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<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a gene or protein "Hepatocyte nuclear factor-6" and a disease "type II diabetes". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion.
- Abstract: Sentence 2: The transcription factor hepatocyte nuclear factor (HNF)-6 is an upstream regulator of several genes involved in the pathogenesis of maturity-onset diabetes of the young.
Sentence 3: We therefore tested the hypothesis that variability in the HNF-6 gene is associated with subsets of Type II (non-insulin-dependent) diabetes mellitus and estimates of insulin secretion in glucose tolerant subjects.
Sentence 4: We cloned the coding region as well as the intron-exon boundaries of the HNF-6 gene.
Sentence 5: We then examined them on genomic DNA in six MODY probands without mutations in the MODY1, MODY3 and MODY4 genes and in 54 patients with late-onset Type II diabetes by combined single strand conformational polymorphism-heteroduplex analysis followed by direct sequencing of identified variants.
Sentence 6: An identified missense variant was examined in association studies and genotype-phenotype studies.
Sentence 7: We identified two silent and one missense (Pro75 Ala) variant.
Sentence 8: In an association study the allelic frequency of the Pro75Ala polymorphism was 3.2% (95% confidence interval, 1.9-4.5) in 330 patients with Type II diabetes mellitus compared with 4.2% (2.4-6.0) in 238 age-matched glucose tolerant control subjects.
Sentence 9: Moreover, in studies of 238 middle-aged glucose tolerant subjects, of 226 glucose tolerant offspring of Type II diabetic patients and of 367 young healthy subjects, the carriers of the polymorphism did not differ from non-carriers in glucose induced serum insulin or C-peptide responses.
Sentence 10: Mutations in the coding region of the HNF-6 gene are not associated with Type II diabetes or with changes in insulin responses to glucose among the Caucasians examined.
Tips for Analysis:Sentences mentioning a gene or protein "Hepatocyte nuclear factor-6": Sentence 4, Sentence 2, Sentence 1, Sentence 10, Sentence 3
Sentences mentioning a disease "type II diabetes": Sentence 5, Sentence 2, Sentence 9, Sentence 1, Sentence 10, Sentence 3
Sentences mentioning both entities a gene or protein "Hepatocyte nuclear factor-6" and a disease "type II diabetes": Sentence 1, Sentence 3, Sentence 2, Sentence 10
Task: Identify the relationship between a gene or protein "Hepatocyte nuclear factor-6" and a disease "type II diabetes" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' here means that the relation between a gene and a disease is direct and increases the likelihood of the disease. This includes cases where too much protein causes the disease, removing the gene prevents the disease, or a side effect from the protein or drug results in the disease.
'Negative_Correlation' indicates that when a protein (or gene) is present, it helps to treat or prevent a disease. Conversely, the absence of this protein or the deactivation of its gene can lead to the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Association</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a chemical "glucose" and a gene or protein "insulin". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion.
- Abstract: Sentence 2: The transcription factor hepatocyte nuclear factor (HNF)-6 is an upstream regulator of several genes involved in the pathogenesis of maturity-onset diabetes of the young.
Sentence 3: We therefore tested the hypothesis that variability in the HNF-6 gene is associated with subsets of Type II (non-insulin-dependent) diabetes mellitus and estimates of insulin secretion in glucose tolerant subjects.
Sentence 4: We cloned the coding region as well as the intron-exon boundaries of the HNF-6 gene.
Sentence 5: We then examined them on genomic DNA in six MODY probands without mutations in the MODY1, MODY3 and MODY4 genes and in 54 patients with late-onset Type II diabetes by combined single strand conformational polymorphism-heteroduplex analysis followed by direct sequencing of identified variants.
Sentence 6: An identified missense variant was examined in association studies and genotype-phenotype studies.
Sentence 7: We identified two silent and one missense (Pro75 Ala) variant.
Sentence 8: In an association study the allelic frequency of the Pro75Ala polymorphism was 3.2% (95% confidence interval, 1.9-4.5) in 330 patients with Type II diabetes mellitus compared with 4.2% (2.4-6.0) in 238 age-matched glucose tolerant control subjects.
Sentence 9: Moreover, in studies of 238 middle-aged glucose tolerant subjects, of 226 glucose tolerant offspring of Type II diabetic patients and of 367 young healthy subjects, the carriers of the polymorphism did not differ from non-carriers in glucose induced serum insulin or C-peptide responses.
Sentence 10: Mutations in the coding region of the HNF-6 gene are not associated with Type II diabetes or with changes in insulin responses to glucose among the Caucasians examined.
Tips for Analysis:Sentences mentioning a chemical "glucose": Sentence 3, Sentence 10, Sentence 9
Sentences mentioning a gene or protein "insulin": Sentence 1, Sentence 3, Sentence 10, Sentence 9
Sentences mentioning both entities a chemical "glucose" and a gene or protein "insulin": Sentence 3, Sentence 10, Sentence 9
Task: Identify the relationship between a chemical "glucose" and a gene or protein "insulin" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a chemical leads to higher gene expression, or higher gene expression increases sensitivity to the chemical, or a gene variant exacerbates the chemical's side effects, or a gene causes an over-response to the chemical, or there is a positive interaction between two genes in any manner.
'Negative_Correlation' indicates that a chemical leads to reduced gene expression, or higher gene expression results in decreased sensitivity or resistance to the chemical, or a gene variant offers protection against the chemical's adverse effects, or a gene contributes to resistance against the chemical, or there exists a negative interaction between two genes in any form.
'Bind' means that a chemical either connects to a gene's promoter region or a protein acts as a receptor for that chemical.
'Association' is used to describe relation that don't clearly fall under categories like positive correlation, negative correlation and bind , or when the nature of the relation lack a clear description. [/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a chemical "glucose" and a disease "Type II diabetes mellitus". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion.
- Abstract: Sentence 2: The transcription factor hepatocyte nuclear factor (HNF)-6 is an upstream regulator of several genes involved in the pathogenesis of maturity-onset diabetes of the young.
Sentence 3: We therefore tested the hypothesis that variability in the HNF-6 gene is associated with subsets of Type II (non-insulin-dependent) diabetes mellitus and estimates of insulin secretion in glucose tolerant subjects.
Sentence 4: We cloned the coding region as well as the intron-exon boundaries of the HNF-6 gene.
Sentence 5: We then examined them on genomic DNA in six MODY probands without mutations in the MODY1, MODY3 and MODY4 genes and in 54 patients with late-onset Type II diabetes by combined single strand conformational polymorphism-heteroduplex analysis followed by direct sequencing of identified variants.
Sentence 6: An identified missense variant was examined in association studies and genotype-phenotype studies.
Sentence 7: We identified two silent and one missense (Pro75 Ala) variant.
Sentence 8: In an association study the allelic frequency of the Pro75Ala polymorphism was 3.2% (95% confidence interval, 1.9-4.5) in 330 patients with Type II diabetes mellitus compared with 4.2% (2.4-6.0) in 238 age-matched glucose tolerant control subjects.
Sentence 9: Moreover, in studies of 238 middle-aged glucose tolerant subjects, of 226 glucose tolerant offspring of Type II diabetic patients and of 367 young healthy subjects, the carriers of the polymorphism did not differ from non-carriers in glucose induced serum insulin or C-peptide responses.
Sentence 10: Mutations in the coding region of the HNF-6 gene are not associated with Type II diabetes or with changes in insulin responses to glucose among the Caucasians examined.
Tips for Analysis:Sentences mentioning a chemical "glucose": Sentence 3, Sentence 10, Sentence 9
Sentences mentioning a disease "Type II diabetes mellitus": Sentence 5, Sentence 2, Sentence 9, Sentence 1, Sentence 10, Sentence 3
Sentences mentioning both entities a chemical "glucose" and a disease "Type II diabetes mellitus": Sentence 3, Sentence 10, Sentence 9
Task: Identify the relationship between a chemical "glucose" and a disease "Type II diabetes mellitus" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on.
'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Association</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a gene or protein "type II Ca2+-dependent lectin" and a chemical "mannose". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules.
- Abstract: Sentence 2: We have identified a type II Ca2+-dependent lectin displaying mannose-binding specificity, exclusively expressed by Langerhans cells (LC), and named Langerin.
Sentence 3: LC are uniquely characterized by Birbeck granules (BG), which are organelles consisting of superimposed and zippered membranes.
Sentence 4: Here, we have shown that Langerin is constitutively associated with BG and that antibody to Langerin is internalized into these structures.
Sentence 5: Remarkably, transfection of Langerin cDNA into fibroblasts created a compact network of membrane structures with typical features of BG.
Sentence 6: Langerin is thus a potent inducer of membrane superimposition and zippering leading to BG formation.
Sentence 7: Our data suggest that induction of BG is a consequence of the antigen-capture function of Langerin, allowing routing into these organelles and providing access to a nonclassical antigen-processing pathway.
Tips for Analysis:Sentences mentioning a gene or protein "type II Ca2+-dependent lectin": Sentence 4, Sentence 6, Sentence 1, Sentence 2, Sentence 5, Sentence 7
Sentences mentioning a chemical "mannose": Sentence 2
Sentences mentioning both entities a gene or protein "type II Ca2+-dependent lectin" and a chemical "mannose": Sentence 2
Task: Identify the relationship between a gene or protein "type II Ca2+-dependent lectin" and a chemical "mannose" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a chemical leads to higher gene expression, or higher gene expression increases sensitivity to the chemical, or a gene variant exacerbates the chemical's side effects, or a gene causes an over-response to the chemical, or there is a positive interaction between two genes in any manner.
'Negative_Correlation' indicates that a chemical leads to reduced gene expression, or higher gene expression results in decreased sensitivity or resistance to the chemical, or a gene variant offers protection against the chemical's adverse effects, or a gene contributes to resistance against the chemical, or there exists a negative interaction between two genes in any form.
'Bind' means that a chemical either connects to a gene's promoter region or a protein acts as a receptor for that chemical.
'Association' is used to describe relation that don't clearly fall under categories like positive correlation, negative correlation and bind , or when the nature of the relation lack a clear description. [/INST] Bind</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a disease "breast cancer" and a variant "5382insC". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract: Sentence 2: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population.
Sentence 3: The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years.
Sentence 4: A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only.
Sentence 5: Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family.
Sentence 6: The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants.
Sentence 7: Mutations were found in 35 (53%) of the 66 families studied.
Sentence 8: All but one of the mutations were detected within the BRCA1 gene.
Sentence 9: BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only.
Sentence 10: The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome.
Sentence 11: Seven distinct mutations were identified; five of these occurred in two or more families.
Sentence 12: In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations.
Sentence 13: Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Sentence 14:
Tips for Analysis:Sentences mentioning a disease "breast cancer": Sentence 9, Sentence 4
Sentences mentioning a variant "5382insC": Sentence 13
Sentences mentioning both entities a disease "breast cancer" and a variant "5382insC": No sentences found.
Task: Identify the relationship between a disease "breast cancer" and a variant "5382insC" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined. [/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a disease "breast cancer" and a variant "4153delA". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract: Sentence 2: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population.
Sentence 3: The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years.
Sentence 4: A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only.
Sentence 5: Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family.
Sentence 6: The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants.
Sentence 7: Mutations were found in 35 (53%) of the 66 families studied.
Sentence 8: All but one of the mutations were detected within the BRCA1 gene.
Sentence 9: BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only.
Sentence 10: The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome.
Sentence 11: Seven distinct mutations were identified; five of these occurred in two or more families.
Sentence 12: In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations.
Sentence 13: Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Sentence 14:
Tips for Analysis:Sentences mentioning a disease "breast cancer": Sentence 9, Sentence 4
Sentences mentioning a variant "4153delA": Sentence 13
Sentences mentioning both entities a disease "breast cancer" and a variant "4153delA": No sentences found.
Task: Identify the relationship between a disease "breast cancer" and a variant "4153delA" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined. [/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a disease "breast cancer" and a variant "C61G". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract: Sentence 2: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population.
Sentence 3: The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years.
Sentence 4: A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only.
Sentence 5: Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family.
Sentence 6: The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants.
Sentence 7: Mutations were found in 35 (53%) of the 66 families studied.
Sentence 8: All but one of the mutations were detected within the BRCA1 gene.
Sentence 9: BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only.
Sentence 10: The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome.
Sentence 11: Seven distinct mutations were identified; five of these occurred in two or more families.
Sentence 12: In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations.
Sentence 13: Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Sentence 14:
Tips for Analysis:Sentences mentioning a disease "breast cancer": Sentence 9, Sentence 4
Sentences mentioning a variant "C61G": Sentence 13
Sentences mentioning both entities a disease "breast cancer" and a variant "C61G": No sentences found.
Task: Identify the relationship between a disease "breast cancer" and a variant "C61G" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined. [/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a disease "ovarian cancer" and a variant "5382insC". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract: Sentence 2: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population.
Sentence 3: The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years.
Sentence 4: A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only.
Sentence 5: Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family.
Sentence 6: The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants.
Sentence 7: Mutations were found in 35 (53%) of the 66 families studied.
Sentence 8: All but one of the mutations were detected within the BRCA1 gene.
Sentence 9: BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only.
Sentence 10: The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome.
Sentence 11: Seven distinct mutations were identified; five of these occurred in two or more families.
Sentence 12: In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations.
Sentence 13: Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Sentence 14:
Tips for Analysis:Sentences mentioning a disease "ovarian cancer": Sentence 9, Sentence 4
Sentences mentioning a variant "5382insC": Sentence 13
Sentences mentioning both entities a disease "ovarian cancer" and a variant "5382insC": No sentences found.
