data
stringlengths 2.77k
11.7k
|
|---|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a gene or protein [Hepatocyte nuclear factor-6] and a disease [type II diabetes]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion.
- Abstract of the Paper: The transcription factor hepatocyte nuclear factor (HNF)-6 is an upstream regulator of several genes involved in the pathogenesis of maturity-onset diabetes of the young. We therefore tested the hypothesis that variability in the HNF-6 gene is associated with subsets of Type II (non-insulin-dependent) diabetes mellitus and estimates of insulin secretion in glucose tolerant subjects. We cloned the coding region as well as the intron-exon boundaries of the HNF-6 gene. We then examined them on genomic DNA in six MODY probands without mutations in the MODY1, MODY3 and MODY4 genes and in 54 patients with late-onset Type II diabetes by combined single strand conformational polymorphism-heteroduplex analysis followed by direct sequencing of identified variants. An identified missense variant was examined in association studies and genotype-phenotype studies. We identified two silent and one missense (Pro75 Ala) variant. In an association study the allelic frequency of the Pro75Ala polymorphism was 3.2% (95% confidence interval, 1.9-4.5) in 330 patients with Type II diabetes mellitus compared with 4.2% (2.4-6.0) in 238 age-matched glucose tolerant control subjects. Moreover, in studies of 238 middle-aged glucose tolerant subjects, of 226 glucose tolerant offspring of Type II diabetic patients and of 367 young healthy subjects, the carriers of the polymorphism did not differ from non-carriers in glucose induced serum insulin or C-peptide responses. Mutations in the coding region of the HNF-6 gene are not associated with Type II diabetes or with changes in insulin responses to glucose among the Caucasians examined.
Which sentences in the title and abstract that mention a gene or protein [Hepatocyte nuclear factor-6]? [/INST] 1. The transcription factor hepatocyte nuclear factor (HNF)-6 is an upstream regulator of several genes involved in the pathogenesis of maturity-onset diabetes of the young. 2. We cloned the coding region as well as the intron-exon boundaries of the HNF-6 gene. 3. Mutations in the coding region of the HNF-6 gene are not associated with Type II diabetes or with changes in insulin responses to glucose among the Caucasians examined. 4. We therefore tested the hypothesis that variability in the HNF-6 gene is associated with subsets of Type II (non-insulin-dependent) diabetes mellitus and estimates of insulin secretion in glucose tolerant subjects. 5. Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [type II diabetes]? [/INST] 1. The transcription factor hepatocyte nuclear factor (HNF)-6 is an upstream regulator of several genes involved in the pathogenesis of maturity-onset diabetes of the young. 2. In an association study the allelic frequency of the Pro75Ala polymorphism was 3.2% (95% confidence interval, 1.9-4.5) in 330 patients with Type II diabetes mellitus compared with 4.2% (2.4-6.0) in 238 age-matched glucose tolerant control subjects. 3. Mutations in the coding region of the HNF-6 gene are not associated with Type II diabetes or with changes in insulin responses to glucose among the Caucasians examined. 4. We then examined them on genomic DNA in six MODY probands without mutations in the MODY1, MODY3 and MODY4 genes and in 54 patients with late-onset Type II diabetes by combined single strand conformational polymorphism-heteroduplex analysis followed by direct sequencing of identified variants. 5. Moreover, in studies of 238 middle-aged glucose tolerant subjects, of 226 glucose tolerant offspring of Type II diabetic patients and of 367 young healthy subjects, the carriers of the polymorphism did not differ from non-carriers in glucose induced serum insulin or C-peptide responses. 6. We therefore tested the hypothesis that variability in the HNF-6 gene is associated with subsets of Type II (non-insulin-dependent) diabetes mellitus and estimates of insulin secretion in glucose tolerant subjects. 7. Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion.</s>\ <s>[INST] Which sentences mention both the entities a gene or protein [Hepatocyte nuclear factor-6] and a disease [type II diabetes]? [/INST] 1. The transcription factor hepatocyte nuclear factor (HNF)-6 is an upstream regulator of several genes involved in the pathogenesis of maturity-onset diabetes of the young. 2. We therefore tested the hypothesis that variability in the HNF-6 gene is associated with subsets of Type II (non-insulin-dependent) diabetes mellitus and estimates of insulin secretion in glucose tolerant subjects. 3. Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion. 4. Mutations in the coding region of the HNF-6 gene are not associated with Type II diabetes or with changes in insulin responses to glucose among the Caucasians examined.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the gene or protein [Hepatocyte nuclear factor-6] and the disease [type II diabetes]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' here means that the relation between a gene and a disease is direct and increases the likelihood of the disease. This includes cases where too much protein causes the disease, removing the gene prevents the disease, or a side effect from the protein or drug results in the disease.
'Negative_Correlation' indicates that when a protein (or gene) is present, it helps to treat or prevent a disease. Conversely, the absence of this protein or the deactivation of its gene can lead to the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Association</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [glucose] and a gene or protein [insulin]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion.
- Abstract of the Paper: The transcription factor hepatocyte nuclear factor (HNF)-6 is an upstream regulator of several genes involved in the pathogenesis of maturity-onset diabetes of the young. We therefore tested the hypothesis that variability in the HNF-6 gene is associated with subsets of Type II (non-insulin-dependent) diabetes mellitus and estimates of insulin secretion in glucose tolerant subjects. We cloned the coding region as well as the intron-exon boundaries of the HNF-6 gene. We then examined them on genomic DNA in six MODY probands without mutations in the MODY1, MODY3 and MODY4 genes and in 54 patients with late-onset Type II diabetes by combined single strand conformational polymorphism-heteroduplex analysis followed by direct sequencing of identified variants. An identified missense variant was examined in association studies and genotype-phenotype studies. We identified two silent and one missense (Pro75 Ala) variant. In an association study the allelic frequency of the Pro75Ala polymorphism was 3.2% (95% confidence interval, 1.9-4.5) in 330 patients with Type II diabetes mellitus compared with 4.2% (2.4-6.0) in 238 age-matched glucose tolerant control subjects. Moreover, in studies of 238 middle-aged glucose tolerant subjects, of 226 glucose tolerant offspring of Type II diabetic patients and of 367 young healthy subjects, the carriers of the polymorphism did not differ from non-carriers in glucose induced serum insulin or C-peptide responses. Mutations in the coding region of the HNF-6 gene are not associated with Type II diabetes or with changes in insulin responses to glucose among the Caucasians examined.
Which sentences in the title and abstract that mention a chemical [glucose]? [/INST] 1. We therefore tested the hypothesis that variability in the HNF-6 gene is associated with subsets of Type II (non-insulin-dependent) diabetes mellitus and estimates of insulin secretion in glucose tolerant subjects. 2. In an association study the allelic frequency of the Pro75Ala polymorphism was 3.2% (95% confidence interval, 1.9-4.5) in 330 patients with Type II diabetes mellitus compared with 4.2% (2.4-6.0) in 238 age-matched glucose tolerant control subjects. 3. Moreover, in studies of 238 middle-aged glucose tolerant subjects, of 226 glucose tolerant offspring of Type II diabetic patients and of 367 young healthy subjects, the carriers of the polymorphism did not differ from non-carriers in glucose induced serum insulin or C-peptide responses. 4. Mutations in the coding region of the HNF-6 gene are not associated with Type II diabetes or with changes in insulin responses to glucose among the Caucasians examined.</s>\ <s>[INST] Which sentences in the title and abstract that mention a gene or protein [insulin]? [/INST] 1. We therefore tested the hypothesis that variability in the HNF-6 gene is associated with subsets of Type II (non-insulin-dependent) diabetes mellitus and estimates of insulin secretion in glucose tolerant subjects. 2. Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion. 3. Moreover, in studies of 238 middle-aged glucose tolerant subjects, of 226 glucose tolerant offspring of Type II diabetic patients and of 367 young healthy subjects, the carriers of the polymorphism did not differ from non-carriers in glucose induced serum insulin or C-peptide responses. 4. Mutations in the coding region of the HNF-6 gene are not associated with Type II diabetes or with changes in insulin responses to glucose among the Caucasians examined.</s>\ <s>[INST] Which sentences mention both the entities a chemical [glucose] and a gene or protein [insulin]? [/INST] 1. We therefore tested the hypothesis that variability in the HNF-6 gene is associated with subsets of Type II (non-insulin-dependent) diabetes mellitus and estimates of insulin secretion in glucose tolerant subjects. 2. Moreover, in studies of 238 middle-aged glucose tolerant subjects, of 226 glucose tolerant offspring of Type II diabetic patients and of 367 young healthy subjects, the carriers of the polymorphism did not differ from non-carriers in glucose induced serum insulin or C-peptide responses. 3. Mutations in the coding region of the HNF-6 gene are not associated with Type II diabetes or with changes in insulin responses to glucose among the Caucasians examined.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [glucose] and the gene or protein [insulin]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association']
Option Descriptions:'Positive_Correlation' means that a chemical leads to higher gene expression, or higher gene expression increases sensitivity to the chemical, or a gene variant exacerbates the chemical's side effects, or a gene causes an over-response to the chemical, or there is a positive interaction between two genes in any manner.
'Negative_Correlation' indicates that a chemical leads to reduced gene expression, or higher gene expression results in decreased sensitivity or resistance to the chemical, or a gene variant offers protection against the chemical's adverse effects, or a gene contributes to resistance against the chemical, or there exists a negative interaction between two genes in any form.
'Bind' means that a chemical either connects to a gene's promoter region or a protein acts as a receptor for that chemical.
'Association' is used to describe relation that don't clearly fall under categories like positive correlation, negative correlation and bind , or when the nature of the relation lack a clear description.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [glucose] and a disease [Type II diabetes mellitus]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion.
- Abstract of the Paper: The transcription factor hepatocyte nuclear factor (HNF)-6 is an upstream regulator of several genes involved in the pathogenesis of maturity-onset diabetes of the young. We therefore tested the hypothesis that variability in the HNF-6 gene is associated with subsets of Type II (non-insulin-dependent) diabetes mellitus and estimates of insulin secretion in glucose tolerant subjects. We cloned the coding region as well as the intron-exon boundaries of the HNF-6 gene. We then examined them on genomic DNA in six MODY probands without mutations in the MODY1, MODY3 and MODY4 genes and in 54 patients with late-onset Type II diabetes by combined single strand conformational polymorphism-heteroduplex analysis followed by direct sequencing of identified variants. An identified missense variant was examined in association studies and genotype-phenotype studies. We identified two silent and one missense (Pro75 Ala) variant. In an association study the allelic frequency of the Pro75Ala polymorphism was 3.2% (95% confidence interval, 1.9-4.5) in 330 patients with Type II diabetes mellitus compared with 4.2% (2.4-6.0) in 238 age-matched glucose tolerant control subjects. Moreover, in studies of 238 middle-aged glucose tolerant subjects, of 226 glucose tolerant offspring of Type II diabetic patients and of 367 young healthy subjects, the carriers of the polymorphism did not differ from non-carriers in glucose induced serum insulin or C-peptide responses. Mutations in the coding region of the HNF-6 gene are not associated with Type II diabetes or with changes in insulin responses to glucose among the Caucasians examined.
