Daily Papers

Recent unified multi-modal encoders align a wide range of modalities into a shared representation space, enabling diverse cross-modal tasks. Despite their impressive capabilities, the robustness of these models under adversarial perturbations remains underexplored, which is a critical concern for safety-sensitive applications. In this work, we present the first comprehensive study of adversarial vulnerability in unified multi-modal encoders. We find that even mild adversarial perturbations lead to substantial performance drops across all modalities. Non-visual inputs, such as audio and point clouds, are especially fragile, while visual inputs like images and videos also degrade significantly. To address this, we propose an efficient adversarial calibration framework that improves robustness across modalities without modifying pretrained encoders or semantic centers, ensuring compatibility with existing foundation models. Our method introduces modality-specific projection heads trained solely on adversarial examples, while keeping the backbone and embeddings frozen. We explore three training objectives: fixed-center cross-entropy, clean-to-adversarial L2 alignment, and clean-adversarial InfoNCE, and we introduce a regularization strategy to ensure modality-consistent alignment under attack. Experiments on six modalities and three Bind-style models show that our method improves adversarial robustness by up to 47.3 percent at epsilon = 4/255, while preserving or even improving clean zero-shot and retrieval performance with less than 1 percent trainable parameters.

We propose a visual-linguistic representation learning approach within a self-supervised learning framework by introducing a new operation, loss, and data augmentation strategy. First, we generate diverse features for the image-text matching (ITM) task via soft-masking the regions in an image, which are most relevant to a certain word in the corresponding caption, instead of completely removing them. Since our framework relies only on image-caption pairs with no fine-grained annotations, we identify the relevant regions to each word by computing the word-conditional visual attention using multi-modal encoder. Second, we encourage the model to focus more on hard but diverse examples by proposing a focal loss for the image-text contrastive learning (ITC) objective, which alleviates the inherent limitations of overfitting and bias issues. Last, we perform multi-modal data augmentations for self-supervised learning via mining various examples by masking texts and rendering distortions on images. We show that the combination of these three innovations is effective for learning a pretrained model, leading to outstanding performance on multiple vision-language downstream tasks.

Misinformation has become a pressing issue. Fake media, in both visual and textual forms, is widespread on the web. While various deepfake detection and text fake news detection methods have been proposed, they are only designed for single-modality forgery based on binary classification, let alone analyzing and reasoning subtle forgery traces across different modalities. In this paper, we highlight a new research problem for multi-modal fake media, namely Detecting and Grounding Multi-Modal Media Manipulation (DGM^4). DGM^4 aims to not only detect the authenticity of multi-modal media, but also ground the manipulated content (i.e., image bounding boxes and text tokens), which requires deeper reasoning of multi-modal media manipulation. To support a large-scale investigation, we construct the first DGM^4 dataset, where image-text pairs are manipulated by various approaches, with rich annotation of diverse manipulations. Moreover, we propose a novel HierArchical Multi-modal Manipulation rEasoning tRansformer (HAMMER) to fully capture the fine-grained interaction between different modalities. HAMMER performs 1) manipulation-aware contrastive learning between two uni-modal encoders as shallow manipulation reasoning, and 2) modality-aware cross-attention by multi-modal aggregator as deep manipulation reasoning. Dedicated manipulation detection and grounding heads are integrated from shallow to deep levels based on the interacted multi-modal information. Finally, we build an extensive benchmark and set up rigorous evaluation metrics for this new research problem. Comprehensive experiments demonstrate the superiority of our model; several valuable observations are also revealed to facilitate future research in multi-modal media manipulation.

Contrastive Language--Image Pre-training (CLIP) has manifested remarkable improvements in zero-shot classification and cross-modal vision-language tasks. Yet, from a geometrical point of view, the CLIP embedding space has been found to have a pronounced modality gap. This gap renders the embedding space overly sparse and disconnected, with different modalities being densely distributed in distinct subregions of the hypersphere. In this work, we aim at answering two main questions: 1. Does sharing the parameter space between the multi-modal encoders reduce the modality gap? 2. Can the gap be mitigated by pushing apart the uni-modal embeddings via intra-modality separation? We design AlignCLIP, in order to answer these questions and show that answers to both questions are positive. Through extensive experiments, we show that AlignCLIP achieves noticeable enhancements in the cross-modal alignment of the embeddings, and thereby, reduces the modality gap, while maintaining the performance across several downstream evaluations, such as zero-shot image classification, zero-shot multi-modal retrieval and zero-shot semantic text similarity.

The goal of protein representation learning is to extract knowledge from protein databases that can be applied to various protein-related downstream tasks. Although protein sequence, structure, and function are the three key modalities for a comprehensive understanding of proteins, existing methods for protein representation learning have utilized only one or two of these modalities due to the difficulty of capturing the asymmetric interrelationships between them. To account for this asymmetry, we introduce our novel asymmetric multi-modal masked autoencoder (AMMA). AMMA adopts (1) a unified multi-modal encoder to integrate all three modalities into a unified representation space and (2) asymmetric decoders to ensure that sequence latent features reflect structural and functional information. The experiments demonstrate that the proposed AMMA is highly effective in learning protein representations that exhibit well-aligned inter-modal relationships, which in turn makes it effective for various downstream protein-related tasks.

Recently, the astonishing performance of large language models (LLMs) in natural language comprehension and generation tasks triggered lots of exploration of using them as central controllers to build agent systems. Multiple studies focus on bridging the LLMs to external tools to extend the application scenarios. However, the current LLMs' perceiving tool-use ability is limited to a single text query, which may result in ambiguity in understanding the users' real intentions. LLMs are expected to eliminate that by perceiving the visual- or auditory-grounded instructions' information. Therefore, in this paper, we propose MLLM-Tool, a system incorporating open-source LLMs and multi-modal encoders so that the learnt LLMs can be conscious of multi-modal input instruction and then select the function-matched tool correctly. To facilitate the evaluation of the model's capability, we collect a dataset featured by consisting of multi-modal input tools from HuggingFace. Another important feature of our dataset is that our dataset also contains multiple potential choices for the same instruction due to the existence of identical functions and synonymous functions, which provides more potential solutions for the same query. The experiments reveal that our MLLM-Tool is capable of recommending appropriate tools for multi-modal instructions. Codes and data are available at https://github.com/MLLM-Tool/MLLM-Tool.

The ability to provide fine-grained control for generating and editing visual imagery has profound implications for computer vision and its applications. Previous works have explored extending controllability in two directions: instruction tuning with text-based prompts and multi-modal conditioning. However, these works make one or more unnatural assumptions on the number and/or type of modality inputs used to express controllability. We propose InstructAny2Pix, a flexible multi-modal instruction-following system that enables users to edit an input image using instructions involving audio, images, and text. InstructAny2Pix consists of three building blocks that facilitate this capability: a multi-modal encoder that encodes different modalities such as images and audio into a unified latent space, a diffusion model that learns to decode representations in this latent space into images, and a multi-modal LLM that can understand instructions involving multiple images and audio pieces and generate a conditional embedding of the desired output, which can be used by the diffusion decoder. Additionally, to facilitate training efficiency and improve generation quality, we include an additional refinement prior module that enhances the visual quality of LLM outputs. These designs are critical to the performance of our system. We demonstrate that our system can perform a series of novel instruction-guided editing tasks. The code is available at https://github.com/jacklishufan/InstructAny2Pix.git

We propose a novel architecture and method of explainable classification with Concept Bottleneck Models (CBMs). While SOTA approaches to Image Classification task work as a black box, there is a growing demand for models that would provide interpreted results. Such a models often learn to predict the distribution over class labels using additional description of this target instances, called concepts. However, existing Bottleneck methods have a number of limitations: their accuracy is lower than that of a standard model and CBMs require an additional set of concepts to leverage. We provide a framework for creating Concept Bottleneck Model from pre-trained multi-modal encoder and new CLIP-like architectures. By introducing a new type of layers known as Concept Bottleneck Layers, we outline three methods for training them: with ell_1-loss, contrastive loss and loss function based on Gumbel-Softmax distribution (Sparse-CBM), while final FC layer is still trained with Cross-Entropy. We show a significant increase in accuracy using sparse hidden layers in CLIP-based bottleneck models. Which means that sparse representation of concepts activation vector is meaningful in Concept Bottleneck Models. Moreover, with our Concept Matrix Search algorithm we can improve CLIP predictions on complex datasets without any additional training or fine-tuning. The code is available at: https://github.com/Andron00e/SparseCBM.

Medical vision-and-language pre-training (Med-VLP) has received considerable attention owing to its applicability to extracting generic vision-and-language representations from medical images and texts. Most existing methods mainly contain three elements: uni-modal encoders (i.e., a vision encoder and a language encoder), a multi-modal fusion module, and pretext tasks, with few studies considering the importance of medical domain expert knowledge and explicitly exploiting such knowledge to facilitate Med-VLP. Although there exist knowledge-enhanced vision-and-language pre-training (VLP) methods in the general domain, most require off-the-shelf toolkits (e.g., object detectors and scene graph parsers), which are unavailable in the medical domain. In this paper, we propose a systematic and effective approach to enhance Med-VLP by structured medical knowledge from three perspectives. First, considering knowledge can be regarded as the intermediate medium between vision and language, we align the representations of the vision encoder and the language encoder through knowledge. Second, we inject knowledge into the multi-modal fusion model to enable the model to perform reasoning using knowledge as the supplementation of the input image and text. Third, we guide the model to put emphasis on the most critical information in images and texts by designing knowledge-induced pretext tasks. To perform a comprehensive evaluation and facilitate further research, we construct a medical vision-and-language benchmark including three tasks. Experimental results illustrate the effectiveness of our approach, where state-of-the-art performance is achieved on all downstream tasks. Further analyses explore the effects of different components of our approach and various settings of pre-training.

Time series data is essential in various applications, including climate modeling, healthcare monitoring, and financial analytics. Understanding the contextual information associated with real-world time series data is often essential for accurate and reliable event predictions. In this paper, we introduce TimeCAP, a time-series processing framework that creatively employs Large Language Models (LLMs) as contextualizers of time series data, extending their typical usage as predictors. TimeCAP incorporates two independent LLM agents: one generates a textual summary capturing the context of the time series, while the other uses this enriched summary to make more informed predictions. In addition, TimeCAP employs a multi-modal encoder that synergizes with the LLM agents, enhancing predictive performance through mutual augmentation of inputs with in-context examples. Experimental results on real-world datasets demonstrate that TimeCAP outperforms state-of-the-art methods for time series event prediction, including those utilizing LLMs as predictors, achieving an average improvement of 28.75% in F1 score.

We propose a novel framework for ID-preserving generation using a multi-modal encoding strategy rather than injecting identity features via adapters into pre-trained models. Our method treats identity and text as a unified conditioning input. To achieve this, we introduce FaceCLIP, a multi-modal encoder that learns a joint embedding space for both identity and textual semantics. Given a reference face and a text prompt, FaceCLIP produces a unified representation that encodes both identity and text, which conditions a base diffusion model to generate images that are identity-consistent and text-aligned. We also present a multi-modal alignment algorithm to train FaceCLIP, using a loss that aligns its joint representation with face, text, and image embedding spaces. We then build FaceCLIP-SDXL, an ID-preserving image synthesis pipeline by integrating FaceCLIP with Stable Diffusion XL (SDXL). Compared to prior methods, FaceCLIP-SDXL enables photorealistic portrait generation with better identity preservation and textual relevance. Extensive experiments demonstrate its quantitative and qualitative superiority.

Multimodal large language models (MLLMs) have recently become a focal point of research due to their formidable multimodal understanding capabilities. For example, in the audio and speech domains, an LLM can be equipped with (automatic) speech recognition (ASR) abilities by just concatenating the audio tokens, computed with an audio encoder, and the text tokens to achieve state-of-the-art results. On the contrary, tasks like visual and audio-visual speech recognition (VSR/AVSR), which also exploit noise-invariant lip movement information, have received little or no attention. To bridge this gap, we propose Llama-AVSR, a new MLLM with strong audio-visual speech recognition capabilities. It leverages pre-trained audio and video encoders to produce modality-specific tokens which, together with the text tokens, are processed by a pre-trained LLM (e.g., Llama3.1-8B) to yield the resulting response in an auto-regressive fashion. Llama-AVSR requires a small number of trainable parameters as only modality-specific projectors and LoRA modules are trained whereas the multi-modal encoders and LLM are kept frozen. We evaluate our proposed approach on LRS3, the largest public AVSR benchmark, and we achieve new state-of-the-art results for the tasks of ASR and AVSR with a WER of 0.81% and 0.77%, respectively. To bolster our results, we investigate the key factors that underpin the effectiveness of Llama-AVSR: the choice of the pre-trained encoders and LLM, the efficient integration of LoRA modules, and the optimal performance-efficiency trade-off obtained via modality-aware compression rates.

In this paper, we design and train a Generative Image-to-text Transformer, GIT, to unify vision-language tasks such as image/video captioning and question answering. While generative models provide a consistent network architecture between pre-training and fine-tuning, existing work typically contains complex structures (uni/multi-modal encoder/decoder) and depends on external modules such as object detectors/taggers and optical character recognition (OCR). In GIT, we simplify the architecture as one image encoder and one text decoder under a single language modeling task. We also scale up the pre-training data and the model size to boost the model performance. Without bells and whistles, our GIT establishes new state of the arts on 12 challenging benchmarks with a large margin. For instance, our model surpasses the human performance for the first time on TextCaps (138.2 vs. 125.5 in CIDEr). Furthermore, we present a new scheme of generation-based image classification and scene text recognition, achieving decent performance on standard benchmarks. Codes are released at https://github.com/microsoft/GenerativeImage2Text.

Knowledge-Intensive Visual Question Answering (KI-VQA) refers to answering a question about an image whose answer does not lie in the image. This paper presents a new pipeline for KI-VQA tasks, consisting of a retriever and a reader. First, we introduce DEDR, a symmetric dual encoding dense retrieval framework in which documents and queries are encoded into a shared embedding space using uni-modal (textual) and multi-modal encoders. We introduce an iterative knowledge distillation approach that bridges the gap between the representation spaces in these two encoders. Extensive evaluation on two well-established KI-VQA datasets, i.e., OK-VQA and FVQA, suggests that DEDR outperforms state-of-the-art baselines by 11.6% and 30.9% on OK-VQA and FVQA, respectively. Utilizing the passages retrieved by DEDR, we further introduce MM-FiD, an encoder-decoder multi-modal fusion-in-decoder model, for generating a textual answer for KI-VQA tasks. MM-FiD encodes the question, the image, and each retrieved passage separately and uses all passages jointly in its decoder. Compared to competitive baselines in the literature, this approach leads to 5.5% and 8.5% improvements in terms of question answering accuracy on OK-VQA and FVQA, respectively.

Introducing user-specified visual concepts in image editing is highly practical as these concepts convey the user's intent more precisely than text-based descriptions. We propose FreeEdit, a novel approach for achieving such reference-based image editing, which can accurately reproduce the visual concept from the reference image based on user-friendly language instructions. Our approach leverages the multi-modal instruction encoder to encode language instructions to guide the editing process. This implicit way of locating the editing area eliminates the need for manual editing masks. To enhance the reconstruction of reference details, we introduce the Decoupled Residual ReferAttention (DRRA) module. This module is designed to integrate fine-grained reference features extracted by a detail extractor into the image editing process in a residual way without interfering with the original self-attention. Given that existing datasets are unsuitable for reference-based image editing tasks, particularly due to the difficulty in constructing image triplets that include a reference image, we curate a high-quality dataset, FreeBench, using a newly developed twice-repainting scheme. FreeBench comprises the images before and after editing, detailed editing instructions, as well as a reference image that maintains the identity of the edited object, encompassing tasks such as object addition, replacement, and deletion. By conducting phased training on FreeBench followed by quality tuning, FreeEdit achieves high-quality zero-shot editing through convenient language instructions. We conduct extensive experiments to evaluate the effectiveness of FreeEdit across multiple task types, demonstrating its superiority over existing methods. The code will be available at: https://freeedit.github.io/.

