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<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [Fentanyl] and a disease [myoclonus]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Prevention of etomidate-induced myoclonus: which is superior: Fentanyl, midazolam, or a combination? A Retrospective comparative study. - Abstract of the Paper: BACKGROUND: In this retrospective comparative study, we aimed to compare the effectiveness of fentanyl, midazolam, and a combination of fentanyl and midazolam to prevent etomidate-induced myoclonus. MATERIAL AND METHODS: This study was performed based on anesthesia records. Depending on the drugs that would be given before the induction of anesthesia with etomidate, the patients were separated into 4 groups: no pretreatment (Group NP), fentanyl 1 ug.kg-1 (Group F), midazolam 0.03 mg.kg-1 (Group M), and midazolam 0.015 mg.kg-1 + fentanyl 0.5 ug.kg-1 (Group FM). Patients who received the same anesthetic procedure were selected: 2 minutes after intravenous injections of the pretreatment drugs, anesthesia is induced with 0.3 mg.kg-1 etomidate injected intravenously over a period of 20-30 seconds. Myoclonic movements are evaluated, which were observed and graded according to clinical severity during the 2 minutes after etomidate injection. The severity of pain due to etomidate injection, mean arterial pressure, heart rate, and adverse effects were also evaluated. RESULTS: Study results showed that myoclonus incidence was 85%, 40%, 70%, and 25% in Group NP, Group F, Group M, and Group FM, respectively, and were significantly lower in Group F and Group FM. CONCLUSIONS: We conclude that pretreatment with fentanyl or combination of fentanyl and midazolam was effective in preventing etomidate-induced myoclonus. Which sentences in the title and abstract that mention a chemical [Fentanyl]? [/INST] 1. CONCLUSIONS: We conclude that pretreatment with fentanyl or combination of fentanyl and midazolam was effective in preventing etomidate-induced myoclonus. 2. Depending on the drugs that would be given before the induction of anesthesia with etomidate, the patients were separated into 4 groups: no pretreatment (Group NP), fentanyl 1 ug.kg-1 (Group F), midazolam 0.03 mg.kg-1 (Group M), and midazolam 0.015 mg.kg-1 + fentanyl 0.5 ug.kg-1 (Group FM). 3. BACKGROUND: In this retrospective comparative study, we aimed to compare the effectiveness of fentanyl, midazolam, and a combination of fentanyl and midazolam to prevent etomidate-induced myoclonus. 4. Prevention of etomidate-induced myoclonus: which is superior: Fentanyl, midazolam, or a combination?</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [myoclonus]? [/INST] 1. CONCLUSIONS: We conclude that pretreatment with fentanyl or combination of fentanyl and midazolam was effective in preventing etomidate-induced myoclonus. 2. RESULTS: Study results showed that myoclonus incidence was 85%, 40%, 70%, and 25% in Group NP, Group F, Group M, and Group FM, respectively, and were significantly lower in Group F and Group FM. 3. BACKGROUND: In this retrospective comparative study, we aimed to compare the effectiveness of fentanyl, midazolam, and a combination of fentanyl and midazolam to prevent etomidate-induced myoclonus. 4. Prevention of etomidate-induced myoclonus: which is superior: Fentanyl, midazolam, or a combination?</s>\ <s>[INST] Which sentences mention both the entities a chemical [Fentanyl] and a disease [myoclonus]? [/INST] 1. CONCLUSIONS: We conclude that pretreatment with fentanyl or combination of fentanyl and midazolam was effective in preventing etomidate-induced myoclonus. 2. BACKGROUND: In this retrospective comparative study, we aimed to compare the effectiveness of fentanyl, midazolam, and a combination of fentanyl and midazolam to prevent etomidate-induced myoclonus. 3. Prevention of etomidate-induced myoclonus: which is superior: Fentanyl, midazolam, or a combination?</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [Fentanyl] and the disease [myoclonus]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association'] Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on. 'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease. 'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Negative_Correlation</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [Fentanyl] and a chemical [etomidate]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Prevention of etomidate-induced myoclonus: which is superior: Fentanyl, midazolam, or a combination? A Retrospective comparative study. - Abstract of the Paper: BACKGROUND: In this retrospective comparative study, we aimed to compare the effectiveness of fentanyl, midazolam, and a combination of fentanyl and midazolam to prevent etomidate-induced myoclonus. MATERIAL AND METHODS: This study was performed based on anesthesia records. Depending on the drugs that would be given before the induction of anesthesia with etomidate, the patients were separated into 4 groups: no pretreatment (Group NP), fentanyl 1 ug.kg-1 (Group F), midazolam 0.03 mg.kg-1 (Group M), and midazolam 0.015 mg.kg-1 + fentanyl 0.5 ug.kg-1 (Group FM). Patients who received the same anesthetic procedure were selected: 2 minutes after intravenous injections of the pretreatment drugs, anesthesia is induced with 0.3 mg.kg-1 etomidate injected intravenously over a period of 20-30 seconds. Myoclonic movements are evaluated, which were observed and graded according to clinical severity during the 2 minutes after etomidate injection. The severity of pain due to etomidate injection, mean arterial pressure, heart rate, and adverse effects were also evaluated. RESULTS: Study results showed that myoclonus incidence was 85%, 40%, 70%, and 25% in Group NP, Group F, Group M, and Group FM, respectively, and were significantly lower in Group F and Group FM. CONCLUSIONS: We conclude that pretreatment with fentanyl or combination of fentanyl and midazolam was effective in preventing etomidate-induced myoclonus. Which sentences in the title and abstract that mention a chemical [Fentanyl]? [/INST] 1. CONCLUSIONS: We conclude that pretreatment with fentanyl or combination of fentanyl and midazolam was effective in preventing etomidate-induced myoclonus. 2. Depending on the drugs that would be given before the induction of anesthesia with etomidate, the patients were separated into 4 groups: no pretreatment (Group NP), fentanyl 1 ug.kg-1 (Group F), midazolam 0.03 mg.kg-1 (Group M), and midazolam 0.015 mg.kg-1 + fentanyl 0.5 ug.kg-1 (Group FM). 3. BACKGROUND: In this retrospective comparative study, we aimed to compare the effectiveness of fentanyl, midazolam, and a combination of fentanyl and midazolam to prevent etomidate-induced myoclonus. 4. Prevention of etomidate-induced myoclonus: which is superior: Fentanyl, midazolam, or a combination?</s>\ <s>[INST] Which sentences in the title and abstract that mention a chemical [etomidate]? [/INST] 1. The severity of pain due to etomidate injection, mean arterial pressure, heart rate, and adverse effects were also evaluated. 2. Myoclonic movements are evaluated, which were observed and graded according to clinical severity during the 2 minutes after etomidate injection. 3. Patients who received the same anesthetic procedure were selected: 2 minutes after intravenous injections of the pretreatment drugs, anesthesia is induced with 0.3 mg.kg-1 etomidate injected intravenously over a period of 20-30 seconds. 4. Depending on the drugs that would be given before the induction of anesthesia with etomidate, the patients were separated into 4 groups: no pretreatment (Group NP), fentanyl 1 ug.kg-1 (Group F), midazolam 0.03 mg.kg-1 (Group M), and midazolam 0.015 mg.kg-1 + fentanyl 0.5 ug.kg-1 (Group FM). 5. BACKGROUND: In this retrospective comparative study, we aimed to compare the effectiveness of fentanyl, midazolam, and a combination of fentanyl and midazolam to prevent etomidate-induced myoclonus. 6. Prevention of etomidate-induced myoclonus: which is superior: Fentanyl, midazolam, or a combination? 7. CONCLUSIONS: We conclude that pretreatment with fentanyl or combination of fentanyl and midazolam was effective in preventing etomidate-induced myoclonus.</s>\ <s>[INST] Which sentences mention both the entities a chemical [Fentanyl] and a chemical [etomidate]? [/INST] 1. CONCLUSIONS: We conclude that pretreatment with fentanyl or combination of fentanyl and midazolam was effective in preventing etomidate-induced myoclonus. 2. Depending on the drugs that would be given before the induction of anesthesia with etomidate, the patients were separated into 4 groups: no pretreatment (Group NP), fentanyl 1 ug.kg-1 (Group F), midazolam 0.03 mg.kg-1 (Group M), and midazolam 0.015 mg.kg-1 + fentanyl 0.5 ug.kg-1 (Group FM). 3. BACKGROUND: In this retrospective comparative study, we aimed to compare the effectiveness of fentanyl, midazolam, and a combination of fentanyl and midazolam to prevent etomidate-induced myoclonus. 4. Prevention of etomidate-induced myoclonus: which is superior: Fentanyl, midazolam, or a combination?</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [Fentanyl] and the chemical [etomidate]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Drug_Interaction', 'Cotreatment', 'Conversion', 'Comparison', 'Association'] Option Descriptions:'Positive_Correlation' indicates that Chemical A increases the effectiveness of Chemical B. This includes making Chemical B more sensitive, enhancing its ability to treat or induce a disease, or boosting its role in gene activation. 'Negative_Correlation' means that Chemical A reduces the effectiveness and impact of Chemical B. This includes decreasing Chemical B's sensitivity, reducing its ability to treat or induce a disease, diminishing its side effects, and lowering the gene activation it causes. 'Drug_Interaction' is when two different drugs or chemicals affect each other's action in the body, happening when they are used at the same time. 'Cotreatment' means that two different drugs or chemicals are used in combination therapy. 'Conversion' means that one chemical changes into another chemical. 'Comparison' means that two different drugs or chemicals have some differences and similarities in their effects. 'Association' refers to the relation between two chemicals that do not fit into any specific, predefined categories of relations. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Negative_Correlation</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a disease [pain] and a chemical [etomidate]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Prevention of etomidate-induced myoclonus: which is superior: Fentanyl, midazolam, or a combination? A Retrospective comparative study. - Abstract of the Paper: BACKGROUND: In this retrospective comparative study, we aimed to compare the effectiveness of fentanyl, midazolam, and a combination of fentanyl and midazolam to prevent etomidate-induced myoclonus. MATERIAL AND METHODS: This study was performed based on anesthesia records. Depending on the drugs that would be given before the induction of anesthesia with etomidate, the patients were separated into 4 groups: no pretreatment (Group NP), fentanyl 1 ug.kg-1 (Group F), midazolam 0.03 mg.kg-1 (Group M), and midazolam 0.015 mg.kg-1 + fentanyl 0.5 ug.kg-1 (Group FM). Patients who received the same anesthetic procedure were selected: 2 minutes after intravenous injections of the pretreatment drugs, anesthesia is induced with 0.3 mg.kg-1 etomidate injected intravenously over a period of 20-30 seconds. Myoclonic movements are evaluated, which were observed and graded according to clinical severity during the 2 minutes after etomidate injection. The severity of pain due to etomidate injection, mean arterial pressure, heart rate, and adverse effects were also evaluated. RESULTS: Study results showed that myoclonus incidence was 85%, 40%, 70%, and 25% in Group NP, Group F, Group M, and Group FM, respectively, and were significantly lower in Group F and Group FM. CONCLUSIONS: We conclude that pretreatment with fentanyl or combination of fentanyl and midazolam was effective in preventing etomidate-induced myoclonus. Which sentences in the title and abstract that mention a disease [pain]? [/INST] 1. The severity of pain due to etomidate injection, mean arterial pressure, heart rate, and adverse effects were also evaluated.