Task: Identify the relationship between a disease "ovarian cancer" and a variant "5382insC" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined. [/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a disease "ovarian cancer" and a variant "4153delA". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract: Sentence 2: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population.
Sentence 3: The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years.
Sentence 4: A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only.
Sentence 5: Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family.
Sentence 6: The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants.
Sentence 7: Mutations were found in 35 (53%) of the 66 families studied.
Sentence 8: All but one of the mutations were detected within the BRCA1 gene.
Sentence 9: BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only.
Sentence 10: The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome.
Sentence 11: Seven distinct mutations were identified; five of these occurred in two or more families.
Sentence 12: In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations.
Sentence 13: Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Sentence 14:
Tips for Analysis:Sentences mentioning a disease "ovarian cancer": Sentence 9, Sentence 4
Sentences mentioning a variant "4153delA": Sentence 13
Sentences mentioning both entities a disease "ovarian cancer" and a variant "4153delA": No sentences found.
Task: Identify the relationship between a disease "ovarian cancer" and a variant "4153delA" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined. [/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a disease "ovarian cancer" and a variant "C61G". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract: Sentence 2: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population.
Sentence 3: The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years.
Sentence 4: A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only.
Sentence 5: Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family.
Sentence 6: The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants.
Sentence 7: Mutations were found in 35 (53%) of the 66 families studied.
Sentence 8: All but one of the mutations were detected within the BRCA1 gene.
Sentence 9: BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only.
Sentence 10: The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome.
Sentence 11: Seven distinct mutations were identified; five of these occurred in two or more families.
Sentence 12: In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations.
Sentence 13: Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Sentence 14:
Tips for Analysis:Sentences mentioning a disease "ovarian cancer": Sentence 9, Sentence 4
Sentences mentioning a variant "C61G": Sentence 13
Sentences mentioning both entities a disease "ovarian cancer" and a variant "C61G": No sentences found.
Task: Identify the relationship between a disease "ovarian cancer" and a variant "C61G" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined. [/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a variant "5382insC" and a disease "breast-ovarian cancer syndrome". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract: Sentence 2: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population.
Sentence 3: The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years.
Sentence 4: A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only.
Sentence 5: Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family.
Sentence 6: The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants.
Sentence 7: Mutations were found in 35 (53%) of the 66 families studied.
Sentence 8: All but one of the mutations were detected within the BRCA1 gene.
Sentence 9: BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only.
Sentence 10: The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome.
Sentence 11: Seven distinct mutations were identified; five of these occurred in two or more families.
Sentence 12: In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations.
Sentence 13: Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Sentence 14:
Tips for Analysis:Sentences mentioning a variant "5382insC": Sentence 13
Sentences mentioning a disease "breast-ovarian cancer syndrome": Sentence 1, Sentence 10
Sentences mentioning both entities a variant "5382insC" and a disease "breast-ovarian cancer syndrome": No sentences found.
Task: Identify the relationship between a variant "5382insC" and a disease "breast-ovarian cancer syndrome" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined. [/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a variant "4153delA" and a disease "breast-ovarian cancer syndrome". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract: Sentence 2: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population.
Sentence 3: The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years.
Sentence 4: A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only.
Sentence 5: Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family.
Sentence 6: The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants.
Sentence 7: Mutations were found in 35 (53%) of the 66 families studied.
Sentence 8: All but one of the mutations were detected within the BRCA1 gene.
Sentence 9: BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only.
Sentence 10: The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome.
Sentence 11: Seven distinct mutations were identified; five of these occurred in two or more families.
Sentence 12: In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations.
Sentence 13: Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Sentence 14:
Tips for Analysis:Sentences mentioning a variant "4153delA": Sentence 13
Sentences mentioning a disease "breast-ovarian cancer syndrome": Sentence 1, Sentence 10
Sentences mentioning both entities a variant "4153delA" and a disease "breast-ovarian cancer syndrome": No sentences found.
Task: Identify the relationship between a variant "4153delA" and a disease "breast-ovarian cancer syndrome" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined. [/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a variant "C61G" and a disease "breast-ovarian cancer syndrome". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract: Sentence 2: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population.
Sentence 3: The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years.
Sentence 4: A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only.
Sentence 5: Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family.
Sentence 6: The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants.
Sentence 7: Mutations were found in 35 (53%) of the 66 families studied.
Sentence 8: All but one of the mutations were detected within the BRCA1 gene.
Sentence 9: BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only.
Sentence 10: The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome.
Sentence 11: Seven distinct mutations were identified; five of these occurred in two or more families.
Sentence 12: In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations.
Sentence 13: Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Sentence 14:
Tips for Analysis:Sentences mentioning a variant "C61G": Sentence 13
Sentences mentioning a disease "breast-ovarian cancer syndrome": Sentence 1, Sentence 10
Sentences mentioning both entities a variant "C61G" and a disease "breast-ovarian cancer syndrome": No sentences found.
Task: Identify the relationship between a variant "C61G" and a disease "breast-ovarian cancer syndrome" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined. [/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a disease "BRCA1 abnormalities" and a variant "5382insC". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract: Sentence 2: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population.
Sentence 3: The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years.
Sentence 4: A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only.
Sentence 5: Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family.
Sentence 6: The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants.
Sentence 7: Mutations were found in 35 (53%) of the 66 families studied.
Sentence 8: All but one of the mutations were detected within the BRCA1 gene.
Sentence 9: BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only.
Sentence 10: The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome.
Sentence 11: Seven distinct mutations were identified; five of these occurred in two or more families.
Sentence 12: In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations.
Sentence 13: Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Sentence 14:
Tips for Analysis:Sentences mentioning a disease "BRCA1 abnormalities": Sentence 13, Sentence 9
Sentences mentioning a variant "5382insC": Sentence 13
Sentences mentioning both entities a disease "BRCA1 abnormalities" and a variant "5382insC": Sentence 13
Task: Identify the relationship between a disease "BRCA1 abnormalities" and a variant "5382insC" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined. [/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a disease "BRCA1 abnormalities" and a variant "4153delA". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract: Sentence 2: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population.
Sentence 3: The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years.
Sentence 4: A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only.
Sentence 5: Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family.
Sentence 6: The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants.
Sentence 7: Mutations were found in 35 (53%) of the 66 families studied.
Sentence 8: All but one of the mutations were detected within the BRCA1 gene.
Sentence 9: BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only.
Sentence 10: The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome.
Sentence 11: Seven distinct mutations were identified; five of these occurred in two or more families.
Sentence 12: In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations.
Sentence 13: Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Sentence 14:
Tips for Analysis:Sentences mentioning a disease "BRCA1 abnormalities": Sentence 13, Sentence 9
Sentences mentioning a variant "4153delA": Sentence 13
Sentences mentioning both entities a disease "BRCA1 abnormalities" and a variant "4153delA": Sentence 13
Task: Identify the relationship between a disease "BRCA1 abnormalities" and a variant "4153delA" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined. [/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a disease "BRCA1 abnormalities" and a variant "C61G". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract: Sentence 2: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population.
Sentence 3: The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years.
Sentence 4: A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only.
Sentence 5: Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family.
Sentence 6: The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants.
Sentence 7: Mutations were found in 35 (53%) of the 66 families studied.
Sentence 8: All but one of the mutations were detected within the BRCA1 gene.
Sentence 9: BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only.
Sentence 10: The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome.
Sentence 11: Seven distinct mutations were identified; five of these occurred in two or more families.
Sentence 12: In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations.
Sentence 13: Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Sentence 14:
Tips for Analysis:Sentences mentioning a disease "BRCA1 abnormalities": Sentence 13, Sentence 9
Sentences mentioning a variant "C61G": Sentence 13
Sentences mentioning both entities a disease "BRCA1 abnormalities" and a variant "C61G": Sentence 13
Task: Identify the relationship between a disease "BRCA1 abnormalities" and a variant "C61G" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined. [/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a gene or protein "BRCA1" and a disease "breast cancers". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract: Sentence 2: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population.
Sentence 3: The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years.
Sentence 4: A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only.
Sentence 5: Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family.
Sentence 6: The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants.
Sentence 7: Mutations were found in 35 (53%) of the 66 families studied.
Sentence 8: All but one of the mutations were detected within the BRCA1 gene.
Sentence 9: BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only.
Sentence 10: The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome.
Sentence 11: Seven distinct mutations were identified; five of these occurred in two or more families.
Sentence 12: In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations.
Sentence 13: Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Sentence 14:
Tips for Analysis:Sentences mentioning a gene or protein "BRCA1": Sentence 2, Sentence 1, Sentence 6, Sentence 8
Sentences mentioning a disease "breast cancers": Sentence 9, Sentence 4
Sentences mentioning both entities a gene or protein "BRCA1" and a disease "breast cancers": No sentences found.
Task: Identify the relationship between a gene or protein "BRCA1" and a disease "breast cancers" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' here means that the relation between a gene and a disease is direct and increases the likelihood of the disease. This includes cases where too much protein causes the disease, removing the gene prevents the disease, or a side effect from the protein or drug results in the disease.
'Negative_Correlation' indicates that when a protein (or gene) is present, it helps to treat or prevent a disease. Conversely, the absence of this protein or the deactivation of its gene can lead to the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Association</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a gene or protein "BRCA1" and a disease "ovarian cancer". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract: Sentence 2: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population.
Sentence 3: The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years.
Sentence 4: A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only.
Sentence 5: Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family.
Sentence 6: The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants.
Sentence 7: Mutations were found in 35 (53%) of the 66 families studied.
Sentence 8: All but one of the mutations were detected within the BRCA1 gene.
Sentence 9: BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only.
Sentence 10: The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome.
Sentence 11: Seven distinct mutations were identified; five of these occurred in two or more families.
Sentence 12: In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations.
Sentence 13: Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Sentence 14:
Tips for Analysis:Sentences mentioning a gene or protein "BRCA1": Sentence 2, Sentence 1, Sentence 6, Sentence 8
Sentences mentioning a disease "ovarian cancer": Sentence 9, Sentence 4
Sentences mentioning both entities a gene or protein "BRCA1" and a disease "ovarian cancer": No sentences found.
Task: Identify the relationship between a gene or protein "BRCA1" and a disease "ovarian cancer" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' here means that the relation between a gene and a disease is direct and increases the likelihood of the disease. This includes cases where too much protein causes the disease, removing the gene prevents the disease, or a side effect from the protein or drug results in the disease.
'Negative_Correlation' indicates that when a protein (or gene) is present, it helps to treat or prevent a disease. Conversely, the absence of this protein or the deactivation of its gene can lead to the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Association</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a gene or protein "BRCA1" and a disease "BRCA1 abnormalities". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract: Sentence 2: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population.
Sentence 3: The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years.
Sentence 4: A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only.
Sentence 5: Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family.
Sentence 6: The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants.
Sentence 7: Mutations were found in 35 (53%) of the 66 families studied.
Sentence 8: All but one of the mutations were detected within the BRCA1 gene.
Sentence 9: BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only.
Sentence 10: The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome.
Sentence 11: Seven distinct mutations were identified; five of these occurred in two or more families.
Sentence 12: In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations.
Sentence 13: Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Sentence 14:
Tips for Analysis:Sentences mentioning a gene or protein "BRCA1": Sentence 2, Sentence 1, Sentence 6, Sentence 8
Sentences mentioning a disease "BRCA1 abnormalities": Sentence 13, Sentence 9
Sentences mentioning both entities a gene or protein "BRCA1" and a disease "BRCA1 abnormalities": No sentences found.
Task: Identify the relationship between a gene or protein "BRCA1" and a disease "BRCA1 abnormalities" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' here means that the relation between a gene and a disease is direct and increases the likelihood of the disease. This includes cases where too much protein causes the disease, removing the gene prevents the disease, or a side effect from the protein or drug results in the disease.
'Negative_Correlation' indicates that when a protein (or gene) is present, it helps to treat or prevent a disease. Conversely, the absence of this protein or the deactivation of its gene can lead to the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Association</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a gene or protein "BRCA1" and a disease "breast-ovarian cancer". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract: Sentence 2: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population.
Sentence 3: The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years.
Sentence 4: A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only.
Sentence 5: Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family.
Sentence 6: The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants.
Sentence 7: Mutations were found in 35 (53%) of the 66 families studied.
Sentence 8: All but one of the mutations were detected within the BRCA1 gene.
Sentence 9: BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only.
Sentence 10: The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome.
Sentence 11: Seven distinct mutations were identified; five of these occurred in two or more families.
Sentence 12: In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations.
Sentence 13: Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Sentence 14:
Tips for Analysis:Sentences mentioning a gene or protein "BRCA1": Sentence 2, Sentence 1, Sentence 6, Sentence 8
Sentences mentioning a disease "breast-ovarian cancer": Sentence 1, Sentence 10
Sentences mentioning both entities a gene or protein "BRCA1" and a disease "breast-ovarian cancer": Sentence 1
Task: Identify the relationship between a gene or protein "BRCA1" and a disease "breast-ovarian cancer" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' here means that the relation between a gene and a disease is direct and increases the likelihood of the disease. This includes cases where too much protein causes the disease, removing the gene prevents the disease, or a side effect from the protein or drug results in the disease.