Pre-training of text and layout has proved effective in a variety of visually-rich document understanding tasks due to its effective model architecture and the advantage of large-scale unlabeled scanned/digital-born documents. We propose LayoutLMv2 architecture with new pre-training tasks to model the interaction among text, layout, and image in a single multi-modal framework. Specifically, with a two-stream multi-modal Transformer encoder, LayoutLMv2 uses not only the existing masked visual-language modeling task but also the new text-image alignment and text-image matching tasks, which make it better capture the cross-modality interaction in the pre-training stage. Meanwhile, it also integrates a spatial-aware self-attention mechanism into the Transformer architecture so that the model can fully understand the relative positional relationship among different text blocks. Experiment results show that LayoutLMv2 outperforms LayoutLM by a large margin and achieves new state-of-the-art results on a wide variety of downstream visually-rich document understanding tasks, including FUNSD (0.7895 to 0.8420), CORD (0.9493 to 0.9601), SROIE (0.9524 to 0.9781), Kleister-NDA (0.8340 to 0.8520), RVL-CDIP (0.9443 to 0.9564), and DocVQA (0.7295 to 0.8672). We made our model and code publicly available at https://aka.ms/layoutlmv2.

Prior studies on Remote Sensing Foundation Model (RSFM) reveal immense potential towards a generic model for Earth Observation. Nevertheless, these works primarily focus on a single modality without temporal and geo-context modeling, hampering their capabilities for diverse tasks. In this study, we present SkySense, a generic billion-scale model, pre-trained on a curated multi-modal Remote Sensing Imagery (RSI) dataset with 21.5 million temporal sequences. SkySense incorporates a factorized multi-modal spatiotemporal encoder taking temporal sequences of optical and Synthetic Aperture Radar (SAR) data as input. This encoder is pre-trained by our proposed Multi-Granularity Contrastive Learning to learn representations across different modal and spatial granularities. To further enhance the RSI representations by the geo-context clue, we introduce Geo-Context Prototype Learning to learn region-aware prototypes upon RSI's multi-modal spatiotemporal features. To our best knowledge, SkySense is the largest Multi-Modal RSFM to date, whose modules can be flexibly combined or used individually to accommodate various tasks. It demonstrates remarkable generalization capabilities on a thorough evaluation encompassing 16 datasets over 7 tasks, from single- to multi-modal, static to temporal, and classification to localization. SkySense surpasses 18 recent RSFMs in all test scenarios. Specifically, it outperforms the latest models such as GFM, SatLas and Scale-MAE by a large margin, i.e., 2.76%, 3.67% and 3.61% on average respectively. We will release the pre-trained weights to facilitate future research and Earth Observation applications.

Transformers are increasingly dominating multi-modal reasoning tasks, such as visual question answering, achieving state-of-the-art results thanks to their ability to contextualize information using the self-attention and co-attention mechanisms. These attention modules also play a role in other computer vision tasks including object detection and image segmentation. Unlike Transformers that only use self-attention, Transformers with co-attention require to consider multiple attention maps in parallel in order to highlight the information that is relevant to the prediction in the model's input. In this work, we propose the first method to explain prediction by any Transformer-based architecture, including bi-modal Transformers and Transformers with co-attentions. We provide generic solutions and apply these to the three most commonly used of these architectures: (i) pure self-attention, (ii) self-attention combined with co-attention, and (iii) encoder-decoder attention. We show that our method is superior to all existing methods which are adapted from single modality explainability.

The style transfer task in Text-to-Speech refers to the process of transferring style information into text content to generate corresponding speech with a specific style. However, most existing style transfer approaches are either based on fixed emotional labels or reference speech clips, which cannot achieve flexible style transfer. Recently, some methods have adopted text descriptions to guide style transfer. In this paper, we propose a more flexible multi-modal and style controllable TTS framework named MM-TTS. It can utilize any modality as the prompt in unified multi-modal prompt space, including reference speech, emotional facial images, and text descriptions, to control the style of the generated speech in a system. The challenges of modeling such a multi-modal style controllable TTS mainly lie in two aspects:1)aligning the multi-modal information into a unified style space to enable the input of arbitrary modality as the style prompt in a single system, and 2)efficiently transferring the unified style representation into the given text content, thereby empowering the ability to generate prompt style-related voice. To address these problems, we propose an aligned multi-modal prompt encoder that embeds different modalities into a unified style space, supporting style transfer for different modalities. Additionally, we present a new adaptive style transfer method named Style Adaptive Convolutions to achieve a better style representation. Furthermore, we design a Rectified Flow based Refiner to solve the problem of over-smoothing Mel-spectrogram and generate audio of higher fidelity. Since there is no public dataset for multi-modal TTS, we construct a dataset named MEAD-TTS, which is related to the field of expressive talking head. Our experiments on the MEAD-TTS dataset and out-of-domain datasets demonstrate that MM-TTS can achieve satisfactory results based on multi-modal prompts.

In this paper, we introduce CineBrain, the first large-scale dataset featuring simultaneous EEG and fMRI recordings during dynamic audiovisual stimulation. Recognizing the complementary strengths of EEG's high temporal resolution and fMRI's deep-brain spatial coverage, CineBrain provides approximately six hours of narrative-driven content from the popular television series The Big Bang Theory for each of six participants. Building upon this unique dataset, we propose CineSync, an innovative multimodal decoding framework integrates a Multi-Modal Fusion Encoder with a diffusion-based Neural Latent Decoder. Our approach effectively fuses EEG and fMRI signals, significantly improving the reconstruction quality of complex audiovisual stimuli. To facilitate rigorous evaluation, we introduce Cine-Benchmark, a comprehensive evaluation protocol that assesses reconstructions across semantic and perceptual dimensions. Experimental results demonstrate that CineSync achieves state-of-the-art video reconstruction performance and highlight our initial success in combining fMRI and EEG for reconstructing both video and audio stimuli. Project Page: https://jianxgao.github.io/CineBrain.

We present YORO - a multi-modal transformer encoder-only architecture for the Visual Grounding (VG) task. This task involves localizing, in an image, an object referred via natural language. Unlike the recent trend in the literature of using multi-stage approaches that sacrifice speed for accuracy, YORO seeks a better trade-off between speed an accuracy by embracing a single-stage design, without CNN backbone. YORO consumes natural language queries, image patches, and learnable detection tokens and predicts coordinates of the referred object, using a single transformer encoder. To assist the alignment between text and visual objects, a novel patch-text alignment loss is proposed. Extensive experiments are conducted on 5 different datasets with ablations on architecture design choices. YORO is shown to support real-time inference and outperform all approaches in this class (single-stage methods) by large margins. It is also the fastest VG model and achieves the best speed/accuracy trade-off in the literature.

Textual and semantic comprehension of images is essential for generating proper captions. The comprehension requires detection of objects, modeling of relations between them, an assessment of the semantics of the scene and, finally, representing the extracted knowledge in a language space. To achieve rich language capabilities while ensuring good image-language mappings, pretrained language models (LMs) were conditioned on pretrained multi-modal (image-text) models that allow for image inputs. This requires an alignment of the image representation of the multi-modal model with the language representations of a generative LM. However, it is not clear how to best transfer semantics detected by the vision encoder of the multi-modal model to the LM. We introduce two novel ways of constructing a linear mapping that successfully transfers semantics between the embedding spaces of the two pretrained models. The first aligns the embedding space of the multi-modal language encoder with the embedding space of the pretrained LM via token correspondences. The latter leverages additional data that consists of image-text pairs to construct the mapping directly from vision to language space. Using our semantic mappings, we unlock image captioning for LMs without access to gradient information. By using different sources of data we achieve strong captioning performance on MS-COCO and Flickr30k datasets. Even in the face of limited data, our method partly exceeds the performance of other zero-shot and even finetuned competitors. Our ablation studies show that even LMs at a scale of merely 250M parameters can generate decent captions employing our semantic mappings. Our approach makes image captioning more accessible for institutions with restricted computational resources.

This paper introduces MultiBooth, a novel and efficient technique for multi-concept customization in image generation from text. Despite the significant advancements in customized generation methods, particularly with the success of diffusion models, existing methods often struggle with multi-concept scenarios due to low concept fidelity and high inference cost. MultiBooth addresses these issues by dividing the multi-concept generation process into two phases: a single-concept learning phase and a multi-concept integration phase. During the single-concept learning phase, we employ a multi-modal image encoder and an efficient concept encoding technique to learn a concise and discriminative representation for each concept. In the multi-concept integration phase, we use bounding boxes to define the generation area for each concept within the cross-attention map. This method enables the creation of individual concepts within their specified regions, thereby facilitating the formation of multi-concept images. This strategy not only improves concept fidelity but also reduces additional inference cost. MultiBooth surpasses various baselines in both qualitative and quantitative evaluations, showcasing its superior performance and computational efficiency. Project Page: https://multibooth.github.io/

Compositional reasoning is a hallmark of human visual intelligence; yet despite the size of large vision-language models, they struggle to represent simple compositions by combining objects with their attributes. To measure this lack of compositional capability, we design Cola, a text-to-image retrieval benchmark to Compose Objects Localized with Attributes. Using Cola as a testbed, we explore modeling designs to adapt pre-trained vision-language models to reason compositionally about multiple attributes attached to multiple objects. We explore 6 finetuning strategies on 2 seminal vision-language models, using 3 finetuning datasets and 2 test benchmarks (Cola and CREPE). Surprisingly, our optimal finetuning strategy improves a 151M parameter CLIP, which disjointly encodes image and language during pretraining, to perform as well as a 241M parameter FLAVA, which uses a multi-modal transformer encoder during pretraining to attend over both vision and language modalities. This optimal finetuning strategy is a lightweight multi-modal adapter that jointly attends over both image and language features generated by the pretrained model. We show this works better than common strategies such as prompt/fine-tuning, or tuning a comparable number of unimodal layers.

Video and audio are closely correlated modalities that humans naturally perceive together. While recent advancements have enabled the generation of audio or video from text, producing both modalities simultaneously still typically relies on either a cascaded process or multi-modal contrastive encoders. These approaches, however, often lead to suboptimal results due to inherent information losses during inference and conditioning. In this paper, we introduce SyncFlow, a system that is capable of simultaneously generating temporally synchronized audio and video from text. The core of SyncFlow is the proposed dual-diffusion-transformer (d-DiT) architecture, which enables joint video and audio modelling with proper information fusion. To efficiently manage the computational cost of joint audio and video modelling, SyncFlow utilizes a multi-stage training strategy that separates video and audio learning before joint fine-tuning. Our empirical evaluations demonstrate that SyncFlow produces audio and video outputs that are more correlated than baseline methods with significantly enhanced audio quality and audio-visual correspondence. Moreover, we demonstrate strong zero-shot capabilities of SyncFlow, including zero-shot video-to-audio generation and adaptation to novel video resolutions without further training.

In the field of autonomous vehicles (AVs), accurately discerning commander intent and executing linguistic commands within a visual context presents a significant challenge. This paper introduces a sophisticated encoder-decoder framework, developed to address visual grounding in AVs.Our Context-Aware Visual Grounding (CAVG) model is an advanced system that integrates five core encoders-Text, Image, Context, and Cross-Modal-with a Multimodal decoder. This integration enables the CAVG model to adeptly capture contextual semantics and to learn human emotional features, augmented by state-of-the-art Large Language Models (LLMs) including GPT-4. The architecture of CAVG is reinforced by the implementation of multi-head cross-modal attention mechanisms and a Region-Specific Dynamic (RSD) layer for attention modulation. This architectural design enables the model to efficiently process and interpret a range of cross-modal inputs, yielding a comprehensive understanding of the correlation between verbal commands and corresponding visual scenes. Empirical evaluations on the Talk2Car dataset, a real-world benchmark, demonstrate that CAVG establishes new standards in prediction accuracy and operational efficiency. Notably, the model exhibits exceptional performance even with limited training data, ranging from 50% to 75% of the full dataset. This feature highlights its effectiveness and potential for deployment in practical AV applications. Moreover, CAVG has shown remarkable robustness and adaptability in challenging scenarios, including long-text command interpretation, low-light conditions, ambiguous command contexts, inclement weather conditions, and densely populated urban environments. The code for the proposed model is available at our Github.

Existing top-performance autonomous driving systems typically rely on the multi-modal fusion strategy for reliable scene understanding. This design is however fundamentally restricted due to overlooking the modality-specific strengths and finally hampering the model performance. To address this limitation, in this work, we introduce a novel modality interaction strategy that allows individual per-modality representations to be learned and maintained throughout, enabling their unique characteristics to be exploited during the whole perception pipeline. To demonstrate the effectiveness of the proposed strategy, we design DeepInteraction++, a multi-modal interaction framework characterized by a multi-modal representational interaction encoder and a multi-modal predictive interaction decoder. Specifically, the encoder is implemented as a dual-stream Transformer with specialized attention operation for information exchange and integration between separate modality-specific representations. Our multi-modal representational learning incorporates both object-centric, precise sampling-based feature alignment and global dense information spreading, essential for the more challenging planning task. The decoder is designed to iteratively refine the predictions by alternately aggregating information from separate representations in a unified modality-agnostic manner, realizing multi-modal predictive interaction. Extensive experiments demonstrate the superior performance of the proposed framework on both 3D object detection and end-to-end autonomous driving tasks. Our code is available at https://github.com/fudan-zvg/DeepInteraction.

Pioneering dual-encoder pre-training works (e.g., CLIP and ALIGN) have revealed the potential of aligning multi-modal representations with contrastive learning. However, these works require a tremendous amount of data and computational resources (e.g., billion-level web data and hundreds of GPUs), which prevent researchers with limited resources from reproduction and further exploration. To this end, we propose a stack of novel methods, which significantly cut down the heavy resource dependency and allow us to conduct dual-encoder multi-modal representation alignment with limited resources. Besides, we provide a reproducible baseline of competitive results, namely ZeroVL, with only 14M publicly accessible academic datasets and 8 V100 GPUs. Additionally, we collect 100M web data for pre-training, and achieve comparable or superior results than state-of-the-art methods, further proving the effectiveness of our methods on large-scale data. We hope that this work will provide useful data points and experience for future research in contrastive vision-language pre-training. Code is available at https://github.com/zerovl/ZeroVL.

Existing top-performance 3D object detectors typically rely on the multi-modal fusion strategy. This design is however fundamentally restricted due to overlooking the modality-specific useful information and finally hampering the model performance. To address this limitation, in this work we introduce a novel modality interaction strategy where individual per-modality representations are learned and maintained throughout for enabling their unique characteristics to be exploited during object detection. To realize this proposed strategy, we design a DeepInteraction architecture characterized by a multi-modal representational interaction encoder and a multi-modal predictive interaction decoder. Experiments on the large-scale nuScenes dataset show that our proposed method surpasses all prior arts often by a large margin. Crucially, our method is ranked at the first position at the highly competitive nuScenes object detection leaderboard.

Multi-modal Large Language Models (MLLMs) have made significant strides in expanding the capabilities of Large Language Models (LLMs) through the incorporation of visual perception interfaces. Despite the emergence of exciting applications and the availability of diverse instruction tuning data, existing approaches often rely on CLIP or its variants as the visual branch, and merely extract features from the deep layers. However, these methods lack a comprehensive analysis of the visual encoders in MLLMs. In this paper, we conduct an extensive investigation into the effectiveness of different vision encoders within MLLMs. Our findings reveal that the shallow layer features of CLIP offer particular advantages for fine-grained tasks such as grounding and region understanding. Surprisingly, the vision-only model DINO, which is not pretrained with text-image alignment, demonstrates promising performance as a visual branch within MLLMs. By simply equipping it with an MLP layer for alignment, DINO surpasses CLIP in fine-grained related perception tasks. Building upon these observations, we propose a simple yet effective feature merging strategy, named COMM, that integrates CLIP and DINO with Multi-level features Merging, to enhance the visual capabilities of MLLMs. We evaluate COMM through comprehensive experiments on a wide range of benchmarks, including image captioning, visual question answering, visual grounding, and object hallucination. Experimental results demonstrate the superior performance of COMM compared to existing methods, showcasing its enhanced visual capabilities within MLLMs. Code will be made available at https://github.com/YuchenLiu98/COMM.