</s>\ <s>[INST] Which sentences in the title and abstract that mention a chemical [etomidate]? [/INST] 1. The severity of pain due to etomidate injection, mean arterial pressure, heart rate, and adverse effects were also evaluated. 2. Myoclonic movements are evaluated, which were observed and graded according to clinical severity during the 2 minutes after etomidate injection. 3. Patients who received the same anesthetic procedure were selected: 2 minutes after intravenous injections of the pretreatment drugs, anesthesia is induced with 0.3 mg.kg-1 etomidate injected intravenously over a period of 20-30 seconds. 4. Depending on the drugs that would be given before the induction of anesthesia with etomidate, the patients were separated into 4 groups: no pretreatment (Group NP), fentanyl 1 ug.kg-1 (Group F), midazolam 0.03 mg.kg-1 (Group M), and midazolam 0.015 mg.kg-1 + fentanyl 0.5 ug.kg-1 (Group FM). 5. BACKGROUND: In this retrospective comparative study, we aimed to compare the effectiveness of fentanyl, midazolam, and a combination of fentanyl and midazolam to prevent etomidate-induced myoclonus. 6. Prevention of etomidate-induced myoclonus: which is superior: Fentanyl, midazolam, or a combination? 7. CONCLUSIONS: We conclude that pretreatment with fentanyl or combination of fentanyl and midazolam was effective in preventing etomidate-induced myoclonus.</s>\ <s>[INST] Which sentences mention both the entities a disease [pain] and a chemical [etomidate]? [/INST] 1. The severity of pain due to etomidate injection, mean arterial pressure, heart rate, and adverse effects were also evaluated.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the disease [pain] and the chemical [etomidate]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association'] Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on. 'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease. 'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Positive_Correlation</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a disease [Myoclonic movements] and a chemical [etomidate]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Prevention of etomidate-induced myoclonus: which is superior: Fentanyl, midazolam, or a combination? A Retrospective comparative study. - Abstract of the Paper: BACKGROUND: In this retrospective comparative study, we aimed to compare the effectiveness of fentanyl, midazolam, and a combination of fentanyl and midazolam to prevent etomidate-induced myoclonus. MATERIAL AND METHODS: This study was performed based on anesthesia records. Depending on the drugs that would be given before the induction of anesthesia with etomidate, the patients were separated into 4 groups: no pretreatment (Group NP), fentanyl 1 ug.kg-1 (Group F), midazolam 0.03 mg.kg-1 (Group M), and midazolam 0.015 mg.kg-1 + fentanyl 0.5 ug.kg-1 (Group FM). Patients who received the same anesthetic procedure were selected: 2 minutes after intravenous injections of the pretreatment drugs, anesthesia is induced with 0.3 mg.kg-1 etomidate injected intravenously over a period of 20-30 seconds. Myoclonic movements are evaluated, which were observed and graded according to clinical severity during the 2 minutes after etomidate injection. The severity of pain due to etomidate injection, mean arterial pressure, heart rate, and adverse effects were also evaluated. RESULTS: Study results showed that myoclonus incidence was 85%, 40%, 70%, and 25% in Group NP, Group F, Group M, and Group FM, respectively, and were significantly lower in Group F and Group FM. CONCLUSIONS: We conclude that pretreatment with fentanyl or combination of fentanyl and midazolam was effective in preventing etomidate-induced myoclonus. Which sentences in the title and abstract that mention a disease [Myoclonic movements]? [/INST] 1. Myoclonic movements are evaluated, which were observed and graded according to clinical severity during the 2 minutes after etomidate injection.</s>\ <s>[INST] Which sentences in the title and abstract that mention a chemical [etomidate]? [/INST] 1. The severity of pain due to etomidate injection, mean arterial pressure, heart rate, and adverse effects were also evaluated. 2. Myoclonic movements are evaluated, which were observed and graded according to clinical severity during the 2 minutes after etomidate injection. 3. Patients who received the same anesthetic procedure were selected: 2 minutes after intravenous injections of the pretreatment drugs, anesthesia is induced with 0.3 mg.kg-1 etomidate injected intravenously over a period of 20-30 seconds. 4. Depending on the drugs that would be given before the induction of anesthesia with etomidate, the patients were separated into 4 groups: no pretreatment (Group NP), fentanyl 1 ug.kg-1 (Group F), midazolam 0.03 mg.kg-1 (Group M), and midazolam 0.015 mg.kg-1 + fentanyl 0.5 ug.kg-1 (Group FM). 5. BACKGROUND: In this retrospective comparative study, we aimed to compare the effectiveness of fentanyl, midazolam, and a combination of fentanyl and midazolam to prevent etomidate-induced myoclonus. 6. Prevention of etomidate-induced myoclonus: which is superior: Fentanyl, midazolam, or a combination? 7. CONCLUSIONS: We conclude that pretreatment with fentanyl or combination of fentanyl and midazolam was effective in preventing etomidate-induced myoclonus.</s>\ <s>[INST] Which sentences mention both the entities a disease [Myoclonic movements] and a chemical [etomidate]? [/INST] 1. Myoclonic movements are evaluated, which were observed and graded according to clinical severity during the 2 minutes after etomidate injection.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the disease [Myoclonic movements] and the chemical [etomidate]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association'] Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on. 'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease. 'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Positive_Correlation</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [etomidate] and a disease [myoclonus]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Prevention of etomidate-induced myoclonus: which is superior: Fentanyl, midazolam, or a combination? A Retrospective comparative study. - Abstract of the Paper: BACKGROUND: In this retrospective comparative study, we aimed to compare the effectiveness of fentanyl, midazolam, and a combination of fentanyl and midazolam to prevent etomidate-induced myoclonus. MATERIAL AND METHODS: This study was performed based on anesthesia records. Depending on the drugs that would be given before the induction of anesthesia with etomidate, the patients were separated into 4 groups: no pretreatment (Group NP), fentanyl 1 ug.kg-1 (Group F), midazolam 0.03 mg.kg-1 (Group M), and midazolam 0.015 mg.kg-1 + fentanyl 0.5 ug.kg-1 (Group FM). Patients who received the same anesthetic procedure were selected: 2 minutes after intravenous injections of the pretreatment drugs, anesthesia is induced with 0.3 mg.kg-1 etomidate injected intravenously over a period of 20-30 seconds. Myoclonic movements are evaluated, which were observed and graded according to clinical severity during the 2 minutes after etomidate injection. The severity of pain due to etomidate injection, mean arterial pressure, heart rate, and adverse effects were also evaluated. RESULTS: Study results showed that myoclonus incidence was 85%, 40%, 70%, and 25% in Group NP, Group F, Group M, and Group FM, respectively, and were significantly lower in Group F and Group FM. CONCLUSIONS: We conclude that pretreatment with fentanyl or combination of fentanyl and midazolam was effective in preventing etomidate-induced myoclonus. Which sentences in the title and abstract that mention a chemical [etomidate]? [/INST] 1. The severity of pain due to etomidate injection, mean arterial pressure, heart rate, and adverse effects were also evaluated. 2. Myoclonic movements are evaluated, which were observed and graded according to clinical severity during the 2 minutes after etomidate injection. 3. Patients who received the same anesthetic procedure were selected: 2 minutes after intravenous injections of the pretreatment drugs, anesthesia is induced with 0.3 mg.kg-1 etomidate injected intravenously over a period of 20-30 seconds. 4. Depending on the drugs that would be given before the induction of anesthesia with etomidate, the patients were separated into 4 groups: no pretreatment (Group NP), fentanyl 1 ug.kg-1 (Group F), midazolam 0.03 mg.kg-1 (Group M), and midazolam 0.015 mg.kg-1 + fentanyl 0.5 ug.kg-1 (Group FM). 5. BACKGROUND: In this retrospective comparative study, we aimed to compare the effectiveness of fentanyl, midazolam, and a combination of fentanyl and midazolam to prevent etomidate-induced myoclonus. 6. Prevention of etomidate-induced myoclonus: which is superior: Fentanyl, midazolam, or a combination? 7. CONCLUSIONS: We conclude that pretreatment with fentanyl or combination of fentanyl and midazolam was effective in preventing etomidate-induced myoclonus.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [myoclonus]? [/INST] 1. CONCLUSIONS: We conclude that pretreatment with fentanyl or combination of fentanyl and midazolam was effective in preventing etomidate-induced myoclonus. 2. RESULTS: Study results showed that myoclonus incidence was 85%, 40%, 70%, and 25% in Group NP, Group F, Group M, and Group FM, respectively, and were significantly lower in Group F and Group FM. 3. BACKGROUND: In this retrospective comparative study, we aimed to compare the effectiveness of fentanyl, midazolam, and a combination of fentanyl and midazolam to prevent etomidate-induced myoclonus. 4. Prevention of etomidate-induced myoclonus: which is superior: Fentanyl, midazolam, or a combination?</s>\ <s>[INST] Which sentences mention both the entities a chemical [etomidate] and a disease [myoclonus]? [/INST] 1. CONCLUSIONS: We conclude that pretreatment with fentanyl or combination of fentanyl and midazolam was effective in preventing etomidate-induced myoclonus. 2. BACKGROUND: In this retrospective comparative study, we aimed to compare the effectiveness of fentanyl, midazolam, and a combination of fentanyl and midazolam to prevent etomidate-induced myoclonus. 3. Prevention of etomidate-induced myoclonus: which is superior: Fentanyl, midazolam, or a combination?</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [etomidate] and the disease [myoclonus]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association'] Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on. 'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease. 'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Positive_Correlation</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [letrozole] and a disease [memory impairment]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Testosterone ameliorates streptozotocin-induced memory impairment in male rats. - Abstract of the Paper: AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. METHODS: Adult male Wistar rats were intracerebroventricularly (icv) infused with STZ (750 ug) on d 1 and d 3, and a passive avoidance task was assessed 2 weeks after the first injection of STZ. Castration surgery was performed in another group of rats, and the passive avoidance task was assessed 4 weeks after the operation. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. RESULTS: STZ administration and castration markedly decreased both STL1 (the short memory) and STL2 (the long memory) in passive avoidance tests. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. Which sentences in the title and abstract that mention a chemical [letrozole]? [/INST] 1. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. 2. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [memory impairment]? [/INST] 1. AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. 2. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. 3. Testosterone ameliorates streptozotocin-induced memory impairment in male rats. 4. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.</s>\ <s>[INST] Which sentences mention both the entities a chemical [letrozole] and a disease [memory impairment]? [/INST] 1. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [letrozole] and the disease [memory impairment]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association'] Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on. 'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease. 'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Positive_Correlation</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a gene or protein [aromatase] and a chemical [letrozole]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Testosterone ameliorates streptozotocin-induced memory impairment in male rats. - Abstract of the Paper: AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. METHODS: Adult male Wistar rats were intracerebroventricularly (icv) infused with STZ (750 ug) on d 1 and d 3, and a passive avoidance task was assessed 2 weeks after the first injection of STZ. Castration surgery was performed in another group of rats, and the passive avoidance task was assessed 4 weeks after the operation. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. RESULTS: STZ administration and castration markedly decreased both STL1 (the short memory) and STL2 (the long memory) in passive avoidance tests. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. Which sentences in the title and abstract that mention a gene or protein [aromatase]? [/INST] 1. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ.</s>\ <s>[INST] Which sentences in the title and abstract that mention a chemical [letrozole]? [/INST] 1. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. 2. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.</s>\ <s>[INST] Which sentences mention both the entities a gene or protein [aromatase] and a chemical [letrozole]? [/INST] 1. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the gene or protein [aromatase] and the chemical [letrozole]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'] Option Descriptions:'Positive_Correlation' means that a chemical leads to higher gene expression, or higher gene expression increases sensitivity to the chemical, or a gene variant exacerbates the chemical's side effects, or a gene causes an over-response to the chemical, or there is a positive interaction between two genes in any manner. 'Negative_Correlation' indicates that a chemical leads to reduced gene expression, or higher gene expression results in decreased sensitivity or resistance to the chemical, or a gene variant offers protection against the chemical's adverse effects, or a gene contributes to resistance against the chemical, or there exists a negative interaction between two genes in any form. 'Bind' means that a chemical either connects to a gene's promoter region or a protein acts as a receptor for that chemical. 'Association' is used to describe relation that don't clearly fall under categories like positive correlation, negative correlation and bind , or when the nature of the relation lack a clear description. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Negative_Correlation</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [tamoxifen] and a disease [memory impairment]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Testosterone ameliorates streptozotocin-induced memory impairment in male rats. - Abstract of the Paper: AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. METHODS: Adult male Wistar rats were intracerebroventricularly (icv) infused with STZ (750 ug) on d 1 and d 3, and a passive avoidance task was assessed 2 weeks after the first injection of STZ. Castration surgery was performed in another group of rats, and the passive avoidance task was assessed 4 weeks after the operation. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. RESULTS: STZ administration and castration markedly decreased both STL1 (the short memory) and STL2 (the long memory) in passive avoidance tests. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. Which sentences in the title and abstract that mention a chemical [tamoxifen]? [/INST] 1. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. 2. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [memory impairment]? [/INST] 1. AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. 2. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. 3. Testosterone ameliorates streptozotocin-induced memory impairment in male rats. 4. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.</s>\ <s>[INST] Which sentences mention both the entities a chemical [tamoxifen] and a disease [memory impairment]? [/INST] 1. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [tamoxifen] and the disease [memory impairment]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association'] Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on. 'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease. 'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Positive_Correlation</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a gene or protein [estrogen receptor] and a chemical [tamoxifen]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Testosterone ameliorates streptozotocin-induced memory impairment in male rats. - Abstract of the Paper: AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. METHODS: Adult male Wistar rats were intracerebroventricularly (icv) infused with STZ (750 ug) on d 1 and d 3, and a passive avoidance task was assessed 2 weeks after the first injection of STZ. Castration surgery was performed in another group of rats, and the passive avoidance task was assessed 4 weeks after the operation. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. RESULTS: STZ administration and castration markedly decreased both STL1 (the short memory) and STL2 (the long memory) in passive avoidance tests. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. Which sentences in the title and abstract that mention a gene or protein [estrogen receptor]? [/INST] 1. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ.</s>\ <s>[INST] Which sentences in the title and abstract that mention a chemical [tamoxifen]? [/INST] 1. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. 2. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.</s>\ <s>[INST] Which sentences mention both the entities a gene or protein [estrogen receptor] and a chemical [tamoxifen]? [/INST] 1. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the gene or protein [estrogen receptor] and the chemical [tamoxifen]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'] Option Descriptions:'Positive_Correlation' means that a chemical leads to higher gene expression, or higher gene expression increases sensitivity to the chemical, or a gene variant exacerbates the chemical's side effects, or a gene causes an over-response to the chemical, or there is a positive interaction between two genes in any manner. 'Negative_Correlation' indicates that a chemical leads to reduced gene expression, or higher gene expression results in decreased sensitivity or resistance to the chemical, or a gene variant offers protection against the chemical's adverse effects, or a gene contributes to resistance against the chemical, or there exists a negative interaction between two genes in any form. 'Bind' means that a chemical either connects to a gene's promoter region or a protein acts as a receptor for that chemical. 'Association' is used to describe relation that don't clearly fall under categories like positive correlation, negative correlation and bind , or when the nature of the relation lack a clear description. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Negative_Correlation</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [flutamide] and a disease [memory impairment]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Testosterone ameliorates streptozotocin-induced memory impairment in male rats. - Abstract of the Paper: AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. METHODS: Adult male Wistar rats were intracerebroventricularly (icv) infused with STZ (750 ug) on d 1 and d 3, and a passive avoidance task was assessed 2 weeks after the first injection of STZ. Castration surgery was performed in another group of rats, and the passive avoidance task was assessed 4 weeks after the operation. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. RESULTS: STZ administration and castration markedly decreased both STL1 (the short memory) and STL2 (the long memory) in passive avoidance tests. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. Which sentences in the title and abstract that mention a chemical [flutamide]? [/INST] 1. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. 2. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [memory impairment]? [/INST] 1. AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. 2. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. 3. Testosterone ameliorates streptozotocin-induced memory impairment in male rats. 4. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.</s>\ <s>[INST] Which sentences mention both the entities a chemical [flutamide] and a disease [memory impairment]? [/INST] 1. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [flutamide] and the disease [memory impairment]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association'] Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on. 'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease. 'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Positive_Correlation</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a gene or protein [androgen receptor] and a chemical [flutamide]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Testosterone ameliorates streptozotocin-induced memory impairment in male rats. - Abstract of the Paper: AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. METHODS: Adult male Wistar rats were intracerebroventricularly (icv) infused with STZ (750 ug) on d 1 and d 3, and a passive avoidance task was assessed 2 weeks after the first injection of STZ. Castration surgery was performed in another group of rats, and the passive avoidance task was assessed 4 weeks after the operation. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. RESULTS: STZ administration and castration markedly decreased both STL1 (the short memory) and STL2 (the long memory) in passive avoidance tests. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. Which sentences in the title and abstract that mention a gene or protein [androgen receptor]? [/INST] 1. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ.</s>\ <s>[INST] Which sentences in the title and abstract that mention a chemical [flutamide]? [/INST] 1. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. 2. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.</s>\ <s>[INST] Which sentences mention both the entities a gene or protein [androgen receptor] and a chemical [flutamide]? [/INST] 1. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the gene or protein [androgen receptor] and the chemical [flutamide]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'] Option Descriptions:'Positive_Correlation' means that a chemical leads to higher gene expression, or higher gene expression increases sensitivity to the chemical, or a gene variant exacerbates the chemical's side effects, or a gene causes an over-response to the chemical, or there is a positive interaction between two genes in any manner. 'Negative_Correlation' indicates that a chemical leads to reduced gene expression, or higher gene expression results in decreased sensitivity or resistance to the chemical, or a gene variant offers protection against the chemical's adverse effects, or a gene contributes to resistance against the chemical, or there exists a negative interaction between two genes in any form. 'Bind' means that a chemical either connects to a gene's promoter region or a protein acts as a receptor for that chemical. 'Association' is used to describe relation that don't clearly fall under categories like positive correlation, negative correlation and bind , or when the nature of the relation lack a clear description. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Negative_Correlation</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [STZ] and a gene or protein [STL2]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Testosterone ameliorates streptozotocin-induced memory impairment in male rats. - Abstract of the Paper: AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. METHODS: Adult male Wistar rats were intracerebroventricularly (icv) infused with STZ (750 ug) on d 1 and d 3, and a passive avoidance task was assessed 2 weeks after the first injection of STZ. Castration surgery was performed in another group of rats, and the passive avoidance task was assessed 4 weeks after the operation. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. RESULTS: STZ administration and castration markedly decreased both STL1 (the short memory) and STL2 (the long memory) in passive avoidance tests. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. Which sentences in the title and abstract that mention a chemical [STZ]? [/INST] 1. AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. 2. METHODS: Adult male Wistar rats were intracerebroventricularly (icv) infused with STZ (750 ug) on d 1 and d 3, and a passive avoidance task was assessed 2 weeks after the first injection of STZ. 3. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. 4. RESULTS: STZ administration and castration markedly decreased both STL1 (the short memory) and STL2 (the long memory) in passive avoidance tests. 5. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. 6. Testosterone ameliorates streptozotocin-induced memory impairment in male rats. 7. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats. 8. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.</s>\ <s>[INST] Which sentences in the title and abstract that mention a gene or protein [STL2]? [/INST] 1. RESULTS: STZ administration and castration markedly decreased both STL1 (the short memory) and STL2 (the long memory) in passive avoidance tests. 2. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats.</s>\ <s>[INST] Which sentences mention both the entities a chemical [STZ] and a gene or protein [STL2]? [/INST] 1. RESULTS: STZ administration and castration markedly decreased both STL1 (the short memory) and STL2 (the long memory) in passive avoidance tests. 2. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [STZ] and the gene or protein [STL2]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'] Option Descriptions:'Positive_Correlation' means that a chemical leads to higher gene expression, or higher gene expression increases sensitivity to the chemical, or a gene variant exacerbates the chemical's side effects, or a gene causes an over-response to the chemical, or there is a positive interaction between two genes in any manner. 'Negative_Correlation' indicates that a chemical leads to reduced gene expression, or higher gene expression results in decreased sensitivity or resistance to the chemical, or a gene variant offers protection against the chemical's adverse effects, or a gene contributes to resistance against the chemical, or there exists a negative interaction between two genes in any form. 'Bind' means that a chemical either connects to a gene's promoter region or a protein acts as a receptor for that chemical. 'Association' is used to describe relation that don't clearly fall under categories like positive correlation, negative correlation and bind , or when the nature of the relation lack a clear description. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Negative_Correlation</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [STZ] and a gene or protein [STL1]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Testosterone ameliorates streptozotocin-induced memory impairment in male rats. - Abstract of the Paper: AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. METHODS: Adult male Wistar rats were intracerebroventricularly (icv) infused with STZ (750 ug) on d 1 and d 3, and a passive avoidance task was assessed 2 weeks after the first injection of STZ. Castration surgery was performed in another group of rats, and the passive avoidance task was assessed 4 weeks after the operation. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. RESULTS: STZ administration and castration markedly decreased both STL1 (the short memory) and STL2 (the long memory) in passive avoidance tests. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. Which sentences in the title and abstract that mention a chemical [STZ]? [/INST] 1. AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. 2. METHODS: Adult male Wistar rats were intracerebroventricularly (icv) infused with STZ (750 ug) on d 1 and d 3, and a passive avoidance task was assessed 2 weeks after the first injection of STZ. 3. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. 4. RESULTS: STZ administration and castration markedly decreased both STL1 (the short memory) and STL2 (the long memory) in passive avoidance tests. 5. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. 6. Testosterone ameliorates streptozotocin-induced memory impairment in male rats. 7. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats. 8. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.</s>\ <s>[INST] Which sentences in the title and abstract that mention a gene or protein [STL1]? [/INST] 1. RESULTS: STZ administration and castration markedly decreased both STL1 (the short memory) and STL2 (the long memory) in passive avoidance tests. 2. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats.</s>\ <s>[INST] Which sentences mention both the entities a chemical [STZ] and a gene or protein [STL1]? [/INST] 1. RESULTS: STZ administration and castration markedly decreased both STL1 (the short memory) and STL2 (the long memory) in passive avoidance tests. 2. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [STZ] and the gene or protein [STL1]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'] Option Descriptions:'Positive_Correlation' means that a chemical leads to higher gene expression, or higher gene expression increases sensitivity to the chemical, or a gene variant exacerbates the chemical's side effects, or a gene causes an over-response to the chemical, or there is a positive interaction between two genes in any manner. 'Negative_Correlation' indicates that a chemical leads to reduced gene expression, or higher gene expression results in decreased sensitivity or resistance to the chemical, or a gene variant offers protection against the chemical's adverse effects, or a gene contributes to resistance against the chemical, or there exists a negative interaction between two genes in any form. 'Bind' means that a chemical either connects to a gene's promoter region or a protein acts as a receptor for that chemical. 'Association' is used to describe relation that don't clearly fall under categories like positive correlation, negative correlation and bind , or when the nature of the relation lack a clear description. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Negative_Correlation</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [streptozotocin] and a disease [memory impairment]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Testosterone ameliorates streptozotocin-induced memory impairment in male rats. - Abstract of the Paper: AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. METHODS: Adult male Wistar rats were intracerebroventricularly (icv) infused with STZ (750 ug) on d 1 and d 3, and a passive avoidance task was assessed 2 weeks after the first injection of STZ. Castration surgery was performed in another group of rats, and the passive avoidance task was assessed 4 weeks after the operation. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. RESULTS: STZ administration and castration markedly decreased both STL1 (the short memory) and STL2 (the long memory) in passive avoidance tests. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. Which sentences in the title and abstract that mention a chemical [streptozotocin]? [/INST] 1. AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. 2. METHODS: Adult male Wistar rats were intracerebroventricularly (icv) infused with STZ (750 ug) on d 1 and d 3, and a passive avoidance task was assessed 2 weeks after the first injection of STZ. 3. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. 4. RESULTS: STZ administration and castration markedly decreased both STL1 (the short memory) and STL2 (the long memory) in passive avoidance tests. 5. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. 6. Testosterone ameliorates streptozotocin-induced memory impairment in male rats. 7. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats. 8. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [memory impairment]? [/INST] 1. AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. 2. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. 3. Testosterone ameliorates streptozotocin-induced memory impairment in male rats. 4. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.</s>\ <s>[INST] Which sentences mention both the entities a chemical [streptozotocin] and a disease [memory impairment]? [/INST] 1. AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. 2. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. 3. Testosterone ameliorates streptozotocin-induced memory impairment in male rats. 4. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [streptozotocin] and the disease [memory impairment]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association'] Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on. 'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease. 'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Positive_Correlation</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [Testosterone] and a gene or protein [STL2]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Testosterone ameliorates streptozotocin-induced memory impairment in male rats. - Abstract of the Paper: AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. METHODS: Adult male Wistar rats were intracerebroventricularly (icv) infused with STZ (750 ug) on d 1 and d 3, and a passive avoidance task was assessed 2 weeks after the first injection of STZ. Castration surgery was performed in another group of rats, and the passive avoidance task was assessed 4 weeks after the operation. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. RESULTS: STZ administration and castration markedly decreased both STL1 (the short memory) and STL2 (the long memory) in passive avoidance tests. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. Which sentences in the title and abstract that mention a chemical [Testosterone]? [/INST] 1. AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. 2. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. 3. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. 4. Testosterone ameliorates streptozotocin-induced memory impairment in male rats. 5. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats. 6. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.</s>\ <s>[INST] Which sentences in the title and abstract that mention a gene or protein [STL2]? [/INST] 1. RESULTS: STZ administration and castration markedly decreased both STL1 (the short memory) and STL2 (the long memory) in passive avoidance tests. 2. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats.</s>\ <s>[INST] Which sentences mention both the entities a chemical [Testosterone] and a gene or protein [STL2]? [/INST] 1. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [Testosterone] and the gene or protein [STL2]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'] Option Descriptions:'Positive_Correlation' means that a chemical leads to higher gene expression, or higher gene expression increases sensitivity to the chemical, or a gene variant exacerbates the chemical's side effects, or a gene causes an over-response to the chemical, or there is a positive interaction between two genes in any manner. 'Negative_Correlation' indicates that a chemical leads to reduced gene expression, or higher gene expression results in decreased sensitivity or resistance to the chemical, or a gene variant offers protection against the chemical's adverse effects, or a gene contributes to resistance against the chemical, or there exists a negative interaction between two genes in any form. 'Bind' means that a chemical either connects to a gene's promoter region or a protein acts as a receptor for that chemical. 'Association' is used to describe relation that don't clearly fall under categories like positive correlation, negative correlation and bind , or when the nature of the relation lack a clear description. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Association</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [Testosterone] and a gene or protein [STL1]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Testosterone ameliorates streptozotocin-induced memory impairment in male rats. - Abstract of the Paper: AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. METHODS: Adult male Wistar rats were intracerebroventricularly (icv) infused with STZ (750 ug) on d 1 and d 3, and a passive avoidance task was assessed 2 weeks after the first injection of STZ. Castration surgery was performed in another group of rats, and the passive avoidance task was assessed 4 weeks after the operation. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. RESULTS: STZ administration and castration markedly decreased both STL1 (the short memory) and STL2 (the long memory) in passive avoidance tests. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. Which sentences in the title and abstract that mention a chemical [Testosterone]? [/INST] 1. AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. 2. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. 3. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. 4. Testosterone ameliorates streptozotocin-induced memory impairment in male rats. 5. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats. 6. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.</s>\ <s>[INST] Which sentences in the title and abstract that mention a gene or protein [STL1]? [/INST] 1. RESULTS: STZ administration and castration markedly decreased both STL1 (the short memory) and STL2 (the long memory) in passive avoidance tests. 2. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats.</s>\ <s>[INST] Which sentences mention both the entities a chemical [Testosterone] and a gene or protein [STL1]? [/INST] 1. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [Testosterone] and the gene or protein [STL1]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'] Option Descriptions:'Positive_Correlation' means that a chemical leads to higher gene expression, or higher gene expression increases sensitivity to the chemical, or a gene variant exacerbates the chemical's side effects, or a gene causes an over-response to the chemical, or there is a positive interaction between two genes in any manner. 'Negative_Correlation' indicates that a chemical leads to reduced gene expression, or higher gene expression results in decreased sensitivity or resistance to the chemical, or a gene variant offers protection against the chemical's adverse effects, or a gene contributes to resistance against the chemical, or there exists a negative interaction between two genes in any form. 'Bind' means that a chemical either connects to a gene's promoter region or a protein acts as a receptor for that chemical. 'Association' is used to describe relation that don't clearly fall under categories like positive correlation, negative correlation and bind , or when the nature of the relation lack a clear description. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Association</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [Testosterone] and a disease [memory impairment]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Testosterone ameliorates streptozotocin-induced memory impairment in male rats. - Abstract of the Paper: AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. METHODS: Adult male Wistar rats were intracerebroventricularly (icv) infused with STZ (750 ug) on d 1 and d 3, and a passive avoidance task was assessed 2 weeks after the first injection of STZ. Castration surgery was performed in another group of rats, and the passive avoidance task was assessed 4 weeks after the operation. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. RESULTS: STZ administration and castration markedly decreased both STL1 (the short memory) and STL2 (the long memory) in passive avoidance tests. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. Which sentences in the title and abstract that mention a chemical [Testosterone]? [/INST] 1. AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. 2. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. 3. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. 4. Testosterone ameliorates streptozotocin-induced memory impairment in male rats. 5. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats. 6. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [memory impairment]? [/INST] 1. AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. 2. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. 3. Testosterone ameliorates streptozotocin-induced memory impairment in male rats. 4. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.</s>\ <s>[INST] Which sentences mention both the entities a chemical [Testosterone] and a disease [memory impairment]? [/INST] 1. AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. 2. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. 3. Testosterone ameliorates streptozotocin-induced memory impairment in male rats. 4. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [Testosterone] and the disease [memory impairment]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association'] Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on. 'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease. 'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Negative_Correlation</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [Testosterone] and a chemical [streptozotocin]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Testosterone ameliorates streptozotocin-induced memory impairment in male rats. - Abstract of the Paper: AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. METHODS: Adult male Wistar rats were intracerebroventricularly (icv) infused with STZ (750 ug) on d 1 and d 3, and a passive avoidance task was assessed 2 weeks after the first injection of STZ. Castration surgery was performed in another group of rats, and the passive avoidance task was assessed 4 weeks after the operation. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. RESULTS: STZ administration and castration markedly decreased both STL1 (the short memory) and STL2 (the long memory) in passive avoidance tests. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. Which sentences in the title and abstract that mention a chemical [Testosterone]? [/INST] 1. AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. 2. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. 3. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. 4. Testosterone ameliorates streptozotocin-induced memory impairment in male rats. 5. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats. 6. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.</s>\ <s>[INST] Which sentences in the title and abstract that mention a chemical [streptozotocin]? [/INST] 1. AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. 2. METHODS: Adult male Wistar rats were intracerebroventricularly (icv) infused with STZ (750 ug) on d 1 and d 3, and a passive avoidance task was assessed 2 weeks after the first injection of STZ. 3. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. 4. RESULTS: STZ administration and castration markedly decreased both STL1 (the short memory) and STL2 (the long memory) in passive avoidance tests. 5. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. 6. Testosterone ameliorates streptozotocin-induced memory impairment in male rats. 7. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats. 8. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.</s>\ <s>[INST] Which sentences mention both the entities a chemical [Testosterone] and a chemical [streptozotocin]? [/INST] 1. AIM: To study the effects of testosterone on streptozotocin (STZ)-induced memory impairment in male rats. 2. Testosterone (1 mg.kg(-1).d(-1), sc), the androgen receptor antagonist flutamide (10 mg.kg(-1).d(-1), ip), the estrogen receptor antagonist tamoxifen (1 mg.kg(-1).d(-1), ip) or the aromatase inhibitor letrozole (4 mg.kg(-1).d(-1), ip) were administered for 6 d after the first injection of STZ. 3. CONCLUSION: Testosterone administration ameliorates STZ- and castration-induced memory impairment in male Wistar rats. 4. Testosterone ameliorates streptozotocin-induced memory impairment in male rats. 5. Testosterone replacement almost restored the STL1 and STL2 in castrated rats, and significantly prolonged the STL1 and STL2 in STZ-treated rats. 6. Administration of flutamide, letrozole or tamoxifen significantly impaired the memory in intact rats, and significantly attenuated the testosterone replacement in improving STZ- and castration-induced memory impairment.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [Testosterone] and the chemical [streptozotocin]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Drug_Interaction', 'Cotreatment', 'Conversion', 'Comparison', 'Association'] Option Descriptions:'Positive_Correlation' indicates that Chemical A increases the effectiveness of Chemical B. This includes making Chemical B more sensitive, enhancing its ability to treat or induce a disease, or boosting its role in gene activation. 'Negative_Correlation' means that Chemical A reduces the effectiveness and impact of Chemical B. This includes decreasing Chemical B's sensitivity, reducing its ability to treat or induce a disease, diminishing its side effects, and lowering the gene activation it causes. 'Drug_Interaction' is when two different drugs or chemicals affect each other's action in the body, happening when they are used at the same time. 'Cotreatment' means that two different drugs or chemicals are used in combination therapy. 'Conversion' means that one chemical changes into another chemical. 'Comparison' means that two different drugs or chemicals have some differences and similarities in their effects. 'Association' refers to the relation between two chemicals that do not fit into any specific, predefined categories of relations. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Negative_Correlation</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [pegylated interferon] and a disease [hepatitis C virus infection]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin. - Abstract of the Paper: A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir. The patient also received simvastatin. One month after starting the antiviral therapy, the patient was admitted to the hospital because he developed rhabdomyolysis. At admission simvastatin and all antiviral drugs were discontinued because toxicity due to a drug-drug interaction was suspected. The creatine kinase peaked at 62,246 IU/L and the patient was treated with intravenous normal saline. The patient's renal function remained unaffected. Fourteen days after hospitalization, creatine kinase level had returned to 230 IU/L and the patient was discharged. Telaprevir was considered the probable causative agent of an interaction with simvastatin according to the Drug Interaction Probability Scale. The interaction is due to inhibition of CYP3A4-mediated simvastatin clearance. Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood. In conclusion, with this case we illustrate that telaprevir as well as statins are susceptible to clinical relevant drug-drug interactions. Which sentences in the title and abstract that mention a chemical [pegylated interferon]? [/INST] 1. A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [hepatitis C virus infection]? [/INST] 1. A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir. 2. Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin.</s>\ <s>[INST] Which sentences mention both the entities a chemical [pegylated interferon] and a disease [hepatitis C virus infection]? [/INST] 1. A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [pegylated interferon] and the disease [hepatitis C virus infection]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association'] Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on. 'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease. 'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Negative_Correlation</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [pegylated interferon] and a chemical [telaprevir]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin. - Abstract of the Paper: A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir. The patient also received simvastatin. One month after starting the antiviral therapy, the patient was admitted to the hospital because he developed rhabdomyolysis. At admission simvastatin and all antiviral drugs were discontinued because toxicity due to a drug-drug interaction was suspected. The creatine kinase peaked at 62,246 IU/L and the patient was treated with intravenous normal saline. The patient's renal function remained unaffected. Fourteen days after hospitalization, creatine kinase level had returned to 230 IU/L and the patient was discharged. Telaprevir was considered the probable causative agent of an interaction with simvastatin according to the Drug Interaction Probability Scale. The interaction is due to inhibition of CYP3A4-mediated simvastatin clearance. Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood. In conclusion, with this case we illustrate that telaprevir as well as statins are susceptible to clinical relevant drug-drug interactions. Which sentences in the title and abstract that mention a chemical [pegylated interferon]? [/INST] 1. A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir.</s>\ <s>[INST] Which sentences in the title and abstract that mention a chemical [telaprevir]? [/INST] 1. In conclusion, with this case we illustrate that telaprevir as well as statins are susceptible to clinical relevant drug-drug interactions. 2. A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir. 3. Telaprevir was considered the probable causative agent of an interaction with simvastatin according to the Drug Interaction Probability Scale. 4. Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin.</s>\ <s>[INST] Which sentences mention both the entities a chemical [pegylated interferon] and a chemical [telaprevir]? [/INST] 1. A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [pegylated interferon] and the chemical [telaprevir]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Drug_Interaction', 'Cotreatment', 'Conversion', 'Comparison', 'Association'] Option Descriptions:'Positive_Correlation' indicates that Chemical A increases the effectiveness of Chemical B. This includes making Chemical B more sensitive, enhancing its ability to treat or induce a disease, or boosting its role in gene activation. 'Negative_Correlation' means that Chemical A reduces the effectiveness and impact of Chemical B. This includes decreasing Chemical B's sensitivity, reducing its ability to treat or induce a disease, diminishing its side effects, and lowering the gene activation it causes. 'Drug_Interaction' is when two different drugs or chemicals affect each other's action in the body, happening when they are used at the same time. 'Cotreatment' means that two different drugs or chemicals are used in combination therapy. 'Conversion' means that one chemical changes into another chemical. 'Comparison' means that two different drugs or chemicals have some differences and similarities in their effects. 'Association' refers to the relation between two chemicals that do not fit into any specific, predefined categories of relations. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Cotreatment</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [ribavirin] and a chemical [pegylated interferon]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin. - Abstract of the Paper: A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir. The patient also received simvastatin. One month after starting the antiviral therapy, the patient was admitted to the hospital because he developed rhabdomyolysis. At admission simvastatin and all antiviral drugs were discontinued because toxicity due to a drug-drug interaction was suspected. The creatine kinase peaked at 62,246 IU/L and the patient was treated with intravenous normal saline. The patient's renal function remained unaffected. Fourteen days after hospitalization, creatine kinase level had returned to 230 IU/L and the patient was discharged. Telaprevir was considered the probable causative agent of an interaction with simvastatin according to the Drug Interaction Probability Scale. The interaction is due to inhibition of CYP3A4-mediated simvastatin clearance. Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood. In conclusion, with this case we illustrate that telaprevir as well as statins are susceptible to clinical relevant drug-drug interactions. Which sentences in the title and abstract that mention a chemical [ribavirin]? [/INST] 1. A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir.</s>\ <s>[INST] Which sentences in the title and abstract that mention a chemical [pegylated interferon]? [/INST] 1. A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir.</s>\ <s>[INST] Which sentences mention both the entities a chemical [ribavirin] and a chemical [pegylated interferon]? [/INST] 1. A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [ribavirin] and the chemical [pegylated interferon]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Drug_Interaction', 'Cotreatment', 'Conversion', 'Comparison', 'Association'] Option Descriptions:'Positive_Correlation' indicates that Chemical A increases the effectiveness of Chemical B. This includes making Chemical B more sensitive, enhancing its ability to treat or induce a disease, or boosting its role in gene activation. 'Negative_Correlation' means that Chemical A reduces the effectiveness and impact of Chemical B. This includes decreasing Chemical B's sensitivity, reducing its ability to treat or induce a disease, diminishing its side effects, and lowering the gene activation it causes. 'Drug_Interaction' is when two different drugs or chemicals affect each other's action in the body, happening when they are used at the same time. 'Cotreatment' means that two different drugs or chemicals are used in combination therapy. 'Conversion' means that one chemical changes into another chemical. 'Comparison' means that two different drugs or chemicals have some differences and similarities in their effects. 'Association' refers to the relation between two chemicals that do not fit into any specific, predefined categories of relations. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Cotreatment</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [ribavirin] and a disease [hepatitis C virus infection]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin. - Abstract of the Paper: A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir. The patient also received simvastatin. One month after starting the antiviral therapy, the patient was admitted to the hospital because he developed rhabdomyolysis. At admission simvastatin and all antiviral drugs were discontinued because toxicity due to a drug-drug interaction was suspected. The creatine kinase peaked at 62,246 IU/L and the patient was treated with intravenous normal saline. The patient's renal function remained unaffected. Fourteen days after hospitalization, creatine kinase level had returned to 230 IU/L and the patient was discharged. Telaprevir was considered the probable causative agent of an interaction with simvastatin according to the Drug Interaction Probability Scale. The interaction is due to inhibition of CYP3A4-mediated simvastatin clearance. Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood. In conclusion, with this case we illustrate that telaprevir as well as statins are susceptible to clinical relevant drug-drug interactions. Which sentences in the title and abstract that mention a chemical [ribavirin]? [/INST] 1. A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [hepatitis C virus infection]? [/INST] 1. A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir. 2. Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin.</s>\ <s>[INST] Which sentences mention both the entities a chemical [ribavirin] and a disease [hepatitis C virus infection]? [/INST] 1. A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [ribavirin] and the disease [hepatitis C virus infection]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association'] Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on. 'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease. 'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Negative_Correlation</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [ribavirin] and a chemical [telaprevir]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin. - Abstract of the Paper: A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir. The patient also received simvastatin. One month after starting the antiviral therapy, the patient was admitted to the hospital because he developed rhabdomyolysis. At admission simvastatin and all antiviral drugs were discontinued because toxicity due to a drug-drug interaction was suspected. The creatine kinase peaked at 62,246 IU/L and the patient was treated with intravenous normal saline. The patient's renal function remained unaffected. Fourteen days after hospitalization, creatine kinase level had returned to 230 IU/L and the patient was discharged. Telaprevir was considered the probable causative agent of an interaction with simvastatin according to the Drug Interaction Probability Scale. The interaction is due to inhibition of CYP3A4-mediated simvastatin clearance. Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood. In conclusion, with this case we illustrate that telaprevir as well as statins are susceptible to clinical relevant drug-drug interactions. Which sentences in the title and abstract that mention a chemical [ribavirin]? [/INST] 1. A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir.</s>\ <s>[INST] Which sentences in the title and abstract that mention a chemical [telaprevir]? [/INST] 1. In conclusion, with this case we illustrate that telaprevir as well as statins are susceptible to clinical relevant drug-drug interactions. 2. A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir. 3. Telaprevir was considered the probable causative agent of an interaction with simvastatin according to the Drug Interaction Probability Scale. 4. Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin.</s>\ <s>[INST] Which sentences mention both the entities a chemical [ribavirin] and a chemical [telaprevir]? [/INST] 1. A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [ribavirin] and the chemical [telaprevir]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Drug_Interaction', 'Cotreatment', 'Conversion', 'Comparison', 'Association'] Option Descriptions:'Positive_Correlation' indicates that Chemical A increases the effectiveness of Chemical B. This includes making Chemical B more sensitive, enhancing its ability to treat or induce a disease, or boosting its role in gene activation. 'Negative_Correlation' means that Chemical A reduces the effectiveness and impact of Chemical B. This includes decreasing Chemical B's sensitivity, reducing its ability to treat or induce a disease, diminishing its side effects, and lowering the gene activation it causes. 'Drug_Interaction' is when two different drugs or chemicals affect each other's action in the body, happening when they are used at the same time. 'Cotreatment' means that two different drugs or chemicals are used in combination therapy. 'Conversion' means that one chemical changes into another chemical. 'Comparison' means that two different drugs or chemicals have some differences and similarities in their effects. 'Association' refers to the relation between two chemicals that do not fit into any specific, predefined categories of relations. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Cotreatment</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a gene or protein [CYP3A4] and a chemical [simvastatin]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin. - Abstract of the Paper: A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir. The patient also received simvastatin. One month after starting the antiviral therapy, the patient was admitted to the hospital because he developed rhabdomyolysis. At admission simvastatin and all antiviral drugs were discontinued because toxicity due to a drug-drug interaction was suspected. The creatine kinase peaked at 62,246 IU/L and the patient was treated with intravenous normal saline. The patient's renal function remained unaffected. Fourteen days after hospitalization, creatine kinase level had returned to 230 IU/L and the patient was discharged. Telaprevir was considered the probable causative agent of an interaction with simvastatin according to the Drug Interaction Probability Scale. The interaction is due to inhibition of CYP3A4-mediated simvastatin clearance. Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood. In conclusion, with this case we illustrate that telaprevir as well as statins are susceptible to clinical relevant drug-drug interactions. Which sentences in the title and abstract that mention a gene or protein [CYP3A4]? [/INST] 1. The interaction is due to inhibition of CYP3A4-mediated simvastatin clearance.</s>\ <s>[INST] Which sentences in the title and abstract that mention a chemical [simvastatin]? [/INST] 1. Telaprevir was considered the probable causative agent of an interaction with simvastatin according to the Drug Interaction Probability Scale. 2. Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin. 3. The interaction is due to inhibition of CYP3A4-mediated simvastatin clearance. 4. At admission simvastatin and all antiviral drugs were discontinued because toxicity due to a drug-drug interaction was suspected. 5. In conclusion, with this case we illustrate that telaprevir as well as statins are susceptible to clinical relevant drug-drug interactions. 6. Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood. 7. The patient also received simvastatin.</s>\ <s>[INST] Which sentences mention both the entities a gene or protein [CYP3A4] and a chemical [simvastatin]? [/INST] 1. The interaction is due to inhibition of CYP3A4-mediated simvastatin clearance.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the gene or protein [CYP3A4] and the chemical [simvastatin]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Bind', 'Association'] Option Descriptions:'Positive_Correlation' means that a chemical leads to higher gene expression, or higher gene expression increases sensitivity to the chemical, or a gene variant exacerbates the chemical's side effects, or a gene causes an over-response to the chemical, or there is a positive interaction between two genes in any manner. 'Negative_Correlation' indicates that a chemical leads to reduced gene expression, or higher gene expression results in decreased sensitivity or resistance to the chemical, or a gene variant offers protection against the chemical's adverse effects, or a gene contributes to resistance against the chemical, or there exists a negative interaction between two genes in any form. 'Bind' means that a chemical either connects to a gene's promoter region or a protein acts as a receptor for that chemical. 'Association' is used to describe relation that don't clearly fall under categories like positive correlation, negative correlation and bind , or when the nature of the relation lack a clear description. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Association</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [statin] and a disease [muscle toxicity]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin. - Abstract of the Paper: A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir. The patient also received simvastatin. One month after starting the antiviral therapy, the patient was admitted to the hospital because he developed rhabdomyolysis. At admission simvastatin and all antiviral drugs were discontinued because toxicity due to a drug-drug interaction was suspected. The creatine kinase peaked at 62,246 IU/L and the patient was treated with intravenous normal saline. The patient's renal function remained unaffected. Fourteen days after hospitalization, creatine kinase level had returned to 230 IU/L and the patient was discharged. Telaprevir was considered the probable causative agent of an interaction with simvastatin according to the Drug Interaction Probability Scale. The interaction is due to inhibition of CYP3A4-mediated simvastatin clearance. Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood. In conclusion, with this case we illustrate that telaprevir as well as statins are susceptible to clinical relevant drug-drug interactions. Which sentences in the title and abstract that mention a chemical [statin]? [/INST] 1. Telaprevir was considered the probable causative agent of an interaction with simvastatin according to the Drug Interaction Probability Scale. 2. Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin. 3. The interaction is due to inhibition of CYP3A4-mediated simvastatin clearance. 4. At admission simvastatin and all antiviral drugs were discontinued because toxicity due to a drug-drug interaction was suspected. 5. In conclusion, with this case we illustrate that telaprevir as well as statins are susceptible to clinical relevant drug-drug interactions. 6. Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood. 7. The patient also received simvastatin.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [muscle toxicity]? [/INST] 1. Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood.</s>\ <s>[INST] Which sentences mention both the entities a chemical [statin] and a disease [muscle toxicity]? [/INST] 1. Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [statin] and the disease [muscle toxicity]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association'] Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on. 'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease. 'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Positive_Correlation</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [simvastatin] and a chemical [antiviral drugs]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin. - Abstract of the Paper: A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir. The patient also received simvastatin. One month after starting the antiviral therapy, the patient was admitted to the hospital because he developed rhabdomyolysis. At admission simvastatin and all antiviral drugs were discontinued because toxicity due to a drug-drug interaction was suspected. The creatine kinase peaked at 62,246 IU/L and the patient was treated with intravenous normal saline. The patient's renal function remained unaffected. Fourteen days after hospitalization, creatine kinase level had returned to 230 IU/L and the patient was discharged. Telaprevir was considered the probable causative agent of an interaction with simvastatin according to the Drug Interaction Probability Scale. The interaction is due to inhibition of CYP3A4-mediated simvastatin clearance. Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood. In conclusion, with this case we illustrate that telaprevir as well as statins are susceptible to clinical relevant drug-drug interactions. Which sentences in the title and abstract that mention a chemical [simvastatin]? [/INST] 1. Telaprevir was considered the probable causative agent of an interaction with simvastatin according to the Drug Interaction Probability Scale. 2. Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin. 3. The interaction is due to inhibition of CYP3A4-mediated simvastatin clearance. 4. At admission simvastatin and all antiviral drugs were discontinued because toxicity due to a drug-drug interaction was suspected. 5. In conclusion, with this case we illustrate that telaprevir as well as statins are susceptible to clinical relevant drug-drug interactions. 6. Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood. 7. The patient also received simvastatin.</s>\ <s>[INST] Which sentences in the title and abstract that mention a chemical [antiviral drugs]? [/INST] 1. At admission simvastatin and all antiviral drugs were discontinued because toxicity due to a drug-drug interaction was suspected.</s>\ <s>[INST] Which sentences mention both the entities a chemical [simvastatin] and a chemical [antiviral drugs]? [/INST] 1. At admission simvastatin and all antiviral drugs were discontinued because toxicity due to a drug-drug interaction was suspected.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [simvastatin] and the chemical [antiviral drugs]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Drug_Interaction', 'Cotreatment', 'Conversion', 'Comparison', 'Association'] Option Descriptions:'Positive_Correlation' indicates that Chemical A increases the effectiveness of Chemical B. This includes making Chemical B more sensitive, enhancing its ability to treat or induce a disease, or boosting its role in gene activation. 'Negative_Correlation' means that Chemical A reduces the effectiveness and impact of Chemical B. This includes decreasing Chemical B's sensitivity, reducing its ability to treat or induce a disease, diminishing its side effects, and lowering the gene activation it causes. 'Drug_Interaction' is when two different drugs or chemicals affect each other's action in the body, happening when they are used at the same time. 'Cotreatment' means that two different drugs or chemicals are used in combination therapy. 'Conversion' means that one chemical changes into another chemical. 'Comparison' means that two different drugs or chemicals have some differences and similarities in their effects. 'Association' refers to the relation between two chemicals that do not fit into any specific, predefined categories of relations. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Drug_Interaction</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [simvastatin] and a disease [hepatitis C virus infection]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin. - Abstract of the Paper: A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir. The patient also received simvastatin. One month after starting the antiviral therapy, the patient was admitted to the hospital because he developed rhabdomyolysis. At admission simvastatin and all antiviral drugs were discontinued because toxicity due to a drug-drug interaction was suspected. The creatine kinase peaked at 62,246 IU/L and the patient was treated with intravenous normal saline. The patient's renal function remained unaffected. Fourteen days after hospitalization, creatine kinase level had returned to 230 IU/L and the patient was discharged. Telaprevir was considered the probable causative agent of an interaction with simvastatin according to the Drug Interaction Probability Scale. The interaction is due to inhibition of CYP3A4-mediated simvastatin clearance. Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood. In conclusion, with this case we illustrate that telaprevir as well as statins are susceptible to clinical relevant drug-drug interactions. Which sentences in the title and abstract that mention a chemical [simvastatin]? [/INST] 1. Telaprevir was considered the probable causative agent of an interaction with simvastatin according to the Drug Interaction Probability Scale. 2. Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin. 3. The interaction is due to inhibition of CYP3A4-mediated simvastatin clearance. 4. At admission simvastatin and all antiviral drugs were discontinued because toxicity due to a drug-drug interaction was suspected. 5. In conclusion, with this case we illustrate that telaprevir as well as statins are susceptible to clinical relevant drug-drug interactions. 6. Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood. 7. The patient also received simvastatin.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [hepatitis C virus infection]? [/INST] 1. A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir. 2. Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin.</s>\ <s>[INST] Which sentences mention both the entities a chemical [simvastatin] and a disease [hepatitis C virus infection]? [/INST] 1. Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [simvastatin] and the disease [hepatitis C virus infection]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association'] Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on. 'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease. 'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Negative_Correlation</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [simvastatin] and a disease [rhabdomyolysis]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin. - Abstract of the Paper: A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir. The patient also received simvastatin. One month after starting the antiviral therapy, the patient was admitted to the hospital because he developed rhabdomyolysis. At admission simvastatin and all antiviral drugs were discontinued because toxicity due to a drug-drug interaction was suspected. The creatine kinase peaked at 62,246 IU/L and the patient was treated with intravenous normal saline. The patient's renal function remained unaffected. Fourteen days after hospitalization, creatine kinase level had returned to 230 IU/L and the patient was discharged. Telaprevir was considered the probable causative agent of an interaction with simvastatin according to the Drug Interaction Probability Scale. The interaction is due to inhibition of CYP3A4-mediated simvastatin clearance. Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood. In conclusion, with this case we illustrate that telaprevir as well as statins are susceptible to clinical relevant drug-drug interactions. Which sentences in the title and abstract that mention a chemical [simvastatin]? [/INST] 1. Telaprevir was considered the probable causative agent of an interaction with simvastatin according to the Drug Interaction Probability Scale. 2. Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin. 3. The interaction is due to inhibition of CYP3A4-mediated simvastatin clearance. 4. At admission simvastatin and all antiviral drugs were discontinued because toxicity due to a drug-drug interaction was suspected. 5. In conclusion, with this case we illustrate that telaprevir as well as statins are susceptible to clinical relevant drug-drug interactions. 6. Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood. 7. The patient also received simvastatin.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [rhabdomyolysis]? [/INST] 1. One month after starting the antiviral therapy, the patient was admitted to the hospital because he developed rhabdomyolysis. 2. Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin.</s>\ <s>[INST] Which sentences mention both the entities a chemical [simvastatin] and a disease [rhabdomyolysis]? [/INST] 1. Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [simvastatin] and the disease [rhabdomyolysis]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association'] Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on. 'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease. 'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Positive_Correlation</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [telaprevir] and a disease [hepatitis C virus infected]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin. - Abstract of the Paper: A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir. The patient also received simvastatin. One month after starting the antiviral therapy, the patient was admitted to the hospital because he developed rhabdomyolysis. At admission simvastatin and all antiviral drugs were discontinued because toxicity due to a drug-drug interaction was suspected. The creatine kinase peaked at 62,246 IU/L and the patient was treated with intravenous normal saline. The patient's renal function remained unaffected. Fourteen days after hospitalization, creatine kinase level had returned to 230 IU/L and the patient was discharged. Telaprevir was considered the probable causative agent of an interaction with simvastatin according to the Drug Interaction Probability Scale. The interaction is due to inhibition of CYP3A4-mediated simvastatin clearance. Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood. In conclusion, with this case we illustrate that telaprevir as well as statins are susceptible to clinical relevant drug-drug interactions. Which sentences in the title and abstract that mention a chemical [telaprevir]? [/INST] 1. In conclusion, with this case we illustrate that telaprevir as well as statins are susceptible to clinical relevant drug-drug interactions. 2. A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir. 3. Telaprevir was considered the probable causative agent of an interaction with simvastatin according to the Drug Interaction Probability Scale. 4. Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [hepatitis C virus infected]? [/INST] 1. A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir. 2. Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin.</s>\ <s>[INST] Which sentences mention both the entities a chemical [telaprevir] and a disease [hepatitis C virus infected]? [/INST] 1. A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir. 2. Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [telaprevir] and the disease [hepatitis C virus infected]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association'] Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on. 'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease. 'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Negative_Correlation</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [telaprevir] and a chemical [simvastatin]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin. - Abstract of the Paper: A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir. The patient also received simvastatin. One month after starting the antiviral therapy, the patient was admitted to the hospital because he developed rhabdomyolysis. At admission simvastatin and all antiviral drugs were discontinued because toxicity due to a drug-drug interaction was suspected. The creatine kinase peaked at 62,246 IU/L and the patient was treated with intravenous normal saline. The patient's renal function remained unaffected. Fourteen days after hospitalization, creatine kinase level had returned to 230 IU/L and the patient was discharged. Telaprevir was considered the probable causative agent of an interaction with simvastatin according to the Drug Interaction Probability Scale. The interaction is due to inhibition of CYP3A4-mediated simvastatin clearance. Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood. In conclusion, with this case we illustrate that telaprevir as well as statins are susceptible to clinical relevant drug-drug interactions. Which sentences in the title and abstract that mention a chemical [telaprevir]? [/INST] 1. In conclusion, with this case we illustrate that telaprevir as well as statins are susceptible to clinical relevant drug-drug interactions. 2. A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir. 3. Telaprevir was considered the probable causative agent of an interaction with simvastatin according to the Drug Interaction Probability Scale. 4. Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin.</s>\ <s>[INST] Which sentences in the title and abstract that mention a chemical [simvastatin]? [/INST] 1. Telaprevir was considered the probable causative agent of an interaction with simvastatin according to the Drug Interaction Probability Scale. 2. Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin. 3. The interaction is due to inhibition of CYP3A4-mediated simvastatin clearance. 4. At admission simvastatin and all antiviral drugs were discontinued because toxicity due to a drug-drug interaction was suspected. 5. In conclusion, with this case we illustrate that telaprevir as well as statins are susceptible to clinical relevant drug-drug interactions. 6. Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood. 7. The patient also received simvastatin.</s>\ <s>[INST] Which sentences mention both the entities a chemical [telaprevir] and a chemical [simvastatin]? [/INST] 1. In conclusion, with this case we illustrate that telaprevir as well as statins are susceptible to clinical relevant drug-drug interactions. 2. Telaprevir was considered the probable causative agent of an interaction with simvastatin according to the Drug Interaction Probability Scale. 3. Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [telaprevir] and the chemical [simvastatin]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Drug_Interaction', 'Cotreatment', 'Conversion', 'Comparison', 'Association'] Option Descriptions:'Positive_Correlation' indicates that Chemical A increases the effectiveness of Chemical B. This includes making Chemical B more sensitive, enhancing its ability to treat or induce a disease, or boosting its role in gene activation. 'Negative_Correlation' means that Chemical A reduces the effectiveness and impact of Chemical B. This includes decreasing Chemical B's sensitivity, reducing its ability to treat or induce a disease, diminishing its side effects, and lowering the gene activation it causes. 'Drug_Interaction' is when two different drugs or chemicals affect each other's action in the body, happening when they are used at the same time. 'Cotreatment' means that two different drugs or chemicals are used in combination therapy. 'Conversion' means that one chemical changes into another chemical. 'Comparison' means that two different drugs or chemicals have some differences and similarities in their effects. 'Association' refers to the relation between two chemicals that do not fit into any specific, predefined categories of relations. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Drug_Interaction</s>
<s>[INST] <<SYS>> Your task is to analyze the provided abstract of a medical article to answer questions about the relationship between two entities: a chemical [telaprevir] and a disease [Rhabdomyolysis]. Pay close attention to how these entities are discussed in the context of the article. <</SYS>> - Title of the Paper: Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin. - Abstract of the Paper: A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir. The patient also received simvastatin. One month after starting the antiviral therapy, the patient was admitted to the hospital because he developed rhabdomyolysis. At admission simvastatin and all antiviral drugs were discontinued because toxicity due to a drug-drug interaction was suspected. The creatine kinase peaked at 62,246 IU/L and the patient was treated with intravenous normal saline. The patient's renal function remained unaffected. Fourteen days after hospitalization, creatine kinase level had returned to 230 IU/L and the patient was discharged. Telaprevir was considered the probable causative agent of an interaction with simvastatin according to the Drug Interaction Probability Scale. The interaction is due to inhibition of CYP3A4-mediated simvastatin clearance. Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood. In conclusion, with this case we illustrate that telaprevir as well as statins are susceptible to clinical relevant drug-drug interactions. Which sentences in the title and abstract that mention a chemical [telaprevir]? [/INST] 1. In conclusion, with this case we illustrate that telaprevir as well as statins are susceptible to clinical relevant drug-drug interactions. 2. A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir. 3. Telaprevir was considered the probable causative agent of an interaction with simvastatin according to the Drug Interaction Probability Scale. 4. Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin.</s>\ <s>[INST] Which sentences in the title and abstract that mention a disease [Rhabdomyolysis]? [/INST] 1. One month after starting the antiviral therapy, the patient was admitted to the hospital because he developed rhabdomyolysis. 2. Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin.</s>\ <s>[INST] Which sentences mention both the entities a chemical [telaprevir] and a disease [Rhabdomyolysis]? [/INST] 1. Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin.</s>\ <s>[INST] Based on your previous answers and articles,analyze the relationship between the chemical [telaprevir] and the disease [Rhabdomyolysis]. Choose the most accurate description of their relationship from the following options: ['Positive_Correlation', 'Negative_Correlation', 'Association'] Option Descriptions:'Positive_Correlation' means there's a direct link between a chemical and a disease. This includes cases where the chemical causes the disease, higher doses of the chemical increase disease risk, the disease raises the chemical's level in the body, there's a direct positive link between the chemical's level and disease risk, or exposure to the chemical during development affects disease susceptibility later on. 'Negative_Correlation' means there's an inverse relation between a chemical substance and a disease. This includes situations where the chemical or drug is used to treat the disease, the presence of the disease lowers the level of the chemical in the body, or the chemical or drug reduces the likelihood of the disease. 'Association' is used to describe relation that don't clearly fall under categories like positive or negative correlation, or when the nature of the relation lack a clear description. Select the most appropriate option to describe their relationship, based on the abstract. No additional explanation is required. [/INST] Positive_Correlation</s>

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