'Negative_Correlation' indicates that when a protein (or gene) is present, it helps to treat or prevent a disease. Conversely, the absence of this protein or the deactivation of its gene can lead to the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Association</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a chemical "levodopa" and a disease "dyskinesias". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Apomorphine: an underutilized therapy for Parkinson's disease.
- Abstract: Sentence 2: Apomorphine was the first dopaminergic drug ever used to treat symptoms of Parkinson's disease.
Sentence 3: While powerful antiparkinsonian effects had been observed as early as 1951, the potential of treating fluctuating Parkinson's disease by subcutaneous administration of apomorphine has only recently become the subject of systematic study.
Sentence 4: A number of small scale clinical trials have unequivocally shown that intermittent subcutaneous apomorphine injections produce antiparkinsonian benefit close if not identical to that seen with levodopa and that apomorphine rescue injections can reliably revert off-periods even in patients with complex on-off motor swings.
Sentence 5: Continuous subcutaneous apomorphine infusions can reduce daily off-time by more than 50% in this group of patients, which appears to be a stronger effect than that generally seen with add-on therapy with oral dopamine agonists or COMT inhibitors.
Sentence 6: Extended follow-up studies of up to 8 years have demonstrated long-term persistence of apomorphine efficacy.
Sentence 7: In addition, there is convincing clinical evidence that monotherapy with continuous subcutaneous apomorphine infusions is associated with marked reductions of preexisting levodopa-induced dyskinesias.
Sentence 8: The main side effects of subcutaneous apomorphine treatment are related to cutaneous tolerability problems, whereas sedation and psychiatric complications play a lesser role.
Sentence 9: Given the marked degree of efficacy of subcutaneous apomorphine treatment in fluctuating Parkinson's disease, this approach seems to deserve more widespread clinical use.
Tips for Analysis:Sentences mentioning a chemical "levodopa": Sentence 7, Sentence 4
Sentences mentioning a disease "dyskinesias": Sentence 7
Sentences mentioning both entities a chemical "levodopa" and a disease "dyskinesias": Sentence 7
Task: Identify the relationship between a chemical "levodopa" and a disease "dyskinesias" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on.
'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a chemical "apomorphine" and a chemical "levodopa". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Apomorphine: an underutilized therapy for Parkinson's disease.
- Abstract: Sentence 2: Apomorphine was the first dopaminergic drug ever used to treat symptoms of Parkinson's disease.
Sentence 3: While powerful antiparkinsonian effects had been observed as early as 1951, the potential of treating fluctuating Parkinson's disease by subcutaneous administration of apomorphine has only recently become the subject of systematic study.
Sentence 4: A number of small scale clinical trials have unequivocally shown that intermittent subcutaneous apomorphine injections produce antiparkinsonian benefit close if not identical to that seen with levodopa and that apomorphine rescue injections can reliably revert off-periods even in patients with complex on-off motor swings.
Sentence 5: Continuous subcutaneous apomorphine infusions can reduce daily off-time by more than 50% in this group of patients, which appears to be a stronger effect than that generally seen with add-on therapy with oral dopamine agonists or COMT inhibitors.
Sentence 6: Extended follow-up studies of up to 8 years have demonstrated long-term persistence of apomorphine efficacy.
Sentence 7: In addition, there is convincing clinical evidence that monotherapy with continuous subcutaneous apomorphine infusions is associated with marked reductions of preexisting levodopa-induced dyskinesias.
Sentence 8: The main side effects of subcutaneous apomorphine treatment are related to cutaneous tolerability problems, whereas sedation and psychiatric complications play a lesser role.
Sentence 9: Given the marked degree of efficacy of subcutaneous apomorphine treatment in fluctuating Parkinson's disease, this approach seems to deserve more widespread clinical use.
Tips for Analysis:Sentences mentioning a chemical "apomorphine": Sentence 1, Sentence 7, Sentence 6, Sentence 3, Sentence 9, Sentence 5, Sentence 8, Sentence 2, Sentence 4
Sentences mentioning a chemical "levodopa": Sentence 7, Sentence 4
Sentences mentioning both entities a chemical "apomorphine" and a chemical "levodopa": Sentence 7, Sentence 4
Task: Identify the relationship between a chemical "apomorphine" and a chemical "levodopa" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Drug_Interaction', 'Cotreatment', 'Conversion', 'Comparison', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' indicates that Chemical A increases the effectiveness of Chemical B. This includes making Chemical B more sensitive, enhancing its ability to treat or induce a disease, or boosting its role in gene activation.
'Negative_Correlation' means that Chemical A reduces the effectiveness and impact of Chemical B. This includes decreasing Chemical B's sensitivity, reducing its ability to treat or induce a disease, diminishing its side effects, and lowering the gene activation it causes.
'Drug_Interaction' is when two different drugs or chemicals affect each other's action in the body, happening when they are used at the same time.
'Cotreatment' means that two different drugs or chemicals are used in combination therapy.
'Conversion' means that one chemical changes into another chemical.
'Comparison' means that two different drugs or chemicals have some differences and similarities in their effects.
'Association' refers to the relation between two chemicals that do not fit into any specific, predefined categories of relations. [/INST] Negative_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a chemical "apomorphine" and a disease "dyskinesias". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Apomorphine: an underutilized therapy for Parkinson's disease.
- Abstract: Sentence 2: Apomorphine was the first dopaminergic drug ever used to treat symptoms of Parkinson's disease.
Sentence 3: While powerful antiparkinsonian effects had been observed as early as 1951, the potential of treating fluctuating Parkinson's disease by subcutaneous administration of apomorphine has only recently become the subject of systematic study.
Sentence 4: A number of small scale clinical trials have unequivocally shown that intermittent subcutaneous apomorphine injections produce antiparkinsonian benefit close if not identical to that seen with levodopa and that apomorphine rescue injections can reliably revert off-periods even in patients with complex on-off motor swings.
Sentence 5: Continuous subcutaneous apomorphine infusions can reduce daily off-time by more than 50% in this group of patients, which appears to be a stronger effect than that generally seen with add-on therapy with oral dopamine agonists or COMT inhibitors.
Sentence 6: Extended follow-up studies of up to 8 years have demonstrated long-term persistence of apomorphine efficacy.
Sentence 7: In addition, there is convincing clinical evidence that monotherapy with continuous subcutaneous apomorphine infusions is associated with marked reductions of preexisting levodopa-induced dyskinesias.
Sentence 8: The main side effects of subcutaneous apomorphine treatment are related to cutaneous tolerability problems, whereas sedation and psychiatric complications play a lesser role.
Sentence 9: Given the marked degree of efficacy of subcutaneous apomorphine treatment in fluctuating Parkinson's disease, this approach seems to deserve more widespread clinical use.
Tips for Analysis:Sentences mentioning a chemical "apomorphine": Sentence 1, Sentence 7, Sentence 6, Sentence 3, Sentence 9, Sentence 5, Sentence 8, Sentence 2, Sentence 4
Sentences mentioning a disease "dyskinesias": Sentence 7
Sentences mentioning both entities a chemical "apomorphine" and a disease "dyskinesias": Sentence 7
Task: Identify the relationship between a chemical "apomorphine" and a disease "dyskinesias" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on.
'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Negative_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a chemical "Apomorphine" and a disease "Parkinson's disease". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Apomorphine: an underutilized therapy for Parkinson's disease.
- Abstract: Sentence 2: Apomorphine was the first dopaminergic drug ever used to treat symptoms of Parkinson's disease.
Sentence 3: While powerful antiparkinsonian effects had been observed as early as 1951, the potential of treating fluctuating Parkinson's disease by subcutaneous administration of apomorphine has only recently become the subject of systematic study.
Sentence 4: A number of small scale clinical trials have unequivocally shown that intermittent subcutaneous apomorphine injections produce antiparkinsonian benefit close if not identical to that seen with levodopa and that apomorphine rescue injections can reliably revert off-periods even in patients with complex on-off motor swings.
Sentence 5: Continuous subcutaneous apomorphine infusions can reduce daily off-time by more than 50% in this group of patients, which appears to be a stronger effect than that generally seen with add-on therapy with oral dopamine agonists or COMT inhibitors.
Sentence 6: Extended follow-up studies of up to 8 years have demonstrated long-term persistence of apomorphine efficacy.
Sentence 7: In addition, there is convincing clinical evidence that monotherapy with continuous subcutaneous apomorphine infusions is associated with marked reductions of preexisting levodopa-induced dyskinesias.
Sentence 8: The main side effects of subcutaneous apomorphine treatment are related to cutaneous tolerability problems, whereas sedation and psychiatric complications play a lesser role.
Sentence 9: Given the marked degree of efficacy of subcutaneous apomorphine treatment in fluctuating Parkinson's disease, this approach seems to deserve more widespread clinical use.
Tips for Analysis:Sentences mentioning a chemical "Apomorphine": Sentence 1, Sentence 7, Sentence 6, Sentence 3, Sentence 9, Sentence 5, Sentence 8, Sentence 2, Sentence 4
Sentences mentioning a disease "Parkinson's disease": Sentence 1, Sentence 9, Sentence 3, Sentence 2
Sentences mentioning both entities a chemical "Apomorphine" and a disease "Parkinson's disease": Sentence 1, Sentence 9, Sentence 3, Sentence 2
Task: Identify the relationship between a chemical "Apomorphine" and a disease "Parkinson's disease" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on.
'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Negative_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a disease "uterine sarcoma" and a gene or protein "Rab6c". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells.
- Abstract: Sentence 2: A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique.
Sentence 3: Rab6c was found to be under-expressed in MCF7/AdrR and MES-SA/Dx5 (a human MDR uterine sarcoma cell line) compared with their non-MDR parental cell lines.
Sentence 4: MCF7/AdrR cells expressing the exogenous Rab6c exhibited less resistance to several anti-cancer drugs, such as doxorubicin (DOX), taxol, vinblastine, and vincristine, than the control cells containing the empty vector.
Sentence 5: Flow cytometry experiments confirmed that the transfectants' diminished resistance to DOX was caused by increased drug accumulation induced by the exogenous Rab6c.
Sentence 6: These results indicate that Rab6c is involved in drug resistance in MCF7/AdrR cells.
Tips for Analysis:Sentences mentioning a disease "uterine sarcoma": Sentence 3
Sentences mentioning a gene or protein "Rab6c": Sentence 4, Sentence 1, Sentence 2, Sentence 6, Sentence 3, Sentence 5
Sentences mentioning both entities a disease "uterine sarcoma" and a gene or protein "Rab6c": Sentence 3
Task: Identify the relationship between a disease "uterine sarcoma" and a gene or protein "Rab6c" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' here means that the relation between a protein or gene and a disease is direct and increases the likelihood of the disease. This includes cases where too much protein causes the disease, removing the gene prevents the disease, or a side effect from the protein or drug results in the disease.
'Negative_Correlation' indicates that when a protein (or drug) is present, it helps to treat or prevent a disease. Conversely, the absence of this protein or the deactivation of its gene can lead to the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Association</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a gene or protein "Rab6c" and a chemical "vincristine". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells.
- Abstract: Sentence 2: A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique.
Sentence 3: Rab6c was found to be under-expressed in MCF7/AdrR and MES-SA/Dx5 (a human MDR uterine sarcoma cell line) compared with their non-MDR parental cell lines.
Sentence 4: MCF7/AdrR cells expressing the exogenous Rab6c exhibited less resistance to several anti-cancer drugs, such as doxorubicin (DOX), taxol, vinblastine, and vincristine, than the control cells containing the empty vector.
Sentence 5: Flow cytometry experiments confirmed that the transfectants' diminished resistance to DOX was caused by increased drug accumulation induced by the exogenous Rab6c.
Sentence 6: These results indicate that Rab6c is involved in drug resistance in MCF7/AdrR cells.
Tips for Analysis:Sentences mentioning a gene or protein "Rab6c": Sentence 4, Sentence 1, Sentence 2, Sentence 6, Sentence 3, Sentence 5
Sentences mentioning a chemical "vincristine": Sentence 4
Sentences mentioning both entities a gene or protein "Rab6c" and a chemical "vincristine": Sentence 4
Task: Identify the relationship between a gene or protein "Rab6c" and a chemical "vincristine" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a chemical leads to higher gene expression, or higher gene expression increases sensitivity to the chemical, or a gene variant exacerbates the chemical's side effects, or a gene causes an over-response to the chemical, or there is a positive interaction between two genes in any manner.
'Negative_Correlation' indicates that a chemical leads to reduced gene expression, or higher gene expression results in decreased sensitivity or resistance to the chemical, or a gene variant offers protection against the chemical's adverse effects, or a gene contributes to resistance against the chemical, or there exists a negative interaction between two genes in any form.
'Bind' means that a chemical either connects to a gene's promoter region or a protein acts as a receptor for that chemical.
'Association' is used to describe relation that don't clearly fall under categories like positive correlation, negative correlation and bind , or when the nature of the relation lack a clear description. [/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a gene or protein "Rab6c" and a chemical "vinblastine". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells.
- Abstract: Sentence 2: A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique.
Sentence 3: Rab6c was found to be under-expressed in MCF7/AdrR and MES-SA/Dx5 (a human MDR uterine sarcoma cell line) compared with their non-MDR parental cell lines.
Sentence 4: MCF7/AdrR cells expressing the exogenous Rab6c exhibited less resistance to several anti-cancer drugs, such as doxorubicin (DOX), taxol, vinblastine, and vincristine, than the control cells containing the empty vector.
Sentence 5: Flow cytometry experiments confirmed that the transfectants' diminished resistance to DOX was caused by increased drug accumulation induced by the exogenous Rab6c.