Open-domain extractive question answering works well on textual data by first retrieving candidate texts and then extracting the answer from those candidates. However, some questions cannot be answered by text alone but require information stored in tables. In this paper, we present an approach for retrieving both texts and tables relevant to a question by jointly encoding texts, tables and questions into a single vector space. To this end, we create a new multi-modal dataset based on text and table datasets from related work and compare the retrieval performance of different encoding schemata. We find that dense vector embeddings of transformer models outperform sparse embeddings on four out of six evaluation datasets. Comparing different dense embedding models, tri-encoders with one encoder for each question, text and table, increase retrieval performance compared to bi-encoders with one encoder for the question and one for both text and tables. We release the newly created multi-modal dataset to the community so that it can be used for training and evaluation.

Masked Language Models (MLMs) have proven to be effective for second-pass rescoring in Automatic Speech Recognition (ASR) systems. In this work, we propose Masked Audio Text Encoder (MATE), a multi-modal masked language model rescorer which incorporates acoustic representations into the input space of MLM. We adopt contrastive learning for effectively aligning the modalities by learning shared representations. We show that using a multi-modal rescorer is beneficial for domain generalization of the ASR system when target domain data is unavailable. MATE reduces word error rate (WER) by 4%-16% on in-domain, and 3%-7% on out-of-domain datasets, over the text-only baseline. Additionally, with very limited amount of training data (0.8 hours), MATE achieves a WER reduction of 8%-23% over the first-pass baseline.

In this paper, we present the Logically submissions to De-Factify 2 challenge (DE-FACTIFY 2023) on the task 1 of Multi-Modal Fact Checking. We describes our submissions to this challenge including explored evidence retrieval and selection techniques, pre-trained cross-modal and unimodal models, and a cross-modal veracity model based on the well established Transformer Encoder (TE) architecture which is heavily relies on the concept of self-attention. Exploratory analysis is also conducted on this Factify 2 data set that uncovers the salient multi-modal patterns and hypothesis motivating the architecture proposed in this work. A series of preliminary experiments were done to investigate and benchmarking different pre-trained embedding models, evidence retrieval settings and thresholds. The final system, a standard two-stage evidence based veracity detection system, yields weighted avg. 0.79 on both val set and final blind test set on the task 1, which achieves 3rd place with a small margin to the top performing system on the leaderboard among 9 participants.

Understanding food recipe requires anticipating the implicit causal effects of cooking actions, such that the recipe can be converted into a graph describing the temporal workflow of the recipe. This is a non-trivial task that involves common-sense reasoning. However, existing efforts rely on hand-crafted features to extract the workflow graph from recipes due to the lack of large-scale labeled datasets. Moreover, they fail to utilize the cooking images, which constitute an important part of food recipes. In this paper, we build MM-ReS, the first large-scale dataset for cooking workflow construction, consisting of 9,850 recipes with human-labeled workflow graphs. Cooking steps are multi-modal, featuring both text instructions and cooking images. We then propose a neural encoder-decoder model that utilizes both visual and textual information to construct the cooking workflow, which achieved over 20% performance gain over existing hand-crafted baselines.

Histopathology and transcriptomics are fundamental modalities in oncology, encapsulating the morphological and molecular aspects of the disease. Multi-modal self-supervised learning has demonstrated remarkable potential in learning pathological representations by integrating diverse data sources. Conventional multi-modal integration methods primarily emphasize modality alignment, while paying insufficient attention to retaining the modality-specific structures. However, unlike conventional scenarios where multi-modal inputs share highly overlapping features, histopathology and transcriptomics exhibit pronounced heterogeneity, offering orthogonal yet complementary insights. Histopathology provides morphological and spatial context, elucidating tissue architecture and cellular topology, whereas transcriptomics delineates molecular signatures through gene expression patterns. This inherent disparity introduces a major challenge in aligning them while maintaining modality-specific fidelity. To address these challenges, we present MIRROR, a novel multi-modal representation learning method designed to foster both modality alignment and retention. MIRROR employs dedicated encoders to extract comprehensive features for each modality, which is further complemented by a modality alignment module to achieve seamless integration between phenotype patterns and molecular profiles. Furthermore, a modality retention module safeguards unique attributes from each modality, while a style clustering module mitigates redundancy and enhances disease-relevant information by modeling and aligning consistent pathological signatures within a clustering space. Extensive evaluations on TCGA cohorts for cancer subtyping and survival analysis highlight MIRROR's superior performance, demonstrating its effectiveness in constructing comprehensive oncological feature representations and benefiting the cancer diagnosis.

We present Cephalo, a series of multimodal vision large language models (V-LLMs) designed for materials science applications, integrating visual and linguistic data for enhanced understanding and interaction within human-AI and multi-agent AI frameworks. A key innovation of Cephalo is its advanced dataset generation method, which employs a sophisticated algorithm to accurately detect and separate images and their corresponding textual descriptions from PDF documents, such as scientific papers. The method includes a careful refinement of image-text pairs through integrated vision and language processing, ensuring high-quality, contextually relevant, and well reasoned training data. Cephalo is trained on integrated image and text data extracted from thousands of scientific papers and science-focused Wikipedia pages demonstrates can interpret complex visual scenes, generate precise language descriptions, and answer queries about images effectively. The combination of a vision encoder with an autoregressive transformer supports complex natural language understanding in an integrated model, which can be coupled with other generative methods to create an image-to-text-to-image or image-to-text-to-3D pipeline. To explore the development of larger models from smaller ones, we merge sets of layers that originate from different pre-trained source models. This hybrid approach allows us to leverage the domain-specific expertise and general conversational capabilities to harness the strengths of multiple models. We examine the models in diverse use cases that incorporate biological materials, fracture and engineering analysis, protein biophysics, and bio-inspired design based on insect behavior. Generative applications include bio-inspired designs, including pollen-inspired architected materials, as well as the synthesis of bio-inspired material microstructures from a photograph of a solar eclipse.

Visual grounding is the task of locating objects specified by natural language expressions. Existing methods extend generic object detection frameworks to tackle this task. They typically extract visual and textual features separately using independent visual and textual encoders, then fuse these features in a multi-modal decoder for final prediction. However, visual grounding presents unique challenges. It often involves locating objects with different text descriptions within the same image. Existing methods struggle with this task because the independent visual encoder produces identical visual features for the same image, limiting detection performance. Some recently approaches propose various language-guided visual encoders to address this issue, but they mostly rely solely on textual information and require sophisticated designs. In this paper, we introduce Multi-modal Conditional Adaptation (MMCA), which enables the visual encoder to adaptively update weights, directing its focus towards text-relevant regions. Specifically, we first integrate information from different modalities to obtain multi-modal embeddings. Then we utilize a set of weighting coefficients, which generated from the multimodal embeddings, to reorganize the weight update matrices and apply them to the visual encoder of the visual grounding model. Extensive experiments on four widely used datasets demonstrate that MMCA achieves significant improvements and state-of-the-art results. Ablation experiments further demonstrate the lightweight and efficiency of our method. Our source code is available at: https://github.com/Mr-Bigworth/MMCA.

From optical sensors to microwave radars, leveraging the complementary strengths of remote sensing (RS) sensors is crucial for achieving dense spatio-temporal monitoring of our planet. In contrast, recent deep learning models, whether task-specific or foundational, are often specific to single sensors or to fixed combinations: adapting such models to different sensory inputs requires both architectural changes and re-training, limiting scalability and generalization across multiple RS sensors. On the contrary, a single model able to modulate its feature representations to accept diverse sensors as input would pave the way to agile and flexible multi-sensor RS data processing. To address this, we introduce SMARTIES, a generic and versatile foundation model lifting sensor-specific/dependent efforts and enabling scalability and generalization to diverse RS sensors: SMARTIES projects data from heterogeneous sensors into a shared spectrum-aware space, enabling the use of arbitrary combinations of bands both for training and inference. To obtain sensor-agnostic representations, we train a single, unified transformer model reconstructing masked multi-sensor data with cross-sensor token mixup. On both single- and multi-modal tasks across diverse sensors, SMARTIES outperforms previous models that rely on sensor-specific pretraining. Our code and pretrained models are available at https://gsumbul.github.io/SMARTIES.

Zero-shot Human-Object Interaction (HOI) detection has emerged as a frontier topic due to its capability to detect HOIs beyond a predefined set of categories. This task entails not only identifying the interactiveness of human-object pairs and localizing them but also recognizing both seen and unseen interaction categories. In this paper, we introduce a novel framework for zero-shot HOI detection using Conditional Multi-Modal Prompts, namely CMMP. This approach enhances the generalization of large foundation models, such as CLIP, when fine-tuned for HOI detection. Unlike traditional prompt-learning methods, we propose learning decoupled vision and language prompts for interactiveness-aware visual feature extraction and generalizable interaction classification, respectively. Specifically, we integrate prior knowledge of different granularity into conditional vision prompts, including an input-conditioned instance prior and a global spatial pattern prior. The former encourages the image encoder to treat instances belonging to seen or potentially unseen HOI concepts equally while the latter provides representative plausible spatial configuration of the human and object under interaction. Besides, we employ language-aware prompt learning with a consistency constraint to preserve the knowledge of the large foundation model to enable better generalization in the text branch. Extensive experiments demonstrate the efficacy of our detector with conditional multi-modal prompts, outperforming previous state-of-the-art on unseen classes of various zero-shot settings. The code and models are available at https://github.com/ltttpku/CMMP.

Research on large language models has advanced significantly across text, speech, images, and videos. However, multi-modal music understanding and generation remain underexplored due to the lack of well-annotated datasets. To address this, we introduce a dataset with 167.69 hours of multi-modal data, including text, images, videos, and music annotations. Based on this dataset, we propose MuMu-LLaMA, a model that leverages pre-trained encoders for music, images, and videos. For music generation, we integrate AudioLDM 2 and MusicGen. Our evaluation across four tasks--music understanding, text-to-music generation, prompt-based music editing, and multi-modal music generation--demonstrates that MuMu-LLaMA outperforms state-of-the-art models, showing its potential for multi-modal music applications.

The development of Multi-modal Large Language Models (MLLMs) enhances Large Language Models (LLMs) with the ability to perceive data formats beyond text, significantly advancing a range of downstream applications, such as visual question answering and image captioning. However, the substantial computational costs associated with processing high-resolution images and videos pose a barrier to their broader adoption. To address this challenge, compressing vision tokens in MLLMs has emerged as a promising approach to reduce inference costs. While existing methods conduct token reduction in the feature alignment phase. In this paper, we introduce VisToG, a novel grouping mechanism that leverages the capabilities of pre-trained vision encoders to group similar image segments without the need for segmentation masks. Specifically, we concatenate semantic tokens to represent image semantic segments after the linear projection layer before feeding into the vision encoder. Besides, with the isolated attention we adopt, VisToG can identify and eliminate redundant visual tokens utilizing the prior knowledge in the pre-trained vision encoder, which effectively reduces computational demands. Extensive experiments demonstrate the effectiveness of VisToG, maintaining 98.1% of the original performance while achieving a reduction of over 27\% inference time.

Multimodal Large Language Models (MLLMs) have attracted much attention due to their multifunctionality. However, traditional Transformer architectures incur significant overhead due to their secondary computational complexity. To address this issue, we introduce ML-Mamba, a multimodal language model that utilizes the latest and efficient Mamba-2 model for inference. Mamba-2 is known for its linear extension and fast processing of long sequences. We replace the Transformer based backbone with a pre-trained Mamba-2 model and explore methods for integrating 2D visual selective scanning mechanisms into multimodal learning. We also try various visual encoders and Mamba-2 model variants. Our extensive experiments conducted in various multimodal benchmark tests have demonstrated the competitive performance of ML-Mamba and highlighted the potential of state space models in multimodal tasks. The experimental results show that: (1) ML-Mamba achieves performance comparable to state-of-the-art methods such as TinyLaVA and MobileVLM v2 through its linear sequential modeling, while also having faster inference speed; (2) ML-Mamba performs well in visual hallucinations and spatial relationship judgment in closed set benchmark tests; (3) ML-Mamba achieves performance comparable to LLaVA while reducing the number of parameters by 40\%.(4) Compared to the multimodal model using the original Mamba model, the Mamba-2 based large-scale multimodal language model has stronger inference performance and effectiveness.

Most multi-modal tasks can be formulated into problems of either generation or embedding. Existing models usually tackle these two types of problems by decoupling language modules into a text decoder for generation, and a text encoder for embedding. To explore the minimalism of multi-modal paradigms, we attempt to achieve only one model per modality in this work. We propose a Multi-Modal Generative Embedding Model (MM-GEM), whereby the generative and embedding objectives are encapsulated in one Large Language Model. We also propose a PoolAggregator to boost efficiency and enable the ability of fine-grained embedding and generation. A surprising finding is that these two objectives do not significantly conflict with each other. For example, MM-GEM instantiated from ViT-Large and TinyLlama shows competitive performance on benchmarks for multimodal embedding models such as cross-modal retrieval and zero-shot classification, while has good ability of image captioning. Additionally, MM-GEM can seamlessly execute region-level image caption generation and retrieval tasks. Besides, the advanced text model in MM-GEM brings over 5% improvement in Recall@1 for long text and image retrieval.

Multi-modal semantic segmentation significantly enhances AI agents' perception and scene understanding, especially under adverse conditions like low-light or overexposed environments. Leveraging additional modalities (X-modality) like thermal and depth alongside traditional RGB provides complementary information, enabling more robust and reliable segmentation. In this work, we introduce Sigma, a Siamese Mamba network for multi-modal semantic segmentation, utilizing the Selective Structured State Space Model, Mamba. Unlike conventional methods that rely on CNNs, with their limited local receptive fields, or Vision Transformers (ViTs), which offer global receptive fields at the cost of quadratic complexity, our model achieves global receptive fields coverage with linear complexity. By employing a Siamese encoder and innovating a Mamba fusion mechanism, we effectively select essential information from different modalities. A decoder is then developed to enhance the channel-wise modeling ability of the model. Our method, Sigma, is rigorously evaluated on both RGB-Thermal and RGB-Depth segmentation tasks, demonstrating its superiority and marking the first successful application of State Space Models (SSMs) in multi-modal perception tasks. Code is available at https://github.com/zifuwan/Sigma.

We focus on improving the visual understanding capability for boosting the vision-language models. We propose Arcana, a multiModal language model, which introduces two crucial techniques. First, we present Multimodal LoRA (MM-LoRA), a module designed to enhance the decoder. Unlike traditional language-driven decoders, MM-LoRA consists of two parallel LoRAs -- one for vision and one for language -- each with its own parameters. This disentangled parameters design allows for more specialized learning in each modality and better integration of multimodal information. Second, we introduce the Query Ladder adapter (QLadder) to improve the visual encoder. QLadder employs a learnable ``ladder'' structure to deeply aggregates the intermediate representations from the frozen pretrained visual encoder (e.g., CLIP image encoder). This enables the model to learn new and informative visual features, as well as remaining the powerful capabilities of the pretrained visual encoder. These techniques collectively enhance Arcana's visual perception power, enabling it to leverage improved visual information for more accurate and contextually relevant outputs across various multimodal scenarios. Extensive experiments and ablation studies demonstrate the effectiveness and generalization capability of our Arcana. The code and re-annotated data are available at https://arcana-project-page.github.io.