Which sentences in the title and abstract that mention a chemical [glucose]? [/INST] 1. We therefore tested the hypothesis that variability in the HNF-6 gene is associated with subsets of Type II (non-insulin-dependent) diabetes mellitus and estimates of insulin secretion in glucose tolerant subjects. 2. In an association study the allelic frequency of the Pro75Ala polymorphism was 3.2% (95% confidence interval, 1.9-4.5) in 330 patients with Type II diabetes mellitus compared with 4.2% (2.4-6.0) in 238 age-matched glucose tolerant control subjects. 3. Moreover, in studies of 238 middle-aged glucose tolerant subjects, of 226 glucose tolerant offspring of Type II diabetic patients and of 367 young healthy subjects, the carriers of the polymorphism did not differ from non-carriers in glucose induced serum insulin or C-peptide responses. 4. Mutations in the coding region of the HNF-6 gene are not associated with Type II diabetes or with changes in insulin responses to glucose among the Caucasians examined.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [Type II diabetes mellitus]? [/INST] 1. The transcription factor hepatocyte nuclear factor (HNF)-6 is an upstream regulator of several genes involved in the pathogenesis of maturity-onset diabetes of the young. 2. In an association study the allelic frequency of the Pro75Ala polymorphism was 3.2% (95% confidence interval, 1.9-4.5) in 330 patients with Type II diabetes mellitus compared with 4.2% (2.4-6.0) in 238 age-matched glucose tolerant control subjects. 3. Mutations in the coding region of the HNF-6 gene are not associated with Type II diabetes or with changes in insulin responses to glucose among the Caucasians examined. 4. We then examined them on genomic DNA in six MODY probands without mutations in the MODY1, MODY3 and MODY4 genes and in 54 patients with late-onset Type II diabetes by combined single strand conformational polymorphism-heteroduplex analysis followed by direct sequencing of identified variants. 5. Moreover, in studies of 238 middle-aged glucose tolerant subjects, of 226 glucose tolerant offspring of Type II diabetic patients and of 367 young healthy subjects, the carriers of the polymorphism did not differ from non-carriers in glucose induced serum insulin or C-peptide responses. 6. We therefore tested the hypothesis that variability in the HNF-6 gene is associated with subsets of Type II (non-insulin-dependent) diabetes mellitus and estimates of insulin secretion in glucose tolerant subjects. 7. Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion.</s>\ <s>[INST] Which sentences mention both the entities a chemical [glucose] and a disease [Type II diabetes mellitus]? [/INST] 1. We therefore tested the hypothesis that variability in the HNF-6 gene is associated with subsets of Type II (non-insulin-dependent) diabetes mellitus and estimates of insulin secretion in glucose tolerant subjects. 2. In an association study the allelic frequency of the Pro75Ala polymorphism was 3.2% (95% confidence interval, 1.9-4.5) in 330 patients with Type II diabetes mellitus compared with 4.2% (2.4-6.0) in 238 age-matched glucose tolerant control subjects. 3. Moreover, in studies of 238 middle-aged glucose tolerant subjects, of 226 glucose tolerant offspring of Type II diabetic patients and of 367 young healthy subjects, the carriers of the polymorphism did not differ from non-carriers in glucose induced serum insulin or C-peptide responses. 4. Mutations in the coding region of the HNF-6 gene are not associated with Type II diabetes or with changes in insulin responses to glucose among the Caucasians examined.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [glucose] and the disease [Type II diabetes mellitus]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on.
'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Association</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a gene or protein [type II Ca2+-dependent lectin] and a chemical [mannose]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules.
- Abstract of the Paper: We have identified a type II Ca2+-dependent lectin displaying mannose-binding specificity, exclusively expressed by Langerhans cells (LC), and named Langerin. LC are uniquely characterized by Birbeck granules (BG), which are organelles consisting of superimposed and zippered membranes. Here, we have shown that Langerin is constitutively associated with BG and that antibody to Langerin is internalized into these structures. Remarkably, transfection of Langerin cDNA into fibroblasts created a compact network of membrane structures with typical features of BG. Langerin is thus a potent inducer of membrane superimposition and zippering leading to BG formation. Our data suggest that induction of BG is a consequence of the antigen-capture function of Langerin, allowing routing into these organelles and providing access to a nonclassical antigen-processing pathway.
Which sentences in the title and abstract that mention a gene or protein [type II Ca2+-dependent lectin]? [/INST] 1. Remarkably, transfection of Langerin cDNA into fibroblasts created a compact network of membrane structures with typical features of BG. 2. Our data suggest that induction of BG is a consequence of the antigen-capture function of Langerin, allowing routing into these organelles and providing access to a nonclassical antigen-processing pathway. 3. Langerin is thus a potent inducer of membrane superimposition and zippering leading to BG formation. 4. Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. 5. Here, we have shown that Langerin is constitutively associated with BG and that antibody to Langerin is internalized into these structures. 6. We have identified a type II Ca2+-dependent lectin displaying mannose-binding specificity, exclusively expressed by Langerhans cells (LC), and named Langerin.</s>\ <s>[INST] Which sentences in the title and abstract that mention a chemical [mannose]? [/INST] 1. We have identified a type II Ca2+-dependent lectin displaying mannose-binding specificity, exclusively expressed by Langerhans cells (LC), and named Langerin.</s>\ <s>[INST] Which sentences mention both the entities a gene or protein [type II Ca2+-dependent lectin] and a chemical [mannose]? [/INST] 1. We have identified a type II Ca2+-dependent lectin displaying mannose-binding specificity, exclusively expressed by Langerhans cells (LC), and named Langerin.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the gene or protein [type II Ca2+-dependent lectin] and the chemical [mannose]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association']
Option Descriptions:'Positive_Correlation' means that a chemical leads to higher gene expression, or higher gene expression increases sensitivity to the chemical, or a gene variant exacerbates the chemical's side effects, or a gene causes an over-response to the chemical, or there is a positive interaction between two genes in any manner.
'Negative_Correlation' indicates that a chemical leads to reduced gene expression, or higher gene expression results in decreased sensitivity or resistance to the chemical, or a gene variant offers protection against the chemical's adverse effects, or a gene contributes to resistance against the chemical, or there exists a negative interaction between two genes in any form.
'Bind' means that a chemical either connects to a gene's promoter region or a protein acts as a receptor for that chemical.
'Association' is used to describe relation that don't clearly fall under categories like positive correlation, negative correlation and bind , or when the nature of the relation lack a clear description.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Bind</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a disease [breast cancer] and a variant [5382insC]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract of the Paper: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years. A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only. Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family. The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants. Mutations were found in 35 (53%) of the 66 families studied. All but one of the mutations were detected within the BRCA1 gene. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome. Seven distinct mutations were identified; five of these occurred in two or more families. In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Which sentences in the title and abstract that mention a disease [breast cancer]? [/INST] 1. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. 2. A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only.</s>\ <s>[INST] Which sentences in the title and abstract that mention a variant [5382insC]? [/INST] 1. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..</s>\ <s>[INST] Which sentences mention both the entities a disease [breast cancer] and a variant [5382insC]? [/INST] There is no sentence that contains both these two entities.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the disease [breast cancer] and the variant [5382insC]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a disease [breast cancer] and a variant [4153delA]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract of the Paper: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years. A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only. Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family. The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants. Mutations were found in 35 (53%) of the 66 families studied. All but one of the mutations were detected within the BRCA1 gene. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome. Seven distinct mutations were identified; five of these occurred in two or more families. In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Which sentences in the title and abstract that mention a disease [breast cancer]? [/INST] 1. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. 2. A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only.</s>\ <s>[INST] Which sentences in the title and abstract that mention a variant [4153delA]? [/INST] 1. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..</s>\ <s>[INST] Which sentences mention both the entities a disease [breast cancer] and a variant [4153delA]? [/INST] There is no sentence that contains both these two entities.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the disease [breast cancer] and the variant [4153delA]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a disease [breast cancer] and a variant [C61G]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract of the Paper: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years. A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only. Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family. The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants. Mutations were found in 35 (53%) of the 66 families studied. All but one of the mutations were detected within the BRCA1 gene. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome. Seven distinct mutations were identified; five of these occurred in two or more families. In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Which sentences in the title and abstract that mention a disease [breast cancer]? [/INST] 1. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. 2. A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only.</s>\ <s>[INST] Which sentences in the title and abstract that mention a variant [C61G]? [/INST] 1. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..</s>\ <s>[INST] Which sentences mention both the entities a disease [breast cancer] and a variant [C61G]? [/INST] There is no sentence that contains both these two entities.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the disease [breast cancer] and the variant [C61G]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a disease [ovarian cancer] and a variant [5382insC]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract of the Paper: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years. A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only. Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family. The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants. Mutations were found in 35 (53%) of the 66 families studied. All but one of the mutations were detected within the BRCA1 gene. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome. Seven distinct mutations were identified; five of these occurred in two or more families. In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Which sentences in the title and abstract that mention a disease [ovarian cancer]? [/INST] 1. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. 2. A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only.</s>\ <s>[INST] Which sentences in the title and abstract that mention a variant [5382insC]? [/INST] 1. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..</s>\ <s>[INST] Which sentences mention both the entities a disease [ovarian cancer] and a variant [5382insC]? [/INST] There is no sentence that contains both these two entities.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the disease [ovarian cancer] and the variant [5382insC]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a disease [ovarian cancer] and a variant [4153delA]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract of the Paper: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years. A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only. Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family. The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants. Mutations were found in 35 (53%) of the 66 families studied. All but one of the mutations were detected within the BRCA1 gene. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome. Seven distinct mutations were identified; five of these occurred in two or more families. In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Which sentences in the title and abstract that mention a disease [ovarian cancer]? [/INST] 1. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. 2. A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only.</s>\ <s>[INST] Which sentences in the title and abstract that mention a variant [4153delA]? [/INST] 1. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..</s>\ <s>[INST] Which sentences mention both the entities a disease [ovarian cancer] and a variant [4153delA]? [/INST] There is no sentence that contains both these two entities.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the disease [ovarian cancer] and the variant [4153delA]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a disease [ovarian cancer] and a variant [C61G]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract of the Paper: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years. A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only. Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family. The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants. Mutations were found in 35 (53%) of the 66 families studied. All but one of the mutations were detected within the BRCA1 gene. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome. Seven distinct mutations were identified; five of these occurred in two or more families. In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Which sentences in the title and abstract that mention a disease [ovarian cancer]? [/INST] 1. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. 2. A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only.</s>\ <s>[INST] Which sentences in the title and abstract that mention a variant [C61G]? [/INST] 1. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..</s>\ <s>[INST] Which sentences mention both the entities a disease [ovarian cancer] and a variant [C61G]? [/INST] There is no sentence that contains both these two entities.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the disease [ovarian cancer] and the variant [C61G]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a variant [5382insC] and a disease [breast-ovarian cancer syndrome]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract of the Paper: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years. A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only. Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family. The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants. Mutations were found in 35 (53%) of the 66 families studied. All but one of the mutations were detected within the BRCA1 gene. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome. Seven distinct mutations were identified; five of these occurred in two or more families. In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Which sentences in the title and abstract that mention a variant [5382insC]? [/INST] 1. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [breast-ovarian cancer syndrome]? [/INST] 1. The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome. 2. Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.</s>\ <s>[INST] Which sentences mention both the entities a variant [5382insC] and a disease [breast-ovarian cancer syndrome]? [/INST] There is no sentence that contains both these two entities.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the variant [5382insC] and the disease [breast-ovarian cancer syndrome]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a variant [4153delA] and a disease [breast-ovarian cancer syndrome]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract of the Paper: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years. A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only. Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family. The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants. Mutations were found in 35 (53%) of the 66 families studied. All but one of the mutations were detected within the BRCA1 gene. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome. Seven distinct mutations were identified; five of these occurred in two or more families. In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Which sentences in the title and abstract that mention a variant [4153delA]? [/INST] 1. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [breast-ovarian cancer syndrome]? [/INST] 1. The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome. 2. Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.</s>\ <s>[INST] Which sentences mention both the entities a variant [4153delA] and a disease [breast-ovarian cancer syndrome]? [/INST] There is no sentence that contains both these two entities.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the variant [4153delA] and the disease [breast-ovarian cancer syndrome]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a variant [C61G] and a disease [breast-ovarian cancer syndrome]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract of the Paper: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years. A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only. Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family. The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants. Mutations were found in 35 (53%) of the 66 families studied. All but one of the mutations were detected within the BRCA1 gene. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome. Seven distinct mutations were identified; five of these occurred in two or more families. In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Which sentences in the title and abstract that mention a variant [C61G]? [/INST] 1. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [breast-ovarian cancer syndrome]? [/INST] 1. The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome. 2. Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.</s>\ <s>[INST] Which sentences mention both the entities a variant [C61G] and a disease [breast-ovarian cancer syndrome]? [/INST] There is no sentence that contains both these two entities.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the variant [C61G] and the disease [breast-ovarian cancer syndrome]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a disease [BRCA1 abnormalities] and a variant [5382insC]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract of the Paper: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years. A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only. Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family. The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants. Mutations were found in 35 (53%) of the 66 families studied. All but one of the mutations were detected within the BRCA1 gene. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome. Seven distinct mutations were identified; five of these occurred in two or more families. In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Which sentences in the title and abstract that mention a disease [BRCA1 abnormalities]? [/INST] 1. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. 2. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..</s>\ <s>[INST] Which sentences in the title and abstract that mention a variant [5382insC]? [/INST] 1. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..</s>\ <s>[INST] Which sentences mention both the entities a disease [BRCA1 abnormalities] and a variant [5382insC]? [/INST] 1. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the disease [BRCA1 abnormalities] and the variant [5382insC]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a disease [BRCA1 abnormalities] and a variant [4153delA]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract of the Paper: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years. A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only. Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family. The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants. Mutations were found in 35 (53%) of the 66 families studied. All but one of the mutations were detected within the BRCA1 gene. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome. Seven distinct mutations were identified; five of these occurred in two or more families. In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Which sentences in the title and abstract that mention a disease [BRCA1 abnormalities]? [/INST] 1. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. 2. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..</s>\ <s>[INST] Which sentences in the title and abstract that mention a variant [4153delA]? [/INST] 1. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..</s>\ <s>[INST] Which sentences mention both the entities a disease [BRCA1 abnormalities] and a variant [4153delA]? [/INST] 1. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the disease [BRCA1 abnormalities] and the variant [4153delA]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a disease [BRCA1 abnormalities] and a variant [C61G]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract of the Paper: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years. A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only. Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family. The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants. Mutations were found in 35 (53%) of the 66 families studied. All but one of the mutations were detected within the BRCA1 gene. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome. Seven distinct mutations were identified; five of these occurred in two or more families. In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Which sentences in the title and abstract that mention a disease [BRCA1 abnormalities]? [/INST] 1. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. 2. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..</s>\ <s>[INST] Which sentences in the title and abstract that mention a variant [C61G]? [/INST] 1. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..</s>\ <s>[INST] Which sentences mention both the entities a disease [BRCA1 abnormalities] and a variant [C61G]? [/INST] 1. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the disease [BRCA1 abnormalities] and the variant [C61G]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a gene or protein [BRCA1] and a disease [breast cancers]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract of the Paper: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years. A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only. Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family. The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants. Mutations were found in 35 (53%) of the 66 families studied. All but one of the mutations were detected within the BRCA1 gene. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome. Seven distinct mutations were identified; five of these occurred in two or more families. In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Which sentences in the title and abstract that mention a gene or protein [BRCA1]? [/INST] 1. All but one of the mutations were detected within the BRCA1 gene. 2. Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. 3. The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants. 4. We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [breast cancers]? [/INST] 1. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. 2. A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only.</s>\ <s>[INST] Which sentences mention both the entities a gene or protein [BRCA1] and a disease [breast cancers]? [/INST] There is no sentence that contains both these two entities.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the gene or protein [BRCA1] and the disease [breast cancers]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' here means that the relation between a gene and a disease is direct and increases the likelihood of the disease. This includes cases where too much protein causes the disease, removing the gene prevents the disease, or a side effect from the protein or drug results in the disease.