Sentence 6: These results indicate that Rab6c is involved in drug resistance in MCF7/AdrR cells.
Tips for Analysis:Sentences mentioning a gene or protein "Rab6c": Sentence 4, Sentence 1, Sentence 2, Sentence 6, Sentence 3, Sentence 5
Sentences mentioning a chemical "vinblastine": Sentence 4
Sentences mentioning both entities a gene or protein "Rab6c" and a chemical "vinblastine": Sentence 4
Task: Identify the relationship between a gene or protein "Rab6c" and a chemical "vinblastine" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a chemical leads to higher gene expression, or higher gene expression increases sensitivity to the chemical, or a gene variant exacerbates the chemical's side effects, or a gene causes an over-response to the chemical, or there is a positive interaction between two genes in any manner.
'Negative_Correlation' indicates that a chemical leads to reduced gene expression, or higher gene expression results in decreased sensitivity or resistance to the chemical, or a gene variant offers protection against the chemical's adverse effects, or a gene contributes to resistance against the chemical, or there exists a negative interaction between two genes in any form.
'Bind' means that a chemical either connects to a gene's promoter region or a protein acts as a receptor for that chemical.
'Association' is used to describe relation that don't clearly fall under categories like positive correlation, negative correlation and bind , or when the nature of the relation lack a clear description. [/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a gene or protein "Rab6c" and a chemical "taxol". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells.
- Abstract: Sentence 2: A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique.
Sentence 3: Rab6c was found to be under-expressed in MCF7/AdrR and MES-SA/Dx5 (a human MDR uterine sarcoma cell line) compared with their non-MDR parental cell lines.
Sentence 4: MCF7/AdrR cells expressing the exogenous Rab6c exhibited less resistance to several anti-cancer drugs, such as doxorubicin (DOX), taxol, vinblastine, and vincristine, than the control cells containing the empty vector.
Sentence 5: Flow cytometry experiments confirmed that the transfectants' diminished resistance to DOX was caused by increased drug accumulation induced by the exogenous Rab6c.
Sentence 6: These results indicate that Rab6c is involved in drug resistance in MCF7/AdrR cells.
Tips for Analysis:Sentences mentioning a gene or protein "Rab6c": Sentence 4, Sentence 1, Sentence 2, Sentence 6, Sentence 3, Sentence 5
Sentences mentioning a chemical "taxol": Sentence 4
Sentences mentioning both entities a gene or protein "Rab6c" and a chemical "taxol": Sentence 4
Task: Identify the relationship between a gene or protein "Rab6c" and a chemical "taxol" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a chemical leads to higher gene expression, or higher gene expression increases sensitivity to the chemical, or a gene variant exacerbates the chemical's side effects, or a gene causes an over-response to the chemical, or there is a positive interaction between two genes in any manner.
'Negative_Correlation' indicates that a chemical leads to reduced gene expression, or higher gene expression results in decreased sensitivity or resistance to the chemical, or a gene variant offers protection against the chemical's adverse effects, or a gene contributes to resistance against the chemical, or there exists a negative interaction between two genes in any form.
'Bind' means that a chemical either connects to a gene's promoter region or a protein acts as a receptor for that chemical.
'Association' is used to describe relation that don't clearly fall under categories like positive correlation, negative correlation and bind , or when the nature of the relation lack a clear description. [/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a gene or protein "Rab6c" and a chemical "doxorubicin". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells.
- Abstract: Sentence 2: A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique.
Sentence 3: Rab6c was found to be under-expressed in MCF7/AdrR and MES-SA/Dx5 (a human MDR uterine sarcoma cell line) compared with their non-MDR parental cell lines.
Sentence 4: MCF7/AdrR cells expressing the exogenous Rab6c exhibited less resistance to several anti-cancer drugs, such as doxorubicin (DOX), taxol, vinblastine, and vincristine, than the control cells containing the empty vector.
Sentence 5: Flow cytometry experiments confirmed that the transfectants' diminished resistance to DOX was caused by increased drug accumulation induced by the exogenous Rab6c.
Sentence 6: These results indicate that Rab6c is involved in drug resistance in MCF7/AdrR cells.
Tips for Analysis:Sentences mentioning a gene or protein "Rab6c": Sentence 4, Sentence 1, Sentence 2, Sentence 6, Sentence 3, Sentence 5
Sentences mentioning a chemical "doxorubicin": Sentence 4, Sentence 5
Sentences mentioning both entities a gene or protein "Rab6c" and a chemical "doxorubicin": Sentence 4, Sentence 5
Task: Identify the relationship between a gene or protein "Rab6c" and a chemical "doxorubicin" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a chemical leads to higher gene expression, or higher gene expression increases sensitivity to the chemical, or a gene variant exacerbates the chemical's side effects, or a gene causes an over-response to the chemical, or there is a positive interaction between two genes in any manner.
'Negative_Correlation' indicates that a chemical leads to reduced gene expression, or higher gene expression results in decreased sensitivity or resistance to the chemical, or a gene variant offers protection against the chemical's adverse effects, or a gene contributes to resistance against the chemical, or there exists a negative interaction between two genes in any form.
'Bind' means that a chemical either connects to a gene's promoter region or a protein acts as a receptor for that chemical.
'Association' is used to describe relation that don't clearly fall under categories like positive correlation, negative correlation and bind , or when the nature of the relation lack a clear description. [/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a gene or protein "calcineurin" and a chemical "tacrolimus". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment.
- Abstract: Sentence 2: BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic.
Sentence 3: Their use in orthotopic liver transplantation (OLTX) has dramatically improved success rates.
Sentence 4: Recently, however, we have had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD).
Sentence 5: This retrospective study examines the incidence and treatment of ESRD and chronic renal failure (CRF) in OLTX patients.
Sentence 6: METHODS: Patients receiving an OLTX only from June 1985 through December of 1994 who survived 6 months postoperatively were studied (n=834).
Sentence 7: Our prospectively collected database was the source of information.
Sentence 8: Patients were divided into three groups: Controls, no CRF or ESRD, n=748; CRF, sustained serum creatinine >2.5 mg/dl, n=41; and ESRD, n=45.
Sentence 9: Groups were compared for preoperative laboratory variables, diagnosis, postoperative variables, survival, type of ESRD therapy, and survival from onset of ESRD.
Sentence 10: RESULTS: At 13 years after OLTX, the incidence of severe renal dysfunction was 18.1% (CRF 8.6% and ESRD 9.5%).
Sentence 11: Compared with control patients, CRF and ESRD patients had higher preoperative serum creatinine levels, a greater percentage of patients with hepatorenal syndrome, higher percentage requirement for dialysis in the first 3 months postoperatively, and a higher 1-year serum creatinine.
Sentence 12: Multivariate stepwise logistic regression analysis using preoperative and postoperative variables identified that an increase of serum creatinine compared with average at 1 year, 3 months, and 4 weeks postoperatively were independent risk factors for the development of CRF or ESRD with odds ratios of 2.6, 2.2, and 1.6, respectively.
Sentence 13: Overall survival from the time of OLTX was not significantly different among groups, but by year 13, the survival of the patients who had ESRD was only 28.2% compared with 54.6% in the control group.
Sentence 14: Patients developing ESRD had a 6-year survival after onset of ESRD of 27% for the patients receiving hemodialysis versus 71.4% for the patients developing ESRD who subsequently received kidney transplants.
Sentence 15: CONCLUSIONS: Patients who are more than 10 years post-OLTX have CRF and ESRD at a high rate.
Sentence 16: The development of ESRD decreases survival, particularly in those patients treated with dialysis only.
Sentence 17: Patients who develop ESRD have a higher preoperative and 1-year serum creatinine and are more likely to have hepatorenal syndrome.
Sentence 18: However, an increase of serum creatinine at various times postoperatively is more predictive of the development of CRF or ESRD.
Sentence 19: New strategies for long-term immunosuppression may be needed to decrease this complication.
Tips for Analysis:Sentences mentioning a gene or protein "calcineurin": Sentence 1, Sentence 2
Sentences mentioning a chemical "tacrolimus": Sentence 2
Sentences mentioning both entities a gene or protein "calcineurin" and a chemical "tacrolimus": Sentence 2
Task: Identify the relationship between a gene or protein "calcineurin" and a chemical "tacrolimus" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a chemical leads to higher gene expression, or higher gene expression increases sensitivity to the chemical, or a gene variant exacerbates the chemical's side effects, or a gene causes an over-response to the chemical, or there is a positive interaction between two genes in any manner.
'Negative_Correlation' indicates that a chemical leads to reduced gene expression, or higher gene expression results in decreased sensitivity or resistance to the chemical, or a gene variant offers protection against the chemical's adverse effects, or a gene contributes to resistance against the chemical, or there exists a negative interaction between two genes in any form.
'Bind' means that a chemical either connects to a gene's promoter region or a protein acts as a receptor for that chemical.
'Association' is used to describe relation that don't clearly fall under categories like positive correlation, negative correlation and bind , or when the nature of the relation lack a clear description. [/INST] Negative_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a gene or protein "calcineurin" and a chemical "cyclosporine". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment.
- Abstract: Sentence 2: BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic.
Sentence 3: Their use in orthotopic liver transplantation (OLTX) has dramatically improved success rates.
Sentence 4: Recently, however, we have had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD).
Sentence 5: This retrospective study examines the incidence and treatment of ESRD and chronic renal failure (CRF) in OLTX patients.
Sentence 6: METHODS: Patients receiving an OLTX only from June 1985 through December of 1994 who survived 6 months postoperatively were studied (n=834).
Sentence 7: Our prospectively collected database was the source of information.
Sentence 8: Patients were divided into three groups: Controls, no CRF or ESRD, n=748; CRF, sustained serum creatinine >2.5 mg/dl, n=41; and ESRD, n=45.
Sentence 9: Groups were compared for preoperative laboratory variables, diagnosis, postoperative variables, survival, type of ESRD therapy, and survival from onset of ESRD.
Sentence 10: RESULTS: At 13 years after OLTX, the incidence of severe renal dysfunction was 18.1% (CRF 8.6% and ESRD 9.5%).
Sentence 11: Compared with control patients, CRF and ESRD patients had higher preoperative serum creatinine levels, a greater percentage of patients with hepatorenal syndrome, higher percentage requirement for dialysis in the first 3 months postoperatively, and a higher 1-year serum creatinine.
Sentence 12: Multivariate stepwise logistic regression analysis using preoperative and postoperative variables identified that an increase of serum creatinine compared with average at 1 year, 3 months, and 4 weeks postoperatively were independent risk factors for the development of CRF or ESRD with odds ratios of 2.6, 2.2, and 1.6, respectively.
Sentence 13: Overall survival from the time of OLTX was not significantly different among groups, but by year 13, the survival of the patients who had ESRD was only 28.2% compared with 54.6% in the control group.
Sentence 14: Patients developing ESRD had a 6-year survival after onset of ESRD of 27% for the patients receiving hemodialysis versus 71.4% for the patients developing ESRD who subsequently received kidney transplants.
Sentence 15: CONCLUSIONS: Patients who are more than 10 years post-OLTX have CRF and ESRD at a high rate.
Sentence 16: The development of ESRD decreases survival, particularly in those patients treated with dialysis only.
Sentence 17: Patients who develop ESRD have a higher preoperative and 1-year serum creatinine and are more likely to have hepatorenal syndrome.
Sentence 18: However, an increase of serum creatinine at various times postoperatively is more predictive of the development of CRF or ESRD.
Sentence 19: New strategies for long-term immunosuppression may be needed to decrease this complication.
Tips for Analysis:Sentences mentioning a gene or protein "calcineurin": Sentence 1, Sentence 2
Sentences mentioning a chemical "cyclosporine": Sentence 2
Sentences mentioning both entities a gene or protein "calcineurin" and a chemical "cyclosporine": Sentence 2
Task: Identify the relationship between a gene or protein "calcineurin" and a chemical "cyclosporine" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a chemical leads to higher gene expression, or higher gene expression increases sensitivity to the chemical, or a gene variant exacerbates the chemical's side effects, or a gene causes an over-response to the chemical, or there is a positive interaction between two genes in any manner.
'Negative_Correlation' indicates that a chemical leads to reduced gene expression, or higher gene expression results in decreased sensitivity or resistance to the chemical, or a gene variant offers protection against the chemical's adverse effects, or a gene contributes to resistance against the chemical, or there exists a negative interaction between two genes in any form.
'Bind' means that a chemical either connects to a gene's promoter region or a protein acts as a receptor for that chemical.
'Association' is used to describe relation that don't clearly fall under categories like positive correlation, negative correlation and bind , or when the nature of the relation lack a clear description. [/INST] Negative_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a disease "hepatorenal syndrome" and a chemical "creatinine". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment.
- Abstract: Sentence 2: BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic.
Sentence 3: Their use in orthotopic liver transplantation (OLTX) has dramatically improved success rates.
Sentence 4: Recently, however, we have had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD).
Sentence 5: This retrospective study examines the incidence and treatment of ESRD and chronic renal failure (CRF) in OLTX patients.
Sentence 6: METHODS: Patients receiving an OLTX only from June 1985 through December of 1994 who survived 6 months postoperatively were studied (n=834).
Sentence 7: Our prospectively collected database was the source of information.
Sentence 8: Patients were divided into three groups: Controls, no CRF or ESRD, n=748; CRF, sustained serum creatinine >2.5 mg/dl, n=41; and ESRD, n=45.