Large language models (LLMs), renowned for their powerful conversational abilities, are widely recognized as exceptional tools in the field of education, particularly in the context of automated intelligent instruction systems for language learning. In this paper, we propose a scoring system based on LLMs, motivated by their positive impact on text-related scoring tasks. Specifically, the speech encoder first maps the learner's speech into contextual features. The adapter layer then transforms these features to align with the text embedding in latent space. The assessment task-specific prefix and prompt text are embedded and concatenated with the features generated by the modality adapter layer, enabling the LLMs to predict accuracy and fluency scores. Our experiments demonstrate that the proposed scoring systems achieve competitive results compared to the baselines on the Speechocean762 datasets. Moreover, we also conducted an ablation study to better understand the contributions of the prompt text and training strategy in the proposed scoring system.

In this report, we introduce MammothModa, yet another multi-modal large language model (MLLM) designed to achieve state-of-the-art performance starting from an elementary baseline. We focus on three key design insights: (i) Integrating Visual Capabilities while Maintaining Complex Language Understanding: In addition to the vision encoder, we incorporated the Visual Attention Experts into the LLM to enhance its visual capabilities. (ii) Extending Context Window for High-Resolution and Long-Duration Visual Feature: We explore the Visual Merger Module to effectively reduce the token number of high-resolution images and incorporated frame position ids to avoid position interpolation. (iii) High-Quality Bilingual Datasets: We meticulously curated and filtered a high-quality bilingual multimodal dataset to reduce visual hallucinations. With above recipe we build MammothModa that consistently outperforms the state-of-the-art models, e.g., LLaVA-series, across main real-world visual language benchmarks without bells and whistles.

We present a novel approach for the prediction of anticancer compound sensitivity by means of multi-modal attention-based neural networks (PaccMann). In our approach, we integrate three key pillars of drug sensitivity, namely, the molecular structure of compounds, transcriptomic profiles of cancer cells as well as prior knowledge about interactions among proteins within cells. Our models ingest a drug-cell pair consisting of SMILES encoding of a compound and the gene expression profile of a cancer cell and predicts an IC50 sensitivity value. Gene expression profiles are encoded using an attention-based encoding mechanism that assigns high weights to the most informative genes. We present and study three encoders for SMILES string of compounds: 1) bidirectional recurrent 2) convolutional 3) attention-based encoders. We compare our devised models against a baseline model that ingests engineered fingerprints to represent the molecular structure. We demonstrate that using our attention-based encoders, we can surpass the baseline model. The use of attention-based encoders enhance interpretability and enable us to identify genes, bonds and atoms that were used by the network to make a prediction.

Establishing the relationship between 3D structures and the energy states of molecular systems has proven to be a promising approach for learning 3D molecular representations. However, existing methods are limited to modeling the molecular energy states from classical mechanics. This limitation results in a significant oversight of quantum mechanical effects, such as quantized (discrete) energy level structures, which offer a more accurate estimation of molecular energy and can be experimentally measured through energy spectra. In this paper, we propose to utilize the energy spectra to enhance the pre-training of 3D molecular representations (MolSpectra), thereby infusing the knowledge of quantum mechanics into the molecular representations. Specifically, we propose SpecFormer, a multi-spectrum encoder for encoding molecular spectra via masked patch reconstruction. By further aligning outputs from the 3D encoder and spectrum encoder using a contrastive objective, we enhance the 3D encoder's understanding of molecules. Evaluations on public benchmarks reveal that our pre-trained representations surpass existing methods in predicting molecular properties and modeling dynamics.

Plane geometry problem solving (PGPS) has recently gained significant attention as a benchmark to assess the multi-modal reasoning capabilities of large vision-language models. Despite the growing interest in PGPS, the research community still lacks a comprehensive overview that systematically synthesizes recent work in PGPS. To fill this gap, we present a survey of existing PGPS studies. We first categorize PGPS methods into an encoder-decoder framework and summarize the corresponding output formats used by their encoders and decoders. Subsequently, we classify and analyze these encoders and decoders according to their architectural designs. Finally, we outline major challenges and promising directions for future research. In particular, we discuss the hallucination issues arising during the encoding phase within encoder-decoder architectures, as well as the problem of data leakage in current PGPS benchmarks.

Multi-modal large language models (MLLMs) have achieved remarkable success in image- and region-level remote sensing (RS) image understanding tasks, such as image captioning, visual question answering, and visual grounding. However, existing RS MLLMs lack the pixel-level dialogue capability, which involves responding to user instructions with segmentation masks for specific instances. In this paper, we propose GeoPix, a RS MLLM that extends image understanding capabilities to the pixel level. This is achieved by equipping the MLLM with a mask predictor, which transforms visual features from the vision encoder into masks conditioned on the LLM's segmentation token embeddings. To facilitate the segmentation of multi-scale objects in RS imagery, a class-wise learnable memory module is integrated into the mask predictor to capture and store class-wise geo-context at the instance level across the entire dataset. In addition, to address the absence of large-scale datasets for training pixel-level RS MLLMs, we construct the GeoPixInstruct dataset, comprising 65,463 images and 140,412 instances, with each instance annotated with text descriptions, bounding boxes, and masks. Furthermore, we develop a two-stage training strategy to balance the distinct requirements of text generation and masks prediction in multi-modal multi-task optimization. Extensive experiments verify the effectiveness and superiority of GeoPix in pixel-level segmentation tasks, while also maintaining competitive performance in image- and region-level benchmarks.

In the diverse field of medical imaging, automatic segmentation has numerous applications and must handle a wide variety of input domains, such as different types of Computed Tomography (CT) scans and Magnetic Resonance (MR) images. This heterogeneity challenges automatic segmentation algorithms to maintain consistent performance across different modalities due to the requirement for spatially aligned and paired images. Typically, segmentation models are trained using a single modality, which limits their ability to generalize to other types of input data without employing transfer learning techniques. Additionally, leveraging complementary information from different modalities to enhance segmentation precision often necessitates substantial modifications to popular encoder-decoder designs, such as introducing multiple branched encoding or decoding paths for each modality. In this work, we propose a simple Multi-Modal Segmentation (MulModSeg) strategy to enhance medical image segmentation across multiple modalities, specifically CT and MR. It incorporates two key designs: a modality-conditioned text embedding framework via a frozen text encoder that adds modality awareness to existing segmentation frameworks without significant structural modifications or computational overhead, and an alternating training procedure that facilitates the integration of essential features from unpaired CT and MR inputs. Through extensive experiments with both Fully Convolutional Network and Transformer-based backbones, MulModSeg consistently outperforms previous methods in segmenting abdominal multi-organ and cardiac substructures for both CT and MR modalities. The code is available in this {https://github.com/ChengyinLee/MulModSeg_2024{link}}.

POI tagging aims to annotate a point of interest (POI) with some informative tags, which facilitates many services related to POIs, including search, recommendation, and so on. Most of the existing solutions neglect the significance of POI images and seldom fuse the textual and visual features of POIs, resulting in suboptimal tagging performance. In this paper, we propose a novel Multi-Modal Model for POI Tagging, namely M3PT, which achieves enhanced POI tagging through fusing the target POI's textual and visual features, and the precise matching between the multi-modal representations. Specifically, we first devise a domain-adaptive image encoder (DIE) to obtain the image embeddings aligned to their gold tags' semantics. Then, in M3PT's text-image fusion module (TIF), the textual and visual representations are fully fused into the POIs' content embeddings for the subsequent matching. In addition, we adopt a contrastive learning strategy to further bridge the gap between the representations of different modalities. To evaluate the tagging models' performance, we have constructed two high-quality POI tagging datasets from the real-world business scenario of Ali Fliggy. Upon the datasets, we conducted the extensive experiments to demonstrate our model's advantage over the baselines of uni-modality and multi-modality, and verify the effectiveness of important components in M3PT, including DIE, TIF and the contrastive learning strategy.

Recent years have witnessed a big convergence of language, vision, and multi-modal pretraining. In this work, we present mPLUG-2, a new unified paradigm with modularized design for multi-modal pretraining, which can benefit from modality collaboration while addressing the problem of modality entanglement. In contrast to predominant paradigms of solely relying on sequence-to-sequence generation or encoder-based instance discrimination, mPLUG-2 introduces a multi-module composition network by sharing common universal modules for modality collaboration and disentangling different modality modules to deal with modality entanglement. It is flexible to select different modules for different understanding and generation tasks across all modalities including text, image, and video. Empirical study shows that mPLUG-2 achieves state-of-the-art or competitive results on a broad range of over 30 downstream tasks, spanning multi-modal tasks of image-text and video-text understanding and generation, and uni-modal tasks of text-only, image-only, and video-only understanding. Notably, mPLUG-2 shows new state-of-the-art results of 48.0 top-1 accuracy and 80.3 CIDEr on the challenging MSRVTT video QA and video caption tasks with a far smaller model size and data scale. It also demonstrates strong zero-shot transferability on vision-language and video-language tasks. Code and models will be released in https://github.com/alibaba/AliceMind.

User interface modeling is inherently multimodal, which involves several distinct types of data: images, structures and language. The tasks are also diverse, including object detection, language generation and grounding. In this paper, we present VUT, a Versatile UI Transformer that takes multimodal input and simultaneously accomplishes 5 distinct tasks with the same model. Our model consists of a multimodal Transformer encoder that jointly encodes UI images and structures, and performs UI object detection when the UI structures are absent in the input. Our model also consists of an auto-regressive Transformer model that encodes the language input and decodes output, for both question-answering and command grounding with respect to the UI. Our experiments show that for most of the tasks, when trained jointly for multi-tasks, VUT substantially reduces the number of models and footprints needed for performing multiple tasks, while achieving accuracy exceeding or on par with baseline models trained for each individual task.

Talking head generation with arbitrary identities and speech audio remains a crucial problem in the realm of the virtual metaverse. Recently, diffusion models have become a popular generative technique in this field with their strong generation capabilities. However, several challenges remain for diffusion-based methods: 1) inefficient inference and visual artifacts caused by the implicit latent space of Variational Auto-Encoders (VAE), which complicates the diffusion process; 2) a lack of authentic facial expressions and head movements due to inadequate multi-modal information fusion. In this paper, MoDA handles these challenges by: 1) defining a joint parameter space that bridges motion generation and neural rendering, and leveraging flow matching to simplify diffusion learning; 2) introducing a multi-modal diffusion architecture to model the interaction among noisy motion, audio, and auxiliary conditions, enhancing overall facial expressiveness. In addition, a coarse-to-fine fusion strategy is employed to progressively integrate different modalities, ensuring effective feature fusion. Experimental results demonstrate that MoDA improves video diversity, realism, and efficiency, making it suitable for real-world applications. Project Page: https://lixinyyang.github.io/MoDA.github.io/

Recently, there has been a surge in the popularity of pre trained large language models (LLMs) (such as GPT-4), sweeping across the entire Natural Language Processing (NLP) and Computer Vision (CV) communities. These LLMs have demonstrated advanced multi-modal understanding capabilities and showcased strong performance across various benchmarks. The LLM has started to embody traits of artificial general intelligence, which holds vital guidance for enhancing brain-like characteristics within visual encoding models. Hence, This paper proposes a new multi-modal training paradigm, aligning with LLM, for encoding fMRI activity in visual cortex. Based on this paradigm, we trained an encoding model in fMRI data named the LLM-Visual Encoding Model (LLM-VEM). Specifically, we utilize LLM (miniGPT4) to generate descriptive text for all stimulus images, forming a high-quality textual description set. Moreover, we use the pre-trained text encoder (CLIP) to process these detailed descriptions, obtaining the text embedding features. Next, we use the contrast loss function to minimize the distance between the image embedding features and the text embedding features to complete the alignment operation of the stimulus image and text information. With the assistance of the pre-trained LLM, this alignment process facilitates better learning of the visual encoding model, resulting in higher precision. The final experimental results indicate that our training paradigm has significantly aided in enhancing the performance of the visual encoding model.

Large-scale pre-trained Vision-Language Models (VLMs) have become essential for transfer learning across diverse tasks. However, adapting these models with limited few-shot data often leads to overfitting, diminishing their performance on new tasks. To tackle this issue, we propose a novel Multi-Modal Representation Learning (MMRL) framework that introduces a shared, learnable, and modality-agnostic representation space. MMRL projects the space tokens to text and image representation tokens, facilitating more effective multi-modal interactions. Unlike previous approaches that solely optimize class token features, MMRL integrates representation tokens at higher layers of the encoders--where dataset-specific features are more prominent--while preserving generalized knowledge in the lower layers. During training, both representation and class features are optimized, with trainable projection layer applied to the representation tokens, whereas the class token projection layer remains frozen to retain pre-trained knowledge. Furthermore, a regularization term is introduced to align the class features and text features with the zero-shot features from the frozen VLM, thereby safeguarding the model's generalization capacity. For inference, a decoupling strategy is employed, wherein both representation and class features are utilized for base classes, while only the class features, which retain more generalized knowledge, are used for new tasks. Extensive experiments across 15 datasets demonstrate that MMRL outperforms state-of-the-art methods, achieving a balanced trade-off between task-specific adaptation and generalization. Code is available at https://github.com/yunncheng/MMRL.

We present M^3-Bench, the first benchmark for evaluating multimodal tool use under the Model Context Protocol. The benchmark targets realistic, multi-hop and multi-threaded workflows that require visual grounding and textual reasoning, cross-tool dependencies, and persistence of intermediate resources across steps. We introduce a similarity-driven alignment that serializes each tool call, embeds signatures with a sentence encoder, and performs similarity-bucketed Hungarian matching to obtain auditable one-to-one correspondences. On top of this alignment, we report interpretable metrics that decouple semantic fidelity from workflow consistency. The benchmark spans 28 servers with 231 tools, and provides standardized trajectories curated through an Executor & Judge pipeline with human verification; an auxiliary four large language models (LLMs) judge ensemble reports end-task Task Completion and information grounding. Evaluations of representative state-of-the-art Multimodal LLMs (MLLMs) reveal persistent gaps in multimodal MCP tool use, particularly in argument fidelity and structure consistency, underscoring the need for methods that jointly reason over images, text, and tool graphs. Our Benchmark's anonymous repository is at https://github.com/EtaYang10th/Open-M3-Bench

Our contribution introduces a groundbreaking multimodal large language model designed to comprehend multi-images, multi-audio, and multi-images-multi-audio within a single multiturn session. Leveraging state-of-the-art models, we utilize the SigLIP encoder for visual inputs and the Whisper Encoder for audio inputs. Notably, this multimodal large language model is bilingual, proficient in understanding both English and Malay simultaneously. We proudly unveil two versions of this model: TinyLlama with 1.1B parameters, and Mistral with 7B parameters. With its ability to navigate diverse modalities and languages, our model represents a significant advancement for the Malaysian context and beyond. All models released at https://huggingface.co/collections/mesolitica/multimodal-malaysian-llm-65c6f893e03f78fa9e5c8859

Multi-modal retrieval becomes increasingly popular in practice. However, the existing retrievers are mostly text-oriented, which lack the capability to process visual information. Despite the presence of vision-language models like CLIP, the current methods are severely limited in representing the text-only and image-only data. In this work, we present a new embedding model VISTA for universal multi-modal retrieval. Our work brings forth threefold technical contributions. Firstly, we introduce a flexible architecture which extends a powerful text encoder with the image understanding capability by introducing visual token embeddings. Secondly, we develop two data generation strategies, which bring high-quality composed image-text to facilitate the training of the embedding model. Thirdly, we introduce a multi-stage training algorithm, which first aligns the visual token embedding with the text encoder using massive weakly labeled data, and then develops multi-modal representation capability using the generated composed image-text data. In our experiments, VISTA achieves superior performances across a variety of multi-modal retrieval tasks in both zero-shot and supervised settings. Our model, data, and source code are available at https://github.com/FlagOpen/FlagEmbedding.