'Negative_Correlation' indicates that when a protein (or gene) is present, it helps to treat or prevent a disease. Conversely, the absence of this protein or the deactivation of its gene can lead to the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Association</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a gene or protein [BRCA1] and a disease [ovarian cancer]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract of the Paper: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years. A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only. Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family. The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants. Mutations were found in 35 (53%) of the 66 families studied. All but one of the mutations were detected within the BRCA1 gene. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome. Seven distinct mutations were identified; five of these occurred in two or more families. In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Which sentences in the title and abstract that mention a gene or protein [BRCA1]? [/INST] 1. All but one of the mutations were detected within the BRCA1 gene. 2. Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. 3. The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants. 4. We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [ovarian cancer]? [/INST] 1. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. 2. A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only.</s>\ <s>[INST] Which sentences mention both the entities a gene or protein [BRCA1] and a disease [ovarian cancer]? [/INST] There is no sentence that contains both these two entities.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the gene or protein [BRCA1] and the disease [ovarian cancer]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' here means that the relation between a gene and a disease is direct and increases the likelihood of the disease. This includes cases where too much protein causes the disease, removing the gene prevents the disease, or a side effect from the protein or drug results in the disease.
'Negative_Correlation' indicates that when a protein (or gene) is present, it helps to treat or prevent a disease. Conversely, the absence of this protein or the deactivation of its gene can lead to the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Association</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a gene or protein [BRCA1] and a disease [BRCA1 abnormalities]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract of the Paper: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years. A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only. Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family. The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants. Mutations were found in 35 (53%) of the 66 families studied. All but one of the mutations were detected within the BRCA1 gene. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome. Seven distinct mutations were identified; five of these occurred in two or more families. In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Which sentences in the title and abstract that mention a gene or protein [BRCA1]? [/INST] 1. All but one of the mutations were detected within the BRCA1 gene. 2. Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. 3. The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants. 4. We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [BRCA1 abnormalities]? [/INST] 1. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. 2. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..</s>\ <s>[INST] Which sentences mention both the entities a gene or protein [BRCA1] and a disease [BRCA1 abnormalities]? [/INST] There is no sentence that contains both these two entities.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the gene or protein [BRCA1] and the disease [BRCA1 abnormalities]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' here means that the relation between a gene and a disease is direct and increases the likelihood of the disease. This includes cases where too much protein causes the disease, removing the gene prevents the disease, or a side effect from the protein or drug results in the disease.
'Negative_Correlation' indicates that when a protein (or gene) is present, it helps to treat or prevent a disease. Conversely, the absence of this protein or the deactivation of its gene can lead to the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Association</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a gene or protein [BRCA1] and a disease [breast-ovarian cancer]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.
- Abstract of the Paper: We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age < 50 years. A total of 26 families had both breast and ovarian cancers, 4 families had ovarian cancers only, and 36 families had breast cancers only. Genomic DNA was prepared from the peripheral blood leukocytes of at least one affected woman from each family. The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants. Mutations were found in 35 (53%) of the 66 families studied. All but one of the mutations were detected within the BRCA1 gene. BRCA1 abnormalities were identified in all four families with ovarian cancer only, in 67% of 27 families with both breast and ovarian cancer, and in 34% of 35 families with breast cancer only. The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome. Seven distinct mutations were identified; five of these occurred in two or more families. In total, recurrent mutations were found in 33 (94%) of the 35 families with detected mutations. Three BRCA1 abnormalities - 5382insC, C61G, and 4153delA - accounted for 51%, 20%, and 11% of the identified mutations, respectively..
Which sentences in the title and abstract that mention a gene or protein [BRCA1]? [/INST] 1. All but one of the mutations were detected within the BRCA1 gene. 2. Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer. 3. The entire coding region of BRCA1 and BRCA2 was screened for the presence of germline mutations, by use of SSCP followed by direct sequencing of observed variants. 4. We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [breast-ovarian cancer]? [/INST] 1. The single family with a BRCA2 mutation had the breast-ovarian cancer syndrome. 2. Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.</s>\ <s>[INST] Which sentences mention both the entities a gene or protein [BRCA1] and a disease [breast-ovarian cancer]? [/INST] 1. Founder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the gene or protein [BRCA1] and the disease [breast-ovarian cancer]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' here means that the relation between a gene and a disease is direct and increases the likelihood of the disease. This includes cases where too much protein causes the disease, removing the gene prevents the disease, or a side effect from the protein or drug results in the disease.
'Negative_Correlation' indicates that when a protein (or gene) is present, it helps to treat or prevent a disease. Conversely, the absence of this protein or the deactivation of its gene can lead to the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Association</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [levodopa] and a disease [dyskinesias]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Apomorphine: an underutilized therapy for Parkinson's disease.
- Abstract of the Paper: Apomorphine was the first dopaminergic drug ever used to treat symptoms of Parkinson's disease. While powerful antiparkinsonian effects had been observed as early as 1951, the potential of treating fluctuating Parkinson's disease by subcutaneous administration of apomorphine has only recently become the subject of systematic study. A number of small scale clinical trials have unequivocally shown that intermittent subcutaneous apomorphine injections produce antiparkinsonian benefit close if not identical to that seen with levodopa and that apomorphine rescue injections can reliably revert off-periods even in patients with complex on-off motor swings. Continuous subcutaneous apomorphine infusions can reduce daily off-time by more than 50% in this group of patients, which appears to be a stronger effect than that generally seen with add-on therapy with oral dopamine agonists or COMT inhibitors. Extended follow-up studies of up to 8 years have demonstrated long-term persistence of apomorphine efficacy. In addition, there is convincing clinical evidence that monotherapy with continuous subcutaneous apomorphine infusions is associated with marked reductions of preexisting levodopa-induced dyskinesias. The main side effects of subcutaneous apomorphine treatment are related to cutaneous tolerability problems, whereas sedation and psychiatric complications play a lesser role. Given the marked degree of efficacy of subcutaneous apomorphine treatment in fluctuating Parkinson's disease, this approach seems to deserve more widespread clinical use.
Which sentences in the title and abstract that mention a chemical [levodopa]? [/INST] 1. In addition, there is convincing clinical evidence that monotherapy with continuous subcutaneous apomorphine infusions is associated with marked reductions of preexisting levodopa-induced dyskinesias. 2. A number of small scale clinical trials have unequivocally shown that intermittent subcutaneous apomorphine injections produce antiparkinsonian benefit close if not identical to that seen with levodopa and that apomorphine rescue injections can reliably revert off-periods even in patients with complex on-off motor swings.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [dyskinesias]? [/INST] 1. In addition, there is convincing clinical evidence that monotherapy with continuous subcutaneous apomorphine infusions is associated with marked reductions of preexisting levodopa-induced dyskinesias.</s>\ <s>[INST] Which sentences mention both the entities a chemical [levodopa] and a disease [dyskinesias]? [/INST] 1. In addition, there is convincing clinical evidence that monotherapy with continuous subcutaneous apomorphine infusions is associated with marked reductions of preexisting levodopa-induced dyskinesias.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [levodopa] and the disease [dyskinesias]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on.
'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [apomorphine] and a chemical [levodopa]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Apomorphine: an underutilized therapy for Parkinson's disease.
- Abstract of the Paper: Apomorphine was the first dopaminergic drug ever used to treat symptoms of Parkinson's disease. While powerful antiparkinsonian effects had been observed as early as 1951, the potential of treating fluctuating Parkinson's disease by subcutaneous administration of apomorphine has only recently become the subject of systematic study. A number of small scale clinical trials have unequivocally shown that intermittent subcutaneous apomorphine injections produce antiparkinsonian benefit close if not identical to that seen with levodopa and that apomorphine rescue injections can reliably revert off-periods even in patients with complex on-off motor swings. Continuous subcutaneous apomorphine infusions can reduce daily off-time by more than 50% in this group of patients, which appears to be a stronger effect than that generally seen with add-on therapy with oral dopamine agonists or COMT inhibitors. Extended follow-up studies of up to 8 years have demonstrated long-term persistence of apomorphine efficacy. In addition, there is convincing clinical evidence that monotherapy with continuous subcutaneous apomorphine infusions is associated with marked reductions of preexisting levodopa-induced dyskinesias. The main side effects of subcutaneous apomorphine treatment are related to cutaneous tolerability problems, whereas sedation and psychiatric complications play a lesser role. Given the marked degree of efficacy of subcutaneous apomorphine treatment in fluctuating Parkinson's disease, this approach seems to deserve more widespread clinical use.