Sentence 9: Groups were compared for preoperative laboratory variables, diagnosis, postoperative variables, survival, type of ESRD therapy, and survival from onset of ESRD.
Sentence 10: RESULTS: At 13 years after OLTX, the incidence of severe renal dysfunction was 18.1% (CRF 8.6% and ESRD 9.5%).
Sentence 11: Compared with control patients, CRF and ESRD patients had higher preoperative serum creatinine levels, a greater percentage of patients with hepatorenal syndrome, higher percentage requirement for dialysis in the first 3 months postoperatively, and a higher 1-year serum creatinine.
Sentence 12: Multivariate stepwise logistic regression analysis using preoperative and postoperative variables identified that an increase of serum creatinine compared with average at 1 year, 3 months, and 4 weeks postoperatively were independent risk factors for the development of CRF or ESRD with odds ratios of 2.6, 2.2, and 1.6, respectively.
Sentence 13: Overall survival from the time of OLTX was not significantly different among groups, but by year 13, the survival of the patients who had ESRD was only 28.2% compared with 54.6% in the control group.
Sentence 14: Patients developing ESRD had a 6-year survival after onset of ESRD of 27% for the patients receiving hemodialysis versus 71.4% for the patients developing ESRD who subsequently received kidney transplants.
Sentence 15: CONCLUSIONS: Patients who are more than 10 years post-OLTX have CRF and ESRD at a high rate.
Sentence 16: The development of ESRD decreases survival, particularly in those patients treated with dialysis only.
Sentence 17: Patients who develop ESRD have a higher preoperative and 1-year serum creatinine and are more likely to have hepatorenal syndrome.
Sentence 18: However, an increase of serum creatinine at various times postoperatively is more predictive of the development of CRF or ESRD.
Sentence 19: New strategies for long-term immunosuppression may be needed to decrease this complication.
Tips for Analysis:Sentences mentioning a disease "hepatorenal syndrome": Sentence 17, Sentence 11
Sentences mentioning a chemical "creatinine": Sentence 17, Sentence 18, Sentence 11
Sentences mentioning both entities a disease "hepatorenal syndrome" and a chemical "creatinine": Sentence 17, Sentence 11
Task: Identify the relationship between a disease "hepatorenal syndrome" and a chemical "creatinine" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on.
'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a chemical "tacrolimus" and a disease "nephrotoxic". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment.
- Abstract: Sentence 2: BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic.
Sentence 3: Their use in orthotopic liver transplantation (OLTX) has dramatically improved success rates.
Sentence 4: Recently, however, we have had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD).
Sentence 5: This retrospective study examines the incidence and treatment of ESRD and chronic renal failure (CRF) in OLTX patients.
Sentence 6: METHODS: Patients receiving an OLTX only from June 1985 through December of 1994 who survived 6 months postoperatively were studied (n=834).
Sentence 7: Our prospectively collected database was the source of information.
Sentence 8: Patients were divided into three groups: Controls, no CRF or ESRD, n=748; CRF, sustained serum creatinine >2.5 mg/dl, n=41; and ESRD, n=45.
Sentence 9: Groups were compared for preoperative laboratory variables, diagnosis, postoperative variables, survival, type of ESRD therapy, and survival from onset of ESRD.
Sentence 10: RESULTS: At 13 years after OLTX, the incidence of severe renal dysfunction was 18.1% (CRF 8.6% and ESRD 9.5%).
Sentence 11: Compared with control patients, CRF and ESRD patients had higher preoperative serum creatinine levels, a greater percentage of patients with hepatorenal syndrome, higher percentage requirement for dialysis in the first 3 months postoperatively, and a higher 1-year serum creatinine.
Sentence 12: Multivariate stepwise logistic regression analysis using preoperative and postoperative variables identified that an increase of serum creatinine compared with average at 1 year, 3 months, and 4 weeks postoperatively were independent risk factors for the development of CRF or ESRD with odds ratios of 2.6, 2.2, and 1.6, respectively.
Sentence 13: Overall survival from the time of OLTX was not significantly different among groups, but by year 13, the survival of the patients who had ESRD was only 28.2% compared with 54.6% in the control group.
Sentence 14: Patients developing ESRD had a 6-year survival after onset of ESRD of 27% for the patients receiving hemodialysis versus 71.4% for the patients developing ESRD who subsequently received kidney transplants.
Sentence 15: CONCLUSIONS: Patients who are more than 10 years post-OLTX have CRF and ESRD at a high rate.
Sentence 16: The development of ESRD decreases survival, particularly in those patients treated with dialysis only.
Sentence 17: Patients who develop ESRD have a higher preoperative and 1-year serum creatinine and are more likely to have hepatorenal syndrome.
Sentence 18: However, an increase of serum creatinine at various times postoperatively is more predictive of the development of CRF or ESRD.
Sentence 19: New strategies for long-term immunosuppression may be needed to decrease this complication.
Tips for Analysis:Sentences mentioning a chemical "tacrolimus": Sentence 2
Sentences mentioning a disease "nephrotoxic": Sentence 2
Sentences mentioning both entities a chemical "tacrolimus" and a disease "nephrotoxic": Sentence 2
Task: Identify the relationship between a chemical "tacrolimus" and a disease "nephrotoxic" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on.
'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a disease "CRF" and a chemical "creatinine". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment.
- Abstract: Sentence 2: BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic.
Sentence 3: Their use in orthotopic liver transplantation (OLTX) has dramatically improved success rates.
Sentence 4: Recently, however, we have had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD).
Sentence 5: This retrospective study examines the incidence and treatment of ESRD and chronic renal failure (CRF) in OLTX patients.
Sentence 6: METHODS: Patients receiving an OLTX only from June 1985 through December of 1994 who survived 6 months postoperatively were studied (n=834).
Sentence 7: Our prospectively collected database was the source of information.
Sentence 8: Patients were divided into three groups: Controls, no CRF or ESRD, n=748; CRF, sustained serum creatinine >2.5 mg/dl, n=41; and ESRD, n=45.
Sentence 9: Groups were compared for preoperative laboratory variables, diagnosis, postoperative variables, survival, type of ESRD therapy, and survival from onset of ESRD.
Sentence 10: RESULTS: At 13 years after OLTX, the incidence of severe renal dysfunction was 18.1% (CRF 8.6% and ESRD 9.5%).
Sentence 11: Compared with control patients, CRF and ESRD patients had higher preoperative serum creatinine levels, a greater percentage of patients with hepatorenal syndrome, higher percentage requirement for dialysis in the first 3 months postoperatively, and a higher 1-year serum creatinine.
Sentence 12: Multivariate stepwise logistic regression analysis using preoperative and postoperative variables identified that an increase of serum creatinine compared with average at 1 year, 3 months, and 4 weeks postoperatively were independent risk factors for the development of CRF or ESRD with odds ratios of 2.6, 2.2, and 1.6, respectively.
Sentence 13: Overall survival from the time of OLTX was not significantly different among groups, but by year 13, the survival of the patients who had ESRD was only 28.2% compared with 54.6% in the control group.
Sentence 14: Patients developing ESRD had a 6-year survival after onset of ESRD of 27% for the patients receiving hemodialysis versus 71.4% for the patients developing ESRD who subsequently received kidney transplants.
Sentence 15: CONCLUSIONS: Patients who are more than 10 years post-OLTX have CRF and ESRD at a high rate.
Sentence 16: The development of ESRD decreases survival, particularly in those patients treated with dialysis only.
Sentence 17: Patients who develop ESRD have a higher preoperative and 1-year serum creatinine and are more likely to have hepatorenal syndrome.
Sentence 18: However, an increase of serum creatinine at various times postoperatively is more predictive of the development of CRF or ESRD.
Sentence 19: New strategies for long-term immunosuppression may be needed to decrease this complication.
Tips for Analysis:Sentences mentioning a disease "CRF": Sentence 17, Sentence 4, Sentence 9, Sentence 18, Sentence 16, Sentence 5, Sentence 15, Sentence 1, Sentence 11
Sentences mentioning a chemical "creatinine": Sentence 17, Sentence 18, Sentence 11
Sentences mentioning both entities a disease "CRF" and a chemical "creatinine": Sentence 17, Sentence 18, Sentence 11
Task: Identify the relationship between a disease "CRF" and a chemical "creatinine" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on.
'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a chemical "cyclosporine" and a disease "nephrotoxic". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment.
- Abstract: Sentence 2: BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic.
Sentence 3: Their use in orthotopic liver transplantation (OLTX) has dramatically improved success rates.
Sentence 4: Recently, however, we have had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD).
Sentence 5: This retrospective study examines the incidence and treatment of ESRD and chronic renal failure (CRF) in OLTX patients.
Sentence 6: METHODS: Patients receiving an OLTX only from June 1985 through December of 1994 who survived 6 months postoperatively were studied (n=834).
Sentence 7: Our prospectively collected database was the source of information.
Sentence 8: Patients were divided into three groups: Controls, no CRF or ESRD, n=748; CRF, sustained serum creatinine >2.5 mg/dl, n=41; and ESRD, n=45.
Sentence 9: Groups were compared for preoperative laboratory variables, diagnosis, postoperative variables, survival, type of ESRD therapy, and survival from onset of ESRD.
Sentence 10: RESULTS: At 13 years after OLTX, the incidence of severe renal dysfunction was 18.1% (CRF 8.6% and ESRD 9.5%).
Sentence 11: Compared with control patients, CRF and ESRD patients had higher preoperative serum creatinine levels, a greater percentage of patients with hepatorenal syndrome, higher percentage requirement for dialysis in the first 3 months postoperatively, and a higher 1-year serum creatinine.
Sentence 12: Multivariate stepwise logistic regression analysis using preoperative and postoperative variables identified that an increase of serum creatinine compared with average at 1 year, 3 months, and 4 weeks postoperatively were independent risk factors for the development of CRF or ESRD with odds ratios of 2.6, 2.2, and 1.6, respectively.
Sentence 13: Overall survival from the time of OLTX was not significantly different among groups, but by year 13, the survival of the patients who had ESRD was only 28.2% compared with 54.6% in the control group.
Sentence 14: Patients developing ESRD had a 6-year survival after onset of ESRD of 27% for the patients receiving hemodialysis versus 71.4% for the patients developing ESRD who subsequently received kidney transplants.
Sentence 15: CONCLUSIONS: Patients who are more than 10 years post-OLTX have CRF and ESRD at a high rate.
Sentence 16: The development of ESRD decreases survival, particularly in those patients treated with dialysis only.
Sentence 17: Patients who develop ESRD have a higher preoperative and 1-year serum creatinine and are more likely to have hepatorenal syndrome.
Sentence 18: However, an increase of serum creatinine at various times postoperatively is more predictive of the development of CRF or ESRD.
Sentence 19: New strategies for long-term immunosuppression may be needed to decrease this complication.
Tips for Analysis:Sentences mentioning a chemical "cyclosporine": Sentence 2
Sentences mentioning a disease "nephrotoxic": Sentence 2
Sentences mentioning both entities a chemical "cyclosporine" and a disease "nephrotoxic": Sentence 2
Task: Identify the relationship between a chemical "cyclosporine" and a disease "nephrotoxic" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on.
'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a gene or protein "SOD1" and a disease "amyotrophic lateral sclerosis". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: D90A-SOD1 mediated amyotrophic lateral sclerosis: a single founder for all cases with evidence for a Cis-acting disease modifier in the recessive haplotype.
- Abstract: Sentence 2: More than 100 different heterozygous mutations in copper/zinc superoxide dismutase (SOD1) have been found in patients with amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease.
Sentence 3: Uniquely, D90A-SOD1 has been identified in recessive, dominant and apparently sporadic pedigrees.
Sentence 4: The phenotype of homozygotes is stereotyped with an extended survival, whereas that of affected heterozygotes varies.
Sentence 5: The frequency of D90A-SOD1 is 50 times higher in Scandinavia (2.5%) than elsewhere, though ALS prevalence is not raised there.
Sentence 6: Our earlier study indicated separate founders for recessive and dominant/sporadic ALS and we proposed a disease-modifying factor linked to the recessive mutation.
Sentence 7: Here we have doubled our sample set and employed novel markers to characterise the mutation's origin and localise any modifying factor.
Sentence 8: Linkage disequilibrium analysis indicates that D90A homozygotes and heterozygotes share a rare haplotype and are all descended from a single ancient founder (alpha 0.974) c.895 generations ago.
Sentence 9: Homozygotes arose subsequently only c.63 generations ago (alpha 0.878).
Sentence 10: Recombination has reduced the region shared by recessive kindreds to 97-265 kb around SOD1, excluding all neighbouring genes.
Sentence 11: We propose that a cis-acting regulatory polymorphism has arisen close to D90A-SOD1 in the recessive founder, which decreases ALS susceptibility in heterozygotes and slows disease progression.
Tips for Analysis:Sentences mentioning a gene or protein "SOD1": Sentence 1, Sentence 2, Sentence 3, Sentence 10, Sentence 11
Sentences mentioning a disease "amyotrophic lateral sclerosis": Sentence 1, Sentence 2, Sentence 6, Sentence 11
Sentences mentioning both entities a gene or protein "SOD1" and a disease "amyotrophic lateral sclerosis": Sentence 1, Sentence 2, Sentence 11
Task: Identify the relationship between a gene or protein "SOD1" and a disease "amyotrophic lateral sclerosis" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' here means that the relation between a gene and a disease is direct and increases the likelihood of the disease. This includes cases where too much protein causes the disease, removing the gene prevents the disease, or a side effect from the protein or drug results in the disease.