The parcellation of Cranial Nerves (CNs) serves as a crucial quantitative methodology for evaluating the morphological characteristics and anatomical pathways of specific CNs. Multi-modal CNs parcellation networks have achieved promising segmentation performance, which combine structural Magnetic Resonance Imaging (MRI) and diffusion MRI. However, insufficient exploration of diffusion MRI information has led to low performance of existing multi-modal fusion. In this work, we propose a tractography-guided Dual-label Collaborative Learning Network (DCLNet) for multi-modal CNs parcellation. The key contribution of our DCLNet is the introduction of coarse labels of CNs obtained from fiber tractography through CN atlas, and collaborative learning with precise labels annotated by experts. Meanwhile, we introduce a Modality-adaptive Encoder Module (MEM) to achieve soft information swapping between structural MRI and diffusion MRI. Extensive experiments conducted on the publicly available Human Connectome Project (HCP) dataset demonstrate performance improvements compared to single-label network. This systematic validation underscores the effectiveness of dual-label strategies in addressing inherent ambiguities in CNs parcellation tasks.

Recent works of music representation learning mainly focus on learning acoustic music representations with unlabeled audios or further attempt to acquire multi-modal music representations with scarce annotated audio-text pairs. They either ignore the language semantics or rely on labeled audio datasets that are difficult and expensive to create. Moreover, merely modeling semantic space usually fails to achieve satisfactory performance on music recommendation tasks since the user preference space is ignored. In this paper, we propose a novel Hierarchical Two-stage Contrastive Learning (HTCL) method that models similarity from the semantic perspective to the user perspective hierarchically to learn a comprehensive music representation bridging the gap between semantic and user preference spaces. We devise a scalable audio encoder and leverage a pre-trained BERT model as the text encoder to learn audio-text semantics via large-scale contrastive pre-training. Further, we explore a simple yet effective way to exploit interaction data from our online music platform to adapt the semantic space to user preference space via contrastive fine-tuning, which differs from previous works that follow the idea of collaborative filtering. As a result, we obtain a powerful audio encoder that not only distills language semantics from the text encoder but also models similarity in user preference space with the integrity of semantic space preserved. Experimental results on both music semantic and recommendation tasks confirm the effectiveness of our method.

Does the prior knowledge of the vision encoder constrain the capability boundary of Multi-modal Large Language Models (MLLMs)? While most existing research treats MLLMs as unified systems optimized through end-to-end training, the impact of vision encoder's prior knowledge is seldom investigated. In this work, we introduce a novel metric, Rank_e, to quantify the effect of the vision encoder's prior knowledge on MLLM performance. Our analysis reveals a positive correlation between prior knowledge and MLLM performance. Moreover, we find that domain-specific fine-tuning using solely end-to-end visual question answering (VQA) data is insufficient--particularly for entities with low inherent visual prior knowledge. To address this issue, we propose VisPRE (Vision Prior Remediation), a two-stage training framework that explicitly incorporates prior knowledge at the vision encoder level. Experimental results demonstrate that augmenting vision encoder's prior knowledge substantially boosts the visual understanding capabilities of MLLMs, offering a novel and effective strategy for improving performance, especially in scenarios involving uncommon visual entities.

Foundation models in computational pathology promise to unlock the development of new clinical decision support systems and models for precision medicine. However, there is a mismatch between most clinical analysis, which is defined at the level of one or more whole slide images, and foundation models to date, which process the thousands of image tiles contained in a whole slide image separately. The requirement to train a network to aggregate information across a large number of tiles in multiple whole slide images limits these models' impact. In this work, we present a slide-level foundation model for H&E-stained histopathology, PRISM, that builds on Virchow tile embeddings and leverages clinical report text for pre-training. Using the tile embeddings, PRISM produces slide-level embeddings with the ability to generate clinical reports, resulting in several modes of use. Using text prompts, PRISM achieves zero-shot cancer detection and sub-typing performance approaching and surpassing that of a supervised aggregator model. Using the slide embeddings with linear classifiers, PRISM surpasses supervised aggregator models. Furthermore, we demonstrate that fine-tuning of the PRISM slide encoder yields label-efficient training for biomarker prediction, a task that typically suffers from low availability of training data; an aggregator initialized with PRISM and trained on as little as 10% of the training data can outperform a supervised baseline that uses all of the data.

Speech-driven 3D facial animation has improved a lot recently while most related works only utilize acoustic modality and neglect the influence of visual and textual cues, leading to unsatisfactory results in terms of precision and coherence. We argue that visual and textual cues are not trivial information. Therefore, we present a novel framework, namely PMMTalk, using complementary Pseudo Multi-Modal features for improving the accuracy of facial animation. The framework entails three modules: PMMTalk encoder, cross-modal alignment module, and PMMTalk decoder. Specifically, the PMMTalk encoder employs the off-the-shelf talking head generation architecture and speech recognition technology to extract visual and textual information from speech, respectively. Subsequently, the cross-modal alignment module aligns the audio-image-text features at temporal and semantic levels. Then PMMTalk decoder is employed to predict lip-syncing facial blendshape coefficients. Contrary to prior methods, PMMTalk only requires an additional random reference face image but yields more accurate results. Additionally, it is artist-friendly as it seamlessly integrates into standard animation production workflows by introducing facial blendshape coefficients. Finally, given the scarcity of 3D talking face datasets, we introduce a large-scale 3D Chinese Audio-Visual Facial Animation (3D-CAVFA) dataset. Extensive experiments and user studies show that our approach outperforms the state of the art. We recommend watching the supplementary video.

There is increasing interest in the use of multimodal data in various web applications, such as digital advertising and e-commerce. Typical methods for extracting important information from multimodal data rely on a mid-fusion architecture that combines the feature representations from multiple encoders. However, as the number of modalities increases, several potential problems with the mid-fusion model structure arise, such as an increase in the dimensionality of the concatenated multimodal features and missing modalities. To address these problems, we propose a new concept that considers multimodal inputs as a set of sequences, namely, deep multimodal sequence sets (DM^2S^2). Our set-aware concept consists of three components that capture the relationships among multiple modalities: (a) a BERT-based encoder to handle the inter- and intra-order of elements in the sequences, (b) intra-modality residual attention (IntraMRA) to capture the importance of the elements in a modality, and (c) inter-modality residual attention (InterMRA) to enhance the importance of elements with modality-level granularity further. Our concept exhibits performance that is comparable to or better than the previous set-aware models. Furthermore, we demonstrate that the visualization of the learned InterMRA and IntraMRA weights can provide an interpretation of the prediction results.

Large language models (LLMs) have enabled the creation of multi-modal LLMs that exhibit strong comprehension of visual data such as images and videos. However, these models usually rely on extensive visual tokens from visual encoders, leading to high computational demands, which limits their applicability in resource-constrained environments and for long-context tasks. In this work, we propose a training-free adaptive inference method for multi-modal LLMs that can accommodate a broad range of efficiency requirements with a minimum performance drop. Our method consists of a) iterative token merging based on embedding similarity before LLMs, and b) progressive token pruning within LLM layers based on multi-modal importance. With a minimalist design, our method can be applied to both video and image LLMs. Extensive experiments on diverse video and image benchmarks demonstrate that, our method substantially reduces computation load (e.g., a 7-fold reduction in FLOPs) while preserving the performance of video and image LLMs. Further, under a similar computational cost, our method outperforms the state-of-the-art methods in long video understanding (e.g., +4.6 on MLVU). Additionally, our in-depth analysis provides insights into token redundancy and LLM layer behaviors, offering guidance for future research in designing efficient multi-modal LLMs. Our code will be available at https://github.com/LaVi-Lab/AIM.

Existing text-to-video diffusion models rely solely on text-only encoders for their pretraining. This limitation stems from the absence of large-scale multimodal prompt video datasets, resulting in a lack of visual grounding and restricting their versatility and application in multimodal integration. To address this, we construct a large-scale multimodal prompt dataset by employing retrieval methods to pair in-context examples with the given text prompts and then utilize a two-stage training strategy to enable diverse video generation tasks within the same model. In the first stage, we propose a multimodal conditional video generation framework for pretraining on these augmented datasets, establishing a foundational model for grounded video generation. Secondly, we finetune the model from the first stage on three video generation tasks, incorporating multi-modal instructions. This process further refines the model's ability to handle diverse inputs and tasks, ensuring seamless integration of multi-modal information. After this two-stage train-ing process, VIMI demonstrates multimodal understanding capabilities, producing contextually rich and personalized videos grounded in the provided inputs, as shown in Figure 1. Compared to previous visual grounded video generation methods, VIMI can synthesize consistent and temporally coherent videos with large motion while retaining the semantic control. Lastly, VIMI also achieves state-of-the-art text-to-video generation results on UCF101 benchmark.

Recent AI advances have enabled multi-modal systems to model and translate diverse information spaces. Extending beyond text and vision, we introduce OneProt, a multi-modal AI for proteins that integrates structural, sequence, alignment, and binding site data. Using the ImageBind framework, OneProt aligns the latent spaces of modality encoders along protein sequences. It demonstrates strong performance in retrieval tasks and surpasses state-of-the-art methods in various downstream tasks, including metal ion binding classification, gene-ontology annotation, and enzyme function prediction. This work expands multi-modal capabilities in protein models, paving the way for applications in drug discovery, biocatalytic reaction planning, and protein engineering.

There is a gap in the understanding of occluded objects in existing large-scale visual language multi-modal models. Current state-of-the-art multi-modal models fail to provide satisfactory results in describing occluded objects through universal visual encoders and supervised learning strategies. Therefore, we introduce a multi-modal large language framework and corresponding self-supervised learning strategy with support of 3D generation. We start our experiments comparing with the state-of-the-art models in the evaluation of a large-scale dataset SOMVideo [18]. The initial results demonstrate the improvement of 16.92% in comparison with the state-of-the-art VLM models.

Recent advancements in multi-modal large language models have propelled the development of joint probabilistic models capable of both image understanding and generation. However, we have identified that recent methods inevitably suffer from loss of image information during understanding task, due to either image discretization or diffusion denoising steps. To address this issue, we propose a novel Multi-Modal Auto-Regressive (MMAR) probabilistic modeling framework. Unlike discretization line of method, MMAR takes in continuous-valued image tokens to avoid information loss. Differing from diffusion-based approaches, we disentangle the diffusion process from auto-regressive backbone model by employing a light-weight diffusion head on top each auto-regressed image patch embedding. In this way, when the model transits from image generation to understanding through text generation, the backbone model's hidden representation of the image is not limited to the last denoising step. To successfully train our method, we also propose a theoretically proven technique that addresses the numerical stability issue and a training strategy that balances the generation and understanding task goals. Through extensive evaluations on 18 image understanding benchmarks, MMAR demonstrates much more superior performance than other joint multi-modal models, matching the method that employs pretrained CLIP vision encoder, meanwhile being able to generate high quality images at the same time. We also showed that our method is scalable with larger data and model size.

Foundation models have revolutionized artificial intelligence across numerous domains, yet their transformative potential remains largely untapped in Extreme Multi-label Classification (XMC). Queries in XMC are associated with relevant labels from extremely large label spaces, where it is critical to strike a balance between efficiency and performance. Therefore, many recent approaches efficiently pose XMC as a maximum inner product search between embeddings learned from small encoder-only transformer architectures. In this paper, we address two important aspects in XMC: how to effectively harness larger decoder-only models, and how to exploit visual information while maintaining computational efficiency. We demonstrate that both play a critical role in XMC separately and can be combined for improved performance. We show that a few billion-size decoder can deliver substantial improvements while keeping computational overhead manageable. Furthermore, our Vision-enhanced eXtreme Multi-label Learning framework (ViXML) efficiently integrates foundation vision models by pooling a single embedding per image. This limits computational growth while unlocking multi-modal capabilities. Remarkably, ViXML with small encoders outperforms text-only decoder in most cases, showing that an image is worth billions of parameters. Finally, we present an extension of existing text-only datasets to exploit visual metadata and make them available for future benchmarking. Comprehensive experiments across four public text-only datasets and their corresponding image enhanced versions validate our proposals' effectiveness, surpassing previous state-of-the-art by up to +8.21\% in P@1 on the largest dataset. ViXML's code is available at https://github.com/DiegoOrtego/vixml.

Contrastive pretraining of image-text foundation models, such as CLIP, demonstrated excellent zero-shot performance and improved robustness on a wide range of downstream tasks. However, these models utilize large transformer-based encoders with significant memory and latency overhead which pose challenges for deployment on mobile devices. In this work, we introduce MobileCLIP -- a new family of efficient image-text models optimized for runtime performance along with a novel and efficient training approach, namely multi-modal reinforced training. The proposed training approach leverages knowledge transfer from an image captioning model and an ensemble of strong CLIP encoders to improve the accuracy of efficient models. Our approach avoids train-time compute overhead by storing the additional knowledge in a reinforced dataset. MobileCLIP sets a new state-of-the-art latency-accuracy tradeoff for zero-shot classification and retrieval tasks on several datasets. Our MobileCLIP-S2 variant is 2.3times faster while more accurate compared to previous best CLIP model based on ViT-B/16. We further demonstrate the effectiveness of our multi-modal reinforced training by training a CLIP model based on ViT-B/16 image backbone and achieving +2.9% average performance improvement on 38 evaluation benchmarks compared to the previous best. Moreover, we show that the proposed approach achieves 10times-1000times improved learning efficiency when compared with non-reinforced CLIP training.

Multi-modal information retrieval (MMIR) is a rapidly evolving field, where significant progress, particularly in image-text pairing, has been made through advanced representation learning and cross-modality alignment research. However, current benchmarks for evaluating MMIR performance in image-text pairing within the scientific domain show a notable gap, where chart and table images described in scholarly language usually do not play a significant role. To bridge this gap, we develop a specialised scientific MMIR (SciMMIR) benchmark by leveraging open-access paper collections to extract data relevant to the scientific domain. This benchmark comprises 530K meticulously curated image-text pairs, extracted from figures and tables with detailed captions in scientific documents. We further annotate the image-text pairs with two-level subset-subcategory hierarchy annotations to facilitate a more comprehensive evaluation of the baselines. We conducted zero-shot and fine-tuning evaluations on prominent multi-modal image-captioning and visual language models, such as CLIP and BLIP. Our analysis offers critical insights for MMIR in the scientific domain, including the impact of pre-training and fine-tuning settings and the influence of the visual and textual encoders. All our data and checkpoints are publicly available at https://github.com/Wusiwei0410/SciMMIR.

Jointly processing information from multiple sensors is crucial to achieving accurate and robust perception for reliable autonomous driving systems. However, current 3D perception research follows a modality-specific paradigm, leading to additional computation overheads and inefficient collaboration between different sensor data. In this paper, we present an efficient multi-modal backbone for outdoor 3D perception named UniTR, which processes a variety of modalities with unified modeling and shared parameters. Unlike previous works, UniTR introduces a modality-agnostic transformer encoder to handle these view-discrepant sensor data for parallel modal-wise representation learning and automatic cross-modal interaction without additional fusion steps. More importantly, to make full use of these complementary sensor types, we present a novel multi-modal integration strategy by both considering semantic-abundant 2D perspective and geometry-aware 3D sparse neighborhood relations. UniTR is also a fundamentally task-agnostic backbone that naturally supports different 3D perception tasks. It sets a new state-of-the-art performance on the nuScenes benchmark, achieving +1.1 NDS higher for 3D object detection and +12.0 higher mIoU for BEV map segmentation with lower inference latency. Code will be available at https://github.com/Haiyang-W/UniTR .

We introduce new jailbreak attacks on vision language models (VLMs), which use aligned LLMs and are resilient to text-only jailbreak attacks. Specifically, we develop cross-modality attacks on alignment where we pair adversarial images going through the vision encoder with textual prompts to break the alignment of the language model. Our attacks employ a novel compositional strategy that combines an image, adversarially targeted towards toxic embeddings, with generic prompts to accomplish the jailbreak. Thus, the LLM draws the context to answer the generic prompt from the adversarial image. The generation of benign-appearing adversarial images leverages a novel embedding-space-based methodology, operating with no access to the LLM model. Instead, the attacks require access only to the vision encoder and utilize one of our four embedding space targeting strategies. By not requiring access to the LLM, the attacks lower the entry barrier for attackers, particularly when vision encoders such as CLIP are embedded in closed-source LLMs. The attacks achieve a high success rate across different VLMs, highlighting the risk of cross-modality alignment vulnerabilities, and the need for new alignment approaches for multi-modal models.