Which sentences in the title and abstract that mention a chemical [apomorphine]? [/INST] 1. Given the marked degree of efficacy of subcutaneous apomorphine treatment in fluctuating Parkinson's disease, this approach seems to deserve more widespread clinical use. 2. While powerful antiparkinsonian effects had been observed as early as 1951, the potential of treating fluctuating Parkinson's disease by subcutaneous administration of apomorphine has only recently become the subject of systematic study. 3. Apomorphine was the first dopaminergic drug ever used to treat symptoms of Parkinson's disease. 4. The main side effects of subcutaneous apomorphine treatment are related to cutaneous tolerability problems, whereas sedation and psychiatric complications play a lesser role. 5. In addition, there is convincing clinical evidence that monotherapy with continuous subcutaneous apomorphine infusions is associated with marked reductions of preexisting levodopa-induced dyskinesias. 6. Continuous subcutaneous apomorphine infusions can reduce daily off-time by more than 50% in this group of patients, which appears to be a stronger effect than that generally seen with add-on therapy with oral dopamine agonists or COMT inhibitors. 7. A number of small scale clinical trials have unequivocally shown that intermittent subcutaneous apomorphine injections produce antiparkinsonian benefit close if not identical to that seen with levodopa and that apomorphine rescue injections can reliably revert off-periods even in patients with complex on-off motor swings. 8. Apomorphine: an underutilized therapy for Parkinson's disease. 9. Extended follow-up studies of up to 8 years have demonstrated long-term persistence of apomorphine efficacy.</s>\ <s>[INST] Which sentences in the title and abstract that mention a chemical [levodopa]? [/INST] 1. In addition, there is convincing clinical evidence that monotherapy with continuous subcutaneous apomorphine infusions is associated with marked reductions of preexisting levodopa-induced dyskinesias. 2. A number of small scale clinical trials have unequivocally shown that intermittent subcutaneous apomorphine injections produce antiparkinsonian benefit close if not identical to that seen with levodopa and that apomorphine rescue injections can reliably revert off-periods even in patients with complex on-off motor swings.</s>\ <s>[INST] Which sentences mention both the entities a chemical [apomorphine] and a chemical [levodopa]? [/INST] 1. In addition, there is convincing clinical evidence that monotherapy with continuous subcutaneous apomorphine infusions is associated with marked reductions of preexisting levodopa-induced dyskinesias. 2. A number of small scale clinical trials have unequivocally shown that intermittent subcutaneous apomorphine injections produce antiparkinsonian benefit close if not identical to that seen with levodopa and that apomorphine rescue injections can reliably revert off-periods even in patients with complex on-off motor swings.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [apomorphine] and the chemical [levodopa]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Drug_Interaction', 'Cotreatment', 'Conversion', 'Comparison', 'Association']
Option Descriptions:'Positive_Correlation' indicates that Chemical A increases the effectiveness of Chemical B. This includes making Chemical B more sensitive, enhancing its ability to treat or induce a disease, or boosting its role in gene activation.
'Negative_Correlation' means that Chemical A reduces the effectiveness and impact of Chemical B. This includes decreasing Chemical B's sensitivity, reducing its ability to treat or induce a disease, diminishing its side effects, and lowering the gene activation it causes.
'Drug_Interaction' is when two different drugs or chemicals affect each other's action in the body, happening when they are used at the same time.
'Cotreatment' means that two different drugs or chemicals are used in combination therapy.
'Conversion' means that one chemical changes into another chemical.
'Comparison' means that two different drugs or chemicals have some differences and similarities in their effects.
'Association' refers to the relation between two chemicals that do not fit into any specific, predefined categories of relations.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Negative_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [apomorphine] and a disease [dyskinesias]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Apomorphine: an underutilized therapy for Parkinson's disease.
- Abstract of the Paper: Apomorphine was the first dopaminergic drug ever used to treat symptoms of Parkinson's disease. While powerful antiparkinsonian effects had been observed as early as 1951, the potential of treating fluctuating Parkinson's disease by subcutaneous administration of apomorphine has only recently become the subject of systematic study. A number of small scale clinical trials have unequivocally shown that intermittent subcutaneous apomorphine injections produce antiparkinsonian benefit close if not identical to that seen with levodopa and that apomorphine rescue injections can reliably revert off-periods even in patients with complex on-off motor swings. Continuous subcutaneous apomorphine infusions can reduce daily off-time by more than 50% in this group of patients, which appears to be a stronger effect than that generally seen with add-on therapy with oral dopamine agonists or COMT inhibitors. Extended follow-up studies of up to 8 years have demonstrated long-term persistence of apomorphine efficacy. In addition, there is convincing clinical evidence that monotherapy with continuous subcutaneous apomorphine infusions is associated with marked reductions of preexisting levodopa-induced dyskinesias. The main side effects of subcutaneous apomorphine treatment are related to cutaneous tolerability problems, whereas sedation and psychiatric complications play a lesser role. Given the marked degree of efficacy of subcutaneous apomorphine treatment in fluctuating Parkinson's disease, this approach seems to deserve more widespread clinical use.
Which sentences in the title and abstract that mention a chemical [apomorphine]? [/INST] 1. Given the marked degree of efficacy of subcutaneous apomorphine treatment in fluctuating Parkinson's disease, this approach seems to deserve more widespread clinical use. 2. While powerful antiparkinsonian effects had been observed as early as 1951, the potential of treating fluctuating Parkinson's disease by subcutaneous administration of apomorphine has only recently become the subject of systematic study. 3. Apomorphine was the first dopaminergic drug ever used to treat symptoms of Parkinson's disease. 4. The main side effects of subcutaneous apomorphine treatment are related to cutaneous tolerability problems, whereas sedation and psychiatric complications play a lesser role. 5. In addition, there is convincing clinical evidence that monotherapy with continuous subcutaneous apomorphine infusions is associated with marked reductions of preexisting levodopa-induced dyskinesias. 6. Continuous subcutaneous apomorphine infusions can reduce daily off-time by more than 50% in this group of patients, which appears to be a stronger effect than that generally seen with add-on therapy with oral dopamine agonists or COMT inhibitors. 7. A number of small scale clinical trials have unequivocally shown that intermittent subcutaneous apomorphine injections produce antiparkinsonian benefit close if not identical to that seen with levodopa and that apomorphine rescue injections can reliably revert off-periods even in patients with complex on-off motor swings. 8. Apomorphine: an underutilized therapy for Parkinson's disease. 9. Extended follow-up studies of up to 8 years have demonstrated long-term persistence of apomorphine efficacy.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [dyskinesias]? [/INST] 1. In addition, there is convincing clinical evidence that monotherapy with continuous subcutaneous apomorphine infusions is associated with marked reductions of preexisting levodopa-induced dyskinesias.</s>\ <s>[INST] Which sentences mention both the entities a chemical [apomorphine] and a disease [dyskinesias]? [/INST] 1. In addition, there is convincing clinical evidence that monotherapy with continuous subcutaneous apomorphine infusions is associated with marked reductions of preexisting levodopa-induced dyskinesias.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [apomorphine] and the disease [dyskinesias]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on.
'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Negative_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [Apomorphine] and a disease [Parkinson's disease]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Apomorphine: an underutilized therapy for Parkinson's disease.
- Abstract of the Paper: Apomorphine was the first dopaminergic drug ever used to treat symptoms of Parkinson's disease. While powerful antiparkinsonian effects had been observed as early as 1951, the potential of treating fluctuating Parkinson's disease by subcutaneous administration of apomorphine has only recently become the subject of systematic study. A number of small scale clinical trials have unequivocally shown that intermittent subcutaneous apomorphine injections produce antiparkinsonian benefit close if not identical to that seen with levodopa and that apomorphine rescue injections can reliably revert off-periods even in patients with complex on-off motor swings. Continuous subcutaneous apomorphine infusions can reduce daily off-time by more than 50% in this group of patients, which appears to be a stronger effect than that generally seen with add-on therapy with oral dopamine agonists or COMT inhibitors. Extended follow-up studies of up to 8 years have demonstrated long-term persistence of apomorphine efficacy. In addition, there is convincing clinical evidence that monotherapy with continuous subcutaneous apomorphine infusions is associated with marked reductions of preexisting levodopa-induced dyskinesias. The main side effects of subcutaneous apomorphine treatment are related to cutaneous tolerability problems, whereas sedation and psychiatric complications play a lesser role. Given the marked degree of efficacy of subcutaneous apomorphine treatment in fluctuating Parkinson's disease, this approach seems to deserve more widespread clinical use.
Which sentences in the title and abstract that mention a chemical [Apomorphine]? [/INST] 1. Given the marked degree of efficacy of subcutaneous apomorphine treatment in fluctuating Parkinson's disease, this approach seems to deserve more widespread clinical use. 2. While powerful antiparkinsonian effects had been observed as early as 1951, the potential of treating fluctuating Parkinson's disease by subcutaneous administration of apomorphine has only recently become the subject of systematic study. 3. Apomorphine was the first dopaminergic drug ever used to treat symptoms of Parkinson's disease. 4. The main side effects of subcutaneous apomorphine treatment are related to cutaneous tolerability problems, whereas sedation and psychiatric complications play a lesser role. 5. In addition, there is convincing clinical evidence that monotherapy with continuous subcutaneous apomorphine infusions is associated with marked reductions of preexisting levodopa-induced dyskinesias. 6. Continuous subcutaneous apomorphine infusions can reduce daily off-time by more than 50% in this group of patients, which appears to be a stronger effect than that generally seen with add-on therapy with oral dopamine agonists or COMT inhibitors. 7. A number of small scale clinical trials have unequivocally shown that intermittent subcutaneous apomorphine injections produce antiparkinsonian benefit close if not identical to that seen with levodopa and that apomorphine rescue injections can reliably revert off-periods even in patients with complex on-off motor swings. 8. Apomorphine: an underutilized therapy for Parkinson's disease. 9. Extended follow-up studies of up to 8 years have demonstrated long-term persistence of apomorphine efficacy.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [Parkinson's disease]? [/INST] 1. While powerful antiparkinsonian effects had been observed as early as 1951, the potential of treating fluctuating Parkinson's disease by subcutaneous administration of apomorphine has only recently become the subject of systematic study. 2. Given the marked degree of efficacy of subcutaneous apomorphine treatment in fluctuating Parkinson's disease, this approach seems to deserve more widespread clinical use. 3. Apomorphine was the first dopaminergic drug ever used to treat symptoms of Parkinson's disease. 4. Apomorphine: an underutilized therapy for Parkinson's disease.</s>\ <s>[INST] Which sentences mention both the entities a chemical [Apomorphine] and a disease [Parkinson's disease]? [/INST] 1. Given the marked degree of efficacy of subcutaneous apomorphine treatment in fluctuating Parkinson's disease, this approach seems to deserve more widespread clinical use. 2. Apomorphine was the first dopaminergic drug ever used to treat symptoms of Parkinson's disease. 3. Apomorphine: an underutilized therapy for Parkinson's disease. 4. While powerful antiparkinsonian effects had been observed as early as 1951, the potential of treating fluctuating Parkinson's disease by subcutaneous administration of apomorphine has only recently become the subject of systematic study.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [Apomorphine] and the disease [Parkinson's disease]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on.
'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Negative_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a disease [uterine sarcoma] and a gene or protein [Rab6c]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells.
- Abstract of the Paper: A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique. Rab6c was found to be under-expressed in MCF7/AdrR and MES-SA/Dx5 (a human MDR uterine sarcoma cell line) compared with their non-MDR parental cell lines. MCF7/AdrR cells expressing the exogenous Rab6c exhibited less resistance to several anti-cancer drugs, such as doxorubicin (DOX), taxol, vinblastine, and vincristine, than the control cells containing the empty vector. Flow cytometry experiments confirmed that the transfectants' diminished resistance to DOX was caused by increased drug accumulation induced by the exogenous Rab6c. These results indicate that Rab6c is involved in drug resistance in MCF7/AdrR cells.
Which sentences in the title and abstract that mention a disease [uterine sarcoma]? [/INST] 1. Rab6c was found to be under-expressed in MCF7/AdrR and MES-SA/Dx5 (a human MDR uterine sarcoma cell line) compared with their non-MDR parental cell lines.</s>\ <s>[INST] Which sentences in the title and abstract that mention a gene or protein [Rab6c]? [/INST] 1. Rab6c was found to be under-expressed in MCF7/AdrR and MES-SA/Dx5 (a human MDR uterine sarcoma cell line) compared with their non-MDR parental cell lines. 2. Flow cytometry experiments confirmed that the transfectants' diminished resistance to DOX was caused by increased drug accumulation induced by the exogenous Rab6c. 3. A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique. 4. These results indicate that Rab6c is involved in drug resistance in MCF7/AdrR cells. 5. Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells. 6. MCF7/AdrR cells expressing the exogenous Rab6c exhibited less resistance to several anti-cancer drugs, such as doxorubicin (DOX), taxol, vinblastine, and vincristine, than the control cells containing the empty vector.</s>\ <s>[INST] Which sentences mention both the entities a disease [uterine sarcoma] and a gene or protein [Rab6c]? [/INST] 1. Rab6c was found to be under-expressed in MCF7/AdrR and MES-SA/Dx5 (a human MDR uterine sarcoma cell line) compared with their non-MDR parental cell lines.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the disease [uterine sarcoma] and the gene or protein [Rab6c]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' here means that the relation between a protein or gene and a disease is direct and increases the likelihood of the disease. This includes cases where too much protein causes the disease, removing the gene prevents the disease, or a side effect from the protein or drug results in the disease.