'Negative_Correlation' indicates that when a protein (or gene) is present, it helps to treat or prevent a disease. Conversely, the absence of this protein or the deactivation of its gene can lead to the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Association</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a variant "D90A" and a disease "ALS". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: D90A-SOD1 mediated amyotrophic lateral sclerosis: a single founder for all cases with evidence for a Cis-acting disease modifier in the recessive haplotype.
- Abstract: Sentence 2: More than 100 different heterozygous mutations in copper/zinc superoxide dismutase (SOD1) have been found in patients with amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease.
Sentence 3: Uniquely, D90A-SOD1 has been identified in recessive, dominant and apparently sporadic pedigrees.
Sentence 4: The phenotype of homozygotes is stereotyped with an extended survival, whereas that of affected heterozygotes varies.
Sentence 5: The frequency of D90A-SOD1 is 50 times higher in Scandinavia (2.5%) than elsewhere, though ALS prevalence is not raised there.
Sentence 6: Our earlier study indicated separate founders for recessive and dominant/sporadic ALS and we proposed a disease-modifying factor linked to the recessive mutation.
Sentence 7: Here we have doubled our sample set and employed novel markers to characterise the mutation's origin and localise any modifying factor.
Sentence 8: Linkage disequilibrium analysis indicates that D90A homozygotes and heterozygotes share a rare haplotype and are all descended from a single ancient founder (alpha 0.974) c.895 generations ago.
Sentence 9: Homozygotes arose subsequently only c.63 generations ago (alpha 0.878).
Sentence 10: Recombination has reduced the region shared by recessive kindreds to 97-265 kb around SOD1, excluding all neighbouring genes.
Sentence 11: We propose that a cis-acting regulatory polymorphism has arisen close to D90A-SOD1 in the recessive founder, which decreases ALS susceptibility in heterozygotes and slows disease progression.
Tips for Analysis:Sentences mentioning a variant "D90A": Sentence 1, Sentence 3, Sentence 11
Sentences mentioning a disease "ALS": Sentence 1, Sentence 2, Sentence 6, Sentence 11
Sentences mentioning both entities a variant "D90A" and a disease "ALS": Sentence 1, Sentence 11
Task: Identify the relationship between a variant "D90A" and a disease "ALS" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined. [/INST] Negative_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a gene or protein "arylsulfatase A" and a disease "metachromatic leukodystrophy". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Late-onset metachromatic leukodystrophy: molecular pathology in two siblings.
- Abstract: Sentence 2: We report on a new allele at the arylsulfatase A (ARSA) locus causing late-onset metachromatic leukodystrophy (MLD).
Sentence 3: In that allele arginine84, a residue that is highly conserved in the arylsulfatase gene family, is replaced by glutamine.
Sentence 4: In contrast to alleles that cause early-onset MLD, the arginine84 to glutamine substitution is associated with some residual ARSA activity.
Sentence 5: A comparison of genotypes, ARSA activities, and clinical data on 4 individuals carrying the allele of 81 patients with MLD examined, further validates the concept that different degrees of residual ARSA activity are the basis of phenotypical variation in MLD..
Sentence 6:
Tips for Analysis:Sentences mentioning a gene or protein "arylsulfatase A": Sentence 4, Sentence 5, Sentence 3, Sentence 2
Sentences mentioning a disease "metachromatic leukodystrophy": Sentence 4, Sentence 5, Sentence 1, Sentence 2
Sentences mentioning both entities a gene or protein "arylsulfatase A" and a disease "metachromatic leukodystrophy": Sentence 5, Sentence 4, Sentence 2
Task: Identify the relationship between a gene or protein "arylsulfatase A" and a disease "metachromatic leukodystrophy" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' here means that the relation between a gene and a disease is direct and increases the likelihood of the disease. This includes cases where too much protein causes the disease, removing the gene prevents the disease, or a side effect from the protein or drug results in the disease.
'Negative_Correlation' indicates that when a protein (or gene) is present, it helps to treat or prevent a disease. Conversely, the absence of this protein or the deactivation of its gene can lead to the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Association</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a variant "arginine84" and a disease "MLD". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Late-onset metachromatic leukodystrophy: molecular pathology in two siblings.
- Abstract: Sentence 2: We report on a new allele at the arylsulfatase A (ARSA) locus causing late-onset metachromatic leukodystrophy (MLD).
Sentence 3: In that allele arginine84, a residue that is highly conserved in the arylsulfatase gene family, is replaced by glutamine.
Sentence 4: In contrast to alleles that cause early-onset MLD, the arginine84 to glutamine substitution is associated with some residual ARSA activity.
Sentence 5: A comparison of genotypes, ARSA activities, and clinical data on 4 individuals carrying the allele of 81 patients with MLD examined, further validates the concept that different degrees of residual ARSA activity are the basis of phenotypical variation in MLD..
Sentence 6:
Tips for Analysis:Sentences mentioning a variant "arginine84": Sentence 3, Sentence 4
Sentences mentioning a disease "MLD": Sentence 4, Sentence 5, Sentence 1, Sentence 2
Sentences mentioning both entities a variant "arginine84" and a disease "MLD": Sentence 4
Task: Identify the relationship between a variant "arginine84" and a disease "MLD" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined. [/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a gene or protein "GJB2" and a disease "non-syndromic autosomal recessive deafness". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Low frequency of deafness-associated GJB2 variants in Kenya and Sudan and novel GJB2 variants.
- Abstract: Sentence 2: A large proportion of non-syndromic autosomal recessive deafness (NSARD) in many populations is caused by variants of the GJB2 gene.
Sentence 3: Here, the frequency of GJB2 variants was studied in 406 and 183 apparently unrelated children from Kenya and Sudan, respectively, with mostly severe to profound non-syndromic deafness.
Sentence 4: Nine (2.2 %) Kenyan and 12 (6.6 %) of the Sudanese children only were carriers of variants within the coding sequence of the GJB2 gene.
Sentence 5: Variants in the 5'-adjacent region were detected in further 115 individuals.
Sentence 6: A total of 10 novel variants was recognized, among them four variants in the adjacent 5'-region of the GJB2 coding exon 2 (g.3318-6T>A, g.3318-15C>T, g.3318-34C>T, g.3318-35T>G), a 6 base-pair deletion (g.3455_3460del [p.Asp46_Gln48delinsGlu]), a variant leading to a stop codon (g.3512C>A [p.Tyr65X]), synonymous variants (g.3395C>T [p.Thr26], g.3503C>T [p.Asn62], g.3627A>C [p.Arg104]), and one non-synonymous variant (g.3816C>A [p.Val167Met]).
Sentence 7: In addition, the previously described variants g.3352delG (commonly designated 30delG or 35 delG), g.3426G>A [p.Val37Ile], g.3697G>A [p.Arg127His], g.3774G>A [p.Val153Ile], and g.3795G>A [p.Gly160Ser] were identified.
Sentence 8: With the exception of g.3318-34C>T and g.3352delG, all variants occurred heterozygously.
Sentence 9: For most of the variants identified in the Kenyan and Sudanese study population, a causative association with NSARD appears to be unlikely.
Sentence 10: Compared to many other ethnic groups, deafness-associated variants of the coding region of GJB2 are rare in Sudan and Kenya, suggesting a role of other genetic, or epigenetic factors as a cause for deafness in these countries.
Tips for Analysis:Sentences mentioning a gene or protein "GJB2": Sentence 2, Sentence 10, Sentence 3, Sentence 1
Sentences mentioning a disease "non-syndromic autosomal recessive deafness": Sentence 9, Sentence 2
Sentences mentioning both entities a gene or protein "GJB2" and a disease "non-syndromic autosomal recessive deafness": Sentence 2
Task: Identify the relationship between a gene or protein "GJB2" and a disease "non-syndromic autosomal recessive deafness" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' here means that the relation between a gene and a disease is direct and increases the likelihood of the disease. This includes cases where too much protein causes the disease, removing the gene prevents the disease, or a side effect from the protein or drug results in the disease.
'Negative_Correlation' indicates that when a protein (or gene) is present, it helps to treat or prevent a disease. Conversely, the absence of this protein or the deactivation of its gene can lead to the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Association</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a variant "N157K" and a disease "autosomal dominant hypercholesterolemia". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia.
- Abstract: Sentence 2: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is at a locus for autosomal dominant hypercholesterolemia, and recent data indicate that the PCSK9 gene is involved in cholesterol biosynthesis.
Sentence 3: Mutations within this gene have previously been found to segregate with hypercholesterolemia.
Sentence 4: In this study, DNA sequencing of the 12 exons of the PCSK9 gene has been performed in 51 Norwegian subjects with a clinical diagnosis of familial hypercholesterolemia where mutations in the low-density lipoprotein receptor gene and mutation R3500Q in the apolipoprotein B-100 gene had been excluded.
Sentence 5: Two novel missense mutations were detected in the catalytic subdomain of the PCSK9 gene.
Sentence 6: Two patients were heterozygotes for D374Y, and one patient was a double heterozygote for D374Y and N157K.
Sentence 7: D374Y segregated with hypercholesterolemia in the two former families where family members were available for study.
Sentence 8: Our findings support the notion that mutations in the PCSK9 gene cause autosomal dominant hypercholesterolemia.
Tips for Analysis:Sentences mentioning a variant "N157K": Sentence 6
Sentences mentioning a disease "autosomal dominant hypercholesterolemia": Sentence 2, Sentence 8, Sentence 1
Sentences mentioning both entities a variant "N157K" and a disease "autosomal dominant hypercholesterolemia": No sentences found.
Task: Identify the relationship between a variant "N157K" and a disease "autosomal dominant hypercholesterolemia" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined. [/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a disease "autosomal dominant hypercholesterolemia" and a gene or protein "PCSK9". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia.
- Abstract: Sentence 2: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is at a locus for autosomal dominant hypercholesterolemia, and recent data indicate that the PCSK9 gene is involved in cholesterol biosynthesis.
Sentence 3: Mutations within this gene have previously been found to segregate with hypercholesterolemia.
Sentence 4: In this study, DNA sequencing of the 12 exons of the PCSK9 gene has been performed in 51 Norwegian subjects with a clinical diagnosis of familial hypercholesterolemia where mutations in the low-density lipoprotein receptor gene and mutation R3500Q in the apolipoprotein B-100 gene had been excluded.
Sentence 5: Two novel missense mutations were detected in the catalytic subdomain of the PCSK9 gene.
Sentence 6: Two patients were heterozygotes for D374Y, and one patient was a double heterozygote for D374Y and N157K.
Sentence 7: D374Y segregated with hypercholesterolemia in the two former families where family members were available for study.
Sentence 8: Our findings support the notion that mutations in the PCSK9 gene cause autosomal dominant hypercholesterolemia.
Tips for Analysis:Sentences mentioning a disease "autosomal dominant hypercholesterolemia": Sentence 2, Sentence 8, Sentence 1
Sentences mentioning a gene or protein "PCSK9": Sentence 2, Sentence 4, Sentence 8, Sentence 1, Sentence 5
Sentences mentioning both entities a disease "autosomal dominant hypercholesterolemia" and a gene or protein "PCSK9": Sentence 2, Sentence 8, Sentence 1
Task: Identify the relationship between a disease "autosomal dominant hypercholesterolemia" and a gene or protein "PCSK9" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' here means that the relation between a protein or gene and a disease is direct and increases the likelihood of the disease. This includes cases where too much protein causes the disease, removing the gene prevents the disease, or a side effect from the protein or drug results in the disease.
'Negative_Correlation' indicates that when a protein (or drug) is present, it helps to treat or prevent a disease. Conversely, the absence of this protein or the deactivation of its gene can lead to the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Association</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a gene or protein "PCSK9" and a chemical "cholesterol". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia.
- Abstract: Sentence 2: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is at a locus for autosomal dominant hypercholesterolemia, and recent data indicate that the PCSK9 gene is involved in cholesterol biosynthesis.
Sentence 3: Mutations within this gene have previously been found to segregate with hypercholesterolemia.
Sentence 4: In this study, DNA sequencing of the 12 exons of the PCSK9 gene has been performed in 51 Norwegian subjects with a clinical diagnosis of familial hypercholesterolemia where mutations in the low-density lipoprotein receptor gene and mutation R3500Q in the apolipoprotein B-100 gene had been excluded.
Sentence 5: Two novel missense mutations were detected in the catalytic subdomain of the PCSK9 gene.
Sentence 6: Two patients were heterozygotes for D374Y, and one patient was a double heterozygote for D374Y and N157K.
Sentence 7: D374Y segregated with hypercholesterolemia in the two former families where family members were available for study.
Sentence 8: Our findings support the notion that mutations in the PCSK9 gene cause autosomal dominant hypercholesterolemia.
Tips for Analysis:Sentences mentioning a gene or protein "PCSK9": Sentence 2, Sentence 4, Sentence 8, Sentence 1, Sentence 5
Sentences mentioning a chemical "cholesterol": Sentence 2
Sentences mentioning both entities a gene or protein "PCSK9" and a chemical "cholesterol": Sentence 2
Task: Identify the relationship between a gene or protein "PCSK9" and a chemical "cholesterol" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a chemical leads to higher gene expression, or higher gene expression increases sensitivity to the chemical, or a gene variant exacerbates the chemical's side effects, or a gene causes an over-response to the chemical, or there is a positive interaction between two genes in any manner.