3D vision and spatial reasoning have long been recognized as preferable for accurately perceiving our three-dimensional world, especially when compared with traditional visual reasoning based on 2D images. Due to the difficulties in collecting high-quality 3D data, research in this area has only recently gained momentum. With the advent of powerful large language models (LLMs), multi-modal LLMs for 3D vision have been developed over the past few years. However, most of these models focus primarily on the vision encoder for 3D data. In this paper, we propose converting existing densely activated LLMs into mixture-of-experts (MoE) models, which have proven effective for multi-modal data processing. In addition to leveraging these models' instruction-following capabilities, we further enable embodied task planning by attaching a diffusion head, Pose-DiT, that employs a novel rectified flow diffusion scheduler. Experimental results on 3D question answering and task-planning tasks demonstrate that our 3D-MoE framework achieves improved performance with fewer activated parameters.

Human perception of similarity across uni- and multimodal inputs is highly complex, making it challenging to develop automated metrics that accurately mimic it. General purpose vision-language models, such as CLIP and large multi-modal models (LMMs), can be applied as zero-shot perceptual metrics, and several recent works have developed models specialized in narrow perceptual tasks. However, the extent to which existing perceptual metrics align with human perception remains unclear. To investigate this question, we introduce UniSim-Bench, a benchmark encompassing 7 multi-modal perceptual similarity tasks, with a total of 25 datasets. Our evaluation reveals that while general-purpose models perform reasonably well on average, they often lag behind specialized models on individual tasks. Conversely, metrics fine-tuned for specific tasks fail to generalize well to unseen, though related, tasks. As a first step towards a unified multi-task perceptual similarity metric, we fine-tune both encoder-based and generative vision-language models on a subset of the UniSim-Bench tasks. This approach yields the highest average performance, and in some cases, even surpasses taskspecific models. Nevertheless, these models still struggle with generalization to unseen tasks, highlighting the ongoing challenge of learning a robust, unified perceptual similarity metric capable of capturing the human notion of similarity. The code and models are available at https://github.com/SaraGhazanfari/UniSim.

Large-scale vision-language pre-training has achieved significant performance in multi-modal understanding and generation tasks. However, existing methods often perform poorly on image-text matching tasks that require structured representations, i.e., representations of objects, attributes, and relations. As illustrated in Fig.~reffig:case (a), the models cannot make a distinction between ``An astronaut rides a horse" and ``A horse rides an astronaut". This is because they fail to fully leverage structured knowledge when learning representations in multi-modal scenarios. In this paper, we present an end-to-end framework Structure-CLIP, which integrates Scene Graph Knowledge (SGK) to enhance multi-modal structured representations. Firstly, we use scene graphs to guide the construction of semantic negative examples, which results in an increased emphasis on learning structured representations. Moreover, a Knowledge-Enhance Encoder (KEE) is proposed to leverage SGK as input to further enhance structured representations. To verify the effectiveness of the proposed framework, we pre-train our model with the aforementioned approaches and conduct experiments on downstream tasks. Experimental results demonstrate that Structure-CLIP achieves state-of-the-art (SOTA) performance on VG-Attribution and VG-Relation datasets, with 12.5% and 4.1% ahead of the multi-modal SOTA model respectively. Meanwhile, the results on MSCOCO indicate that Structure-CLIP significantly enhances the structured representations while maintaining the ability of general representations. Our code is available at https://github.com/zjukg/Structure-CLIP.

Visual grounding is a common vision task that involves grounding descriptive sentences to the corresponding regions of an image. Most existing methods use independent image-text encoding and apply complex hand-crafted modules or encoder-decoder architectures for modal interaction and query reasoning. However, their performance significantly drops when dealing with complex textual expressions. This is because the former paradigm only utilizes limited downstream data to fit the multi-modal feature fusion. Therefore, it is only effective when the textual expressions are relatively simple. In contrast, given the wide diversity of textual expressions and the uniqueness of downstream training data, the existing fusion module, which extracts multimodal content from a visual-linguistic context, has not been fully investigated. In this paper, we present a simple yet robust transformer-based framework, SimVG, for visual grounding. Specifically, we decouple visual-linguistic feature fusion from downstream tasks by leveraging existing multimodal pre-trained models and incorporating additional object tokens to facilitate deep integration of downstream and pre-training tasks. Furthermore, we design a dynamic weight-balance distillation method in the multi-branch synchronous learning process to enhance the representation capability of the simpler branch. This branch only consists of a lightweight MLP, which simplifies the structure and improves reasoning speed. Experiments on six widely used VG datasets, i.e., RefCOCO/+/g, ReferIt, Flickr30K, and GRefCOCO, demonstrate the superiority of SimVG. Finally, the proposed method not only achieves improvements in efficiency and convergence speed but also attains new state-of-the-art performance on these benchmarks. Codes and models will be available at https://github.com/Dmmm1997/SimVG.

Recent advances in tuning-free personalized image generation based on diffusion models are impressive. However, to improve subject fidelity, existing methods either retrain the diffusion model or infuse it with dense visual embeddings, both of which suffer from poor generalization and efficiency. Also, these methods falter in multi-subject image generation due to the unconstrained cross-attention mechanism. In this paper, we propose MM-Diff, a unified and tuning-free image personalization framework capable of generating high-fidelity images of both single and multiple subjects in seconds. Specifically, to simultaneously enhance text consistency and subject fidelity, MM-Diff employs a vision encoder to transform the input image into CLS and patch embeddings. CLS embeddings are used on the one hand to augment the text embeddings, and on the other hand together with patch embeddings to derive a small number of detail-rich subject embeddings, both of which are efficiently integrated into the diffusion model through the well-designed multimodal cross-attention mechanism. Additionally, MM-Diff introduces cross-attention map constraints during the training phase, ensuring flexible multi-subject image sampling during inference without any predefined inputs (e.g., layout). Extensive experiments demonstrate the superior performance of MM-Diff over other leading methods.

Recent progress in unified models for image understanding and generation has been impressive, yet most approaches remain limited to single-modal generation conditioned on multiple modalities. In this paper, we present Mogao, a unified framework that advances this paradigm by enabling interleaved multi-modal generation through a causal approach. Mogao integrates a set of key technical improvements in architecture design, including a deep-fusion design, dual vision encoders, interleaved rotary position embeddings, and multi-modal classifier-free guidance, which allow it to harness the strengths of both autoregressive models for text generation and diffusion models for high-quality image synthesis. These practical improvements also make Mogao particularly effective to process interleaved sequences of text and images arbitrarily. To further unlock the potential of unified models, we introduce an efficient training strategy on a large-scale, in-house dataset specifically curated for joint text and image generation. Extensive experiments show that Mogao not only achieves state-of-the-art performance in multi-modal understanding and text-to-image generation, but also excels in producing high-quality, coherent interleaved outputs. Its emergent capabilities in zero-shot image editing and compositional generation highlight Mogao as a practical omni-modal foundation model, paving the way for future development and scaling the unified multi-modal systems.

3D human motion generation has seen substantial advancement in recent years. While state-of-the-art approaches have improved performance significantly, they still struggle with complex and detailed motions unseen in training data, largely due to the scarcity of motion datasets and the prohibitive cost of generating new training examples. To address these challenges, we introduce CoMA, an agent-based solution for complex human motion generation, editing, and comprehension. CoMA leverages multiple collaborative agents powered by large language and vision models, alongside a mask transformer-based motion generator featuring body part-specific encoders and codebooks for fine-grained control. Our framework enables generation of both short and long motion sequences with detailed instructions, text-guided motion editing, and self-correction for improved quality. Evaluations on the HumanML3D dataset demonstrate competitive performance against state-of-the-art methods. Additionally, we create a set of context-rich, compositional, and long text prompts, where user studies show our method significantly outperforms existing approaches.

As lunar exploration missions grow increasingly complex, ensuring safe and autonomous rover-based surface exploration has become one of the key challenges in lunar exploration tasks. In this work, we have developed a lunar surface simulation system called the Lunar Exploration Simulator System (LESS) and the LunarSeg dataset, which provides RGB-D data for lunar obstacle segmentation that includes both positive and negative obstacles. Additionally, we propose a novel two-stage segmentation network called LuSeg. Through contrastive learning, it enforces semantic consistency between the RGB encoder from Stage I and the depth encoder from Stage II. Experimental results on our proposed LunarSeg dataset and additional public real-world NPO road obstacle dataset demonstrate that LuSeg achieves state-of-the-art segmentation performance for both positive and negative obstacles while maintaining a high inference speed of approximately 57\,Hz. We have released the implementation of our LESS system, LunarSeg dataset, and the code of LuSeg at:https://github.com/nubot-nudt/LuSeg.

We propose SPHINX-X, an extensive Multimodality Large Language Model (MLLM) series developed upon SPHINX. To improve the architecture and training efficiency, we modify the SPHINX framework by removing redundant visual encoders, bypassing fully-padded sub-images with skip tokens, and simplifying multi-stage training into a one-stage all-in-one paradigm. To fully unleash the potential of MLLMs, we assemble a comprehensive multi-domain and multimodal dataset covering publicly available resources in language, vision, and vision-language tasks. We further enrich this collection with our curated OCR intensive and Set-of-Mark datasets, extending the diversity and generality. By training over different base LLMs including TinyLlama1.1B, InternLM2-7B, LLaMA2-13B, and Mixtral8x7B, we obtain a spectrum of MLLMs that vary in parameter size and multilingual capabilities. Comprehensive benchmarking reveals a strong correlation between the multi-modal performance with the data and parameter scales. Code and models are released at https://github.com/Alpha-VLLM/LLaMA2-Accessory

Large Multimodal Models have demonstrated impressive capabilities in understanding general vision-language tasks. However, due to the limitation of supported input resolution (e.g., 448 x 448) as well as the inexhaustive description of the training image-text pair, these models often encounter challenges when dealing with intricate scene understandings and narratives. Here we address the problem by proposing the Monkey. Our contributions are two-fold: 1) without pretraining from the start, our method can be built upon an existing vision encoder (e.g., vit-BigHuge) to effectively improve the input resolution capacity up to 896 x 1344 pixels; 2) we propose a multi-level description generation method, which automatically provides rich information that can guide model to learn contextual association between scenes and objects. Our extensive testing across more than 16 distinct datasets reveals that Monkey achieves consistently competitive performance over the existing LMMs on fundamental tasks, such as Image Captioning, General Visual Question Answering (VQA), and Document-oriented VQA. Models, interactive demo, and the source code are provided at the following https://github.com/Yuliang-Liu/Monkey.

Multi-modal brain tumor segmentation is critical for clinical diagnosis, and it requires accurate identification of distinct internal anatomical subregions. While the recent prompt-based segmentation paradigms enable interactive experiences for clinicians, existing methods ignore cross-modal correlations and rely on labor-intensive category-specific prompts, limiting their applicability in real-world scenarios. To address these issues, we propose a MSM-Seg framework for multi-modal brain tumor segmentation. The MSM-Seg introduces a novel dual-memory segmentation paradigm that synergistically integrates multi-modal and inter-slice information with the efficient category-agnostic prompt for brain tumor understanding. To this end, we first devise a modality-and-slice memory attention (MSMA) to exploit the cross-modal and inter-slice relationships among the input scans. Then, we propose a multi-scale category-agnostic prompt encoder (MCP-Encoder) to provide tumor region guidance for decoding. Moreover, we devise a modality-adaptive fusion decoder (MF-Decoder) that leverages the complementary decoding information across different modalities to improve segmentation accuracy. Extensive experiments on different MRI datasets demonstrate that our MSM-Seg framework outperforms state-of-the-art methods in multi-modal metastases and glioma tumor segmentation. The code is available at https://github.com/xq141839/MSM-Seg.

Time-series data are critical in diverse applications, such as industrial monitoring, medical diagnostics, and climate research. However, effectively integrating these high-dimensional temporal signals with natural language for dynamic, interactive tasks remains a significant challenge. To address this, we introduce the Time-Series Question Answering (Time-Series QA) task and release EngineMT-QA, the first large-scale, multi-task, temporal-textual QA dataset designed to capture complex interactions between time-series signals and natural language. Building on this resource, we propose the Instruct Time Transformer (ITFormer), a novel framework that bridges time-series encoders with frozen large language models (LLMs). ITFormer effectively extracts, aligns, and fuses temporal and textual features, achieving a strong improvement in QA accuracy over strong baselines with fewer than 1\% additional trainable parameters. By combining computational efficiency with robust cross-modal modeling, our work establishes a adaptable paradigm for integrating temporal data with natural language, paving the way for new research and applications in multi-modal AI. More details about the project, including datasets and code, are available at: https://pandalin98.github.io/itformer_site/

The prevalence of sarcasm in social media, conveyed through text-image combinations, presents significant challenges for sentiment analysis and intention mining. Current multi-modal sarcasm detection methods have been proven to struggle with biases from spurious cues, leading to a superficial understanding of the complex interactions between text and image. To address these issues, we propose InterCLIP-MEP, a robust framework for multi-modal sarcasm detection. InterCLIP-MEP introduces a refined variant of CLIP, Interactive CLIP (InterCLIP), as the backbone, enhancing sample representations by embedding cross-modality information in each encoder. Furthermore, a novel training strategy is designed to adapt InterCLIP for a Memory-Enhanced Predictor (MEP). MEP uses dynamic dual-channel memory to store valuable historical knowledge of test samples and then leverages this memory as a non-parametric classifier to derive the final prediction. By using InterCLIP to encode text-image interactions more effectively and incorporating MEP, InterCLIP-MEP offers a more robust recognition of multi-modal sarcasm. Experiments demonstrate that InterCLIP-MEP achieves state-of-the-art performance on the MMSD2.0 benchmark. Code and data are available at [https://github.com/CoderChen01/InterCLIP-MEP](https://github.com/CoderChen01/InterCLIP-MEP).

Multi-modal foundation models such as CLIP have showcased impressive zero-shot capabilities. However, their applicability in resource-constrained environments is limited due to their large number of parameters and high inference time. While existing approaches have scaled down the entire CLIP architecture, we focus on training smaller variants of the image encoder, which suffices for efficient zero-shot classification. The use of synthetic data has shown promise in distilling representations from larger teachers, resulting in strong few-shot and linear probe performance. However, we find that this approach surprisingly fails in true zero-shot settings when using contrastive losses. We identify the exploitation of spurious features as being responsible for poor generalization between synthetic and real data. However, by using the image feature-based L2 distillation loss, we mitigate these problems and train students that achieve zero-shot performance which on four domain-specific datasets is on-par with a ViT-B/32 teacher model trained on DataCompXL, while featuring up to 92% fewer parameters.

With the rapid advances in high-throughput sequencing technologies, the focus of survival analysis has shifted from examining clinical indicators to incorporating genomic profiles with pathological images. However, existing methods either directly adopt a straightforward fusion of pathological features and genomic profiles for survival prediction, or take genomic profiles as guidance to integrate the features of pathological images. The former would overlook intrinsic cross-modal correlations. The latter would discard pathological information irrelevant to gene expression. To address these issues, we present a Cross-Modal Translation and Alignment (CMTA) framework to explore the intrinsic cross-modal correlations and transfer potential complementary information. Specifically, we construct two parallel encoder-decoder structures for multi-modal data to integrate intra-modal information and generate cross-modal representation. Taking the generated cross-modal representation to enhance and recalibrate intra-modal representation can significantly improve its discrimination for comprehensive survival analysis. To explore the intrinsic crossmodal correlations, we further design a cross-modal attention module as the information bridge between different modalities to perform cross-modal interactions and transfer complementary information. Our extensive experiments on five public TCGA datasets demonstrate that our proposed framework outperforms the state-of-the-art methods.