'Negative_Correlation' indicates that when a protein (or drug) is present, it helps to treat or prevent a disease. Conversely, the absence of this protein or the deactivation of its gene can lead to the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Association</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a gene or protein [Rab6c] and a chemical [vincristine]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells.
- Abstract of the Paper: A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique. Rab6c was found to be under-expressed in MCF7/AdrR and MES-SA/Dx5 (a human MDR uterine sarcoma cell line) compared with their non-MDR parental cell lines. MCF7/AdrR cells expressing the exogenous Rab6c exhibited less resistance to several anti-cancer drugs, such as doxorubicin (DOX), taxol, vinblastine, and vincristine, than the control cells containing the empty vector. Flow cytometry experiments confirmed that the transfectants' diminished resistance to DOX was caused by increased drug accumulation induced by the exogenous Rab6c. These results indicate that Rab6c is involved in drug resistance in MCF7/AdrR cells.
Which sentences in the title and abstract that mention a gene or protein [Rab6c]? [/INST] 1. Rab6c was found to be under-expressed in MCF7/AdrR and MES-SA/Dx5 (a human MDR uterine sarcoma cell line) compared with their non-MDR parental cell lines. 2. Flow cytometry experiments confirmed that the transfectants' diminished resistance to DOX was caused by increased drug accumulation induced by the exogenous Rab6c. 3. A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique. 4. These results indicate that Rab6c is involved in drug resistance in MCF7/AdrR cells. 5. Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells. 6. MCF7/AdrR cells expressing the exogenous Rab6c exhibited less resistance to several anti-cancer drugs, such as doxorubicin (DOX), taxol, vinblastine, and vincristine, than the control cells containing the empty vector.</s>\ <s>[INST] Which sentences in the title and abstract that mention a chemical [vincristine]? [/INST] 1. MCF7/AdrR cells expressing the exogenous Rab6c exhibited less resistance to several anti-cancer drugs, such as doxorubicin (DOX), taxol, vinblastine, and vincristine, than the control cells containing the empty vector.</s>\ <s>[INST] Which sentences mention both the entities a gene or protein [Rab6c] and a chemical [vincristine]? [/INST] 1. MCF7/AdrR cells expressing the exogenous Rab6c exhibited less resistance to several anti-cancer drugs, such as doxorubicin (DOX), taxol, vinblastine, and vincristine, than the control cells containing the empty vector.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the gene or protein [Rab6c] and the chemical [vincristine]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association']
Option Descriptions:'Positive_Correlation' means that a chemical leads to higher gene expression, or higher gene expression increases sensitivity to the chemical, or a gene variant exacerbates the chemical's side effects, or a gene causes an over-response to the chemical, or there is a positive interaction between two genes in any manner.
'Negative_Correlation' indicates that a chemical leads to reduced gene expression, or higher gene expression results in decreased sensitivity or resistance to the chemical, or a gene variant offers protection against the chemical's adverse effects, or a gene contributes to resistance against the chemical, or there exists a negative interaction between two genes in any form.
'Bind' means that a chemical either connects to a gene's promoter region or a protein acts as a receptor for that chemical.
'Association' is used to describe relation that don't clearly fall under categories like positive correlation, negative correlation and bind , or when the nature of the relation lack a clear description.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a gene or protein [Rab6c] and a chemical [vinblastine]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells.
- Abstract of the Paper: A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique. Rab6c was found to be under-expressed in MCF7/AdrR and MES-SA/Dx5 (a human MDR uterine sarcoma cell line) compared with their non-MDR parental cell lines. MCF7/AdrR cells expressing the exogenous Rab6c exhibited less resistance to several anti-cancer drugs, such as doxorubicin (DOX), taxol, vinblastine, and vincristine, than the control cells containing the empty vector. Flow cytometry experiments confirmed that the transfectants' diminished resistance to DOX was caused by increased drug accumulation induced by the exogenous Rab6c. These results indicate that Rab6c is involved in drug resistance in MCF7/AdrR cells.
Which sentences in the title and abstract that mention a gene or protein [Rab6c]? [/INST] 1. Rab6c was found to be under-expressed in MCF7/AdrR and MES-SA/Dx5 (a human MDR uterine sarcoma cell line) compared with their non-MDR parental cell lines. 2. Flow cytometry experiments confirmed that the transfectants' diminished resistance to DOX was caused by increased drug accumulation induced by the exogenous Rab6c. 3. A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique. 4. These results indicate that Rab6c is involved in drug resistance in MCF7/AdrR cells. 5. Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells. 6. MCF7/AdrR cells expressing the exogenous Rab6c exhibited less resistance to several anti-cancer drugs, such as doxorubicin (DOX), taxol, vinblastine, and vincristine, than the control cells containing the empty vector.</s>\ <s>[INST] Which sentences in the title and abstract that mention a chemical [vinblastine]? [/INST] 1. MCF7/AdrR cells expressing the exogenous Rab6c exhibited less resistance to several anti-cancer drugs, such as doxorubicin (DOX), taxol, vinblastine, and vincristine, than the control cells containing the empty vector.</s>\ <s>[INST] Which sentences mention both the entities a gene or protein [Rab6c] and a chemical [vinblastine]? [/INST] 1. MCF7/AdrR cells expressing the exogenous Rab6c exhibited less resistance to several anti-cancer drugs, such as doxorubicin (DOX), taxol, vinblastine, and vincristine, than the control cells containing the empty vector.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the gene or protein [Rab6c] and the chemical [vinblastine]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association']
Option Descriptions:'Positive_Correlation' means that a chemical leads to higher gene expression, or higher gene expression increases sensitivity to the chemical, or a gene variant exacerbates the chemical's side effects, or a gene causes an over-response to the chemical, or there is a positive interaction between two genes in any manner.
'Negative_Correlation' indicates that a chemical leads to reduced gene expression, or higher gene expression results in decreased sensitivity or resistance to the chemical, or a gene variant offers protection against the chemical's adverse effects, or a gene contributes to resistance against the chemical, or there exists a negative interaction between two genes in any form.
'Bind' means that a chemical either connects to a gene's promoter region or a protein acts as a receptor for that chemical.
'Association' is used to describe relation that don't clearly fall under categories like positive correlation, negative correlation and bind , or when the nature of the relation lack a clear description.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a gene or protein [Rab6c] and a chemical [taxol]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells.
- Abstract of the Paper: A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique. Rab6c was found to be under-expressed in MCF7/AdrR and MES-SA/Dx5 (a human MDR uterine sarcoma cell line) compared with their non-MDR parental cell lines. MCF7/AdrR cells expressing the exogenous Rab6c exhibited less resistance to several anti-cancer drugs, such as doxorubicin (DOX), taxol, vinblastine, and vincristine, than the control cells containing the empty vector. Flow cytometry experiments confirmed that the transfectants' diminished resistance to DOX was caused by increased drug accumulation induced by the exogenous Rab6c. These results indicate that Rab6c is involved in drug resistance in MCF7/AdrR cells.
Which sentences in the title and abstract that mention a gene or protein [Rab6c]? [/INST] 1. Rab6c was found to be under-expressed in MCF7/AdrR and MES-SA/Dx5 (a human MDR uterine sarcoma cell line) compared with their non-MDR parental cell lines. 2. Flow cytometry experiments confirmed that the transfectants' diminished resistance to DOX was caused by increased drug accumulation induced by the exogenous Rab6c. 3. A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique. 4. These results indicate that Rab6c is involved in drug resistance in MCF7/AdrR cells. 5. Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells. 6. MCF7/AdrR cells expressing the exogenous Rab6c exhibited less resistance to several anti-cancer drugs, such as doxorubicin (DOX), taxol, vinblastine, and vincristine, than the control cells containing the empty vector.</s>\ <s>[INST] Which sentences in the title and abstract that mention a chemical [taxol]? [/INST] 1. MCF7/AdrR cells expressing the exogenous Rab6c exhibited less resistance to several anti-cancer drugs, such as doxorubicin (DOX), taxol, vinblastine, and vincristine, than the control cells containing the empty vector.</s>\ <s>[INST] Which sentences mention both the entities a gene or protein [Rab6c] and a chemical [taxol]? [/INST] 1. MCF7/AdrR cells expressing the exogenous Rab6c exhibited less resistance to several anti-cancer drugs, such as doxorubicin (DOX), taxol, vinblastine, and vincristine, than the control cells containing the empty vector.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the gene or protein [Rab6c] and the chemical [taxol]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association']
Option Descriptions:'Positive_Correlation' means that a chemical leads to higher gene expression, or higher gene expression increases sensitivity to the chemical, or a gene variant exacerbates the chemical's side effects, or a gene causes an over-response to the chemical, or there is a positive interaction between two genes in any manner.
'Negative_Correlation' indicates that a chemical leads to reduced gene expression, or higher gene expression results in decreased sensitivity or resistance to the chemical, or a gene variant offers protection against the chemical's adverse effects, or a gene contributes to resistance against the chemical, or there exists a negative interaction between two genes in any form.
'Bind' means that a chemical either connects to a gene's promoter region or a protein acts as a receptor for that chemical.
'Association' is used to describe relation that don't clearly fall under categories like positive correlation, negative correlation and bind , or when the nature of the relation lack a clear description.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a gene or protein [Rab6c] and a chemical [doxorubicin]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells.
- Abstract of the Paper: A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique. Rab6c was found to be under-expressed in MCF7/AdrR and MES-SA/Dx5 (a human MDR uterine sarcoma cell line) compared with their non-MDR parental cell lines. MCF7/AdrR cells expressing the exogenous Rab6c exhibited less resistance to several anti-cancer drugs, such as doxorubicin (DOX), taxol, vinblastine, and vincristine, than the control cells containing the empty vector. Flow cytometry experiments confirmed that the transfectants' diminished resistance to DOX was caused by increased drug accumulation induced by the exogenous Rab6c. These results indicate that Rab6c is involved in drug resistance in MCF7/AdrR cells.
Which sentences in the title and abstract that mention a gene or protein [Rab6c]? [/INST] 1. Rab6c was found to be under-expressed in MCF7/AdrR and MES-SA/Dx5 (a human MDR uterine sarcoma cell line) compared with their non-MDR parental cell lines. 2. Flow cytometry experiments confirmed that the transfectants' diminished resistance to DOX was caused by increased drug accumulation induced by the exogenous Rab6c. 3. A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique. 4. These results indicate that Rab6c is involved in drug resistance in MCF7/AdrR cells. 5. Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells. 6. MCF7/AdrR cells expressing the exogenous Rab6c exhibited less resistance to several anti-cancer drugs, such as doxorubicin (DOX), taxol, vinblastine, and vincristine, than the control cells containing the empty vector.</s>\ <s>[INST] Which sentences in the title and abstract that mention a chemical [doxorubicin]? [/INST] 1. MCF7/AdrR cells expressing the exogenous Rab6c exhibited less resistance to several anti-cancer drugs, such as doxorubicin (DOX), taxol, vinblastine, and vincristine, than the control cells containing the empty vector. 2. Flow cytometry experiments confirmed that the transfectants' diminished resistance to DOX was caused by increased drug accumulation induced by the exogenous Rab6c.</s>\ <s>[INST] Which sentences mention both the entities a gene or protein [Rab6c] and a chemical [doxorubicin]? [/INST] 1. MCF7/AdrR cells expressing the exogenous Rab6c exhibited less resistance to several anti-cancer drugs, such as doxorubicin (DOX), taxol, vinblastine, and vincristine, than the control cells containing the empty vector. 2. Flow cytometry experiments confirmed that the transfectants' diminished resistance to DOX was caused by increased drug accumulation induced by the exogenous Rab6c.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the gene or protein [Rab6c] and the chemical [doxorubicin]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association']
Option Descriptions:'Positive_Correlation' means that a chemical leads to higher gene expression, or higher gene expression increases sensitivity to the chemical, or a gene variant exacerbates the chemical's side effects, or a gene causes an over-response to the chemical, or there is a positive interaction between two genes in any manner.
'Negative_Correlation' indicates that a chemical leads to reduced gene expression, or higher gene expression results in decreased sensitivity or resistance to the chemical, or a gene variant offers protection against the chemical's adverse effects, or a gene contributes to resistance against the chemical, or there exists a negative interaction between two genes in any form.
'Bind' means that a chemical either connects to a gene's promoter region or a protein acts as a receptor for that chemical.