'Negative_Correlation' indicates that a chemical leads to reduced gene expression, or higher gene expression results in decreased sensitivity or resistance to the chemical, or a gene variant offers protection against the chemical's adverse effects, or a gene contributes to resistance against the chemical, or there exists a negative interaction between two genes in any form.
'Bind' means that a chemical either connects to a gene's promoter region or a protein acts as a receptor for that chemical.
'Association' is used to describe relation that don't clearly fall under categories like positive correlation, negative correlation and bind , or when the nature of the relation lack a clear description. [/INST] Association</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a gene or protein "PCSK9" and a disease "hypercholesterolemia". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia.
- Abstract: Sentence 2: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is at a locus for autosomal dominant hypercholesterolemia, and recent data indicate that the PCSK9 gene is involved in cholesterol biosynthesis.
Sentence 3: Mutations within this gene have previously been found to segregate with hypercholesterolemia.
Sentence 4: In this study, DNA sequencing of the 12 exons of the PCSK9 gene has been performed in 51 Norwegian subjects with a clinical diagnosis of familial hypercholesterolemia where mutations in the low-density lipoprotein receptor gene and mutation R3500Q in the apolipoprotein B-100 gene had been excluded.
Sentence 5: Two novel missense mutations were detected in the catalytic subdomain of the PCSK9 gene.
Sentence 6: Two patients were heterozygotes for D374Y, and one patient was a double heterozygote for D374Y and N157K.
Sentence 7: D374Y segregated with hypercholesterolemia in the two former families where family members were available for study.
Sentence 8: Our findings support the notion that mutations in the PCSK9 gene cause autosomal dominant hypercholesterolemia.
Tips for Analysis:Sentences mentioning a gene or protein "PCSK9": Sentence 2, Sentence 4, Sentence 8, Sentence 1, Sentence 5
Sentences mentioning a disease "hypercholesterolemia": Sentence 4, Sentence 7, Sentence 3
Sentences mentioning both entities a gene or protein "PCSK9" and a disease "hypercholesterolemia": Sentence 4
Task: Identify the relationship between a gene or protein "PCSK9" and a disease "hypercholesterolemia" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' here means that the relation between a gene and a disease is direct and increases the likelihood of the disease. This includes cases where too much protein causes the disease, removing the gene prevents the disease, or a side effect from the protein or drug results in the disease.
'Negative_Correlation' indicates that when a protein (or gene) is present, it helps to treat or prevent a disease. Conversely, the absence of this protein or the deactivation of its gene can lead to the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Association</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a variant "D374Y" and a disease "autosomal dominant hypercholesterolemia". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia.
- Abstract: Sentence 2: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is at a locus for autosomal dominant hypercholesterolemia, and recent data indicate that the PCSK9 gene is involved in cholesterol biosynthesis.
Sentence 3: Mutations within this gene have previously been found to segregate with hypercholesterolemia.
Sentence 4: In this study, DNA sequencing of the 12 exons of the PCSK9 gene has been performed in 51 Norwegian subjects with a clinical diagnosis of familial hypercholesterolemia where mutations in the low-density lipoprotein receptor gene and mutation R3500Q in the apolipoprotein B-100 gene had been excluded.
Sentence 5: Two novel missense mutations were detected in the catalytic subdomain of the PCSK9 gene.
Sentence 6: Two patients were heterozygotes for D374Y, and one patient was a double heterozygote for D374Y and N157K.
Sentence 7: D374Y segregated with hypercholesterolemia in the two former families where family members were available for study.
Sentence 8: Our findings support the notion that mutations in the PCSK9 gene cause autosomal dominant hypercholesterolemia.
Tips for Analysis:Sentences mentioning a variant "D374Y": Sentence 7, Sentence 6
Sentences mentioning a disease "autosomal dominant hypercholesterolemia": Sentence 2, Sentence 8, Sentence 1
Sentences mentioning both entities a variant "D374Y" and a disease "autosomal dominant hypercholesterolemia": No sentences found.
Task: Identify the relationship between a variant "D374Y" and a disease "autosomal dominant hypercholesterolemia" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined. [/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a disease "hypercholesterolemia" and a variant "D374Y". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia.
- Abstract: Sentence 2: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is at a locus for autosomal dominant hypercholesterolemia, and recent data indicate that the PCSK9 gene is involved in cholesterol biosynthesis.
Sentence 3: Mutations within this gene have previously been found to segregate with hypercholesterolemia.
Sentence 4: In this study, DNA sequencing of the 12 exons of the PCSK9 gene has been performed in 51 Norwegian subjects with a clinical diagnosis of familial hypercholesterolemia where mutations in the low-density lipoprotein receptor gene and mutation R3500Q in the apolipoprotein B-100 gene had been excluded.
Sentence 5: Two novel missense mutations were detected in the catalytic subdomain of the PCSK9 gene.
Sentence 6: Two patients were heterozygotes for D374Y, and one patient was a double heterozygote for D374Y and N157K.
Sentence 7: D374Y segregated with hypercholesterolemia in the two former families where family members were available for study.
Sentence 8: Our findings support the notion that mutations in the PCSK9 gene cause autosomal dominant hypercholesterolemia.
Tips for Analysis:Sentences mentioning a disease "hypercholesterolemia": Sentence 4, Sentence 7, Sentence 3
Sentences mentioning a variant "D374Y": Sentence 7, Sentence 6
Sentences mentioning both entities a disease "hypercholesterolemia" and a variant "D374Y": Sentence 7
Task: Identify the relationship between a disease "hypercholesterolemia" and a variant "D374Y" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined. [/INST] Association</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a gene or protein "alpha-B crystallin" and a disease "DRM". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Desmin-related myopathy with Mallory body-like inclusions is caused by mutations of the selenoprotein N gene.
- Abstract: Sentence 2: Desmin-related myopathies (DRMs) are a heterogeneous group of muscle disorders, morphologically defined by intrasarcoplasmic aggregates of desmin.
Sentence 3: Mutations in the desmin and the alpha-B crystallin genes account for approximately one third of the DRM cases.
Sentence 4: The genetic basis of the other forms remain unknown, including the early-onset, recessive form with Mallory body-like inclusions (MB-DRMs), first described in five related German patients.
Sentence 5: Recently, we identified the selenoprotein N gene (SEPN1) as responsible for SEPN-related myopathy (SEPN-RM), a unique early-onset myopathy formerly divided in two different nosological categories: rigid spine muscular dystrophy and the severe form of classical multiminicore disease.
Sentence 6: The finding of Mallory body-like inclusions in two cases of genetically documented SEPN-RM led us to suspect a relationship between MB-DRM and SEPN1.
Sentence 7: In the original MB-DRM German family, we demonstrated a linkage of the disease to the SEPN1 locus (1p36), and subsequently a homozygous SEPN1 deletion (del 92 nucleotide -19/+73) in the affected patients.
Sentence 8: A comparative reevaluation showed that MB-DRM and SEPN-RM share identical clinical features.
Sentence 9: Therefore, we propose that MB-DRM should be categorized as SEPN-RM.
Sentence 10: These findings substantiate the molecular heterogeneity of DRM, expand the morphological spectrum of SEPN-RM, and implicate a necessary reassessment of the nosological boundaries in early-onset myopathies.
Tips for Analysis:Sentences mentioning a gene or protein "alpha-B crystallin": Sentence 3
Sentences mentioning a disease "DRM": Sentence 4, Sentence 2, Sentence 3, Sentence 1, Sentence 7, Sentence 8, Sentence 10, Sentence 6, Sentence 9
Sentences mentioning both entities a gene or protein "alpha-B crystallin" and a disease "DRM": Sentence 3
Task: Identify the relationship between a gene or protein "alpha-B crystallin" and a disease "DRM" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' here means that the relation between a gene and a disease is direct and increases the likelihood of the disease. This includes cases where too much protein causes the disease, removing the gene prevents the disease, or a side effect from the protein or drug results in the disease.
'Negative_Correlation' indicates that when a protein (or gene) is present, it helps to treat or prevent a disease. Conversely, the absence of this protein or the deactivation of its gene can lead to the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Association</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a gene or protein "desmin" and a disease "DRMs". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Desmin-related myopathy with Mallory body-like inclusions is caused by mutations of the selenoprotein N gene.
- Abstract: Sentence 2: Desmin-related myopathies (DRMs) are a heterogeneous group of muscle disorders, morphologically defined by intrasarcoplasmic aggregates of desmin.
Sentence 3: Mutations in the desmin and the alpha-B crystallin genes account for approximately one third of the DRM cases.
Sentence 4: The genetic basis of the other forms remain unknown, including the early-onset, recessive form with Mallory body-like inclusions (MB-DRMs), first described in five related German patients.
Sentence 5: Recently, we identified the selenoprotein N gene (SEPN1) as responsible for SEPN-related myopathy (SEPN-RM), a unique early-onset myopathy formerly divided in two different nosological categories: rigid spine muscular dystrophy and the severe form of classical multiminicore disease.
Sentence 6: The finding of Mallory body-like inclusions in two cases of genetically documented SEPN-RM led us to suspect a relationship between MB-DRM and SEPN1.
Sentence 7: In the original MB-DRM German family, we demonstrated a linkage of the disease to the SEPN1 locus (1p36), and subsequently a homozygous SEPN1 deletion (del 92 nucleotide -19/+73) in the affected patients.
Sentence 8: A comparative reevaluation showed that MB-DRM and SEPN-RM share identical clinical features.
Sentence 9: Therefore, we propose that MB-DRM should be categorized as SEPN-RM.
Sentence 10: These findings substantiate the molecular heterogeneity of DRM, expand the morphological spectrum of SEPN-RM, and implicate a necessary reassessment of the nosological boundaries in early-onset myopathies.
Tips for Analysis:Sentences mentioning a gene or protein "desmin": Sentence 2, Sentence 3
Sentences mentioning a disease "DRMs": Sentence 4, Sentence 2, Sentence 3, Sentence 1, Sentence 7, Sentence 8, Sentence 10, Sentence 6, Sentence 9
Sentences mentioning both entities a gene or protein "desmin" and a disease "DRMs": Sentence 2, Sentence 3
Task: Identify the relationship between a gene or protein "desmin" and a disease "DRMs" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' here means that the relation between a gene and a disease is direct and increases the likelihood of the disease. This includes cases where too much protein causes the disease, removing the gene prevents the disease, or a side effect from the protein or drug results in the disease.
'Negative_Correlation' indicates that when a protein (or gene) is present, it helps to treat or prevent a disease. Conversely, the absence of this protein or the deactivation of its gene can lead to the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Association</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a gene or protein "SEPN1" and a disease "multiminicore disease". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Desmin-related myopathy with Mallory body-like inclusions is caused by mutations of the selenoprotein N gene.
- Abstract: Sentence 2: Desmin-related myopathies (DRMs) are a heterogeneous group of muscle disorders, morphologically defined by intrasarcoplasmic aggregates of desmin.
Sentence 3: Mutations in the desmin and the alpha-B crystallin genes account for approximately one third of the DRM cases.
Sentence 4: The genetic basis of the other forms remain unknown, including the early-onset, recessive form with Mallory body-like inclusions (MB-DRMs), first described in five related German patients.
Sentence 5: Recently, we identified the selenoprotein N gene (SEPN1) as responsible for SEPN-related myopathy (SEPN-RM), a unique early-onset myopathy formerly divided in two different nosological categories: rigid spine muscular dystrophy and the severe form of classical multiminicore disease.
Sentence 6: The finding of Mallory body-like inclusions in two cases of genetically documented SEPN-RM led us to suspect a relationship between MB-DRM and SEPN1.
Sentence 7: In the original MB-DRM German family, we demonstrated a linkage of the disease to the SEPN1 locus (1p36), and subsequently a homozygous SEPN1 deletion (del 92 nucleotide -19/+73) in the affected patients.
Sentence 8: A comparative reevaluation showed that MB-DRM and SEPN-RM share identical clinical features.
Sentence 9: Therefore, we propose that MB-DRM should be categorized as SEPN-RM.
Sentence 10: These findings substantiate the molecular heterogeneity of DRM, expand the morphological spectrum of SEPN-RM, and implicate a necessary reassessment of the nosological boundaries in early-onset myopathies.
Tips for Analysis:Sentences mentioning a gene or protein "SEPN1": Sentence 1, Sentence 5, Sentence 6, Sentence 7
Sentences mentioning a disease "multiminicore disease": Sentence 5
Sentences mentioning both entities a gene or protein "SEPN1" and a disease "multiminicore disease": Sentence 5
Task: Identify the relationship between a gene or protein "SEPN1" and a disease "multiminicore disease" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' here means that the relation between a gene and a disease is direct and increases the likelihood of the disease. This includes cases where too much protein causes the disease, removing the gene prevents the disease, or a side effect from the protein or drug results in the disease.
'Negative_Correlation' indicates that when a protein (or gene) is present, it helps to treat or prevent a disease. Conversely, the absence of this protein or the deactivation of its gene can lead to the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Association</s>
|
<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a gene or protein "SEPN1" and a disease "rigid spine muscular dystrophy". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Desmin-related myopathy with Mallory body-like inclusions is caused by mutations of the selenoprotein N gene.
- Abstract: Sentence 2: Desmin-related myopathies (DRMs) are a heterogeneous group of muscle disorders, morphologically defined by intrasarcoplasmic aggregates of desmin.
Sentence 3: Mutations in the desmin and the alpha-B crystallin genes account for approximately one third of the DRM cases.