Large language models (LLMs) have demonstrated remarkable language abilities. GPT-4, based on advanced LLMs, exhibits extraordinary multimodal capabilities beyond previous visual language models. We attribute this to the use of more advanced LLMs compared with previous multimodal models. Unfortunately, the model architecture and training strategies of GPT-4 are unknown. To endow LLMs with multimodal capabilities, we propose X-LLM, which converts Multi-modalities (images, speech, videos) into foreign languages using X2L interfaces and inputs them into a large Language model (ChatGLM). Specifically, X-LLM aligns multiple frozen single-modal encoders and a frozen LLM using X2L interfaces, where ``X'' denotes multi-modalities such as image, speech, and videos, and ``L'' denotes languages. X-LLM's training consists of three stages: (1) Converting Multimodal Information: The first stage trains each X2L interface to align with its respective single-modal encoder separately to convert multimodal information into languages. (2) Aligning X2L representations with the LLM: single-modal encoders are aligned with the LLM through X2L interfaces independently. (3) Integrating multiple modalities: all single-modal encoders are aligned with the LLM through X2L interfaces to integrate multimodal capabilities into the LLM. Our experiments show that X-LLM demonstrates impressive multimodel chat abilities, sometimes exhibiting the behaviors of multimodal GPT-4 on unseen images/instructions, and yields a 84.5\% relative score compared with GPT-4 on a synthetic multimodal instruction-following dataset. And we also conduct quantitative tests on using LLM for ASR and multimodal ASR, hoping to promote the era of LLM-based speech recognition.

Vision-language models (VLMs) have improved significantly in multi-modal tasks, but their more complex architecture makes their safety alignment more challenging than the alignment of large language models (LLMs). In this paper, we reveal an unfair distribution of safety across the layers of VLM's vision encoder, with earlier and middle layers being disproportionately vulnerable to malicious inputs compared to the more robust final layers. This 'cross-layer' vulnerability stems from the model's inability to generalize its safety training from the default architectural settings used during training to unseen or out-of-distribution scenarios, leaving certain layers exposed. We conduct a comprehensive analysis by projecting activations from various intermediate layers and demonstrate that these layers are more likely to generate harmful outputs when exposed to malicious inputs. Our experiments with LLaVA-1.5 and Llama 3.2 show discrepancies in attack success rates and toxicity scores across layers, indicating that current safety alignment strategies focused on a single default layer are insufficient.

3D Gaussian Splatting (3DGS) excels in photorealistic scene reconstruction but struggles with stylized scenarios (e.g., cartoons, games) due to fragmented textures, semantic misalignment, and limited adaptability to abstract aesthetics. We propose StyleMe3D, a holistic framework for 3D GS style transfer that integrates multi-modal style conditioning, multi-level semantic alignment, and perceptual quality enhancement. Our key insights include: (1) optimizing only RGB attributes preserves geometric integrity during stylization; (2) disentangling low-, medium-, and high-level semantics is critical for coherent style transfer; (3) scalability across isolated objects and complex scenes is essential for practical deployment. StyleMe3D introduces four novel components: Dynamic Style Score Distillation (DSSD), leveraging Stable Diffusion's latent space for semantic alignment; Contrastive Style Descriptor (CSD) for localized, content-aware texture transfer; Simultaneously Optimized Scale (SOS) to decouple style details and structural coherence; and 3D Gaussian Quality Assessment (3DG-QA), a differentiable aesthetic prior trained on human-rated data to suppress artifacts and enhance visual harmony. Evaluated on NeRF synthetic dataset (objects) and tandt db (scenes) datasets, StyleMe3D outperforms state-of-the-art methods in preserving geometric details (e.g., carvings on sculptures) and ensuring stylistic consistency across scenes (e.g., coherent lighting in landscapes), while maintaining real-time rendering. This work bridges photorealistic 3D GS and artistic stylization, unlocking applications in gaming, virtual worlds, and digital art.

We present Florence-VL, a new family of multimodal large language models (MLLMs) with enriched visual representations produced by Florence-2, a generative vision foundation model. Unlike the widely used CLIP-style vision transformer trained by contrastive learning, Florence-2 can capture different levels and aspects of visual features, which are more versatile to be adapted to diverse downstream tasks. We propose a novel feature-fusion architecture and an innovative training recipe that effectively integrates Florence-2's visual features into pretrained LLMs, such as Phi 3.5 and LLama 3. In particular, we propose "depth-breath fusion (DBFusion)" to fuse the visual features extracted from different depths and under multiple prompts. Our model training is composed of end-to-end pretraining of the whole model followed by finetuning of the projection layer and the LLM, on a carefully designed recipe of diverse open-source datasets that include high-quality image captions and instruction-tuning pairs. Our quantitative analysis and visualization of Florence-VL's visual features show its advantages over popular vision encoders on vision-language alignment, where the enriched depth and breath play important roles. Florence-VL achieves significant improvements over existing state-of-the-art MLLMs across various multi-modal and vision-centric benchmarks covering general VQA, perception, hallucination, OCR, Chart, knowledge-intensive understanding, etc. To facilitate future research, our models and the complete training recipe are open-sourced. https://github.com/JiuhaiChen/Florence-VL

3D visual grounding allows an embodied agent to understand visual information in real-world 3D environments based on human instructions, which is crucial for embodied intelligence. Existing 3D visual grounding methods typically rely on separate encoders for different modalities (e.g., RGB images, text, and 3D point clouds), resulting in large and complex models that are inefficient to train. While some approaches use pre-trained 2D multi-modal models like CLIP for 3D tasks, they still struggle with aligning point cloud data to 2D encoders. As a result, these methods continue to depend on 3D encoders for feature extraction, further increasing model complexity and training inefficiency. In this paper, we propose a unified 2D pre-trained multi-modal network to process all three modalities (RGB images, text, and point clouds), significantly simplifying the architecture. By leveraging a 2D CLIP bi-modal model with adapter-based fine-tuning, this framework effectively adapts to the tri-modal setting, improving both adaptability and performance across modalities. Our Geometric-Aware 2D-3D Feature Recovery and Fusion (GARF) module is designed to fuse geometric multi-scale features from point clouds and images. We then integrate textual features for final modality fusion and introduce a multi-modal decoder to facilitate deep cross-modal understanding. Together, our method achieves unified feature extraction and fusion across the three modalities, enabling an end-to-end 3D visual grounding model. Compared to the baseline, our method reduces the number of trainable parameters by approximately 58\%, while achieving a 6.52\% improvement in the 3D detection task and a 6.25\% improvement in the 3D visual grounding task.

3D object detection and occupancy prediction are critical tasks in autonomous driving, attracting significant attention. Despite the potential of recent vision-based methods, they encounter challenges under adverse conditions. Thus, integrating cameras with next-generation 4D imaging radar to achieve unified multi-task perception is highly significant, though research in this domain remains limited. In this paper, we propose Doracamom, the first framework that fuses multi-view cameras and 4D radar for joint 3D object detection and semantic occupancy prediction, enabling comprehensive environmental perception. Specifically, we introduce a novel Coarse Voxel Queries Generator that integrates geometric priors from 4D radar with semantic features from images to initialize voxel queries, establishing a robust foundation for subsequent Transformer-based refinement. To leverage temporal information, we design a Dual-Branch Temporal Encoder that processes multi-modal temporal features in parallel across BEV and voxel spaces, enabling comprehensive spatio-temporal representation learning. Furthermore, we propose a Cross-Modal BEV-Voxel Fusion module that adaptively fuses complementary features through attention mechanisms while employing auxiliary tasks to enhance feature quality. Extensive experiments on the OmniHD-Scenes, View-of-Delft (VoD), and TJ4DRadSet datasets demonstrate that Doracamom achieves state-of-the-art performance in both tasks, establishing new benchmarks for multi-modal 3D perception. Code and models will be publicly available.

Diffusion models for garment-centric human generation from text or image prompts have garnered emerging attention for their great application potential. However, existing methods often face a dilemma: lightweight approaches, such as adapters, are prone to generate inconsistent textures; while finetune-based methods involve high training costs and struggle to maintain the generalization capabilities of pretrained diffusion models, limiting their performance across diverse scenarios. To address these challenges, we propose DreamFit, which incorporates a lightweight Anything-Dressing Encoder specifically tailored for the garment-centric human generation. DreamFit has three key advantages: (1) Lightweight training: with the proposed adaptive attention and LoRA modules, DreamFit significantly minimizes the model complexity to 83.4M trainable parameters. (2)Anything-Dressing: Our model generalizes surprisingly well to a wide range of (non-)garments, creative styles, and prompt instructions, consistently delivering high-quality results across diverse scenarios. (3) Plug-and-play: DreamFit is engineered for smooth integration with any community control plugins for diffusion models, ensuring easy compatibility and minimizing adoption barriers. To further enhance generation quality, DreamFit leverages pretrained large multi-modal models (LMMs) to enrich the prompt with fine-grained garment descriptions, thereby reducing the prompt gap between training and inference. We conduct comprehensive experiments on both 768 times 512 high-resolution benchmarks and in-the-wild images. DreamFit surpasses all existing methods, highlighting its state-of-the-art capabilities of garment-centric human generation.

Pre-trained multi-modal Vision-Language Models like CLIP are widely used off-the-shelf for a variety of applications. In this paper, we show that the common practice of individually exploiting the text or image encoders of these powerful multi-modal models is highly suboptimal for intra-modal tasks like image-to-image retrieval. We argue that this is inherently due to the CLIP-style inter-modal contrastive loss that does not enforce any intra-modal constraints, leading to what we call intra-modal misalignment. To demonstrate this, we leverage two optimization-based modality inversion techniques that map representations from their input modality to the complementary one without any need for auxiliary data or additional trained adapters. We empirically show that, in the intra-modal tasks of image-to-image and text-to-text retrieval, approaching these tasks inter-modally significantly improves performance with respect to intra-modal baselines on more than fifteen datasets. Additionally, we demonstrate that approaching a native inter-modal task (e.g. zero-shot image classification) intra-modally decreases performance, further validating our findings. Finally, we show that incorporating an intra-modal term in the pre-training objective or narrowing the modality gap between the text and image feature embedding spaces helps reduce the intra-modal misalignment. The code is publicly available at: https://github.com/miccunifi/Cross-the-Gap.

Accurate interpretation of Electrocardiogram (ECG) signals is pivotal for diagnosing cardiovascular diseases. Integrating ECG signals with their accompanying textual reports holds immense potential to enhance clinical diagnostics through the combination of physiological data and qualitative insights. However, this integration faces significant challenges due to inherent modality disparities and the scarcity of labeled data for robust cross-modal learning. To address these obstacles, we propose C-MELT, a novel framework that pre-trains ECG and text data using a contrastive masked auto-encoder architecture. C-MELT uniquely combines the strengths of generative with enhanced discriminative capabilities to achieve robust cross-modal representations. This is accomplished through masked modality modeling, specialized loss functions, and an improved negative sampling strategy tailored for cross-modal alignment. Extensive experiments on five public datasets across diverse downstream tasks demonstrate that C-MELT significantly outperforms existing methods, achieving 15% and 2% increases in linear probing and zero-shot performance over state-of-the-art models, respectively. These results highlight the effectiveness of C-MELT, underscoring its potential to advance automated clinical diagnostics through multi-modal representations.

This paper reveals that large language models (LLMs), despite being trained solely on textual data, are surprisingly strong encoders for purely visual tasks in the absence of language. Even more intriguingly, this can be achieved by a simple yet previously overlooked strategy -- employing a frozen transformer block from pre-trained LLMs as a constituent encoder layer to directly process visual tokens. Our work pushes the boundaries of leveraging LLMs for computer vision tasks, significantly departing from conventional practices that typically necessitate a multi-modal vision-language setup with associated language prompts, inputs, or outputs. We demonstrate that our approach consistently enhances performance across a diverse range of tasks, encompassing pure 2D and 3D visual recognition tasks (e.g., image and point cloud classification), temporal modeling tasks (e.g., action recognition), non-semantic tasks (e.g., motion forecasting), and multi-modal tasks (e.g., 2D/3D visual question answering and image-text retrieval). Such improvements are a general phenomenon, applicable to various types of LLMs (e.g., LLaMA and OPT) and different LLM transformer blocks. We additionally propose the information filtering hypothesis to explain the effectiveness of pre-trained LLMs in visual encoding -- the pre-trained LLM transformer blocks discern informative visual tokens and further amplify their effect. This hypothesis is empirically supported by the observation that the feature activation, after training with LLM transformer blocks, exhibits a stronger focus on relevant regions. We hope that our work inspires new perspectives on utilizing LLMs and deepening our understanding of their underlying mechanisms. Code is available at https://github.com/ziqipang/LM4VisualEncoding.

The development of AI-Generated Video (AIGV) technology has been remarkable in recent years, significantly transforming the paradigm of video content production. However, AIGVs still suffer from noticeable visual quality defects, such as noise, blurriness, frame jitter and low dynamic degree, which severely impact the user's viewing experience. Therefore, an effective automatic visual quality assessment is of great importance for AIGV content regulation and generative model improvement. In this work, we decompose the visual quality of AIGVs into three dimensions: technical quality, motion quality, and video semantics. For each dimension, we design corresponding encoder to achieve effective feature representation. Moreover, considering the outstanding performance of large language models (LLMs) in various vision and language tasks, we introduce a LLM as the quality regression module. To better enable the LLM to establish reasoning associations between multi-dimensional features and visual quality, we propose a specially designed multi-modal prompt engineering framework. Additionally, we incorporate LoRA fine-tuning technology during the training phase, allowing the LLM to better adapt to specific tasks. Our proposed method achieved second place in the NTIRE 2025 Quality Assessment of AI-Generated Content Challenge: Track 2 AI Generated video, demonstrating its effectiveness. Codes can be obtained at https://github.com/QiZelu/AIGVEval.

Generative domain adaptation has achieved remarkable progress, enabling us to adapt a pre-trained generator to a new target domain. However, existing methods simply adapt the generator to a single target domain and are limited to a single modality, either text-driven or image-driven. Moreover, they are prone to overfitting domain-specific attributes, which inevitably compromises cross-domain consistency. In this paper, we propose UniHDA, a unified and versatile framework for generative hybrid domain adaptation with multi-modal references from multiple domains. We use CLIP encoder to project multi-modal references into a unified embedding space and then linear interpolate the direction vectors from multiple target domains to achieve hybrid domain adaptation. To ensure the cross-domain consistency, we propose a novel cross-domain spatial structure (CSS) loss that maintains detailed spatial structure information between source and target generator. Experiments show that the adapted generator can synthesise realistic images with various attribute compositions. Additionally, our framework is versatile to multiple generators, \eg, StyleGAN2 and Diffusion Models.

Multi-modal large language models (MLLMs) have shown strong capability in video understanding but still struggle with fine-grained visual comprehension, as pure visual encoders often lose subtle cues essential for precise reasoning. To address this limitation, we propose FaVChat, a Video-MLLM specifically designed for fine-grained facial understanding. FaVChat introduces a multi-level prompt-guided feature extraction mechanism that progressively captures task-relevant information from three complementary stages: low-level transformer layers for textures and motion, medium-level learnable queries for discriminative regions, and high-level adaptive feature weighting for semantic alignment. These enriched features are dynamically fused and fed into the LLM to enable more accurate fine-grained reasoning. To further enhance the model's ability to capture fine-grained facial attributes and maximize the utility of limited data, we propose Date-Efficient GRPO, a novel data-efficient reinforcement learning (RL) algorithm that maximizes the utility of each training sample through per-instance utility estimation and dynamic lifecycle scheduling. Extensive zero-shot evaluations across emotion recognition, explainable reasoning, and textual expression analysis demonstrate that FaVChat achieves finer-grained understanding, stronger accuracy, and better generalization than existing Video-MLLMs, even when trained with only 10K RL samples.