'Association' is used to describe relation that don't clearly fall under categories like positive correlation, negative correlation and bind , or when the nature of the relation lack a clear description.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a gene or protein [calcineurin] and a chemical [tacrolimus]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment.
- Abstract of the Paper: BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic. Their use in orthotopic liver transplantation (OLTX) has dramatically improved success rates. Recently, however, we have had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD). This retrospective study examines the incidence and treatment of ESRD and chronic renal failure (CRF) in OLTX patients. METHODS: Patients receiving an OLTX only from June 1985 through December of 1994 who survived 6 months postoperatively were studied (n=834). Our prospectively collected database was the source of information. Patients were divided into three groups: Controls, no CRF or ESRD, n=748; CRF, sustained serum creatinine >2.5 mg/dl, n=41; and ESRD, n=45. Groups were compared for preoperative laboratory variables, diagnosis, postoperative variables, survival, type of ESRD therapy, and survival from onset of ESRD. RESULTS: At 13 years after OLTX, the incidence of severe renal dysfunction was 18.1% (CRF 8.6% and ESRD 9.5%). Compared with control patients, CRF and ESRD patients had higher preoperative serum creatinine levels, a greater percentage of patients with hepatorenal syndrome, higher percentage requirement for dialysis in the first 3 months postoperatively, and a higher 1-year serum creatinine. Multivariate stepwise logistic regression analysis using preoperative and postoperative variables identified that an increase of serum creatinine compared with average at 1 year, 3 months, and 4 weeks postoperatively were independent risk factors for the development of CRF or ESRD with odds ratios of 2.6, 2.2, and 1.6, respectively. Overall survival from the time of OLTX was not significantly different among groups, but by year 13, the survival of the patients who had ESRD was only 28.2% compared with 54.6% in the control group. Patients developing ESRD had a 6-year survival after onset of ESRD of 27% for the patients receiving hemodialysis versus 71.4% for the patients developing ESRD who subsequently received kidney transplants. CONCLUSIONS: Patients who are more than 10 years post-OLTX have CRF and ESRD at a high rate. The development of ESRD decreases survival, particularly in those patients treated with dialysis only. Patients who develop ESRD have a higher preoperative and 1-year serum creatinine and are more likely to have hepatorenal syndrome. However, an increase of serum creatinine at various times postoperatively is more predictive of the development of CRF or ESRD. New strategies for long-term immunosuppression may be needed to decrease this complication.
Which sentences in the title and abstract that mention a gene or protein [calcineurin]? [/INST] 1. End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment. 2. BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic.</s>\ <s>[INST] Which sentences in the title and abstract that mention a chemical [tacrolimus]? [/INST] 1. BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic.</s>\ <s>[INST] Which sentences mention both the entities a gene or protein [calcineurin] and a chemical [tacrolimus]? [/INST] 1. BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the gene or protein [calcineurin] and the chemical [tacrolimus]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association']
Option Descriptions:'Positive_Correlation' means that a chemical leads to higher gene expression, or higher gene expression increases sensitivity to the chemical, or a gene variant exacerbates the chemical's side effects, or a gene causes an over-response to the chemical, or there is a positive interaction between two genes in any manner.
'Negative_Correlation' indicates that a chemical leads to reduced gene expression, or higher gene expression results in decreased sensitivity or resistance to the chemical, or a gene variant offers protection against the chemical's adverse effects, or a gene contributes to resistance against the chemical, or there exists a negative interaction between two genes in any form.
'Bind' means that a chemical either connects to a gene's promoter region or a protein acts as a receptor for that chemical.
'Association' is used to describe relation that don't clearly fall under categories like positive correlation, negative correlation and bind , or when the nature of the relation lack a clear description.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Negative_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a gene or protein [calcineurin] and a chemical [cyclosporine]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment.
- Abstract of the Paper: BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic. Their use in orthotopic liver transplantation (OLTX) has dramatically improved success rates. Recently, however, we have had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD). This retrospective study examines the incidence and treatment of ESRD and chronic renal failure (CRF) in OLTX patients. METHODS: Patients receiving an OLTX only from June 1985 through December of 1994 who survived 6 months postoperatively were studied (n=834). Our prospectively collected database was the source of information. Patients were divided into three groups: Controls, no CRF or ESRD, n=748; CRF, sustained serum creatinine >2.5 mg/dl, n=41; and ESRD, n=45. Groups were compared for preoperative laboratory variables, diagnosis, postoperative variables, survival, type of ESRD therapy, and survival from onset of ESRD. RESULTS: At 13 years after OLTX, the incidence of severe renal dysfunction was 18.1% (CRF 8.6% and ESRD 9.5%). Compared with control patients, CRF and ESRD patients had higher preoperative serum creatinine levels, a greater percentage of patients with hepatorenal syndrome, higher percentage requirement for dialysis in the first 3 months postoperatively, and a higher 1-year serum creatinine. Multivariate stepwise logistic regression analysis using preoperative and postoperative variables identified that an increase of serum creatinine compared with average at 1 year, 3 months, and 4 weeks postoperatively were independent risk factors for the development of CRF or ESRD with odds ratios of 2.6, 2.2, and 1.6, respectively. Overall survival from the time of OLTX was not significantly different among groups, but by year 13, the survival of the patients who had ESRD was only 28.2% compared with 54.6% in the control group. Patients developing ESRD had a 6-year survival after onset of ESRD of 27% for the patients receiving hemodialysis versus 71.4% for the patients developing ESRD who subsequently received kidney transplants. CONCLUSIONS: Patients who are more than 10 years post-OLTX have CRF and ESRD at a high rate. The development of ESRD decreases survival, particularly in those patients treated with dialysis only. Patients who develop ESRD have a higher preoperative and 1-year serum creatinine and are more likely to have hepatorenal syndrome. However, an increase of serum creatinine at various times postoperatively is more predictive of the development of CRF or ESRD. New strategies for long-term immunosuppression may be needed to decrease this complication.
Which sentences in the title and abstract that mention a gene or protein [calcineurin]? [/INST] 1. End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment. 2. BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic.</s>\ <s>[INST] Which sentences in the title and abstract that mention a chemical [cyclosporine]? [/INST] 1. BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic.</s>\ <s>[INST] Which sentences mention both the entities a gene or protein [calcineurin] and a chemical [cyclosporine]? [/INST] 1. BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the gene or protein [calcineurin] and the chemical [cyclosporine]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association']
Option Descriptions:'Positive_Correlation' means that a chemical leads to higher gene expression, or higher gene expression increases sensitivity to the chemical, or a gene variant exacerbates the chemical's side effects, or a gene causes an over-response to the chemical, or there is a positive interaction between two genes in any manner.
'Negative_Correlation' indicates that a chemical leads to reduced gene expression, or higher gene expression results in decreased sensitivity or resistance to the chemical, or a gene variant offers protection against the chemical's adverse effects, or a gene contributes to resistance against the chemical, or there exists a negative interaction between two genes in any form.
'Bind' means that a chemical either connects to a gene's promoter region or a protein acts as a receptor for that chemical.
'Association' is used to describe relation that don't clearly fall under categories like positive correlation, negative correlation and bind , or when the nature of the relation lack a clear description.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Negative_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a disease [hepatorenal syndrome] and a chemical [creatinine]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment.
- Abstract of the Paper: BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic. Their use in orthotopic liver transplantation (OLTX) has dramatically improved success rates. Recently, however, we have had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD). This retrospective study examines the incidence and treatment of ESRD and chronic renal failure (CRF) in OLTX patients. METHODS: Patients receiving an OLTX only from June 1985 through December of 1994 who survived 6 months postoperatively were studied (n=834). Our prospectively collected database was the source of information. Patients were divided into three groups: Controls, no CRF or ESRD, n=748; CRF, sustained serum creatinine >2.5 mg/dl, n=41; and ESRD, n=45. Groups were compared for preoperative laboratory variables, diagnosis, postoperative variables, survival, type of ESRD therapy, and survival from onset of ESRD. RESULTS: At 13 years after OLTX, the incidence of severe renal dysfunction was 18.1% (CRF 8.6% and ESRD 9.5%). Compared with control patients, CRF and ESRD patients had higher preoperative serum creatinine levels, a greater percentage of patients with hepatorenal syndrome, higher percentage requirement for dialysis in the first 3 months postoperatively, and a higher 1-year serum creatinine. Multivariate stepwise logistic regression analysis using preoperative and postoperative variables identified that an increase of serum creatinine compared with average at 1 year, 3 months, and 4 weeks postoperatively were independent risk factors for the development of CRF or ESRD with odds ratios of 2.6, 2.2, and 1.6, respectively. Overall survival from the time of OLTX was not significantly different among groups, but by year 13, the survival of the patients who had ESRD was only 28.2% compared with 54.6% in the control group. Patients developing ESRD had a 6-year survival after onset of ESRD of 27% for the patients receiving hemodialysis versus 71.4% for the patients developing ESRD who subsequently received kidney transplants. CONCLUSIONS: Patients who are more than 10 years post-OLTX have CRF and ESRD at a high rate. The development of ESRD decreases survival, particularly in those patients treated with dialysis only. Patients who develop ESRD have a higher preoperative and 1-year serum creatinine and are more likely to have hepatorenal syndrome. However, an increase of serum creatinine at various times postoperatively is more predictive of the development of CRF or ESRD. New strategies for long-term immunosuppression may be needed to decrease this complication.
Which sentences in the title and abstract that mention a disease [hepatorenal syndrome]? [/INST] 1. Compared with control patients, CRF and ESRD patients had higher preoperative serum creatinine levels, a greater percentage of patients with hepatorenal syndrome, higher percentage requirement for dialysis in the first 3 months postoperatively, and a higher 1-year serum creatinine. 2. Patients who develop ESRD have a higher preoperative and 1-year serum creatinine and are more likely to have hepatorenal syndrome.</s>\ <s>[INST] Which sentences in the title and abstract that mention a chemical [creatinine]? [/INST] 1. However, an increase of serum creatinine at various times postoperatively is more predictive of the development of CRF or ESRD. 2. Compared with control patients, CRF and ESRD patients had higher preoperative serum creatinine levels, a greater percentage of patients with hepatorenal syndrome, higher percentage requirement for dialysis in the first 3 months postoperatively, and a higher 1-year serum creatinine. 3. Patients who develop ESRD have a higher preoperative and 1-year serum creatinine and are more likely to have hepatorenal syndrome. 4. Patients were divided into three groups: Controls, no CRF or ESRD, n=748; CRF, sustained serum creatinine >2.5 mg/dl, n=41; and ESRD, n=45. 5. Multivariate stepwise logistic regression analysis using preoperative and postoperative variables identified that an increase of serum creatinine compared with average at 1 year, 3 months, and 4 weeks postoperatively were independent risk factors for the development of CRF or ESRD with odds ratios of 2.6, 2.2, and 1.6, respectively.</s>\ <s>[INST] Which sentences mention both the entities a disease [hepatorenal syndrome] and a chemical [creatinine]? [/INST] 1. Compared with control patients, CRF and ESRD patients had higher preoperative serum creatinine levels, a greater percentage of patients with hepatorenal syndrome, higher percentage requirement for dialysis in the first 3 months postoperatively, and a higher 1-year serum creatinine. 2. Patients who develop ESRD have a higher preoperative and 1-year serum creatinine and are more likely to have hepatorenal syndrome.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the disease [hepatorenal syndrome] and the chemical [creatinine]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on.
'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [tacrolimus] and a disease [nephrotoxic]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment.