Sentence 4: The genetic basis of the other forms remain unknown, including the early-onset, recessive form with Mallory body-like inclusions (MB-DRMs), first described in five related German patients.
Sentence 5: Recently, we identified the selenoprotein N gene (SEPN1) as responsible for SEPN-related myopathy (SEPN-RM), a unique early-onset myopathy formerly divided in two different nosological categories: rigid spine muscular dystrophy and the severe form of classical multiminicore disease.
Sentence 6: The finding of Mallory body-like inclusions in two cases of genetically documented SEPN-RM led us to suspect a relationship between MB-DRM and SEPN1.
Sentence 7: In the original MB-DRM German family, we demonstrated a linkage of the disease to the SEPN1 locus (1p36), and subsequently a homozygous SEPN1 deletion (del 92 nucleotide -19/+73) in the affected patients.
Sentence 8: A comparative reevaluation showed that MB-DRM and SEPN-RM share identical clinical features.
Sentence 9: Therefore, we propose that MB-DRM should be categorized as SEPN-RM.
Sentence 10: These findings substantiate the molecular heterogeneity of DRM, expand the morphological spectrum of SEPN-RM, and implicate a necessary reassessment of the nosological boundaries in early-onset myopathies.
Tips for Analysis:Sentences mentioning a gene or protein "SEPN1": Sentence 1, Sentence 5, Sentence 6, Sentence 7
Sentences mentioning a disease "rigid spine muscular dystrophy": Sentence 5
Sentences mentioning both entities a gene or protein "SEPN1" and a disease "rigid spine muscular dystrophy": Sentence 5
Task: Identify the relationship between a gene or protein "SEPN1" and a disease "rigid spine muscular dystrophy" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' here means that the relation between a gene and a disease is direct and increases the likelihood of the disease. This includes cases where too much protein causes the disease, removing the gene prevents the disease, or a side effect from the protein or drug results in the disease.
'Negative_Correlation' indicates that when a protein (or gene) is present, it helps to treat or prevent a disease. Conversely, the absence of this protein or the deactivation of its gene can lead to the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Association</s>
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<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a gene or protein "SEPN1" and a disease "SEPN-related myopathy". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Desmin-related myopathy with Mallory body-like inclusions is caused by mutations of the selenoprotein N gene.
- Abstract: Sentence 2: Desmin-related myopathies (DRMs) are a heterogeneous group of muscle disorders, morphologically defined by intrasarcoplasmic aggregates of desmin.
Sentence 3: Mutations in the desmin and the alpha-B crystallin genes account for approximately one third of the DRM cases.
Sentence 4: The genetic basis of the other forms remain unknown, including the early-onset, recessive form with Mallory body-like inclusions (MB-DRMs), first described in five related German patients.
Sentence 5: Recently, we identified the selenoprotein N gene (SEPN1) as responsible for SEPN-related myopathy (SEPN-RM), a unique early-onset myopathy formerly divided in two different nosological categories: rigid spine muscular dystrophy and the severe form of classical multiminicore disease.
Sentence 6: The finding of Mallory body-like inclusions in two cases of genetically documented SEPN-RM led us to suspect a relationship between MB-DRM and SEPN1.
Sentence 7: In the original MB-DRM German family, we demonstrated a linkage of the disease to the SEPN1 locus (1p36), and subsequently a homozygous SEPN1 deletion (del 92 nucleotide -19/+73) in the affected patients.
Sentence 8: A comparative reevaluation showed that MB-DRM and SEPN-RM share identical clinical features.
Sentence 9: Therefore, we propose that MB-DRM should be categorized as SEPN-RM.
Sentence 10: These findings substantiate the molecular heterogeneity of DRM, expand the morphological spectrum of SEPN-RM, and implicate a necessary reassessment of the nosological boundaries in early-onset myopathies.
Tips for Analysis:Sentences mentioning a gene or protein "SEPN1": Sentence 1, Sentence 5, Sentence 6, Sentence 7
Sentences mentioning a disease "SEPN-related myopathy": Sentence 2, Sentence 5, Sentence 8, Sentence 10, Sentence 6, Sentence 9
Sentences mentioning both entities a gene or protein "SEPN1" and a disease "SEPN-related myopathy": Sentence 5, Sentence 6
Task: Identify the relationship between a gene or protein "SEPN1" and a disease "SEPN-related myopathy" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' here means that the relation between a gene and a disease is direct and increases the likelihood of the disease. This includes cases where too much protein causes the disease, removing the gene prevents the disease, or a side effect from the protein or drug results in the disease.
'Negative_Correlation' indicates that when a protein (or gene) is present, it helps to treat or prevent a disease. Conversely, the absence of this protein or the deactivation of its gene can lead to the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Association</s>
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<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a disease "DRM" and a variant "del 92 nucleotide -19/+73". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Desmin-related myopathy with Mallory body-like inclusions is caused by mutations of the selenoprotein N gene.
- Abstract: Sentence 2: Desmin-related myopathies (DRMs) are a heterogeneous group of muscle disorders, morphologically defined by intrasarcoplasmic aggregates of desmin.
Sentence 3: Mutations in the desmin and the alpha-B crystallin genes account for approximately one third of the DRM cases.
Sentence 4: The genetic basis of the other forms remain unknown, including the early-onset, recessive form with Mallory body-like inclusions (MB-DRMs), first described in five related German patients.
Sentence 5: Recently, we identified the selenoprotein N gene (SEPN1) as responsible for SEPN-related myopathy (SEPN-RM), a unique early-onset myopathy formerly divided in two different nosological categories: rigid spine muscular dystrophy and the severe form of classical multiminicore disease.
Sentence 6: The finding of Mallory body-like inclusions in two cases of genetically documented SEPN-RM led us to suspect a relationship between MB-DRM and SEPN1.
Sentence 7: In the original MB-DRM German family, we demonstrated a linkage of the disease to the SEPN1 locus (1p36), and subsequently a homozygous SEPN1 deletion (del 92 nucleotide -19/+73) in the affected patients.
Sentence 8: A comparative reevaluation showed that MB-DRM and SEPN-RM share identical clinical features.
Sentence 9: Therefore, we propose that MB-DRM should be categorized as SEPN-RM.
Sentence 10: These findings substantiate the molecular heterogeneity of DRM, expand the morphological spectrum of SEPN-RM, and implicate a necessary reassessment of the nosological boundaries in early-onset myopathies.
Tips for Analysis:Sentences mentioning a disease "DRM": Sentence 4, Sentence 2, Sentence 3, Sentence 1, Sentence 7, Sentence 8, Sentence 10, Sentence 6, Sentence 9
Sentences mentioning a variant "del 92 nucleotide -19/+73": Sentence 7
Sentences mentioning both entities a disease "DRM" and a variant "del 92 nucleotide -19/+73": Sentence 7
Task: Identify the relationship between a disease "DRM" and a variant "del 92 nucleotide -19/+73" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined. [/INST] Positive_Correlation</s>
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<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a disease "Desmin-related myopathy" and a gene or protein "selenoprotein N". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Desmin-related myopathy with Mallory body-like inclusions is caused by mutations of the selenoprotein N gene.
- Abstract: Sentence 2: Desmin-related myopathies (DRMs) are a heterogeneous group of muscle disorders, morphologically defined by intrasarcoplasmic aggregates of desmin.
Sentence 3: Mutations in the desmin and the alpha-B crystallin genes account for approximately one third of the DRM cases.
Sentence 4: The genetic basis of the other forms remain unknown, including the early-onset, recessive form with Mallory body-like inclusions (MB-DRMs), first described in five related German patients.
Sentence 5: Recently, we identified the selenoprotein N gene (SEPN1) as responsible for SEPN-related myopathy (SEPN-RM), a unique early-onset myopathy formerly divided in two different nosological categories: rigid spine muscular dystrophy and the severe form of classical multiminicore disease.
Sentence 6: The finding of Mallory body-like inclusions in two cases of genetically documented SEPN-RM led us to suspect a relationship between MB-DRM and SEPN1.
Sentence 7: In the original MB-DRM German family, we demonstrated a linkage of the disease to the SEPN1 locus (1p36), and subsequently a homozygous SEPN1 deletion (del 92 nucleotide -19/+73) in the affected patients.
Sentence 8: A comparative reevaluation showed that MB-DRM and SEPN-RM share identical clinical features.
Sentence 9: Therefore, we propose that MB-DRM should be categorized as SEPN-RM.
Sentence 10: These findings substantiate the molecular heterogeneity of DRM, expand the morphological spectrum of SEPN-RM, and implicate a necessary reassessment of the nosological boundaries in early-onset myopathies.
Tips for Analysis:Sentences mentioning a disease "Desmin-related myopathy": Sentence 4, Sentence 2, Sentence 3, Sentence 1, Sentence 7, Sentence 8, Sentence 10, Sentence 6, Sentence 9
Sentences mentioning a gene or protein "selenoprotein N": Sentence 1, Sentence 5, Sentence 6, Sentence 7
Sentences mentioning both entities a disease "Desmin-related myopathy" and a gene or protein "selenoprotein N": Sentence 1, Sentence 7, Sentence 6
Task: Identify the relationship between a disease "Desmin-related myopathy" and a gene or protein "selenoprotein N" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' here means that the relation between a protein or gene and a disease is direct and increases the likelihood of the disease. This includes cases where too much protein causes the disease, removing the gene prevents the disease, or a side effect from the protein or drug results in the disease.
'Negative_Correlation' indicates that when a protein (or drug) is present, it helps to treat or prevent a disease. Conversely, the absence of this protein or the deactivation of its gene can lead to the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Association</s>
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<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a gene or protein "Tuple1" and a disease "DiGeorge and Velocardiofacial syndromes". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Altered replication timing of the HIRA/Tuple1 locus in the DiGeorge and Velocardiofacial syndromes.
- Abstract: Sentence 2: DiGeorge and Velocardiofacial syndromes (DGS/VCFS) are endowed by a similar complex phenotype including cardiovascular, craniofacial, and thymic malformations, and are associated with heterozygous deletions of 22q11 chromosomal band.
Sentence 3: The Typically Deleted Region in the 22q11.21 subband (here called TDR22) is very gene-dense, and the extent of the deletion has been defined precisely in several studies.
Sentence 4: However, to date there is no evidence for a mechanism of haploinsufficiency that can fully explain the DGS/VCFS phenotype.
Sentence 5: In this study, we show that the candidate gene HIRA/Tuple1 mapping on the non-deleted TDR22, in DGS/VCFS subjects presents a delayed replication timing.
Sentence 6: Moreover, we observed an increase in the cell ratio showing the HIRA/Tuple1 locus localised toward the nuclear periphery.
Sentence 7: It is known that replication timing and nuclear location are generally correlated to the transcription activity of the relative DNA region.
Sentence 8: We propose that the alteration in the replication/nuclear location pattern of the non-deleted TDR22 indicates an altered gene regulation hence an altered transcritpion in DGS/VCFS.
Tips for Analysis:Sentences mentioning a gene or protein "Tuple1": Sentence 5, Sentence 1, Sentence 6
Sentences mentioning a disease "DiGeorge and Velocardiofacial syndromes": Sentence 4, Sentence 5, Sentence 2, Sentence 8, Sentence 1
Sentences mentioning both entities a gene or protein "Tuple1" and a disease "DiGeorge and Velocardiofacial syndromes": Sentence 5, Sentence 1
Task: Identify the relationship between a gene or protein "Tuple1" and a disease "DiGeorge and Velocardiofacial syndromes" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' here means that the relation between a gene and a disease is direct and increases the likelihood of the disease. This includes cases where too much protein causes the disease, removing the gene prevents the disease, or a side effect from the protein or drug results in the disease.
'Negative_Correlation' indicates that when a protein (or gene) is present, it helps to treat or prevent a disease. Conversely, the absence of this protein or the deactivation of its gene can lead to the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Association</s>
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<s>[INST] <<SYS>>
Your task involves analyzing the title and abstract of a medical article to determine the relationship between two specified entities: a chemical "Catecholamine" and a disease "cardiomyopathy". Follow the context and analysis tips provided to assist in your response.
<</SYS>>
Context:
- Title: Sentence 1: Severe reversible left ventricular systolic and diastolic dysfunction due to accidental iatrogenic epinephrine overdose.
- Abstract: Sentence 2: Catecholamine-induced cardiomyopathy due to chronic excess of endogenous catecholamines has been recognized for decades as a clinical phenomenon.
Sentence 3: In contrast, reports of myocardial dysfunction due to acute iatrogenic overdose are rare.
Sentence 4: A 35-year-old woman whose cervix uteri was inadvertently injected with 8 mg of epinephrine developed myocardial stunning that was characterized by severe hemodynamic compromise, profound, albeit transient, left ventricular systolic and diastolic dysfunction, and only modestly elevated biochemical markers of myocardial necrosis.
Sentence 5: Our case illustrates the serious consequences of medical errors that can be avoided through improved medication labeling and staff supervision.
Tips for Analysis:Sentences mentioning a chemical "Catecholamine": Sentence 2
Sentences mentioning a disease "cardiomyopathy": Sentence 2, Sentence 3, Sentence 4
Sentences mentioning both entities a chemical "Catecholamine" and a disease "cardiomyopathy": Sentence 2
Task: Identify the relationship between a chemical "Catecholamine" and a disease "cardiomyopathy" using the analysis tips. Select from the options: ['Positive_Correlation', 'Negative_Correlation', 'Association']. Your choice should be based on the context and tips provided.
Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on.
'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. [/INST] Positive_Correlation</s>
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