001"/>
                        <swrl:argument1 rdf:resource="urn:swrl:var#x"/>
                        <swrl:argument2 rdf:resource="urn:swrl:var#z"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
                        <swrl:argument1 rdf:resource="urn:swrl:var#y"/>
                        <swrl:argument2 rdf:resource="urn:swrl:var#z"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002264"/>
                                <swrl:argument1 rdf:resource="urn:swrl:var#x"/>
                                <swrl:argument2 rdf:resource="urn:swrl:var#y"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002263"/>
                        <swrl:argument1 rdf:resource="urn:swrl:var#x"/>
                        <swrl:argument2 rdf:resource="urn:swrl:var#z"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
</rdf:RDF>

<!-- Generated by the OWL API (version 4.5.6) https://github.com/owlcs/owlapi -->