- Abstract of the Paper: BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic. Their use in orthotopic liver transplantation (OLTX) has dramatically improved success rates. Recently, however, we have had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD). This retrospective study examines the incidence and treatment of ESRD and chronic renal failure (CRF) in OLTX patients. METHODS: Patients receiving an OLTX only from June 1985 through December of 1994 who survived 6 months postoperatively were studied (n=834). Our prospectively collected database was the source of information. Patients were divided into three groups: Controls, no CRF or ESRD, n=748; CRF, sustained serum creatinine >2.5 mg/dl, n=41; and ESRD, n=45. Groups were compared for preoperative laboratory variables, diagnosis, postoperative variables, survival, type of ESRD therapy, and survival from onset of ESRD. RESULTS: At 13 years after OLTX, the incidence of severe renal dysfunction was 18.1% (CRF 8.6% and ESRD 9.5%). Compared with control patients, CRF and ESRD patients had higher preoperative serum creatinine levels, a greater percentage of patients with hepatorenal syndrome, higher percentage requirement for dialysis in the first 3 months postoperatively, and a higher 1-year serum creatinine. Multivariate stepwise logistic regression analysis using preoperative and postoperative variables identified that an increase of serum creatinine compared with average at 1 year, 3 months, and 4 weeks postoperatively were independent risk factors for the development of CRF or ESRD with odds ratios of 2.6, 2.2, and 1.6, respectively. Overall survival from the time of OLTX was not significantly different among groups, but by year 13, the survival of the patients who had ESRD was only 28.2% compared with 54.6% in the control group. Patients developing ESRD had a 6-year survival after onset of ESRD of 27% for the patients receiving hemodialysis versus 71.4% for the patients developing ESRD who subsequently received kidney transplants. CONCLUSIONS: Patients who are more than 10 years post-OLTX have CRF and ESRD at a high rate. The development of ESRD decreases survival, particularly in those patients treated with dialysis only. Patients who develop ESRD have a higher preoperative and 1-year serum creatinine and are more likely to have hepatorenal syndrome. However, an increase of serum creatinine at various times postoperatively is more predictive of the development of CRF or ESRD. New strategies for long-term immunosuppression may be needed to decrease this complication.
Which sentences in the title and abstract that mention a chemical [tacrolimus]? [/INST] 1. BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [nephrotoxic]? [/INST] 1. BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic. 2. RESULTS: At 13 years after OLTX, the incidence of severe renal dysfunction was 18.1% (CRF 8.6% and ESRD 9.5%).</s>\ <s>[INST] Which sentences mention both the entities a chemical [tacrolimus] and a disease [nephrotoxic]? [/INST] 1. BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [tacrolimus] and the disease [nephrotoxic]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on.
'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a disease [CRF] and a chemical [creatinine]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment.
- Abstract of the Paper: BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic. Their use in orthotopic liver transplantation (OLTX) has dramatically improved success rates. Recently, however, we have had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD). This retrospective study examines the incidence and treatment of ESRD and chronic renal failure (CRF) in OLTX patients. METHODS: Patients receiving an OLTX only from June 1985 through December of 1994 who survived 6 months postoperatively were studied (n=834). Our prospectively collected database was the source of information. Patients were divided into three groups: Controls, no CRF or ESRD, n=748; CRF, sustained serum creatinine >2.5 mg/dl, n=41; and ESRD, n=45. Groups were compared for preoperative laboratory variables, diagnosis, postoperative variables, survival, type of ESRD therapy, and survival from onset of ESRD. RESULTS: At 13 years after OLTX, the incidence of severe renal dysfunction was 18.1% (CRF 8.6% and ESRD 9.5%). Compared with control patients, CRF and ESRD patients had higher preoperative serum creatinine levels, a greater percentage of patients with hepatorenal syndrome, higher percentage requirement for dialysis in the first 3 months postoperatively, and a higher 1-year serum creatinine. Multivariate stepwise logistic regression analysis using preoperative and postoperative variables identified that an increase of serum creatinine compared with average at 1 year, 3 months, and 4 weeks postoperatively were independent risk factors for the development of CRF or ESRD with odds ratios of 2.6, 2.2, and 1.6, respectively. Overall survival from the time of OLTX was not significantly different among groups, but by year 13, the survival of the patients who had ESRD was only 28.2% compared with 54.6% in the control group. Patients developing ESRD had a 6-year survival after onset of ESRD of 27% for the patients receiving hemodialysis versus 71.4% for the patients developing ESRD who subsequently received kidney transplants. CONCLUSIONS: Patients who are more than 10 years post-OLTX have CRF and ESRD at a high rate. The development of ESRD decreases survival, particularly in those patients treated with dialysis only. Patients who develop ESRD have a higher preoperative and 1-year serum creatinine and are more likely to have hepatorenal syndrome. However, an increase of serum creatinine at various times postoperatively is more predictive of the development of CRF or ESRD. New strategies for long-term immunosuppression may be needed to decrease this complication.
Which sentences in the title and abstract that mention a disease [CRF]? [/INST] 1. End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment. 2. Patients developing ESRD had a 6-year survival after onset of ESRD of 27% for the patients receiving hemodialysis versus 71.4% for the patients developing ESRD who subsequently received kidney transplants. 3. This retrospective study examines the incidence and treatment of ESRD and chronic renal failure (CRF) in OLTX patients. 4. The development of ESRD decreases survival, particularly in those patients treated with dialysis only. 5. Groups were compared for preoperative laboratory variables, diagnosis, postoperative variables, survival, type of ESRD therapy, and survival from onset of ESRD. 6. Recently, however, we have had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD). 7. CONCLUSIONS: Patients who are more than 10 years post-OLTX have CRF and ESRD at a high rate. 8. Compared with control patients, CRF and ESRD patients had higher preoperative serum creatinine levels, a greater percentage of patients with hepatorenal syndrome, higher percentage requirement for dialysis in the first 3 months postoperatively, and a higher 1-year serum creatinine. 9. Patients who develop ESRD have a higher preoperative and 1-year serum creatinine and are more likely to have hepatorenal syndrome. 10. However, an increase of serum creatinine at various times postoperatively is more predictive of the development of CRF or ESRD. 11. Patients were divided into three groups: Controls, no CRF or ESRD, n=748; CRF, sustained serum creatinine >2.5 mg/dl, n=41; and ESRD, n=45. 12. Overall survival from the time of OLTX was not significantly different among groups, but by year 13, the survival of the patients who had ESRD was only 28.2% compared with 54.6% in the control group. 13. Multivariate stepwise logistic regression analysis using preoperative and postoperative variables identified that an increase of serum creatinine compared with average at 1 year, 3 months, and 4 weeks postoperatively were independent risk factors for the development of CRF or ESRD with odds ratios of 2.6, 2.2, and 1.6, respectively. 14. RESULTS: At 13 years after OLTX, the incidence of severe renal dysfunction was 18.1% (CRF 8.6% and ESRD 9.5%).</s>\ <s>[INST] Which sentences in the title and abstract that mention a chemical [creatinine]? [/INST] 1. However, an increase of serum creatinine at various times postoperatively is more predictive of the development of CRF or ESRD. 2. Compared with control patients, CRF and ESRD patients had higher preoperative serum creatinine levels, a greater percentage of patients with hepatorenal syndrome, higher percentage requirement for dialysis in the first 3 months postoperatively, and a higher 1-year serum creatinine. 3. Patients who develop ESRD have a higher preoperative and 1-year serum creatinine and are more likely to have hepatorenal syndrome. 4. Patients were divided into three groups: Controls, no CRF or ESRD, n=748; CRF, sustained serum creatinine >2.5 mg/dl, n=41; and ESRD, n=45. 5. Multivariate stepwise logistic regression analysis using preoperative and postoperative variables identified that an increase of serum creatinine compared with average at 1 year, 3 months, and 4 weeks postoperatively were independent risk factors for the development of CRF or ESRD with odds ratios of 2.6, 2.2, and 1.6, respectively.</s>\ <s>[INST] Which sentences mention both the entities a disease [CRF] and a chemical [creatinine]? [/INST] 1. Compared with control patients, CRF and ESRD patients had higher preoperative serum creatinine levels, a greater percentage of patients with hepatorenal syndrome, higher percentage requirement for dialysis in the first 3 months postoperatively, and a higher 1-year serum creatinine. 2. Patients who develop ESRD have a higher preoperative and 1-year serum creatinine and are more likely to have hepatorenal syndrome. 3. However, an increase of serum creatinine at various times postoperatively is more predictive of the development of CRF or ESRD. 4. Patients were divided into three groups: Controls, no CRF or ESRD, n=748; CRF, sustained serum creatinine >2.5 mg/dl, n=41; and ESRD, n=45. 5. Multivariate stepwise logistic regression analysis using preoperative and postoperative variables identified that an increase of serum creatinine compared with average at 1 year, 3 months, and 4 weeks postoperatively were independent risk factors for the development of CRF or ESRD with odds ratios of 2.6, 2.2, and 1.6, respectively.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the disease [CRF] and the chemical [creatinine]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on.
'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [cyclosporine] and a disease [nephrotoxic]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment.
- Abstract of the Paper: BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic. Their use in orthotopic liver transplantation (OLTX) has dramatically improved success rates. Recently, however, we have had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD). This retrospective study examines the incidence and treatment of ESRD and chronic renal failure (CRF) in OLTX patients. METHODS: Patients receiving an OLTX only from June 1985 through December of 1994 who survived 6 months postoperatively were studied (n=834). Our prospectively collected database was the source of information. Patients were divided into three groups: Controls, no CRF or ESRD, n=748; CRF, sustained serum creatinine >2.5 mg/dl, n=41; and ESRD, n=45. Groups were compared for preoperative laboratory variables, diagnosis, postoperative variables, survival, type of ESRD therapy, and survival from onset of ESRD. RESULTS: At 13 years after OLTX, the incidence of severe renal dysfunction was 18.1% (CRF 8.6% and ESRD 9.5%). Compared with control patients, CRF and ESRD patients had higher preoperative serum creatinine levels, a greater percentage of patients with hepatorenal syndrome, higher percentage requirement for dialysis in the first 3 months postoperatively, and a higher 1-year serum creatinine. Multivariate stepwise logistic regression analysis using preoperative and postoperative variables identified that an increase of serum creatinine compared with average at 1 year, 3 months, and 4 weeks postoperatively were independent risk factors for the development of CRF or ESRD with odds ratios of 2.6, 2.2, and 1.6, respectively. Overall survival from the time of OLTX was not significantly different among groups, but by year 13, the survival of the patients who had ESRD was only 28.2% compared with 54.6% in the control group. Patients developing ESRD had a 6-year survival after onset of ESRD of 27% for the patients receiving hemodialysis versus 71.4% for the patients developing ESRD who subsequently received kidney transplants. CONCLUSIONS: Patients who are more than 10 years post-OLTX have CRF and ESRD at a high rate. The development of ESRD decreases survival, particularly in those patients treated with dialysis only. Patients who develop ESRD have a higher preoperative and 1-year serum creatinine and are more likely to have hepatorenal syndrome. However, an increase of serum creatinine at various times postoperatively is more predictive of the development of CRF or ESRD. New strategies for long-term immunosuppression may be needed to decrease this complication.
Which sentences in the title and abstract that mention a chemical [cyclosporine]? [/INST] 1. BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [nephrotoxic]? [/INST] 1. BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic. 2. RESULTS: At 13 years after OLTX, the incidence of severe renal dysfunction was 18.1% (CRF 8.6% and ESRD 9.5%).</s>\ <s>[INST] Which sentences mention both the entities a chemical [cyclosporine] and a disease [nephrotoxic]? [/INST] 1. BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [cyclosporine] and the disease [nephrotoxic]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on.
'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Positive_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a gene or protein [SOD1] and a disease [amyotrophic lateral sclerosis]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: D90A-SOD1 mediated amyotrophic lateral sclerosis: a single founder for all cases with evidence for a Cis-acting disease modifier in the recessive haplotype.
- Abstract of the Paper: More than 100 different heterozygous mutations in copper/zinc superoxide dismutase (SOD1) have been found in patients with amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Uniquely, D90A-SOD1 has been identified in recessive, dominant and apparently sporadic pedigrees. The phenotype of homozygotes is stereotyped with an extended survival, whereas that of affected heterozygotes varies. The frequency of D90A-SOD1 is 50 times higher in Scandinavia (2.5%) than elsewhere, though ALS prevalence is not raised there. Our earlier study indicated separate founders for recessive and dominant/sporadic ALS and we proposed a disease-modifying factor linked to the recessive mutation. Here we have doubled our sample set and employed novel markers to characterise the mutation's origin and localise any modifying factor. Linkage disequilibrium analysis indicates that D90A homozygotes and heterozygotes share a rare haplotype and are all descended from a single ancient founder (alpha 0.974) c.895 generations ago. Homozygotes arose subsequently only c.63 generations ago (alpha 0.878). Recombination has reduced the region shared by recessive kindreds to 97-265 kb around SOD1, excluding all neighbouring genes. We propose that a cis-acting regulatory polymorphism has arisen close to D90A-SOD1 in the recessive founder, which decreases ALS susceptibility in heterozygotes and slows disease progression.