Multi-modal large language models (MLLMs) have enabled numerous advances in understanding and reasoning in domains like vision, but we have not yet seen this broad success for time-series. Although prior works on time-series MLLMs have shown promising performance in time-series forecasting, very few works show how an LLM could be used for time-series reasoning in natural language. We propose a novel multi-modal time-series LLM approach that learns generalizable information across various domains with powerful zero-shot performance. First, we train a lightweight time-series encoder on top of an LLM to directly extract time-series information. Then, we fine-tune our model with chain-of-thought augmented time-series tasks to encourage the model to generate reasoning paths. We show that our model learns a latent representation that reflects specific time-series features (e.g. slope, frequency), as well as outperforming GPT-4o on a set of zero-shot reasoning tasks on a variety of domains.

The recent GPT-4 has demonstrated extraordinary multi-modal abilities, such as directly generating websites from handwritten text and identifying humorous elements within images. These features are rarely observed in previous vision-language models. We believe the primary reason for GPT-4's advanced multi-modal generation capabilities lies in the utilization of a more advanced large language model (LLM). To examine this phenomenon, we present MiniGPT-4, which aligns a frozen visual encoder with a frozen LLM, Vicuna, using just one projection layer. Our findings reveal that MiniGPT-4 possesses many capabilities similar to those exhibited by GPT-4 like detailed image description generation and website creation from hand-written drafts. Furthermore, we also observe other emerging capabilities in MiniGPT-4, including writing stories and poems inspired by given images, providing solutions to problems shown in images, teaching users how to cook based on food photos, etc. In our experiment, we found that only performing the pretraining on raw image-text pairs could produce unnatural language outputs that lack coherency including repetition and fragmented sentences. To address this problem, we curate a high-quality, well-aligned dataset in the second stage to finetune our model using a conversational template. This step proved crucial for augmenting the model's generation reliability and overall usability. Notably, our model is highly computationally efficient, as we only train a projection layer utilizing approximately 5 million aligned image-text pairs. Our code, pre-trained model, and collected dataset are available at https://minigpt-4.github.io/.

Medical vision-language pre-training shows great potential in learning representative features from massive paired radiographs and reports. However, in computed tomography (CT) scans, the distribution of lesions which contain intricate structures is characterized by spatial sparsity. Besides, the complex and implicit relationships between different pathological descriptions in each sentence of the report and their corresponding sub-regions in radiographs pose additional challenges. In this paper, we propose a Similarity-Driven Cross-Granularity Pre-training (SimCroP) framework on chest CTs, which combines similarity-driven alignment and cross-granularity fusion to improve radiograph interpretation. We first leverage multi-modal masked modeling to optimize the encoder for understanding precise low-level semantics from radiographs. Then, similarity-driven alignment is designed to pre-train the encoder to adaptively select and align the correct patches corresponding to each sentence in reports. The cross-granularity fusion module integrates multimodal information across instance level and word-patch level, which helps the model better capture key pathology structures in sparse radiographs, resulting in improved performance for multi-scale downstream tasks. SimCroP is pre-trained on a large-scale paired CT-reports dataset and validated on image classification and segmentation tasks across five public datasets. Experimental results demonstrate that SimCroP outperforms both cutting-edge medical self-supervised learning methods and medical vision-language pre-training methods. Codes and models are available at https://github.com/ToniChopp/SimCroP.

Accurate and interpretable detection of AI-generated images is essential for mitigating risks associated with AI misuse. However, the substantial domain gap among generative models makes it challenging to develop a generalizable forgery detection model. Moreover, since every pixel in an AI-generated image is synthesized, traditional saliency-based forgery explanation methods are not well suited for this task. To address these challenges, we formulate detection and explanation as a unified Forgery Detection and Reasoning task (FDR-Task), leveraging Multi-Modal Large Language Models (MLLMs) to provide accurate detection through reliable reasoning over forgery attributes. To facilitate this task, we introduce the Multi-Modal Forgery Reasoning dataset (MMFR-Dataset), a large-scale dataset containing 120K images across 10 generative models, with 378K reasoning annotations on forgery attributes, enabling comprehensive evaluation of the FDR-Task. Furthermore, we propose FakeReasoning, a forgery detection and reasoning framework with three key components: 1) a dual-branch visual encoder that integrates CLIP and DINO to capture both high-level semantics and low-level artifacts; 2) a Forgery-Aware Feature Fusion Module that leverages DINO's attention maps and cross-attention mechanisms to guide MLLMs toward forgery-related clues; 3) a Classification Probability Mapper that couples language modeling and forgery detection, enhancing overall performance. Experiments across multiple generative models demonstrate that FakeReasoning not only achieves robust generalization but also outperforms state-of-the-art methods on both detection and reasoning tasks.

The field of text-to-image (T2I) generation has made significant progress in recent years, largely driven by advancements in diffusion models. Linguistic control enables effective content creation, but struggles with fine-grained control over image generation. This challenge has been explored, to a great extent, by incorporating additional user-supplied spatial conditions, such as depth maps and edge maps, into pre-trained T2I models through extra encoding. However, multi-control image synthesis still faces several challenges. Specifically, current approaches are limited in handling free combinations of diverse input control signals, overlook the complex relationships among multiple spatial conditions, and often fail to maintain semantic alignment with provided textual prompts. This can lead to suboptimal user experiences. To address these challenges, we propose AnyControl, a multi-control image synthesis framework that supports arbitrary combinations of diverse control signals. AnyControl develops a novel Multi-Control Encoder that extracts a unified multi-modal embedding to guide the generation process. This approach enables a holistic understanding of user inputs, and produces high-quality, faithful results under versatile control signals, as demonstrated by extensive quantitative and qualitative evaluations. Our project page is available in https://any-control.github.io.

Multi-modal contrastive models such as CLIP achieve state-of-the-art performance in zero-shot classification by embedding input images and texts on a joint representational space. Recently, a modality gap has been reported in two-encoder contrastive models like CLIP, meaning that the image and text embeddings reside in disjoint areas of the latent space. Previous studies suggest that this gap exists due to 1) the cone effect, 2) mismatched pairs in the dataset, and 3) insufficient training. We show that, even when accounting for all these factors, and even when using the same modality, the contrastive loss actually creates a gap during training. As a result, We propose that the modality gap is inherent to the two-encoder contrastive loss and rename it the contrastive gap. We present evidence that attributes this contrastive gap to low uniformity in CLIP space, resulting in embeddings that occupy only a small portion of the latent space. To close the gap, we adapt the uniformity and alignment properties of unimodal contrastive loss to the multi-modal setting and show that simply adding these terms to the CLIP loss distributes the embeddings more uniformly in the representational space, closing the gap. In our experiments, we show that the modified representational space achieves better performance than default CLIP loss in downstream tasks such as zero-shot image classification and multi-modal arithmetic.

Visual data comes in various forms, ranging from small icons of just a few pixels to long videos spanning hours. Existing multi-modal LLMs usually standardize these diverse visual inputs to a fixed resolution for visual encoders and yield similar numbers of tokens for LLMs. This approach is non-optimal for multimodal understanding and inefficient for processing inputs with long and short visual contents. To solve the problem, we propose Oryx, a unified multimodal architecture for the spatial-temporal understanding of images, videos, and multi-view 3D scenes. Oryx offers an on-demand solution to seamlessly and efficiently process visual inputs with arbitrary spatial sizes and temporal lengths through two core innovations: 1) a pre-trained OryxViT model that can encode images at any resolution into LLM-friendly visual representations; 2) a dynamic compressor module that supports 1x to 16x compression on visual tokens by request. These design features enable Oryx to accommodate extremely long visual contexts, such as videos, with lower resolution and high compression while maintaining high recognition precision for tasks like document understanding with native resolution and no compression. Beyond the architectural improvements, enhanced data curation and specialized training on long-context retrieval and spatial-aware data help Oryx achieve strong capabilities in image, video, and 3D multimodal understanding simultaneously. Our work is open-sourced at https://github.com/Oryx-mllm/Oryx.

We present Video-LLaMA, a multi-modal framework that empowers Large Language Models (LLMs) with the capability of understanding both visual and auditory content in the video. Video-LLaMA bootstraps cross-modal training from the frozen pre-trained visual \& audio encoders and the frozen LLMs. Unlike previous vision- LLMs that focus on static image comprehensions such as MiniGPT-4~zhu2023minigpt and LLaVA~liu2023visualit, Video-LLaMA tackles two challenges in video understanding: (1) capturing the temporal changes in visual scenes, (2) integrating audio-visual signals. For the first challenge, we propose Video Q-former to extend the pre-trained image encoder to a video encoder and introduce a video-to-text generation task to learn video-language correspondence. For the second challenge, we leverage ImageBind~girdhar2023imagebind as the pre-trained audio encoder which performs exceptionally well in aligning different modalities to a common embedding space. And then introduce an Audio Q-former to learn auditory query tokens. To align the output of both visual \& audio encoder with LLM's embedding space, we train Video-LLaMA on a large-scale vision caption dataset and a hign-quantity vision-instruction-tuning dataset. We found Video-LLaMA showcases the ability to perceive and comprehend video content, generating meaningful responses that are grounded in the visual and auditory information present in the videos. This highlights the potential of Video-LLaMA as a promising prototype for audio-visual AI assistants. Our code, pre-trained model, and demo are available at https://github.com/DAMO-NLP-SG/Video-LLaMA.

The Segment Anything Model (SAM) has demonstrated outstanding adaptation to medical image segmentation but still faces three major challenges. Firstly, the huge computational costs of SAM limit its real-world applicability. Secondly, SAM depends on manual annotations (e.g., points, boxes) as prompts, which are laborious and impractical in clinical scenarios. Thirdly, SAM handles all segmentation targets equally, which is suboptimal for diverse medical modalities with inherent heterogeneity. To address these issues, we propose an Efficient Self-Prompting SAM for universal medical image segmentation, named ESP-MedSAM. We devise a Multi-Modal Decoupled Knowledge Distillation (MMDKD) strategy to distil common image knowledge and domain-specific medical knowledge from the foundation model to train a lightweight image encoder and a modality controller. Further, they combine with the additionally introduced Self-Patch Prompt Generator (SPPG) and Query-Decoupled Modality Decoder (QDMD) to construct ESP-MedSAM. Specifically, SPPG aims to generate a set of patch prompts automatically and QDMD leverages a one-to-one strategy to provide an independent decoding channel for every modality. Extensive experiments indicate that ESP-MedSAM outperforms state-of-the-arts in diverse medical imaging segmentation takes, displaying superior zero-shot learning and modality transfer ability. Especially, our framework uses only 31.4% parameters compared to SAM-Base.

3D molecule generation is crucial for drug discovery and material science, requiring models to process complex multi-modalities, including atom types, chemical bonds, and 3D coordinates. A key challenge is integrating these modalities of different shapes while maintaining SE(3) equivariance for 3D coordinates. To achieve this, existing approaches typically maintain separate latent spaces for invariant and equivariant modalities, reducing efficiency in both training and sampling. In this work, we propose Unified Variational Auto-Encoder for 3D Molecular Latent Diffusion Modeling (UAE-3D), a multi-modal VAE that compresses 3D molecules into latent sequences from a unified latent space, while maintaining near-zero reconstruction error. This unified latent space eliminates the complexities of handling multi-modality and equivariance when performing latent diffusion modeling. We demonstrate this by employing the Diffusion Transformer--a general-purpose diffusion model without any molecular inductive bias--for latent generation. Extensive experiments on GEOM-Drugs and QM9 datasets demonstrate that our method significantly establishes new benchmarks in both de novo and conditional 3D molecule generation, achieving leading efficiency and quality.

In this work, we present a novel framework built to simplify 3D asset generation for amateur users. To enable interactive generation, our method supports a variety of input modalities that can be easily provided by a human, including images, text, partially observed shapes and combinations of these, further allowing to adjust the strength of each input. At the core of our approach is an encoder-decoder, compressing 3D shapes into a compact latent representation, upon which a diffusion model is learned. To enable a variety of multi-modal inputs, we employ task-specific encoders with dropout followed by a cross-attention mechanism. Due to its flexibility, our model naturally supports a variety of tasks, outperforming prior works on shape completion, image-based 3D reconstruction, and text-to-3D. Most interestingly, our model can combine all these tasks into one swiss-army-knife tool, enabling the user to perform shape generation using incomplete shapes, images, and textual descriptions at the same time, providing the relative weights for each input and facilitating interactivity. Despite our approach being shape-only, we further show an efficient method to texture the generated shape using large-scale text-to-image models.

Vector graphic documents present visual elements in a resolution free, compact format and are often seen in creative applications. In this work, we attempt to learn a generative model of vector graphic documents. We define vector graphic documents by a multi-modal set of attributes associated to a canvas and a sequence of visual elements such as shapes, images, or texts, and train variational auto-encoders to learn the representation of the documents. We collect a new dataset of design templates from an online service that features complete document structure including occluded elements. In experiments, we show that our model, named CanvasVAE, constitutes a strong baseline for generative modeling of vector graphic documents.

We consider the problem of localizing a spatio-temporal tube in a video corresponding to a given text query. This is a challenging task that requires the joint and efficient modeling of temporal, spatial and multi-modal interactions. To address this task, we propose TubeDETR, a transformer-based architecture inspired by the recent success of such models for text-conditioned object detection. Our model notably includes: (i) an efficient video and text encoder that models spatial multi-modal interactions over sparsely sampled frames and (ii) a space-time decoder that jointly performs spatio-temporal localization. We demonstrate the advantage of our proposed components through an extensive ablation study. We also evaluate our full approach on the spatio-temporal video grounding task and demonstrate improvements over the state of the art on the challenging VidSTG and HC-STVG benchmarks. Code and trained models are publicly available at https://antoyang.github.io/tubedetr.html.

Understanding biological processes, drug development, and biotechnological advancements requires detailed analysis of protein structures and sequences, a task in protein research that is inherently complex and time-consuming when performed manually. To streamline this process, we introduce ProteinGPT, a state-of-the-art multi-modal protein chat system, that allows users to upload protein sequences and/or structures for comprehensive protein analysis and responsive inquiries. ProteinGPT seamlessly integrates protein sequence and structure encoders with linear projection layers for precise representation adaptation, coupled with a large language model (LLM) to generate accurate and contextually relevant responses. To train ProteinGPT, we construct a large-scale dataset of 132,092 proteins with annotations, and optimize the instruction-tuning process using GPT-4o. This innovative system ensures accurate alignment between the user-uploaded data and prompts, simplifying protein analysis. Experiments show that ProteinGPT can produce promising responses to proteins and their corresponding questions.

Molecular structure elucidation from spectra is a foundational problem in chemistry, with profound implications for compound identification, synthesis, and drug development. Traditional methods rely heavily on expert interpretation and lack scalability. Pioneering machine learning methods have introduced retrieval-based strategies, but their reliance on finite libraries limits generalization to novel molecules. Generative models offer a promising alternative, yet most adopt autoregressive SMILES-based architectures that overlook 3D geometry and struggle to integrate diverse spectral modalities. In this work, we present DiffSpectra, a generative framework that directly infers both 2D and 3D molecular structures from multi-modal spectral data using diffusion models. DiffSpectra formulates structure elucidation as a conditional generation process. Its denoising network is parameterized by Diffusion Molecule Transformer, an SE(3)-equivariant architecture that integrates topological and geometric information. Conditioning is provided by SpecFormer, a transformer-based spectral encoder that captures intra- and inter-spectral dependencies from multi-modal spectra. Extensive experiments demonstrate that DiffSpectra achieves high accuracy in structure elucidation, recovering exact structures with 16.01% top-1 accuracy and 96.86% top-20 accuracy through sampling. The model benefits significantly from 3D geometric modeling, SpecFormer pre-training, and multi-modal conditioning. These results highlight the effectiveness of spectrum-conditioned diffusion modeling in addressing the challenge of molecular structure elucidation. To our knowledge, DiffSpectra is the first framework to unify multi-modal spectral reasoning and joint 2D/3D generative modeling for de novo molecular structure elucidation.