Which sentences in the title and abstract that mention a gene or protein [SOD1]? [/INST] 1. D90A-SOD1 mediated amyotrophic lateral sclerosis: a single founder for all cases with evidence for a Cis-acting disease modifier in the recessive haplotype. 2. The frequency of D90A-SOD1 is 50 times higher in Scandinavia (2.5%) than elsewhere, though ALS prevalence is not raised there. 3. More than 100 different heterozygous mutations in copper/zinc superoxide dismutase (SOD1) have been found in patients with amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. 4. Uniquely, D90A-SOD1 has been identified in recessive, dominant and apparently sporadic pedigrees. 5. We propose that a cis-acting regulatory polymorphism has arisen close to D90A-SOD1 in the recessive founder, which decreases ALS susceptibility in heterozygotes and slows disease progression. 6. Recombination has reduced the region shared by recessive kindreds to 97-265 kb around SOD1, excluding all neighbouring genes.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [amyotrophic lateral sclerosis]? [/INST] 1. D90A-SOD1 mediated amyotrophic lateral sclerosis: a single founder for all cases with evidence for a Cis-acting disease modifier in the recessive haplotype. 2. The frequency of D90A-SOD1 is 50 times higher in Scandinavia (2.5%) than elsewhere, though ALS prevalence is not raised there. 3. More than 100 different heterozygous mutations in copper/zinc superoxide dismutase (SOD1) have been found in patients with amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. 4. We propose that a cis-acting regulatory polymorphism has arisen close to D90A-SOD1 in the recessive founder, which decreases ALS susceptibility in heterozygotes and slows disease progression. 5. Our earlier study indicated separate founders for recessive and dominant/sporadic ALS and we proposed a disease-modifying factor linked to the recessive mutation.</s>\ <s>[INST] Which sentences mention both the entities a gene or protein [SOD1] and a disease [amyotrophic lateral sclerosis]? [/INST] 1. D90A-SOD1 mediated amyotrophic lateral sclerosis: a single founder for all cases with evidence for a Cis-acting disease modifier in the recessive haplotype. 2. The frequency of D90A-SOD1 is 50 times higher in Scandinavia (2.5%) than elsewhere, though ALS prevalence is not raised there. 3. We propose that a cis-acting regulatory polymorphism has arisen close to D90A-SOD1 in the recessive founder, which decreases ALS susceptibility in heterozygotes and slows disease progression. 4. More than 100 different heterozygous mutations in copper/zinc superoxide dismutase (SOD1) have been found in patients with amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the gene or protein [SOD1] and the disease [amyotrophic lateral sclerosis]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' here means that the relation between a gene and a disease is direct and increases the likelihood of the disease. This includes cases where too much protein causes the disease, removing the gene prevents the disease, or a side effect from the protein or drug results in the disease.
'Negative_Correlation' indicates that when a protein (or gene) is present, it helps to treat or prevent a disease. Conversely, the absence of this protein or the deactivation of its gene can lead to the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Association</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a variant [D90A] and a disease [ALS]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: D90A-SOD1 mediated amyotrophic lateral sclerosis: a single founder for all cases with evidence for a Cis-acting disease modifier in the recessive haplotype.
- Abstract of the Paper: More than 100 different heterozygous mutations in copper/zinc superoxide dismutase (SOD1) have been found in patients with amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Uniquely, D90A-SOD1 has been identified in recessive, dominant and apparently sporadic pedigrees. The phenotype of homozygotes is stereotyped with an extended survival, whereas that of affected heterozygotes varies. The frequency of D90A-SOD1 is 50 times higher in Scandinavia (2.5%) than elsewhere, though ALS prevalence is not raised there. Our earlier study indicated separate founders for recessive and dominant/sporadic ALS and we proposed a disease-modifying factor linked to the recessive mutation. Here we have doubled our sample set and employed novel markers to characterise the mutation's origin and localise any modifying factor. Linkage disequilibrium analysis indicates that D90A homozygotes and heterozygotes share a rare haplotype and are all descended from a single ancient founder (alpha 0.974) c.895 generations ago. Homozygotes arose subsequently only c.63 generations ago (alpha 0.878). Recombination has reduced the region shared by recessive kindreds to 97-265 kb around SOD1, excluding all neighbouring genes. We propose that a cis-acting regulatory polymorphism has arisen close to D90A-SOD1 in the recessive founder, which decreases ALS susceptibility in heterozygotes and slows disease progression.
Which sentences in the title and abstract that mention a variant [D90A]? [/INST] 1. D90A-SOD1 mediated amyotrophic lateral sclerosis: a single founder for all cases with evidence for a Cis-acting disease modifier in the recessive haplotype. 2. The frequency of D90A-SOD1 is 50 times higher in Scandinavia (2.5%) than elsewhere, though ALS prevalence is not raised there. 3. Linkage disequilibrium analysis indicates that D90A homozygotes and heterozygotes share a rare haplotype and are all descended from a single ancient founder (alpha 0.974) c.895 generations ago. 4. Uniquely, D90A-SOD1 has been identified in recessive, dominant and apparently sporadic pedigrees. 5. We propose that a cis-acting regulatory polymorphism has arisen close to D90A-SOD1 in the recessive founder, which decreases ALS susceptibility in heterozygotes and slows disease progression.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [ALS]? [/INST] 1. D90A-SOD1 mediated amyotrophic lateral sclerosis: a single founder for all cases with evidence for a Cis-acting disease modifier in the recessive haplotype. 2. The frequency of D90A-SOD1 is 50 times higher in Scandinavia (2.5%) than elsewhere, though ALS prevalence is not raised there. 3. More than 100 different heterozygous mutations in copper/zinc superoxide dismutase (SOD1) have been found in patients with amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. 4. We propose that a cis-acting regulatory polymorphism has arisen close to D90A-SOD1 in the recessive founder, which decreases ALS susceptibility in heterozygotes and slows disease progression. 5. Our earlier study indicated separate founders for recessive and dominant/sporadic ALS and we proposed a disease-modifying factor linked to the recessive mutation.</s>\ <s>[INST] Which sentences mention both the entities a variant [D90A] and a disease [ALS]? [/INST] 1. D90A-SOD1 mediated amyotrophic lateral sclerosis: a single founder for all cases with evidence for a Cis-acting disease modifier in the recessive haplotype. 2. The frequency of D90A-SOD1 is 50 times higher in Scandinavia (2.5%) than elsewhere, though ALS prevalence is not raised there. 3. We propose that a cis-acting regulatory polymorphism has arisen close to D90A-SOD1 in the recessive founder, which decreases ALS susceptibility in heterozygotes and slows disease progression.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the variant [D90A] and the disease [ALS]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Negative_Correlation</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a gene or protein [arylsulfatase A] and a disease [metachromatic leukodystrophy]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Late-onset metachromatic leukodystrophy: molecular pathology in two siblings.
- Abstract of the Paper: We report on a new allele at the arylsulfatase A (ARSA) locus causing late-onset metachromatic leukodystrophy (MLD). In that allele arginine84, a residue that is highly conserved in the arylsulfatase gene family, is replaced by glutamine. In contrast to alleles that cause early-onset MLD, the arginine84 to glutamine substitution is associated with some residual ARSA activity. A comparison of genotypes, ARSA activities, and clinical data on 4 individuals carrying the allele of 81 patients with MLD examined, further validates the concept that different degrees of residual ARSA activity are the basis of phenotypical variation in MLD..
Which sentences in the title and abstract that mention a gene or protein [arylsulfatase A]? [/INST] 1. A comparison of genotypes, ARSA activities, and clinical data on 4 individuals carrying the allele of 81 patients with MLD examined, further validates the concept that different degrees of residual ARSA activity are the basis of phenotypical variation in MLD.. 2. We report on a new allele at the arylsulfatase A (ARSA) locus causing late-onset metachromatic leukodystrophy (MLD). 3. In that allele arginine84, a residue that is highly conserved in the arylsulfatase gene family, is replaced by glutamine. 4. In contrast to alleles that cause early-onset MLD, the arginine84 to glutamine substitution is associated with some residual ARSA activity.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [metachromatic leukodystrophy]? [/INST] 1. A comparison of genotypes, ARSA activities, and clinical data on 4 individuals carrying the allele of 81 patients with MLD examined, further validates the concept that different degrees of residual ARSA activity are the basis of phenotypical variation in MLD.. 2. We report on a new allele at the arylsulfatase A (ARSA) locus causing late-onset metachromatic leukodystrophy (MLD). 3. Late-onset metachromatic leukodystrophy: molecular pathology in two siblings. 4. In contrast to alleles that cause early-onset MLD, the arginine84 to glutamine substitution is associated with some residual ARSA activity.</s>\ <s>[INST] Which sentences mention both the entities a gene or protein [arylsulfatase A] and a disease [metachromatic leukodystrophy]? [/INST] 1. A comparison of genotypes, ARSA activities, and clinical data on 4 individuals carrying the allele of 81 patients with MLD examined, further validates the concept that different degrees of residual ARSA activity are the basis of phenotypical variation in MLD.. 2. We report on a new allele at the arylsulfatase A (ARSA) locus causing late-onset metachromatic leukodystrophy (MLD). 3. In contrast to alleles that cause early-onset MLD, the arginine84 to glutamine substitution is associated with some residual ARSA activity.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the gene or protein [arylsulfatase A] and the disease [metachromatic leukodystrophy]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' here means that the relation between a gene and a disease is direct and increases the likelihood of the disease. This includes cases where too much protein causes the disease, removing the gene prevents the disease, or a side effect from the protein or drug results in the disease.
'Negative_Correlation' indicates that when a protein (or gene) is present, it helps to treat or prevent a disease. Conversely, the absence of this protein or the deactivation of its gene can lead to the disease.
'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Association</s>
|
<s>[INST] <<SYS>>
Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a variant [arginine84] and a disease [MLD]. Pay close attention to how these entities are discussed in the context of the article.
<</SYS>>
- Title of the Paper: Late-onset metachromatic leukodystrophy: molecular pathology in two siblings.
- Abstract of the Paper: We report on a new allele at the arylsulfatase A (ARSA) locus causing late-onset metachromatic leukodystrophy (MLD). In that allele arginine84, a residue that is highly conserved in the arylsulfatase gene family, is replaced by glutamine. In contrast to alleles that cause early-onset MLD, the arginine84 to glutamine substitution is associated with some residual ARSA activity. A comparison of genotypes, ARSA activities, and clinical data on 4 individuals carrying the allele of 81 patients with MLD examined, further validates the concept that different degrees of residual ARSA activity are the basis of phenotypical variation in MLD..
Which sentences in the title and abstract that mention a variant [arginine84]? [/INST] 1. In that allele arginine84, a residue that is highly conserved in the arylsulfatase gene family, is replaced by glutamine. 2. In contrast to alleles that cause early-onset MLD, the arginine84 to glutamine substitution is associated with some residual ARSA activity.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [MLD]? [/INST] 1. A comparison of genotypes, ARSA activities, and clinical data on 4 individuals carrying the allele of 81 patients with MLD examined, further validates the concept that different degrees of residual ARSA activity are the basis of phenotypical variation in MLD.. 2. We report on a new allele at the arylsulfatase A (ARSA) locus causing late-onset metachromatic leukodystrophy (MLD). 3. Late-onset metachromatic leukodystrophy: molecular pathology in two siblings. 4. In contrast to alleles that cause early-onset MLD, the arginine84 to glutamine substitution is associated with some residual ARSA activity.</s>\ <s>[INST] Which sentences mention both the entities a variant [arginine84] and a disease [MLD]? [/INST] 1. In contrast to alleles that cause early-onset MLD, the arginine84 to glutamine substitution is associated with some residual ARSA activity.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the variant [arginine84] and the disease [MLD]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association']
Option Descriptions:'Positive_Correlation' means that a genetic variant is linked to an increased risk of a disease. This includes cases where the variant is more common in those with the disease, causes abnormal gene expression or non-functionality leading to the disease, results in a disease due to a protein deficiency for which the variant is responsible, contributes to genetic susceptibility to the disease, or has a significant impact on the development of the disease.
'Negative_Correlation' indicates that the variant decreases the risk of the disease.
'Association' means that a genetic variant found in some patients is linked to a lower chance of getting the disease, or it makes them less likely to develop the disease. It also covers relation that don't fit into a positive/negative correlation category or relation that are not clearly defined.
Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required.
[/INST] Positive_Correlation</s>
|
End of preview. Expand
in Data Studio
README.md exists but content is empty.
- Downloads last month
- 14